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Neurological updates: neurological complications of CAR-T therapy.

Chimeric antigen receptor (CAR)-expressing T cells now offer an effective treatment option for people with previously refractory B cell malignancies and are under development for a wide range of other tumours. However, neurological toxicity is a common complication of CAR-T cell therapy, seen in over 50% of recipients in some cohorts. Since 2018, the term immune effector cell-associated neurotoxicity syndrome (ICANS) has been used to describe and grade neurotoxicity seen after CAR-T cells and other similar therapies. ICANS following CAR-T therapy is usually self-limiting but can necessitate ad

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… Fig. 3 Best practice recommendations for the management of ICANS following CAR T cell therapy according to the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). … Yakoub-agha I Chabannon C Bader P Management of adults and children undergoing chimeric antigen receptor T cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) Haematologica 2020 …

Access to Fertility Preservation Counselling for Young Women with Haematological Malignancies: Incidence-Adjusted Trends from the Italian PreFerIta Network (2015-2023).

Background: Preserving fertility in young women with cancer is crucial for comprehensive care. Based on GBD 2023 estimates, approximately 1000 women aged 15-39 are diagnosed with haematological malignancies annually in Italy. Guidelines recommend timely fertility preservation (FP) counselling for all at-risk patients, yet real-world access data remain limited. Methods: This multicentre, retrospective observational study analysed FP counselling for women aged 15-39 with haematological malignancies from 2015 to 2023. Counselling data were extracted from the Italian Assisted Reproductive Technolo

Улучшить пересадку аутологической гематопоиетической трансплантации стволовых клеток: сравнить педифилграстим с фугастимом в амбулаторной среде.

КОЛИЧЕСТВО: < < Нейтропенция фебрилов > > -- частое осложнение для пациентов, проходящих аутологическую трансплантацию стволовых клеток, увеличение заболеваемости и расходов на госпитализацию. ЦЕЛЬ: Цель настоящего исследования заключалась в сопоставлении эффективности two Составы пегилированного филграстима с филграстимом у пациентов, которые получили аутлогическую трансплантацию стволовых клеток в качестве амбулаторных для лимфомы или миэломы. МЕТОДЫ: Thirty пациенты были случайными, чтобы получить одноразовый 6 мг эталонного или биоаналогичного пегфилграстима в день +1. Группа р

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… of Cellular Therapy) accreditation. … The study center of this research is a FACT-accredited unit that has operated an outpatient autologous and allogeneic transplant program since 1998 [ 15 ]; the entire ASCT procedure is performed in the outpatient clinic. …

The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018.

IntroductionIf interprofessional collaborative practice is to be an important component of healthcare reform, then an evidentiary base connecting interprofessional education to interprofessional practice with significantly improved health and healthcare outcomes is an unconditional necessity. This study is a scoping review of the current peer reviewed literature linking interprofessional collaborative care and interprofessional collaborative practice to clearly identified healthcare and/or patient health-related outcomes. The research question for this review was: What does the evidence from t

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… Only one study included dentists even though their accreditation standards advocate the importance of oral health to overall health and training that links oral health to colleagues in other professions. [ 41 ] Addressing these identified gaps in future research will strengthen the evidentiary base of … Commission on Dental Accreditation. Accreditation Standards for Dental Hygiene Programs. Available from: ada.org/~/media/coda/files/dh.ashx . 42. Bridges DR, Davidson RA, Odegard RS, Maki IV, Tomkowiak J. Interprofessional collaboration: three best practice models of interprofessional education. …

Cold Atmospheric Plasma in the Treatment of Osteosarcoma.

Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles. Cold atmospheric plasma (CAP), a hig

Европейский статус карты CAR-T и будущие направления улучшения доступа к клеточной терапии CAR для гематологовых маньяков.

