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Mechanisms of bone pain: Progress in research from bench to bedside.

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with va

Улучшают ли упражнения на ногах функции рук и рук для лиц с нееврологическими расстройствами? Обзор.

Цель проведения аналитического обзора, содержащего резюме существующей литературы об использовании упражнений на ногах для улучшения функции руки для лиц, страдающих неврологическими условиями. 5 базы данных (PubMed, Empase, Cumulative Index to Medrsing and Alimate Health Licture, Scopus, Cochrane Central), вторичные ссылки и 9 Серые литературные базы данных с января 1, 1947, по октябрь 28, 2025Студенты по отбору исследователей включали взрослых, живущих в неврологических условиях и осуществляющих программы тренировки с ориентацией на ногу, которые включали в себя конкретные результаты по рука

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… Further exploration of this approach is warranted not only in stroke and PD but also in other neurologic conditions, such as SCI, ALS, multiple sclerosis, and cerebral palsy. …

Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice.

Patients on high-dose bisphosphonate and immunosuppressive therapy have an increased risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ); despite the disease severity, its pathophysiology remains unknown, and appropriate therapy is not established. Here we have developed a mouse model of BRONJ-like disease that recapitulates major clinical and radiographic manifestations of the human disease, including characteristic features of an open alveolar socket, exposed necrotic bone or sequestra, increased inflammatory infiltrates, osseous sclerosis, and radiopaque alveolar bone. We show t

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells. Immunol Res., 2019;67(45):310-324. Manthiram K, Edwards KM, Long SS. “Prolonged, Recurrent, and Periodic Fever Syndromes.” In Principles and Practice of Pediatric Infectious Diseases, 2018:5;117-128. …

Протеин тиросин фосфатаза-рецептор типа каппа (ПТПРК) вернулся к рассмотрению: развивающееся понимание структуры, функций и патологии.

Protein Tyrosine Phosphataze Type Cappa (PTPRK) — мембранная тиросина фосфатаза, кодируемая часто удаляемой областью хромосомы 6q, которая играет ключевую роль в регулировании сигнала, сцепления и иммунной реакции клеток. Структурно PTPRK включает внеклеточную область, связанную с сцеплением клеток, область трансмембрана и две внутриклеточные каталитические области, ответственные за фосфатазу. В частности, PTPRK подвергается протеолитическому декольте с помощью Furin и ADAM10, в результате чего образуется внеклеточная подгруппа E и подгруппа P. Дальнейшая обработка с помощью β-Secretasa выпуск

Совпадение в аннотации оригинала
Protein Tyrosine Phosphatase Receptor Type Kappa (PTPRK) is a membrane-bound tyrosine phosphatase encoded by the frequently deleted region o … cularly in the development of CD4 + T cells, and has been implicated in autoimmune diseases such as multiple sclerosis. In the nervous system, PTPRK is linked to neurite outgrowth and synaptic transmission, with genetic polymorphisms in PTPRK associated with an increased risk of neurodegenerative diseases like Alzheimer's disease. Given its extensive involvement in …

Novel Treatments in Myasthenia Gravis.

Myasthenia gravis (MG) is the prototypical autoimmune disorder caused by specific autoantibodies at the neuromuscular junction. Broad-based immunotherapies, such as corticosteroids, azathioprine, mycophenolate, tacrolimus, and cyclosporine, have been effective in controlling symptoms of myasthenia. While being effective in a majority of MG patients many of these immunosuppressive agents are associated with long-term side effects, often intolerable for patients, and take several months to be effective. With advances in translational research and drug development capabilities, more directed ther

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… Hematopoetic Stem Cell Transplant (Hsct) The data for the use of HSCT in various refractory immune mediated neurological disorders have been accumulating over the past two decades, most notably for multiple sclerosis ( 99 , 100 ). … A subsequent systematic review of HSCT therapy showed that 2.2% of all articles were in MG, 29.4% in graft versus host disease and 19.8% in multiple sclerosis ( 105 ). With better and safer induction regimens, HSCT may be a reasonable treatment option in severe refractory MG in the future. …

Mechanisms of chemotherapy-induced behavioral toxicities.

