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A contribution to the laboratory assay of typhoid vaccines.

In the laboratory assay of typhoid vaccines many questions still remain open. The results of experiments are at times ambiguous, and there is no satisfactory agreement between them and the results of the various field trials. The authors of the present paper have attempted to clear up some of the causes of discrepancy. They have concluded that in evaluating the efficacy of various types of vaccine much depends on the vaccine and challenge doses used. By employing low or high doses of vaccine, it is possible to obtain different results in respect of the qualities of the vaccines compared. The t