Несмотря на свои большие надежды, осуществление терапии CAR-T является индивидуализированным, технически сложным и дорогостоящим лечением, которое по-прежнему сопряжено с трудностями, что затрудняет доступ пациентов в различных странах и внутри стран. С тех пор 2018, six в Европе (т.е. Европейская экономическая зона; утвержден ЕС) 15 Гематологические признаки злоумышленничества. Чтобы лучше понять доступ пациентов к коммерческой терапии CAR-T, одобренной ЕС, мы провели оценку нынешнего положения дел в целом. 30 Страны, в которых одобрение ЕС действительно, плюс Соединенное Королевство, рассмат

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… In 55% of these countries, centers were required to be transplant/JACIE‐accredited (JACIE: Joint Accreditation Committee, ISCT [International Society for Cellular Therapy], and EBMT [European Society for Blood and Marrow Transplantation]). … Other factors included small country, no JACIE‐accredited transplantation centers, and competition with bispecific antibodies. …

Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody.

BACKGROUND: The blood-brain barrier (BBB) presents a major challenge for the development of monoclonal antibody (mAb)-based therapies for brain disorders. To improve the likelihood of success of such therapies, Roche Brainshuttle technology utilizes a single anti-transferrin receptor 1 (TfR1)-antigen-binding antibody fragment linked to a therapeutic antibody, allowing engagement with TfR1 to transport the therapeutic antibody into the brain via receptor-mediated transcytosis. METHODS: We compared Fc-silenced and Fc-competent variants of the Brainshuttle and the parental (non-shuttled) type II

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… Animal husbandry All mouse studies were conducted at Pharma Research, Basel, which is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACi) and were conducted with the approval of the Cantonal Veterinary Authority of Basel‐Stadt, following … Pharma Research and Early Development Basel Facilities are fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC), and all procedures were approved by the Cantonal Veterinary Authority of Basel‐Stadt, following strict adherence to the Swiss …

Resilience and Sub-optimal Social Determinants of Health: Fostering Organizational Resilience in the Medical Profession.

The relationship between social determinants of health (SDOH) and resilience has been investigated at the individual level and, to some extent, at the community level. The aftermath of the COVID-19 pandemic further highlighted the necessity for organizational resilience in the United States. The US public health and health care system began the lengthy process of identifying the resiliency needs of its workforce that expand beyond disaster preparedness. The purpose of this article is to describe the relationship between resilience and SDOH and how medical training can infuse resiliency within

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… mental health throughout training, including higher incidents of anxiety, depression, burnout, self-harm, and suicidality than their same-aged peers. 13 , 14 Both credentialing bodies that set the curriculum content standards, the Liaison Committee on Medical Education (LCME) for medical school and the Accreditation … Although it is still being determined if workload limits and required education on wellness and mental health improve student and resident outcomes, the benefits of meeting the accreditation standards may be washed out by many other factors. …

Adherence to oral anticancer therapy of oncology patients attending the pharmaceutical office of a public hospital in the lower Amazon region.

IntroductionOral anticancer therapy has the benefit of allowing cancer patients to carry out their treatment at home, without being inconvenienced or being at risk of nosocomial infection. However, non-adherence is a public health problem that contributes to the clinical decline of the patient and there are no studies submitted on the adherence of cancer patients to oral anti-anticancer agents in Santarém, PA.ObjectiveIn view of this, the general objective of this work was to evaluate this oral medication adherence.MethodsThe methodology consisted of a cross-sectional documentary study with a

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… The HRBA is a reference in the Northern region for the treatment of malignant tumours, being the first public hospital in this region of Brazil to obtain a certificate of maximum quality, accredited with excellence by the National Accreditation Organisation [ 13 ]. …

Can the sustainable development goals for cancer be met in Brazil? A population-based study.

BackgroundA one-third reduction in premature mortality (30-69 years) from chronic noncommunicable diseases is goal 3.4 of the United Nations Sustainable Development Goals (UN SDG). The burden of NCDs is expected to continue to increase in low- and middle-income countries, including Brazil.ObjectivesThe aim of this study was to assess geographical and temporal patterns in premature cancer mortality in Brazil between 2001 and 2015 and to predict this to 2030 in order to benchmark against the 3.4 SDG target.MethodsWe used data on deaths from cancer in those aged 30-69, by age group, sex and cance

Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: a randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine.

