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A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts.

BACKGROUND: Patients with follicular lymphoma have heterogeneous outcomes. Predictor models to distinguish, at diagnosis, between patients a … patient cohorts from the PRIMA trial (n=178; distinct from the training cohort), the University of Iowa/Mayo Clinic Lymphoma SPORE project (n=201), and the Barcelona Hospital Clinic (n=109). All tissue samples consisted of pretreatment diagnostic biopsies and were confirmed as follicular lymphoma grade 1-3a. The patients were all treated with regimens …

Use of imaging-based dosimetry for personalising radiopharmaceutical therapy of cancer.

Theranostics - i.e., the combination of molecular imaging and radiopharmaceutical therapy of cancer targeting a common biological feature - is a rapidly expanding field owing the recent successes of novel radiopharmaceutical therapies, such as 177Lu-based prostate-specific membrane antigen radioligand therapy of prostate cancer and peptide receptor radionuclide therapy of neuroendocrine tumours. Despite the ongoing technical developments in imaging-based dosimetry, the existence of tumour absorbed dose-efficacy and organ absorbed dose-toxicity relationships, as well as the high interpatient va

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… activity at cycles 2 and 3 based on post-treatment dosimetry | Post-treatment PET/CT at 5 h and 4-timepoint SPECT/CT Whole kidney segmentation Blood sampling for bone marrow | Not reported | Thrombopenia: 0% Neutropenia: 0% Nephrotoxicity: 0% Bushnell et al. [ 16 ] Iowa City, IA, United States | Combined … Combination RPT of neuroendocrine tumours The group from Iowa also reported on a series of three patients with midgut neuroendocrine tumour who were treated with combined 90 Y-DOTATOC PRRT and 131 I-MIBG RPT in a phase 1 trial [ 16 ]. …

Продольный анализ сетчатки и хориокастина у пациентов с множественным склерозом: a 3-year Учёба.

ЦЕЛИ: В рамках этого исследования изучалось продольное развитие структуры сетчатки и микроваскулатуры по сравнению с ней. 3 - годы у пациентов с множественным склерозом (RRMS) с релапсирующим излучением с использованием оптической томографии (OCT) и ангиографии OCT (OCTA). Она также изучила корреляцию между этими изменениями и оценками Расширенной шкалы взносов для инвалидов. МЕТОДЫ: В этом перспективном, продольном исследовании мы зачислялись 66 пациентов с RRMS, не имеющих зрительного неврита и 124 здоровый контроль. Все участники прошли полный офтальмологический осмотр, сканирование OCT/OCT

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… nuclear layer (INL); outer plexiform layer (OPL); outer nuclear layer (ONL); photoreceptor inner/outer segments (IS/OS); outer segment of photoreceptors (OSP); outer segment photoreceptor/retinal pigment epithelium complex (OPR); retinal pigment epithelium (RPE) from the macular OCT images using the Iowa … Reference Algorithm (Retinal Image Analysis Lab, Iowa Institute for Biomedical Imaging, Iowa City, IA, USA) (Fig.  1 ). …