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Evaluation of bla OXA-48-like point mutation carbapenemase-producing Enterobacterales in Prapokklao Hospital, Thailand.

UNLABELLED: Carbapenemase-producing Enterobacterales (CPE) isolates increasingly carry oxacillinase-48 (OXA-48)-like enzymes encoded by bla … nd 3 (2.46%) were Klebsiella pneumoniae, Escherichia coli, Enterobacter aerogenes, and Enterobacter cloacae, respectively. The MHT identified carbapenemase production in 108 isolates (88.52%). Based on the mCIM, 81 isolates (66.39%) were carbapenemase producers. Seventy-three isolates (59.84%) were eCIM-positive, indicating metallo-β-lactamase production …

Diagnostic Performance of BD Phoenix CPO Detect Panels for Detection and Classification of Carbapenemase-Producing Gram-Negative Bacteria.

BD Phoenix CPO Detect panels can identify and classify carbapenemase-producing organisms (CPOs) simultaneously with antimicrobial susceptibility testing (AST) for Gram-negative bacteria. Detection and classification of carbapenemase producers were performed using the BD Phoenix CPO Detect panels NMIC/ID-441 for Enterobacterales, NMIC/ID-442 for nonfermenting bacteria, and NMIC-440 for both. The results were compared with those obtained using comparator methods. A total of 133 strains (32 Klebsiella pneumoniae, 37 Enterobacter cloacae complex, 33 Pseudomonas aeruginosa, and 31 Acinetobacter bau…

Imipenem-Relebactam Susceptibility in Enterobacterales Isolates Recovered from ICU Patients from Spain and Portugal (SUPERIOR and STEP Studies).

Imipenem-relebactam is a novel β-lactam-β-lactamase inhibitor combination. We evaluated the in vitro activity of imipenem-relebactam and com … ainst 1.3% (10/747) isolates, all of them due to carbapenemase production (9 K. pneumoniae and 1 E. cloacae). Imipenem-relebactam was active against 100% of extended-spectrum β-lactamase (ESBL)-E. coli and ESBL-Klebsiella spp. isolates and 80.4% of carbapenemase-Klebsiella spp. producers. Carbapenemase genes were confirmed by WGS in 41 Klebsiella spp.: O …

[Application and clinical efficacy of ultrasound debridement method in residual burn wounds].

Objective: To investigate the application and clinical efficacy of ultrasound debridement method in residual burn wounds. Methods: A retrosp … in 3 cases, Acinetobacter baumannii in 1 cases, Klebsiella pneumoniae in 1 cases, and Enterobacter cloacae in 1 cases. The positive rate of bacteria of wound in ultrasound debridement group was significantly lower than that in traditional debridement group (χ2=5.51, P<0.05). On postoperative day 7, the survival rate of skin grafts in ultrasound debridem …

[Antibiotic resistance and antibiotic consumption in a region - using the example of community-acquired urinary tract infections].

BACKGROUND: In sight of increasing bacterial resistances, appropriate and cautious antibiotic therapy (antibiotic stewardship) is becoming m … ensitivity, Proteus mirabilis and S. aureus showed a slight loss of activity, while in Enterobacter cloacae a clear loss of activity was seen. The E. coli strains detected from urine samples to clarify complicated urinary tract infections show continuously excellent sensitivity for fosfomycin, nitrofurantoin, nitroxoline and mecillinam (> > 90 %), wherea …

[Diversity analysis of biofilm bacteria on tracheal tubes removed from intubated neonates].

OBJECTIVE: The catheter-related infections caused by mechanical ventilation have become a intractable clinical problem, and it is related to … 10 strains (45%) of Klebsiella pneumoniae, 2 strains (9%) of Acinetobacter baumannii, Enterobacter cloacae and non-cultured bacterium in each patient (5%), but only one bacterium isolated from every sputum. Eight sputum samples had normal flora only, corresponding to the ETTs on which Klebsiella and other bacterial genuses were found. CONCLUSION: The d …

Effects of an alternative cefepime dosing strategy in pulmonary and bloodstream infections caused by Enterobacter spp, Citrobacter freundii, and Pseudomonas aeruginosa: a single-center, open-label, prospective, observational study.

