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Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries.

Prostate cancer is the most common cancer in men, with over 52,000 new cases diagnosed every year. Diagnostics and early treatment are potentially hindered by variations in screening protocols, still largely reliant on serum levels of acid phosphatase and prostate-specific antigen, with tumour diagnosis and grading relying on histopathological examination. Current treatment interventions vary in terms of efficacy, cost and severity of side effects, and relapse can be aggressive and resistant to the current standard of care. For these reasons, the scientific community is looking for new chemoth

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… Fungi Sansalvamide A is a cyclic depsipeptide, originally isolated from a marine fungus of the genus Fusarium found on Little San Salvador Island, Bahamas. … Fungi | | | | | Originally from the genus Fusarium | Compounds 5 and 11 (N-methylated sansalvamide A) | 10 µM | 72 h exposure; cell counting; PC3 cells | - | [ 41 ] Isaria felina KMM 4639 | Isariketide A and compound 3 | 5 μM | 48 h exposure; MTT assay; PC3 cells | Apoptosis induction | [ 42 ] Microsporum …

Molecular diagnostics in cancer patients with suspected respiratory mold infections.

Invasive fungal infections (IFIs), including aspergillosis and mucormycosis, are serious complications in cancer patients. Reliable detection of etiologic agents is challenging but important for optimal patient management. In a prospective multicenter study, we compared fungal detection by culture, specific and unspecific qPCRs, and fluorescence in situ hybridization (FISH) targeting Aspergillus and Mucorales in bronchoalveolar lavage fluid (BALF) and serum of adult cancer patients with suspected fungal pneumonia. In subgroups of patients, fungal DNA was amplified from serum. We evaluated 210

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… (n = 2), Hypholoma (n = 2), Fusarium (n = 1), and Aureobasidium (n = 1). c In 6 of 10 (60%) and 6 of 7 (86%) cases, Mucorales DNA was amplified together with Aspergillus DNA. d Unspecific probe and yeast morphology. …

Мультиэкологические испытания на взаимодействие G×E и выявление высокоурожайных, стабильных, среднесрочных генотипов голубей с использованием анализа AMMI, бипло ГПЭ и YREM.

Pigeonpea [Cajanus cajan (L.) Millspaugh] — широко распространенный пульс с высоким содержанием семян белка, который способствует продовольственной безопасности и безопасности питания в индийском субконтиненте. Большинство сортов голубей, выращиваемых в Индии, имеют среднюю продолжительность (см.<180 - дни до зрелости), что делает необходимым, чтобы селекционеры сосредоточили свое внимание на развитии стабильных высокоурожайных разновидностей. Разнообразие агроэкологического режима в индийском субконтиненте требует проведения эффективного многостороннего исследования окружающей среды с учетом

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… Identification of elite pigeonpea genotypes against fusarium wilt and sterility mosaic disease through AMMI and GGE biplot analysis. Leg. Res. 46, 104–111. doi: 10.18805/LR-4838 Ruswandi D., Syafii M., Wicaksana N., Maulana H., Ariyanti M., Indriani N. P., et al. (2022). …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… 5,000; MFC = 10,000 | | E (Water; SLR 2:1, 5 h) >> F | Zagros mountains, Iran | Shallot/red onion; A. ascalonicum; bulb | ( 26 ) Aureobasidium pullulans | | E : MIC = 150–310; MFC = 5,000 | | E (Water; SLR 2:1, 5 h) >> F | Zagros mountains, Iran | Shallot/red onion; A. ascalonicum; bulb | ( 26 ) Fusarium … Ascalin inhibited mycelial growth in the fungus Botrytis cinerea (see Figure 2b ), but not in the fungi Mycosphaerella arachidicola and Fusarium oxysporum ( 45 ). …

Unlocking the potential of tumor-targeting peptides in precision oncology.

