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New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer.

Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments f

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… Vitamin D, gut microbiota, and radiation-related resistance: A love-hate triangle J. Exp. Clin. Cancer Res. 2019 38 493 10.1186/s13046-019-1499-y 31843023 PMC6915920 141. Uribe-Herranz M. Rafail S. Beghi S. Gil-de-Gómez L. Verginadis I. Bittinger K. Pustylnikov S. Pierini S. Perales-Linares R. …

Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.

Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic alterations in cell-free DNA in blood are being adopted for multi-cancer early detection in human medicine and are now available for veterinary use. The CANcer Detection in Dogs (CANDiD) study is an international, multi-center clinical study designed to validate the performance of a novel multi-cancer early detection "liquid biopsy" test developed for noninvasive detection and characterization of cancer in dogs using n

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… Acknowledgments The authors thank all the dogs in the CANDiD study and the humans who love and care for them. Without their support and contributions, this study would not have been possible. …

Biosimilars in Oncology: Latest Trends and Regulatory Status.

Biologic-based medicines are used to treat a variety of diseases and account for around one-quarter of the worldwide pharmaceutical market. The use of biologic medications among cancer patients has resulted in substantial advancements in cancer treatment and supportive care. Biosimilar medications (or biosimilars) are very similar to the reference biologic drugs, although they are not identical. As patent protection for some of the most extensively used biologics begins to expire, biosimilars have the potential to enhance access and provide lower-cost options for cancer treatment. Initially, r

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… Acknowledgments The authors are thankful to the management of Lovely Professional University for providing the necessary facilities for writing this review. Author Contributions Conceptualization, S.K.S., S.G. …

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability.

BackgroundCancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective.MethodsHere, we performed an analysis of 42 MM samples from 21 patients by using enhanced reduced representation bisulfite sequencing (eRRBS). We combined several metrics of epigenetic heterogeneity to analyze DNA methylation heterogeneity in MM patients.ResultsWe show that MM is characterized by the continuous accumulation of stochastic methylation at the promoters of development-related

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… Broad Institute. 2018. 40 Anders S Pyl PT Huber W HTSeq–a python framework to work with high-throughput sequencing data Bioinformatics 2014 31 2 166 9 10.1093/bioinformatics/btu638 25260700 PMC4287950 41 Love MI, Huber W, Anders S. …

Non-coding RNA/microRNA-modulatory dietary factors and natural products for improved cancer therapy and prevention: Alkaloids, organosulfur compounds, aliphatic carboxylic acids and water-soluble vitamins.

Non-coding small RNA molecules, the microRNAs (miRNAs), contribute decisively to the epigenetic regulation processes in cancer cells. Problematic pathogenic properties of cancer cells and the response of cancers towards anticancer drugs are highly influenced by miRNAs. Both increased drug activity and formation of tumor resistance are regulated by miRNAs. Further to this, the survival and proliferation of cancer cells and the formation of metastases is based on the modulated expression of certain miRNAs. In particular, drug-resistant cancer stem-like cells (CSCs) depend on the presence and abs

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… Love R.E. Zhai Y. Giordano T.J. Qin Z.S. Moore B.B. MacDougald O.A. Cho K.R. Fearon E.R. p53-mediated activation of miRNA34 candidate tumor-suppressor genes Curr. Biol. 17 2007 1298 1307 17656095 10.1016/j.cub.2007.06.068 51 Zhang J. Guo H. Qian G. Ge S. Ji H. Hu X. Chen W. …

A Standardized Method for Vertical Sleeve Gastrectomy Bariatric Surgery Investigations in Cancer.

Obesity is a global epidemic that has affected the lives of over 14% of adults worldwide and over a third of Americans. Obesity is associated with the increased risk of thirteen obesity-associated cancers and poor cancer outcomes. Bariatric surgery is the most effective method of sustained weight loss and has been steadily increasing in clinical use over the past 4 decades. Importantly, bariatric surgery is established to decrease cancer risk. Vertical sleeve gastrectomy (VSG) is currently the most common bariatric surgery procedure. To evaluate underlying mechanisms of bariatric associated ca

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… Lovely M. C. Counts B. R. . ( 2022 ). Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery . Elife 11 . doi: 10.7554/eLife.79143 , PMID: 35775614 PMC9342954 Sipe L. M. Chaib M. Pingili A. K. Pierre J. F. Makowski L. ( 2020 ). …

[Консенсус экспертов по комплексному управлению моноклональной гамма-патологией неопределенного значения и склеротическим множественным миеломой в Китае (2025)]

Моноклональная гамма-патология неопределенного значения (MGUS) является наиболее распространенным типом патологии плазматических клеток, характеризующейся клоновой пролиферацией плазматических клеток в костном мозге, легким увеличением моноклонального белка (M-белка) и отсутствием органного повреждения. СмOLDERинг-многофазная миелома (SMM) — это заболевание плазматических клеток, которое находится между MGUS и активной миеломой (AMM), характеризующееся повышенным уровнем M-белка в плазме и увеличенной инфильтрацией плазматических клеток в костном мозге, но без типичных клинических проявлений.

