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Production of a bacteriophage, a phage tail-like bacteriocin and an antibiotic by Bacillus azotofixans.

Twenty-two nitrogen-fixing Bacillus azotofixans strains were shown to produce an inhibition zone against themselves in plate assays. The B. azotofixans type strain P3L-5, chosen for further studies, produced inhibition zones against various Bacillus strains and other bacterial genera. This antibacterial substance was also produced in liquid medium and its production was enhanced in semisolid medium (0.4% agar) after 3 to 5 days of incubation. The substance was suggested to be an antibiotic and its preliminary characterization showed resistance to heat (100 degrees C, 15 minutes), to trypsin, p

[Intestinal absorption of glucose in anesthetized rats. I. Standardization of a method for screening of oral hypoglycemic agents].

This paper presents a method for the screening of natural hypoglycaemic drugs that interfere with the intestinal absorption of glucose. Luminal perfusion of the small intestine (whole length) was carried out on 24 h fasted adult Wistar rats, anaesthetized with sodium pentobarbital. Two rubber Nelaton cannulae were introduced into the organ, the first at the proximal end of the duodenum, just after the pylorus and a second larger one near the ileo-cecal valve. After a preliminary washing with warm physiological saline to remove any alimentary residues and secretions, warm saline containing gluc

Do snake venom cytotoxins exhibit amphiphilicity?

It is suggested, on the basis of the structural information available from the literature, that the molecules of cobramine B and homologous cytotoxins, in contrast to snake venom neurotoxins, are amphiphilic in the sense that they are composed of a predominantly hydrophobic multi-stranded beta-sheet and other regions sharply hydrophilic. It is possible that the direct lytic activity of snake venom cytotoxins is due, at least in part, to their amphiphathy.

Isolation and partial characterization of a protein fraction from the opossum (Didelphis marsupialis) serum, with protecting property against the Bothrops jararaca snake venom.

Two separated methods were used to purify a fraction from the opossum (Didelphis marsupialis) serum able to protect mice against Bothrops jararaca venom. The first of them included an initial batch DEAE-Cellulose ion-exchange of the serum, followed by another ion-exchange chromatography on a Carboxymethyl Sepharose column. The second method was a column ion-exchange chromatography on DEAE-Sephacel. These techniques allowed to obtain a protein fraction which resulted homogeneous in cellulose acetate and conventional polyacrylamide gel electrophoresis. The obtained protein fraction proved to be

Fractionation of castor bean allergens (CB-1A). Isolation of RC-13, a homogeneous allergenic fraction.

Allergens from castor beans (CB-1A) were fractionated by ion-exchange chromatography both on CM- and SP-Sephadex, employing pH gradient. SP-Sephadex showed better results and fractionated the allergens into 7 components, eluted in a narrow pH range (5.0 - 6.6). An attempt to isolate the major acidic fraction of the group involved successive chromatographic steps on the same gel. RC-13, the isolated fraction, proved homogeneous by rechromatography on SP-Sephadex and isolectric focusing with pH range 3.0 - 10.0 polyacrylamide gel. The pl of RC-13 determined by the latter is approximately 4.2 and

The presence of histamine in Cnidosculus oligandrus (Euphorbiaceae).

1) The presence of histamine in prickles and lead and stem tissues of Cnidosculus oligandrus (Mull. Arg) Pax & Hoffm (Euphorbiaceae) is reported. 2) Prickles on stems and leaves have larger amounts of histamine, as determined by the isolated guinea-pig ileum and by fluorimetry of the condensation product of the histamine and ortho-phthalaldehyde (OPT). 3) Additionally, thin-layer chromatography and the increase of vascular permeability bioassay were used to confirm the presence of histamine.

Consensus Statement: Importance of Timely Access to Multiple Myeloma Diagnosis and Treatment in Central America and the Caribbean.

BackgroundIn Central America and the Caribbean, multiple myeloma (MM) patients face significant barriers to diagnosis and treatment. The aim of this study is to describe the current situation of MM in the region, discuss the current barriers to timely diagnosis and proper treatment, and develop consensus recommendations to address these issues.MethodsNine experts from five countries took part in a virtual consensus meeting on MM in Central America and the Caribbean. During the meeting, experts analyzed the disease burden, the current conditions for disease management, and access to treatment i

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… Participants included nine experts from five countries in Central America and the Caribbean with expertise in clinical practice, academia and research, and patient education and support. Third-party consultants were used to facilitate discussion. …

Глобальное состояние исследований и тенденции навязчивого сексуального поведения: всеобъемлющий библиометрический анализ.