While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of lif

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… This has partly been driven by evidence for a role of neuroinflammation in fatigue in patients from non-cancer contexts such as rheumatoid arthritis and multiple sclerosis. … Furthermore, mitochondrial dysfunction has been implicated in the pathophysiology of chronic fatigue syndrome (Myhill et al., 2009 , 2013 ; Murrough et al., 2010 ) as well as fatigue in patients with multiple sclerosis (Roelcke et al., 1997 ), and fatigue in rodents treated with an inflammatory agent …

Hope and Acceptance at the End of Life: Impact of Spirituality on Patients in Palliative Care.

IntroductionPalliative care aims to improve the quality of life of patients with serious illnesses. In this type of care, spirituality is placed alongside other dimensions: physical, psychological, and social. The end of life brings confrontation with dilemmas such as "none of this makes sense" or "was it worth it?" The acceptance or rejection of the journey presents spirituality as a dimension that accompanies the person in their existence. Interventions that allow for a review of life help facilitate reflection on regrets, unresolved issues, and an understanding of the legacy that generates

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… Therefore, the following groups were defined: “autoimmune pathology,” which included primary diagnoses of myasthenia gravis, multiple sclerosis, myelitis, and polymyositis; “neoplasia,” which included diagnoses of paraganglioma, squamous cell carcinoma, genital cancer, lung adenocarcinoma, colon cancer …

Hyperintense lesions of the middle cerebellar peduncle and beyond: a pictorial essay.

The middle cerebellar peduncle (MCP) is the largest afferent system of the cerebellum and consists of fibres from the cortico-ponto-cerebellar tract. Specifically, several relevant diseases can present with hyperintensity in the MCP on T2-weighted/fluid-attenuated inversion recovery (T2/FLAIR) magnetic resonance imaging sequences, including multiple sclerosis; acute disseminated encephalomyelitis; neuromyelitis optica spectrum disorder; progressive multifocal leucoencephalopathy; hepatic encephalopathy; osmotic demyelination syndrome; multiple system atrophy; fragile X-associated tremor/ataxia…

Внеклеточный маркер изменяется в связи с болезнью при повторном выпуске нескольких склерозов.

Множественный склероз (MS), расстройство спектра нейромиелита (NMOSD) и гликопротеиновое заболевание, связанное с антителами (MOGAD), являются аутоиммунными расстройствами CNS, вызывающими серьезные нейрологическое расстройство. Имеющиеся данные свидетельствуют о том, что внеклеточные везикулы (ЭМ) могут играть конкретную роль в оркестре реакции иммунных клеток MS, NMOSD и MOGAD. Кроме того, ЭМ рассматриваются в качестве потенциального источника биомаркеров, которые могут позволить нам установить молекулярные сигнатуры для этих заболеваний и, возможно, следить за последствиями лечения и прогре

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are autoimmune disorders of the CNS causing severe neurologic impairment. Evidence suggests that extracellular vesicles (EVs) may play a disease-specific role in the orchestration of t…

The Role of Gamma Delta T Lymphocytes in Physiological and Pathological Condition-Focus on Psoriasis, Atopic Dermatitis, Autoimmune Disorders, Cancer and Lymphomas.

Gamma delta (γδ) T cells are a heterogeneous population of cells that play roles in inflammation, host tissue repair, clearance of viral and bacterial pathogens, regulation of immune processes, and tumor surveillance. Recent research suggests that these are the main skin cells that produce interleukin-17 (I-17). Furthermore, γδ T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. γδ T cells are found in epithelial tissues, where many cancers develop. There, they participate in antitumor immunity as cytotoxic cells or as immune coordinators.

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… Growing evidence indicates that inappropriately activated γδ T cells may drive the pathogenesis of autoimmune diseases such as psoriasis, vitiligo, autoimmune hepatitis, autoimmune thyroid disease, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and lymphomas [ 10 , 25 ]. … Inappropriately activated γδ T cells may drive the pathogenesis of autoimmune diseases such as psoriasis, vitiligo, autoimmune hepatitis, autoimmune thyroid disease, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and lymphomas. …

Metformin-Associated Functional Vitamin B12 Deficiency Presenting as Subacute Combined Degeneration in a 57-Year-Old Man With Diabetes Mellitus.

