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Каннабиноиды: терапевтические перспективы для борьбы с орофасиальной болью, оральное воспаление и систематическое обследование на предмет вылечения костей.

Каннабиноиды, в частности каннабидиол (КБР) и тетрагидроканнабинол (THC), все чаще изучаются на предмет их терапевтического применения в различных медицинских областях. Целью этого систематического обзора является изучение их роли в оральной хирургии с уделением особого внимания обезболиванию, воспалению и регенерации костей. Систематический обзор был проведен с использованием системы PRISMA для выявления соответствующих исследований из баз данных PubMed, Scopus и Web-сайта науки, опубликованных до ноября 2024. Обзор включал в себя клинические и предклинические исследования, посвященные изучен

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… Also, Se Woong Kim [ 23 ] examined the combined effects of CBD and taurine on inflammatory markers and periodontitis in rats. … Combination of Cannabidiol with Taurine Synergistically Treated Periodontitis in Rats Biomol. Ther. 2025 33 203 209 10.4062/biomolther.2024.104 39632669 PMC11704405 24. Klein K.P. Guastaldi F.P.S. Pereira H.S.G. He Y. Lukas S.E. …

Are medication-induced salivary changes the culprit of osteonecrosis of the jaw? A systematic review.

PURPOSE: This systematic review was performed to assess the potential influence of medication-induced salivary changes on the development of … ng MRONJ owing to the changes in salivary microbiome profiles, cytokine profiles, interleukins, hypotaurine, and binding proteins. CONCLUSION: The reduction in salivary flow and changes in the concentration of salivary proteins were associated with the development of MRONJ. However, due to the availability of limited evidence, the findings of the review …

Sphingolipid metabolism and hematologic disorders: current understanding and future directions.

Sphingolipids are not only key structural components of cell membranes but also serve as important signaling molecules, and their metabolic homeostasis is essential for the maintenance of cellular functions. In recent years, with the advancement of technologies such as metabolomics, studies have revealed that sphingolipid metabolic abnormalities are extensively involved in the occurrence and development of various hematological disorders, including immune thrombocytopenia, myeloproliferative neoplasms, graft-versus-host disease, hereditary hematological diseases, and hematologic malignancies.

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… Among these, the decrease in taurine level was the most significant metabolic marker distinguishing ITP from normal spleen, demonstrating high sensitivity and specificity ( Wen et al., 2022 ). … | Taurine | Spleen tissue | Diagnostic & Prognostic | Diagnostic: Highly sensitive and specific marker to distinguish ITP spleen from normal spleen. …

Metabolism of tauromustine in liver and lung microsomes from various species.

1. The cytochrome P450 (CYP)-mediated metabolism of tauromustine has been evaluated in liver and lung microsomes from various species. Liver microsomes from rat pretreated with typical CYP inducers, human liver microsomes and cDNA-expressed human CYP enzymes were used to study the enzymatic basis of the metabolism. The further metabolism of the monodemethylated product of tauromustine and that of the denitrosated product were also investigated. 2. The major routes of tauromustine metabolism were demethylation to the alkylating active compound, R2, and denitrosation to the inactive metabolite,

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Vitamin C Capsules | Ostreae Concha extract, Taurine, Vitamin C | G20150237 Kemper Brand Sea Cucumber Oyster Capsules | Sea cucumber extract, Ostreae Concha extract | G20160459 Chinese Salamander Brand Marine Fish Oligopeptide Oyster Oral Liquid | Marine fish oligopeptide powder, Ostreae Concha extract … Capsules | Sodium alginate (irradiated), Taurine (irradiated) | G20070380 Juemingzi | Herbalife Brand Cassia Seed Panax ginseng and Fructus Schisandrae chinensis Capsules | Cassiae Semen extract, Notoginseng Radix Et Rhizoma extract, Panacis Quinquefolii Radix extract, Schisandrae Chinensis Fructus …

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.

BACKGROUND: Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-repositioning approach which exploits old drugs approved for non-cachexia disease. Amiloride, a diuretic drug, is clinically used for treatments of hypertension and edema due to heart failure. Here, we explored the effects of the amiloride treatment for ameliorating muscle wasting in murine models of cancer cachexia. METHODS: The CT26 and LLC tumor cells were subcutaneously in

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… Numbers in the three panels represent significantly altered metabolic pathways, which were identified with -ln( p ) > 2.995 (corresponding to p < 0.05) and pathway impact value > 0.2: 1, taurine and hypotaurine metabolism; 2, nicotinate and nicotinamide metabolism; 3, pyruvate metabolism; 4, phenylalanine … Among 17 shared characteristic metabolites, 10 metabolites (glucose, IMP, glycine, creatine, methylmalonate, niacinamide, aspartate, glutamate, fumarate and tyrosine) were increased in the CAC gastrocnemius but consistently decreased in the AM and KD gastrocnemius, and 7 metabolites (lactate, taurine …

Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of motor neurons. Though many molecular and genetic causes are thought to serve as predisposing or disease propagating factors, the underlying pathogenesis of the disease is not known. Recent discoveries have demonstrated the presence of inflammation propagating substrates in the central nervous system of patients afflicted with ALS. Over the past decade, this hypothesis has incited an effort to better understand the role of the immune system in ALS and has led to the trial of sever

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… NP001 Taurine is an amino acid not incorporated into protein, which binds HOCl, as produced by the oxidative burst of activated neutrophils. … The product of this reaction, taurine chloramine, is a less toxic oxidizing agent than HOCl; it is also a signaling molecule that contributes to the self-limiting nature of inflammation. …

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics.