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… Rögnvaldsson S, Love TJ, Thorsteinsdottir S, et al. …

Oxidative Stress Linking Obesity and Cancer: Is Obesity a 'Radical Trigger' to Cancer?

Obesity is on the rise worldwide, and consequently, obesity-related non-communicable diseases are as well. Nutritional overload induces metabolic adaptations in an attempt to restore the disturbed balance, and the byproducts of the mechanisms at hand include an increased generation of reactive species. Obesity-related oxidative stress causes damage to vulnerable systems and ultimately contributes to neoplastic transformation. Dysfunctional obese adipose tissue releases cytokines and induces changes in the cell microenvironment, promoting cell survival and progression of the transformed cancer

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… Apart from cancer being a preventable, possibly deadly, outcome of obesity, affecting the quality of life for both patients and their loved ones, not insignificant is the economic burden obesity brings to society. …

What nature has to offer: Opportunities for immuno-oncology.

Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large body of literature has recognized natural compounds as epigenetic modulators for their immunomodulatory effects and anticancer potential. Unifying our understanding of the role of these biologica

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… L. was an Infinite Love for Kids Fighting Cancer Independent Investigator and Bear Necessities Pediatric Cancer Foundation Independent Investigator (No: 19IN31). Author contributions D.-C. W. and X.-G. L. conceptualization; R. K., C.-H. L., M. H. and X.-G. L. writing original draft; R. K., D.-C. …

Micro and nanotechnologies: The little formulations that could.

The first publication of micro- and nanotechnology in medicine was in 1798 with the use of the Cowpox virus by Edward Jenner as an attenuated vaccine against Smallpox. Since then, there has been an explosion of micro- and nanotechnologies for medical applications. The breadth of these micro- and nanotechnologies is discussed in this piece, presenting the date of their first report and their latest progression (e.g., clinical trials, FDA approval). This includes successes such as the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines from Pfizer, Moderna, and Janssen (

The Extent of Engagement With Telehealth Approaches by Patients With Advanced Cancer: Systematic Review.

BackgroundTelehealth approaches are increasingly being used to support patients with advanced diseases, including cancer. Evidence suggests that telehealth is acceptable to most patients; however, the extent of and factors influencing patient engagement remain unclear.ObjectiveThe aim of this review is to characterize the extent of engagement with telehealth interventions in patients with advanced, incurable cancer reported in the international literature.MethodsThis systematic review was registered with PROSPERO (International Prospective Register of Systematic Reviews) and is reported in lin

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… Weaver A, Love SB, Larsen M, Shanyinde M, Waters R, Grainger L, Shearwood V, Brooks C, Gibson O, Young AM, Tarassenko L. A pilot study: dose adaptation of capecitabine using mobile phone toxicity monitoring - supporting patients in their homes. …

Sarcopenia in Older Adults with Hematologic Malignancies: A Comprehensive Review of Epidemiology, Prognosis, and Interventions.

Hematologic malignancies, including leukemias, lymphomas, and multiple myeloma, are diseases of older adults (age ≥ 60 years). Treatment decisions in older adults with cancer are heavily influenced by patient fitness: the ability of an individual patient to tolerate the off-target effects of anti-cancer therapy. Sarcopenia, defined as low muscle mass and strength, is increasingly recognized as an important marker of fitness. Furthermore, sarcopenia is known to be modifiable with nutrition and exercise interventions in older adults without cancer, but such evidence is limited for patients with

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… Correa-De-Araujo R., Addison O., Miljkovic I., Goodpaster B.H., Bergman B.C., Clark R.V., Elena J.W., Esser K.A., Ferrucci L., Harris-Love M.O., et al. Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging. Front. …

Упражнения для пациентов миэломы с костным заболеванием: аналитическая оценка.

ЦЕЛЬ: Упражнения считаются безопасными для пациентов с миеломой, но неясными являются данные, характерные для множественных заболеваний костей миэломы (ММБД). Обзор преследует следующие цели: 1) Проанализировать литературу о занятиях физкультурой для пациентов миэломы, в том числе для пациентов с MMBD 2) Картографическая отчетность о характеристиках безопасности, оценки и вмешательства 3) Определение связанных с костями результатов измерения изменений в MMBD 4) Выделять приоритеты исследований. МЕТОД: В соответствии с программой Института Джоанны Бриггс всеобъемлющий поиск PubMed, OVID-MedLINE

Insulin Resistance at the Crossroads of Metabolic Inflammation, Cardiovascular Disease, Organ Failure and Cancer.

Insulin resistance (IR) describes impaired hormone signaling that triggers compensatory homeostatic responses resulting in hyperinsulinemia, increased accumulation of fatty substrates, lipotoxicity, oxidative stress, inflammation, cell death and fibrosis in target tissues. These processes ultimately lead to organ dysfunction and predispose certain individuals to various types of cancer. In this context, we will review the molecular pathogenesis and clinical significance of IR, its role in 'metaflammation', and the damage caused by IR in the pancreas, cardiovascular system, liver, and kidneys.