BACKGROUND: Various dosing strategies for cefepime have been developed in an effort to maximize pharmacodynamic exposure of this agent again … remia or pulmonary infection caused by Pseudomonas aeruginosa, Enterobacter aerogenes, Enterobacter cloacae, or Citrobacter freundii were assessed in a noninterventional manner. Infections were identified using an electronic notification system. Patients receiving appropriate monotherapy against the studied isolate within 24 hours of culture attainment w …

Antimicrobial Susceptibility Pattern of Ceftriaxone-Sulbactam-EDTA Against Multidrug-Resistant Gram-Negative Bacilli From ICU Clinical Isolates.

Background Antibiotic therapy remains the mainstay for the management of bacterial infections. However, the rapid emergence of multidrug-res … bsiella pneumoniae, Klebsiella oxytoca, Acinetobacter baumannii, Escherichia coli, and Enterobacter cloacae complex. Among the isolates, 51 were ESBL producers, 48 were MBL producers, and 38 were AmpC producers, indicating a significant burden of beta-lactamase-mediated resistance. High resistance was observed against meropenem (94.57%), netilmicin (93.4 …

Methodology and application of multiplex PCR-dipstick DNA chromatography for the detection of eight respiratory bacterial pathogens.

BACKGROUND: Community-acquired pneumonia is primarily caused by Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Stre … ia, nor with other representative respiratory bacteria, including Acinetobacter junii, Enterobacter cloacae, Klebsiella oxytoca, Haemophilus parainfluenzae, Pseudomonas fluorescens, Aeromonas hydrophila, and Staphylococcus epidermidis. The concordance between the results obtained from the multiplex PCR-dipstick DNA chromatography assay and those from DNA …

[Antimicrobial resistance of Gram-negative bacilli isolated from 13 teaching hospitals across China].

OBJECTIVE: To explore the antimicrobial resistance of nosocomial Gram-negative bacilli across China. METHODS: A total of 1247 consecutive a … amikacin and polymyxin B maintained at over 90%. The activities of antimicrobial agents against E. cloacae, E. aerogenes and Citrobacter freundii were in the following descending order of susceptibility rate: meropenem (96.0%-100%) , imipenem (96.0%-100%) , polymyxin B (95.8%-100%) , amikacin (92.2%-100%) , ertapenem (85.6%-93.3%) , cefepime (77.8%-93.3 …

A review of -multidrug-resistant Enterobacteriaceae in a neonatal unit in Johannesburg, South Africa.

BACKGROUND: Multi-drug resistant organisms are an increasingly important cause of neonatal sepsis. AIM: This study aimed to review neonatal sepsis caused by multi-drug resistant Enterobacteriaceae (MDRE) in neonates in Johannesburg, South Africa. METHODS: This was a cross sectional retrospective review of MDRE in neonates admitted to a tertiary neonatal unit between 1 January 2013 and 31 December 2015. RESULTS: There were 465 infections in 291 neonates. 68.6% were very low birth weight (< 1500 g). The median age of infection was 14.0 days. Risk factors for MDRE included prematurity (p = 0.0

[Transfer of exotic ticks (Acari: ixodida) on reptiles (Reptilia) imported to Poland].

In the of period 2003-2007, a total of 382 specimens of reptiles belonging to the following genera were investigated: Testudo, Iguana, Varan … f the back (54.4%) and on the stomach side of the trunk (29.8%), less frequently in the area of the cloaca (5.6%), around the eyes (3.7%), in the nostril openings (0.9%) and on the remainder of the head (5.6%). On the hosts, ticks were found at different development stages, but adult development stages dominated. The most frequent were males (999 specime …

Impact of intestinal lengthening on the nutritional outcome for children with short bowel syndrome.

Survival among children with short bowel syndrome has increased with the use of supportive nutritional techniques including parenteral and e … luded necrotizing enterocolitis, multiple small bowel atresias, gastroschisis with midgut volvulus, cloacal exstrophy, and long-segment Hirschsprung's disease. The mean length of the residual small bowel was 49 cm (range, 6 to 92 cm). All but one child had surgical resection of the ileocecal valve. The percentage of enteral nutrition calories significant …

[Etiological characteristics, clinical manifestations, and prognosis of patients with endogenous endophthalmitis in 2024: a single-center retrospective cohort study].

Objective: To investigate the etiological characteristics, clinical manifestations, and prognosis of patients with endogenous endophthalmiti … 6%) with Nocardia species, 1 eye (2.6%) with coinfection of Listeria monocytogenes and Enterobacter cloacae complex, and 1 eye (2.6%) with no available etiological test results. Thirteen eyes (34.2%) had fungal infections, including 5 eyes (13.2%) with Candida albicans, 2 eyes (5.3%) with Candida parapsilosis, 2 eyes (5.3%) with Aspergillus fumigatus, 1 …

[Microbiological profiles of pathogens causing nosocomial bacteremia in 2011, 2013 and 2016].