Multiple myeloma (MM) is a malignancy of plasma cells characterized by multifocal osteolytic bone lesions. Macroscopic and genetic heterogeneity has been documented within MM lesions. Understanding the bases of such heterogeneity may unveil relevant features of MM pathobiology. To this aim, we deployed unbiased ¹H high-resolution magic-angle spinning (HR-MAS) nuclear magnetic resonance (NMR) metabolomics to analyze multiple biopsy specimens of osteolytic lesions from one case of pathological fracture caused by MM. Multivariate analyses on normalized metabolite peak integrals allowed clusteriza

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… Also taurine, highly abundant in the cytoplasm, was more abundant in muscle as compared to tumor samples, reflecting its high cytoplasmic content. … Considering the correlation matrix generated using all types of samples ( Figure 4 A) we observed that typical intracellular and cytosolic metabolites (e.g., taurine, creatine, phosphocreatine, glutamate, glutamine and glycine) correlate with the presence of muscle fibers in the specimen. …

SeHCAT [tauroselcholic (selenium-75) acid] for the investigation of bile acid malabsorption and measurement of bile acid pool loss: a systematic review and cost-effectiveness analysis.

BACKGROUND: The principal diagnosis/indication for this assessment is chronic diarrhoea due to bile acid malabsorption (BAM). Diarrhoea can … with unknown cause (i.e. before resection): (1) What are the effects of selenium-75-homocholic acid taurine (SeHCAT) compared with no SeHCAT in terms of chronic diarrhoea, other health outcomes and costs? (2) What are the effects of bile acid sequestrants (BASs) compared with no BASs in people with a positive or negative SeHCAT test? (3) Does a positive o …

Research Communications of the 26th ECVIM‐CA Congress

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… value of pulmonary vein to pulmonary artery ratio in dogs with pulmonary hypertension of pre‐capillary origin 17.45–18.00 | ESVC‐O‐27 | Vezzosi | Echocardiographic evaluation of the right atrial area index in dogs with pulmonary hypertension Saturday 10 September 11.50–12.05 | ESVC‐O‐28 | Basili | Taurine …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… A retrospective study PK-172 Single dose of clarithromycin leads to toxic tacrolimus levels PK-209 Pharmacokinetics of oral taurine in healthy volunteers PK-268 Effect of human immunodeficiency virus-1 protease inhibitors on itraconazole metabolism in V79 Chinese hamster cells expressing human cytochrome …

Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management.

The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlying mechanism and causative factors, with the hope of developing novel therapeutic strategies. Autophagy, a conserved biological process, involves the degradation of damaged organelles or protein aggregates to maintain cellular homeostasis. Disruption of this crucial process leads to increased genomic instability, accumulation of reactive oxygen species (ROS), decreased mitochondrial functions, and suppression of ubiquitination, leading to overall decline in quality of intrac

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… Another study, it was observed that lncRNA taurine up-regulated gene 1 (TUG1) targeted miR-195-5p by modulating HDGF levels, thereby regulating miR-195-5p/HDGF/DDX5/β-catenin axis in CRC resistance [ 66 ]. … Insulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy. Bioengineered. 2022;13(2):2450–69. 67. …

Регулирование питания иммунной системы кишечного мозга происходит на протяжении всей жизни.

Иммунная ось кишечника объединяет микробные, иммунные и нейронные сигналы для регулирования нейроразвития, гомеостаза и подверженности болезням. Раннее питание, в частности молочные олигозакариды, формирует благотворный микробиотический состав, повышает гиппокампальную пластичность, способствует антивоспалительной микроглианской поляризации и поощряет иммунную терпимость. Микробиота - метаболиты гута, включая короткоцепные жирные кислоты, производные триптофана и вторичные желчные кислоты, регулируют микроглиатическое созревание, функцию астроцита, дифференциацию клеток Т, производство нейротр

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… For instance, children with autism spectrum disorder (ASD) are 6-8 times more likely to suffer from chronic gut or digestive conditions. 156 Dysregulation of gut microbiota-derived metabolites is implicated in children with ASD, as levels of 5-aminovaleric acid (5AV) and taurine, weak GABA receptor agonizts … For instance, folate is essential for development of the fetal brain and its supplementation during pregnancy prevents neurodevelopmental disorders in offspring. 177 Recently, taurine supplementation in adulthood has been described to have neuroprotective, cognition-enhancing, and anticonvulsant effects …

Nutritional supplementation for hip fracture aftercare in older people.