СТРОИТЕЛЬНОЕ ПОЛОЖЕНИЕ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ (CSBD) - это состояние психического здоровья, которое привлекло к себе значительное внимание в ходе научных исследований, особенно после его включения в одиннадцатый пересмотренный вариант Международной классификации болезней (International Classification of Beasons) (International Classification of Bisons (CSBDD).ICD-11) Всемирной организацией здравоохранения. Несмотря на это признание, эта область по-прежнему является фрагментарной в связи с продолжающимся обсуждением вопроса о ее классификации и о

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… In the third stage, controversy has emerged in academia regarding the classification of CSBD as an ICD in ICD-11, with numerous researchers advocating for its classification as a behavioral addiction ( Fuss, Lemay, et al., 2019 ; Grubbs, Hoagland, et al., 2020 ; Reed et al., 2022 ). … Furthermore, established citation networks in Western academia often favor intra-group referencing, thereby reinforcing a cycle of marginalization of research from peripheral regions. …

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

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… Table 1 Current challenges • Prevention of chronic kidney disease (CKD) and CKD progression to end-stage renal disease (ESRD) in a global unmet medical need with little awareness in public, academia, and industry. • In developed countries, the current focus on renal replacement therapy (RRT) (dialysis … Although programs in CKD/ESRD prevention are likely to be highly cost-effective for national health care systems all over the world, minimal coordinated efforts are made by public bodies, academia, industry, and society. …

Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation.

Proteolysis targeting chimeras (PROTAC) represents a new type of small molecule induced protein degradation technology that has emerged in recent years. PROTAC uses bifunctional small molecules to induce ubiquitination of target proteins and utilizes intracellular proteasomes for chemical knockdown. It complements the gene editing and RNA interference for protein knockdown. Compared with small molecule inhibitors, PROTAC has shown great advantages in overcoming tumor resistance, affecting the non-enzymatic function of target proteins, degrading undruggable targets, and providing new rapid and

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… The emergence of PROTAC not only opened a new chapter for new drug development, but also brought unprecedented opportunities to industry and academia. … It is believed that through the joint efforts of colleagues in academia and industry, these questions can be answered satisfactorily in the near future. Author Contributions YR designed the project, and reviewed and revised the manuscript. …

Bortezomib-Induced Pulmonary Toxicity: A Case Report and Review of Literature.

Bortezomib, a proteasome inhibitor, is an established therapy against multiple myeloma. Bortezomib-induced lung injury, although not appreciated during the introductory time of the medication, has now been highlighted in multiple case reports. The objective of this study is to report a case of bortezomib-induced lung injury, review current literature, and perform exploratory analysis.

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… Cooperative relationship between pharmaceutical companies, academia, and media explains sharp decrease in frequency of pulmonary complications after bortezomib in Japan. Journal of Clinical Oncology. 2008;26(35):5820–5823. doi: 10.1016/s1470-2045(17)30578-8. 23. Dimopoulos M. …

Perspective: Does personalized medicine hold the future for medicine?

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… treatment which eliminates wastage, PM proves to be cost-effective compared with conventional medicine.[ 4 ] Key Players in the Development of Personalized Medicine The development of PM is a multidisciplinary approach requiring team effort from players which may be categorized as industrial players, the academia …

Nanomedicine: Principles, Properties, and Regulatory Issues.

Several scientific areas have benefited significantly from the introduction of nanotechnology and the respective evolution. This is especially noteworthy in the development of new drug substances and products. This review focuses on the introduction of nanomedicines in the pharmaceutical market, and all the controversy associated to basic concepts related to these nanosystems, and the numerous methodologies applied for enhanced knowledge. Due to the properties conferred by the nanoscale, the challenges for nanotechnology implementation, specifically in the pharmaceutical development of new dru

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… Regulatory agencies, pharmaceutical industry, government, and academia are making efforts to accomplish specific and appropriate guidelines for risk assessment of nanomaterials (Hussain et al., 2015 ). … EMA have already created an expert group on nanomedicines, gathering members from academia and European regulatory network. The main goal of this group is to provide scientific information about nanomedicines in order to develop or review guidelines. …

The ASH Research Collaborative Sickle Cell Disease Research Network: past, present, and future.