BACKGROUND Functional vitamin B12 deficiency, also known as metformin-associated cobalamin deficiency, can occur in patients receiving metformin due to impaired gastrointestinal absorption of vitamin B12. This condition can coexist with diabetic neuropathy and may result in impaired myelin formation in the spinal cord and peripheral nerves, leading to subacute combined degeneration of the spinal cord. This report describes a patient with diabetes mellitus and metformin-associated functional vitamin B12 deficiency who presented with subacute combined degeneration of the spinal cord and gastroin

UMIB Summit 2015

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Potential Role of Bupropion Sustained Release for Cancer-Related Fatigue: a Double-Blind, Placebo-Controlled Study

Background: Cancer-related fatigue (CRF) is very common and can be experienced at all stages of disease and in survivors. CRF causes patients more distress than pain or nausea and vomiting. Different pharmacologic interventions have been evaluated for the management of CRF. The purpose of this study was to determine the efficacy of bupropion sustained release (SR) as a treatment for fatigue in patients with cancer. Methods: In this randomized, double-blind, placebo-controlled trial, patients with fatigue due to cancer were randomly assigned to either 150mg daily of bupropion SR or matching pla

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… It has also been used to treat chronic fatigue syndrome, antidepressant-induced fatigue, and fatigue associated with multiple sclerosis. …

Summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transpla

Текущие данные о связи языковой прочности с когнитивным снижением у пожилых людей и известными факторами риска, связанными со слабостью, саркопией и питанием: протокол аналитического обзора.

ВВЕДЕНИЕ: Факты указывают на то, что патология, лежащая в основе когнитивного упадка, ведущего к слабоумию, начинается 15-20 За годы до появления когнитивных симптомов. Таким образом, идентификация биомаркеров на этом предклиническом этапе имеет исключительно важное значение. Связанное с возрастом снижение массы и силы мышц, что является известным фактором риска для саркопсии, слабость и когнитивное упадок, также влияет на язык. В настоящем документе описывается априори протокол, подготовленный междисциплинарной группой для решения следующих вопросов, касающихся взрослых ≥50 возраст:1) Каковы

Coexistence of double seropositivity for MPO antibody and anti-GBM antibody in ANCA-associated vasculitis concurrent with multiple myeloma: A case report.

RationaleImmune-mediated vasculitis with 2 or more autoantibodies, for example, anti-proteinase-3, combined with anti-myeloperoxidase (MPO) or anti-glomerular basement membrane (GBM) antibodies, is extremely unusual. Furthermore, the coexistence of autoimmune vasculitis and hematological malignancies is uncommon. Herein, we describe a case of double-seropositive anti-neutrophil cytoplasmic antibody (ANCA) vasculitis with multiple myeloma.Patient concernsA 79-year-old Asian man presented with persistent leg edema and kidney dysfunction. His kidney function rapidly decreased, and serologic test

Prospects for Development and Commercialisation of Allogeneic CAR-Based Therapies for Autoimmune Disease.

Chimeric antigen receptor (CAR)-T cell therapies represent a promising therapeutic approach for refractory autoimmune diseases. Although autologous CAR-T cells have achieved success thus far, they require expensive, individualised manufacturing, limiting their commercialisation potential. Allogeneic alternatives could overcome these scalability barriers, providing 'off-the-shelf' treatments, although they raise the issues of graft-vs-host reactions and host-mediated rejection. To mitigate such risks, gene-edited αβ T cells or non-alloreactive host cells (e.g., NK cells, γδ T cells) may be used

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… There are also several autoimmune diseases linked with EBV, with rheumatoid arthritis and multiple sclerosis, for example, correlating specifically with chronic B cell infection [ 82 ], potentially making EBV-CTLs naturally suited to autoimmune therapy [ 81 ]. …

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity.

Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits, at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor (GR) is the site of action for these hormones and a vast body of work has been conducted understanding its function. Traditionally, it was thought that the anti-

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… GRγ typically accounts for around 3.8% to 8.7% of total GR mRNA ( 232 , 233 ); however, as much as 40% of total GR has been seen in PBMC of patients with glucocorticoid-resistant multiple sclerosis (who also had reduced total and GRγ expression compared to glucocorticoid-sensitive controls) ( 234 ). … Primary glucocorticoid resistance has been described in a number of inflammatory diseases including asthma ( 296 , 297 ), RA ( 298 ), IBD ( 299-301 ), SLE ( 302 , 303 ), and multiple sclerosis ( 304 ). …

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an ada

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… In addition, the re-analysis of clinical studies of multiple sclerosis treated rectally with ozone for one month [ 61 ], confirm the modulating effect of O 3 in the balance of Nrf2/NF-κB [ 38 ]. … Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients. Eur. J. Pharmacol. 2017;811:148–154. doi: 10.1016/j.ejphar.2017.06.017. 62. …