Targeted cancer therapy has emerged as a promising alternative to conventional chemotherapy, which is often plagued by poor selectivity, off-target effects, and drug resistance. Among the various targeting agents in development, peptides stand out for their unique advantages, including minimal immunogenicity, high tissue penetration, and ease of modification. Their small size, specificity, and flexibility allow them to target cancer cells while minimizing damage to healthy tissue selectively. Peptide-based therapies have shown great potential in enhancing the efficacy of drug delivery, improvi

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… Unique compounds like Apratoxin A from Lyngbya majuscula halt the cell cycle in G1 phase [ 97 ], while Beauvericin from Fusarium induces caspase-mediated apoptosis [ 98 ]. Collectively, these peptides highlight the therapeutic promise of microbial bioactive compounds in oncology. … necrotic demise | Chlorella pyrenoidosa | [ 96 ] Apratoxin A | – | HeLa and HT29 | Cervical carcinoma and colon adenocarcinoma | Causing a cell cycle stop in the G1 phase | Lyngbya majuscula | [ 97 ] Beauvericin | – | – | Human epidermoid carcinoma | Cytochrome C release and caspase-9/3 activation | Fusarium …

Immune effector cell-associated hematotoxicity: mechanisms, clinical manifestations, and management strategies.

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape for hematologic malignancies. However, it is frequently complicated by immune effector cell-associated hematotoxicity (ICAHT), a potentially life-threatening adverse event encompassing neutropenia, anemia, and thrombocytopenia. These cytopenias elevate the risk of severe infections, transfusion dependence, and prolonged hospital stays, contributing substantially to morbidity and non-relapse mortality. This review delineates the incidence, mechanisms, and risk factors for ICAHT, highlighting the complex inter

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… infections, which predominate in the early phase of CAR T-cell therapy (until day +30). 9 , 15 , 28 While the overall incidence of fungal infections after CAR T-cell therapy is low, 29 cases of marked bone marrow aplasia can facilitate the development of invasive fungal disease including Aspergillus , Fusarium …

Antifungal Management in Patients with Hematological Malignancies: From Primary Prophylaxis to Empirical and Diagnosis-Driven Treatment

Invasive fungal diseases (IFDs) remain a significant cause of morbidity and mortality among patients with hematological malignancies, especially those undergoing intensive chemotherapy or hematopoietic stem cell transplantation (HSCT). This text provides a comprehensive risk-adapted framework for antifungal prophylaxis, stratifying patients into high-, intermediate-, and low-risk categories. Mold-active prophylaxis, primarily with posaconazole, is recommended for high-risk patients such as those with acute myeloid leukemia during remission induction or those with grade III-IV graft-versus-host

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… Prophylaxis reduces invasive mold disease, but prolonged exposure may lead to the selection of azole-resistant Aspergillus strains such as those with CYP51A mutations or non- Aspergillus molds (strains of Mucorales, Fusarium , etc.). …

Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas.

Immunology and microbiology research has witnessed remarkable growth and innovation globally, playing a pivotal role in advancing our understanding of immune mechanisms, disease pathogenesis, and therapeutic interventions. This manuscript presents a comprehensive exploration of the key areas in immunology research, spanning from the utilisation of bacterial proteins as antibody reagents to the intricate realms of clinical immunology and disease management. The utilisation of bacterial immunoglobulin-binding proteins (IBPs), including protein A (SpA), protein G (SpG), and protein L (SpL), has r

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… .; Fusarium dimerum ; Penicillium ; Paecilomyces variotii ; Scedosporium. | Candida spp. Parasites | Giardia duodenalis ; Giardia intestinalis ; Cryptosporidium spp.; Schistosoma species; Blastocystis hominis ; Fasciola spp.; Trichostrongylus spp. …

Оценка терпимости к засухе на большом числе горных хлопковых заводов (Gosypium hirsutum L.) в рамках различных режимов ирригации на стадии селекции.

Завод по производству хлопка имеет важное значение, поскольку он обеспечивает сырьем различные отрасли промышленности. Несмотря на то, что хлопок, как правило, является устойчивым к засухе, на нем негативно сказывается долгосрочная засуха. Испытание проводилось в соответствии с прикладной экспериментальной конструкцией в качестве полностью произвольной конструкции (CRD) three тиражирование для определения группы экспертов 93 Генотипы хлопка в ответ на засуху в контролируемых условиях 2022. Все генотипы были покрыты водой 80 mL-1 Водные ресурсы100% ирригация, полевая мощность) three Появлялись

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… Abiotic stress factors, such as drought and salinity, prevent the water intake of the cotton, and biotic stress factors, such as Verticillium and Fusarium, cause xylem vessels to be clogged and the plant to not receive sufficient water, which causes a decrease in the turgor pressure that provides the …

CAR T-Cell Terrapy Opveiled: Навигация за пределы ССЗ и ИКАНС для решения проблем, связанных с отсроченными последствиями, и оптимизации стратегий управления.