BACKGROUND: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80% of patients with advanced breast cancer. Preclinical models have demonstrated the ability of mechanical stimulation to suppress tumour formation and promote skeletal preservation at bone sites with osteolytic lesions, generating modulatory interference of tumour-driven bone remodelling. Preclinical studies have also demonstrated anti-cancer e

Dependence and clinical fragility in hematopoietic stem cell transplant and CAR-T therapy: a retrospective study.

PurposeAutologous and allogeneic hematopoietic stem cell transplantation and CAR-T cell therapy are standard treatments for patients affected by hematologic malignancies at different stages of their clinical pathway. Several adverse events accompany these therapies during patients' hospital stay, including psycho-emotional distress and various functional and social impairments.MethodsIn this monocentric study on 498 patients, various clinical and social fragility indices, registered within clinical documentation during the hospital stay, specifically at admission (within 24 h of entry) and dis

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… Therefore, DEP-CSF is potentially generalizable to similarly accredited centers [ 45 , 46 ]. … Joint Accreditation Committee of ISCT and EBMT (2023) JACIE Standards, 8th Edition. European Society for Blood and Marrow Transplantation. https://www.ebmt.org/sites/default/files/2023-03/JACIE%208th%20Edition%20Standards.pdf 46. …

20 Years of Legislation - How Australia Has Responded to the Challenge of Regulating Genetically Modified Organisms in the Clinic.

•In contrast to the prior voluntary system, since 2001, gene technology in Australia has been regulated under a legislated national Gene Technology Regulatory Scheme which is administered by the Gene Technology Regulator.•The Scheme provides science-based assessment of the potential risks of gene technology to the health and safety of people and the environment.•It complements the role of the Australian Therapeutic Goods Administration which regulates all therapeutic products in Australia to ensure they are safe and effective.•Recent reforms to the Scheme contribute to, and anticipate, the con

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… Surprises occur when it is belatedly discovered that an OGTR license is required and that the license holder needs to be an OGTR accredited organization. Although the accreditation and license applications can be submitted in parallel, it adds up to 90 business days to the approval processes. … The OGTR accreditation and facility certification systems have ensured clinical applications are sponsored by suitable organizations and conducted in appropriate containment facilities. Clinical trials are overseen by IBCs with appropriate expertise to assess safety of the gene modified products. …

Caregiver burden and quality of life in palliative care: cross-sectional study.

BACKGROUND: Literature on caregiver burden is limited in India and Kerala. We examined the prevalence and factors associated with caregiver burden and its impact on their quality of life. METHODS: We conducted a cross-sectional study among 115 informal caregivers (mean age 70 years, 80% female) of palliative care patients in Kerala. Caregivers were interviewed using the Zarit Burden Interview-22 and the WHOQOL-BREF questionnaires. Factors associated with caregiver burden were analysed using binary logistic regression. RESULTS: The prevalence of moderate to severe burden was 32.1% (95% CI 23.

Financial Toxicity of Hematologic Malignancy Therapies, Including Cellular Therapy and Its Impact on Access to Care: Prospective Pilot Study.

BackgroundPatients with cancer often face significant financial challenges, known as financial toxicity (FT), which is associated with reduced quality of life. Patients with hematologic malignancies (HMs) are especially vulnerable due to intensive and prolonged treatments, frequent hospital visits, and a high risk of complications. While FT affects many in the general population, it is particularly severe among racial and ethnic minorities, especially those below the poverty line. To our knowledge, no studies have specifically examined FT in this vulnerable group in the United States.Objective

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… Patients undergoing scheduled chemotherapy infusions need to make multiple visits to the clinic, which can be burdensome, especially for those in the CT group who must travel long distances to a FACT (Foundation for Accreditation of Cellular Therapy)-accredited center. … Abbreviations chimeric antigen receptor T-cell therapy Comprehensive Score for Financial Toxicity–Functional Assessment of Chronic Illness Therapy cellular therapy Foundation for Accreditation of Cellular Therapy financial toxicity hematologic malignancies newly diagnosed stem cell transplantation …

Onconephrology Fellowship Training: Current Status and Future Outlook.