BACKGROUND: Older people with hip fractures are often malnourished at the time of fracture, and subsequently have poor food intake. This is … ntravenous or oral iron, ornithine alpha-ketoglutarate versus an isonitrogenous peptide supplement, taurine versus placebo, and a supplement with vitamins, minerals and amino acids, provided low- or very low-quality evidence of no clear effect on mortality or complications, where reported.Based on low-quality evidence, one trial evaluating the use of diet …

Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature.

N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus potentiating the endogenous antioxidant mechanism. Late administration of NAC after cisplatin has been shown in different in vivo studies to reduce the side effects caused by various toxicities at different levels without affecting the antitumor efficacy of platinum, improving total and enzymatic antioxidant capacity and decreasing oxidative stress markers. These characteristics provide NAC with a rationale as a potenti

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… Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats. Drug Des Devel Ther . 2017;11:901–908. doi: 10.2147/DDDT.S131316 55. Zhitkovich A. N-Acetylcysteine: antioxidant, aldehyde scavenger, and more. … Possible mechanisms for N-acetyl cysteine and taurine in ameliorating acute renal failure induced by cisplatin in rats. Toxicol Mech Methods . 2011;21(7):538–546. doi: 10.3109/15376516.2011.568985 79. Huang S, You J, Wang K, et al. …

Mass spectrometry-based metabolomics in health and medical science: a systematic review.

Metabolomics is the study of the investigation of small molecules derived from cellular and organism metabolism, which reflects the outcomes of the complex network of biochemical reactions in living systems. As the most recent member of the omics family, there has been notable progress in metabolomics in the last decade, mainly driven by the improvement in mass spectrometry (MS). MS-based metabolomic strategies in modern health and medical science studies provide innovative tools for novel diagnostic and prognostic approaches, as well as an augmented role in drug development, nutrition science

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… Chen et al. recruited four cohorts of 2155 participants to screen potential early CKD biomarkers using MS-based metabolomics. 46 A variety of statistical analysis methods were used, and five metabolites, 5-methoxytryptophan, canavaninosuccinate, acetylcarnitine, tiglylcarnitine, and taurine, can be used … Four metabolites, with the exception of taurine, were recovered significantly, suggesting the effectiveness of these five metabolites in the diagnosis of early CKD. …

Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products.

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences in efficacy have been observed in clinical practice. There is increasing evidence that gut microbial metabolites influence the efficacy of distal tumor immunotherapy via the gut-liver axis, the gut-brain axis and the gut-breast axis, a process that may involve modulating the expression of immune cells and cytokines in the tumor microenvironment (TME). In this review, we systematically explore the relationship between gut microbial metabolites and tumor i

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… . | ( 207 ) Wumei Wan | Tryptophan metabolites (3-indolepropionic acid) | Modulation of 3-indolepropionic acid in serum of CAC mice reduces the PI3K/Akt signaling pathway thereby inhibiting MDSCs | ( 208 ) Pien-Tze-Huang | Bile acids (cholic acid, taurocholic acid) | Promotes the production of taurine … and taurine, increases the content of bile acids and unsaturated fatty acids, and strengthens the function of the intestinal barrier. …

Метаболизм желчной кислоты в множестве склероза поражается и связан с риском подтвержденного ухудшения состояния здоровья.

КОЛИЧЕСТВО: Подлые кислоты (БА) стали важными посредниками в нейроинфламмации и нейродегенерации, которые являются важными особенностями множественного склероза (МС). Цель этого исследования состояла в изучении уровней сыворотки БА у недавно диагностировавшихся людей с MS (PwMS) и изучении их связи с ухудшением положения инвалидов. МЕТОДЫ: Исследование включало 907 ПТМС и 907 Сопоставимый контроль со стороны шведской группы ЭИМС, основанной на населении, с клиническими последующими данными шведского регистра MS. Уровни сыворотки BA были проанализированы с использованием масс-спектрометрии жидк

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… After synthesis in the liver and conjugation with taurine or glycine, BAs are stored in the gallbladder and released during digestion. …

The functional role of long noncoding RNA in resistance to anticancer treatment.

Chemotherapy is one of the fundamental methods of cancer treatment. However, drug resistance remains the main cause of clinical treatment failure. We comprehensively review the newly identified roles of long noncoding RNAs (lncRNAs) in oncobiology that are associated with drug resistance. The expression of lncRNAs is tissue-specific and often dysregulated in human cancers. Accumulating evidence suggests that lncRNAs are involved in chemoresistance of cancer cells. The main lncRNA-driven mechanisms of chemoresistance include regulation of drug efflux, DNA damage repair, cell cycle, apoptosis, e

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… expression of lncRNA ODRUL is increased in adriamycin resistant osteosarcoma cell lines, and the knockdown of ODRUL leads to suppression of the ABCB1 gene. 128 Zhou et al. reported that high expression of SNHG12 mediated adriamycin-resistance in osteosarcoma through the miR-320a/MCL1 axis. 129 The lncRNA taurine … Cancer Chemother Pharmacol 2016 ; 77 : 1061 – 1067 . 27056384 10.1007/s00280-016-3029-3 106 Xie DL Zhang H Hu XH , et al Knockdown of long non-coding RNA taurine up-regulated 1 inhibited doxorubicin resistance of bladder urothelial carcinoma via Wnt/β-catenin pathway . …