Цимерическая антигенная рецепторная (КАР) T-клетологическая терапия положила начало эпохе преобразований в регулировании рецидивов/отсутствий гематологической гематологии. Кульминацией интенсивных испытаний второго этапа, направленных на борьбу с повторной/охотничьей лимфомой, включая различные подтипы, такие, как диффузная большая лимфома B-клеток, фолликулярная лимфома и лимфома мантичной клетки, а также многочисленные миелома и острая лимфоболическая лейкемия B-клеток, стало одобрение различных продуктов CAR-T-клеток для этих конкретных указаний Администрацией по вопросам продовольствия и н

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… Among these, candidemia is the main concern, although various mold species like Aspergillus , Fusarium , and Mucorales have been implicated in lung diseases ( Haidar et al., 2020 ; Jain et al., 2019 ; Kambhampati et al., 2022 ). …

Pulmonary aspergillosis: diagnosis and treatment.

Aspergillus species are the most frequent cause of fungal infections of the lungs with a broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) and chronic pulmonary aspergillosis (CPA). IPA affects immunocompromised populations, which are increasing in number and diversity with the advent of novel anti-cancer therapies. Moreover, IPA has emerged as a complication of severe influenza and coronavirus disease 2019 in apparently immunocompetent hosts. CPA mainly affects patients with pre-existing lung lesions and is recognised increasingly frequently among patie

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… Fusarium, Histoplasma. ¶ ODI 0.5 is recommended by the manufacturer. Higher cut-offs ( e.g. 1.0) are recommended for better specificity, notably in non-serum samples (BAL, cerebrospinal fluid). + Detection of most other fungal pathogens with some exception ( e.g. …

Проверка генотипов чечевиц на предмет выявления болезни стволового ствола и молекулярная идентификация причинно-следственного организма.

Во время сезона сбора урожая 2019-20, 2020-21, и 2021-22С помощью Alpha-Lattice Design с помощью Alpha-Lattice Genoтипы чечевиц были скринингированы на Stemphilium blight. three Репликации в Исследовательском центре Пульса, БАРИ, Ишурди, Pabna-6620 в естественных и искусственных эпифитотических условиях. В случае искусственного инокулума искусственные инокулумы были разбрызганы на 1.3 × 105 Споры/мл концентрации споров для прививки споров на экспериментальных участках. Данные о серьезности заболевания были зарегистрированы следующим образом: 1-9 Кроме того, была произведена оценка шкалы рейтин

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… Source of resistant against Fusarium wilt and Stemphylium blight in lentil ( Lens culinaris Medikus). Inter J. Appl. Sci. Biotech. 5 , 102–110 (2017). 22. Subedi, S. et al. S. …

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).

Patients with haematological malignancies (HM) are at high risk of developing invasive fungal disease (IFD) with high morbidity and attributable mortality. We reviewed data published until September 2021 to update the 2017 antifungal prophylaxis recommendations of the German Society of Haematology and Medical Oncology (DGHO). The strong recommendation to administer antifungal prophylaxis in patients with HM with long-lasting neutropenia, i.e. 7 days remains unchanged. Posaconazole remains the drug of choice for mould-active prophylaxis in these patients. Novel treatment options in HM, such as

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… Antifungal | Mechanism of action | Future areas of use | Future use in prophylaxis | Clinical trials evaluating prophylactic use Fosmanogepix/Manogepix | Inhibition of Gwt1, targets GPI-anchored protein maturation | Invasive infections with Aspergillus spp., Scedosporium spp., Fusarium spp., Mucorales …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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… Other fungal pathogens include P. jirovecii , cryptococci, and molds, such as Mucorales or Fusarium . Among yeasts, Candida is the most frequently isolated organism, usually in bloodstream infections. … Other fungi, such as Cryptococcus, Fusarium , Blastoschizomyces, Trichosporon, and Scedosporium, have been reported sporadically. Finally, infections or reactivations of dimorphic fungi, such as Histoplasma or Coccidioides, are possible in patients who live or used to live in endemic areas. …

Contribution of Population Pharmacokinetics of Glycopeptides and Antifungals to Dosage Adaptation in Paediatric Onco-hematological Malignancies: A Review.