To dynamically investigate the distribution and antimicrobial resistance profiles of bacteremia pathogens isolated from different regions in … organism with 76.7% (23/30). Among 39 colistin-resistant Enterobacteriaceae, E. coli, Enterobacter cloacae and K. pneumoniae were constituted with the percent of 43.6 (17/39), 35.9 (14/39) and 15.4 (6/39), respectively. The Gram-negative bacilli (E. coli and K. pneumoniae were the major organisms) were the major pathogens of nosocomial bacteremia, to wh …

Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.

Anorectal malformation (ARM), a common congenital anomaly of the digestive tract, is a result of insufficient elongation of the urorectal septum. The cytoplasmic protein Receptor of Activated C-Kinase 1 (Rack1) is involved in embryonic neural development; however, its role in embryonic digestive tract development and ARM formation is unexplored. Our study explored the hindgut development and cell death mechanisms in ARM-affected rats using spatial transcriptome analysis. We induced ARM in rats by administering ethylenethiourea via gavage on gestational day (GD) 10. On GDs 14-16, embryos from b

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… A reduction in Gpx4‐positive signalling was observed in the cloaca of the ARM group (Figure 4C ). AOD analysis indicated a statistically significant reduction in Gpx4 expression in the hindgut on GDs 15 and 16 ( p < 0.05; Figure 4D ). … Apoptosis during regression of the tailgut and septation of the cloaca. J Pediatr Surg. 2000;35(11):1556‐1561. 37. Qi BQ, Williams A, Beasley S, Frizelle F. Clarification of the process of separation of the cloaca into rectum and urogenital sinus in the rat embryo. …

COVID-19 pandemic increased ESKAPEEc bloodstream infections and amplified carbapenem resistance in Chinese children: a multicenter surveillance study (2016-2023).

OBJECTIVE: This study investigated the long-term trends in the distribution and antibiograms of ESKAPEEc pathogens in neonatal and pediatric … istance levels were 5.5% in Escherichia coli, 28.0% in Klebsiella pneumoniae, 16.0% in Enterobacter cloacae, 12.5% in Pseudomonas aeruginosa and 38.5% in Acinetobacter baumannii. Both Staphylococcus aureus and Enterococcus faecium remained fully susceptible to vancomycin and linezolid. Between 2016-2019 and 2020-2023, resistance to ceftazidime and gentam …

[Clinical study on intravenous combined with aerosol inhalation of polymyxin B for the treatment of pneumonia caused by multidrug-resistant Gram-negative bacteria].

OBJECTIVE: To investigate the efficacy of intravenous combined with aerosol inhalation of polymyxin B for the treatment of pneumonia caused … 3 patients, Klebsiella pneumoniae in 5 patients, Pseudomonas aeruginosa in 6 patients, Enterobacter cloacae in 1 patient; the sputum culture results of the combination group showed that there were 5 patients of Acinetobacter baumannii, 9 Klebsiella pneumoniae and 6 Pseudomonas aeruginosa. There was no significant difference in the results of sputum cultu …

Literature review on the distribution characteristics and antimicrobial resistance of bacterial pathogens in neonatal sepsis.

PURPOSE: Neonatal sepsis (NS) has no specific clinical manifestations and blood culture analysis requires a long period of time. Knowledge o … 5%); among the Gram-negative bacteria, Klebsiella (14.52%), Escherichia coli (12.12%), Enterobacter cloacae (1.90%), and Pseudomonas (1.41%) had the highest detection rates. The detection rate of Candida and other fungi was 4.29%. Among the pathogens with high clinical detection rates, S. epidermidis and S. aureus are highly resistant to both erythromyci …

[Comparison of the modified Hodge test and the Carba NP test for detection of carbapenemases in Enterobacteriaceae isolates].

A rapid, practical, and accurate identification of carbapenemase-producing Enterobacteriaceae isolates is crucial for the implementation of … t, one E.coli and one K.pneumoniae producing OXA-48, one E.coli producing IMP, and one Enterobacter cloacae producing VIM could not de detected. Three OXA-48-producing isolates (two K.pneumoniae and one E.coli) yielded late and weak positive results with Carba NP test. MHT had false positivity for 31 isolates, while Carba NP test showed no false positivi …