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… -N., Davis T., Lane M., Love A. Exogenous Insulin Antibody Syndrome: A Rare Cause of Extreme Insulin Resistance Treated With High-dose Corticosteroids. Jcem Case Rep. 2025;3 doi: 10.1210/jcemcr/luaf175. 56. Swarup S., Ahmed I., Grigorova Y., Zeltser R. StatPearls. …

Клетки T-бет+CXCR3+B вызывают гиперреактивное взаимодействие клеток B-T в множестве склерозов.

Множественный склероз (MS) — аутоиммунное заболевание центральной нервной системы (CNS). Одним из ключевых механизмов в НР является автораспространение (АП) ячеек В и Т, основанное на самопропитании. Здесь мы показываем, что про-воспаление B-T-обогащенные клетки клеток (BTEC) формируются во время AP и зеркальные особенности реакции микроцентра. T-bet+CXCR3+B — основной подмножество клеток, усиливающих и поддерживающих свои параллельные клетки TH1 с помощью интерферона (IFN)-__, и присутствуют в сильно воспламенённой менингетной ткани. Фундаментальная сигнатура активации клеток В находит свое о

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…  Bismark (0.24.0) Krueger et al., 2011 90 https://www.bioinformatics.babraham.ac.uk/projects/bismark/  Limma (v3.48.3) Ritchie et al., 91 2015 https://bioconductor.org/packages/release/bioc/html/limma.html  Nfcore/rnaseq (v1.0) Ewels et al., 2020 92 https://nf-co.re/rnaseq/1.0  Deseq2 (v1.32.0) Love …

Cancer vaccines: an update on recent achievements and prospects for cancer therapy.

Decades of basic and translational research have led to a momentum shift in dissecting the relationship between immune cells and cancer. This culminated in the emergence of breakthrough immunotherapies that paved the way for oncologists to manage certain hard-to-treat cancers. The application of high-throughput techniques of genomics, transcriptomics, and proteomics was conclusive in making and expediting the manufacturing process of cancer vaccines. Using the latest research technologies has also enabled scientists to interpret complex and multiomics data of the tumour mutanome, thus identify

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… Hu JC, Coffin RS, Davis CJ, Graham NJ, Groves N, Guest PJ, Harrington KJ, James ND, Love CA, McNeish I, et al. A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor. Clin Cancer Res. 2006;12:6737–47. 139. …

Crosstalk between glucocorticoid and mineralocorticoid receptors boosts glucocorticoid-induced killing of multiple myeloma cells.

The glucocorticoid receptor (GR) is a crucial drug target in multiple myeloma as its activation with glucocorticoids effectively triggers myeloma cell death. However, as high-dose glucocorticoids are also associated with deleterious side effects, novel approaches are urgently needed to improve GR action in myeloma. Here, we reveal a functional crosstalk between GR and the mineralocorticoid receptor (MR) that plays a role in improved myeloma cell killing. We show that the GR agonist dexamethasone (Dex) downregulates MR levels in a GR-dependent way in myeloma cells. Co-treatment of Dex with the

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… Love MI Huska MR Jurk M Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation Nucleic Acids Res 2017 45 1805 1819 10.1093/nar/gkw1163 27903902 PMC5389550 10. …

Analysis of medical malpractice liability disputes related to novel antineoplastic drugs and research on risk prevention and control strategies.

OBJECTIVE: To investigate the general characteristics of litigation cases of medical malpractice liability disputes (MMLDs) related to novel antineoplastic drugs (NADs), the drugs involved, as well as the common types of medical errors related to NADs and their damages in the process of diagnosis and treatment, with the aims of improving the level of rational medication use in the clinical application of NADs and actively prevent medical disputes. METHODS: The China Judgments Online was searched for the cause of action using the key word "MMLDs" along with the name of 77 kinds of NADs. A tota

Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier.

Glioblastoma (GBM) is the most malignant form of all primary brain tumors, and it is responsible for around 200,000 deaths each year worldwide. The standard therapy for GBM treatment includes surgical resection followed by temozolomide-based chemotherapy and/or radiotherapy. With this treatment, the median survival rate of GBM patients is only 15 months after its initial diagnosis. Therefore, novel and better treatment modalities for GBM treatment are urgently needed. Mounting evidence indicates that non-coding RNAs (ncRNAs) have critical roles as regulators of gene expression. Long non-coding

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… Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Nat Acad Sci USA. (2014) 111:3955–60. 10.1073/pnas.1322937111 92. Yang ZZ, Li JQ, Wang ZZ, Dong DW, Qi XR. …

Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients.

Osteonecrosis (ON) is a complex and multifactorial complication of systemic lupus erythematosus (SLE). ON is a devastating condition that causes severe pain and compromises the quality of life. The prevalence of ON in SLE patients is variable, ranging from 1.7% to 52%. However, the pathophysiology and risk factors for ON in patients with SLE have not yet been fully determined. Several mechanisms for SLE patients' propensity to develop ON have been proposed. Glucocorticoid is a widely used therapeutic option for SLE patients and high-dose glucocorticoid therapy in SLE patients is strongly assoc