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Laboratory tests of typhoid vaccines used in a controlled field study.

In 1954-55, a controlled field trial of two types of typhoid vaccine-alcoholized ("vaccine A") and phenolized ("vaccine F")-prepared in Yugoslavia was carried out in the town and district of Osijek. In an attempt to correlate the protection conferred on man by these vaccines with their potency in laboratory animals, arrangements were made for laboratory tests to be performed jointly by the Central Institute of Hygiene, Zagreb, Yugoslavia; the Lister Institute of Preventive Medicine, Elstree, Herts, England; and the Walter Reed Army Institute of Research (WRAIR), Washington, D.C., USA. In this