AbstractHistorically, sickle cell disease (SCD) has been overshadowed by progress in other hematologic disorders, but recent advances are reshaping its clinical and research landscape. Despite SCD reducing life expectancy by >20 years even with optimal care, transformative initiatives are fostering hope for improved outcomes. The American Society of Hematology (ASH) established the ASH Research Collaborative Sickle Cell Disease Research Network as a comprehensive program to revolutionize SCD research in the United States. This Network comprises a collection of innovative, research-focused coop

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… ASH recognized that SCD was an area of substantial need and organized a summit that consisted of representatives from academia, patient groups, governmental partners, and industry. …

Towards a unified approach for multiple myeloma care in Kenya - proceedings of the Inaugural Multiple Myeloma Congress.

The rising burden of multiple myeloma in Kenya has not been met by a commensurate effort for control. Patients and practitioners struggle with unavailability and unaffordability of diagnostics, drugs and stem cell transplant leading to presentation at advanced stages and under-treatment with increased morbidities and mortality. A concerted effort among stakeholders is urgently needed to develop strategies for myeloma control. The scarcity of providers also carries grave consequences for Kenyan patients. The Academic Model Providing Access To Healthcare (AMPATH) multiple myeloma program organiz

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… Aga Khan University Hospital | | MP Shah Hospital | | Metropolitan Hospital, Nairobi | International | | | Max Super Specialty Hospital, New Delhi, India | Commercial laboratory, Kenya | | | ScanLab | Pharmaceutical supplies, Kenya | | | Medipoint EA LTD | | Philips Pharmaceuticals Academia …

Mobilising stakeholders to improve access to state-of-the-art radiotherapy in low- and middle-income countries.

In an ongoing effort to improve access to state-of-the-art radiotherapy in low- and middle-income countries (LMICs), a joint symposium was organised by the non-governmental, non-profit organisation Medical physicists in diaspora for Africa e.V. (MephidA e.V.) in collaboration with the Germany-based Cameroon-German medical doctor's association (Camfomedics e.V.) and the Harvard-based Global Health Catalyst summit. The goal of the symposium was to discuss the technical and structural challenges faced in African LMIC settings, re-evaluate strategies to overcome the shortfall of radiotherapy servi

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… Using understandable and local language, reducing academia bureaucracy and improving infrastructure, especially in palliative care access. …

Cutting edge developments in bone oncology - Highlights from the Cancer and Bone Society 2024 annual meeting.

The 2024 Annual Conference of the Cancer and Bone Society (CABS), held jointly with the Bone Research Society at the University of Sheffield, highlighted the Society's enduring mission to advance understanding of cancer-bone interactions through collaboration, mentorship, and scientific excellence. Established from the early Cancer Induced Bone Disease meetings and re-emerging as an independent body in 2016, CABS continues to serve as a global community bridging basic, translational, and clinical research. This year's meeting featured a comprehensive scientific program spanning tumor-bone biol

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… This was particularly valuable for trainees and postdoctoral fellows considering opportunities outside academia. …

The role of funding and policies on innovation in cancer drug development.

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… Strategic alliances and cooperation between industry and academia are key to future oncology discoveries, as the complex nature of oncology research cannot support monopoly in knowledge and creation. …

Use of real-world evidence in the Medicare Drug Price Negotiation Program: A checklist for the Centers for Medicare and Medicaid Services and manufacturers.

Under the Inflation Reduction Act's (IRA's) - Medicare Drug Price Negotiation Program, the Centers for Medicare & Medicaid Services' (CMS's) "maximum fair price" must be informed by evidence on factors such as therapeutic advance of the selected drug compared with its alternative, comparative effectiveness across clinical and patient-reported outcomes, the impact on specific populations, and the ability to address unmet medical needs. This paper describes how real-world evidence could improve CMS decision-making and creates a best practices checklist to help CMS evaluate the quality of any man

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… To ensure all stakeholder perspectives were incorporated, the co-authors had diverse backgrounds, including expertise from the perspective of academia (Bharmal, Shafrin, Tunis, Whittington), government (Shafrin, Than, Tunis), health technology assessment (Tunis, Whittington) pharmaceutical manufacturers …