The response to medications in children differs not only in comparison to adults but also between children of the different age groups and according to the disease. This is true for anti-infectives that are widely prescribed in children with malignancy. In the absence of pharmacokinetic/pharmacodynamic paediatric studies, dosage is frequently based on protocols adapted to adults. After a short presentation of the drugs, we reviewed the population pharmacokinetic studies available for glycopeptides (vancomycin and teicoplanin, n = 5) and antifungals (voriconazole, posaconazole, and amphotericin

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… weight Antifungals Voriconazole | Treatment of | Adults and children aged 2 years and above 1) invasive aspergillosis 2) candidemia in non-neutropenic patients 3) fluconazole-resistant serious invasive Candida infections (including C. krusei) 4) serious fungal infections caused by Scedosporium spp. and Fusarium …

Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.

This review systematically examines the oral complications associated with conventional and novel anti-cancer therapies. It highlights that while molecularly targeted agents including monoclonal antibodies targeting the vascular endothelial growth factor and its receptor, the epidermal growth factor receptor, tyrosine kinase inhibitors, and immune checkpoint inhibitors tend to exhibit a lower overall toxicity profile compared to traditional cytotoxic chemotherapeutics, they are nonetheless linked to significant oral adverse events. These complications encompass inflammatory mucosal reactions k

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… Streptococcus viridans, Streptococcus mitis, and Staphylococcus aureus are commonly involved in bacterial infections, while Candida albicans, Aspergillus species, and Fusarium species contribute to fungal complications. …

Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers.

Chronic venous disease (CVD) is a prevalent condition in adults, significantly affecting the global elderly population, with a higher incidence in women than in men. The modulation of gene expression through microRNA (miRNA) partly regulated the development of cardiovascular disease (CVD). Previous research identified a functional analysis of seven genes (CDS2, HDAC5, PPP6R2, PRRC2B, TBC1D22A, WNK1, and PABPC3) as targets of miRNAs related to CVD. In this context, miRNAs emerge as essential candidates for CVD diagnosis, representing novel molecular and biological knowledge. This work aims to i

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… Exploring microRNA-like small RNAs in the filamentous fungus Fusarium oxysporum PLoS ONE 2014 9 e104956 10.1371/journal.pone.0104956 25141304 PMC4139310 15. Wahid F. Shehzad A. Khan T. Kim Y.Y. MicroRNAs: Synthesis, mechanism, function, and recent clinical trials Biochim. Biophys. …

Promising Activities of Marine Natural Products against Hematopoietic Malignancies.

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially avai

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… approaches have allowed the identification of l -asparaginase from different marine microorganisms, such as the bacteria Bacillus cereus , Bacillus pumilus , Pseudomonas aeruginosa , Enterobacter hormaechei , Streptomyces albidoflavus , Streptomycetes parvulus , and Nocardiopsis alba and the fungi Fusarium …

Structured missingness in biomedical research.

Antipathogen defense; b-caryophyllene; vector-virus mutualism Plants respond to insect herbivory by producing and releasing distinctive blen … inia sclerotiorum, causing white mold disease, and a devastating plant vascular wilt-causing fungus Fusarium oxysporum, indicating its applicability for the management of certain plant pathogenic fungi in agricultural crop production. Gao et al. (2024) demonstrated the increased stability of b-caryophyllene using nanoliposomes during a 14-day storage perio …

Pulmonary and Hepatic Complications of Hematopoietic Cell Transplantation

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… Fungi are historically classified as either yeasts ( Candida , Trichosporon , Cryptococcus ) or molds, with molds subdivided by septate hyphae ( Aspergillus , Scedosporium , Fusarium , Histoplasma , Penicillium ) or aseptate hyphae ( Mucor , Rhizopus ). …