Onconephrology, an emerging discipline nestled at the intersection of nephrology and oncology, has experienced remarkable growth over the past 15 years. This evolution has been punctuated by pivotal events, including establishing the American Society of Onconephrology, dedicated forums, and journals, highlighting its increasing significance. The clinical landscape of onconephrology is diverse, encompassing AKI in patients with cancer, toxicity from anticancer treatments, and a spectrum of electrolyte disorders, necessitating close collaboration between nephrologists and oncologists. However, t

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… Because the onconephrology fellowship is not Accreditation Council for Graduate Medical Education accredited, some training programs require the trainee to be employed under the title of instructor and some require the trainee to treat patients independently and thus be eligible for state medical license …

Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022.

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… JACIE has been increasingly recognised by governmental bodies and competent authorities in several EU member states and extends beyond Europe with accredited centres worldwide. Importantly, JACIE accreditation appears to have an impact on survival outcomes and donor safety [ 232 , 338 – 344 ]. … We also recommend working according to JACIE accreditation standards benchmarking of outcomes to maintain quality in HCT practice. Moving forward, all treatment decisions, whether HCT or non-HCT, need to accommodate the ongoing COVID-19 pandemic. …

Predictors of cardiopulmonary arrest outcome in a comprehensive cancer center intensive care unit.

BackgroundSome comprehensive cancer centers in industrialized countries have reported improved outcomes in their cardiopulmonary arrest (CPA) patients. Little is known about the outcomes and predictors of CPA in cancer centers in other parts of the world. The objective of this study was to examine the predictors of CPA outcome in a comprehensive cancer center closed medical-surgical intensive care unit (ICU) located in Amman, Jordan.MethodsIn this retrospective single-center cohort study, we identified 104 patients who had a CPA during their stay in the ICU between 1/1/2008 and 6/30/2009. Demo

Снижение митохондриальной активности в демиелинизирующей мозжечке прогрессивного множественного склероза и хронической EAE способствует потере клеток Purkinje.

При множественном склерозе (MS) атрофия мозжечного серого вещества, демиелинация белой материи и потеря клеток Purkinje (PC) были связаны с дрожжами, нарушениями управления мотором и утратой координации. Аналогичные патологии наблюдались в модели мыши MS, экспериментальной аутоиммунной энцефаломиэлит (EAE). В этом исследовании гипотезалось, что провокационное демиэлирование мозжечка изменяет общую митохондриальную функцию и способствует аксоновой дегенерации и потере ПК. Посмертные мозговые ткани пациентов MS, особенно пациентов со вторичными прогрессивными MS, показали снижение активности мит

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… Mice were maintained in an Association for Assessment and Accreditation of Laboratory Animal Care-accredited facility under 12 h light/dark cycle and fed standard mouse chow with unrestricted access to food and water. Human Postmortem Cerebellar Brain Section Preparation. …

Guidelines for the use of survivorship care plans: a systematic quality appraisal using the AGREE II instrument.

BackgroundSurvivorship care plans (SCPs) are written treatment summaries and follow-up care plans that are intended to facilitate communication and coordination of care among survivors, cancer care providers, and primary care providers. A growing number of guidelines for the use of SCPs exist, yet SCP use in the United States remains limited. Limited use of SCPs may be due to poor quality of these guidelines. The purpose of the study was to evaluate the quality of guidelines for SCP use, tools that are intended to promote evidence-based medicine.MethodsWe conducted a comprehensive search of th