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Integrating digital and narrative medicine in modern healthcare: a systematic review.

The increasing integration of digital technologies in healthcare, such as electronic health records, telemedicine, and diagnostic algorithms, improved efficiency but raised concerns about the depersonalization of care. Narrative medicine has emerged as a pedagogical and clinical response to this shift, emphasizing the value of patient stories, socio-cultural contexts, and reflective practice. Understanding how digital tools support, rather than undermine, narrative competencies is critical for developing a more human-centered healthcare education. This review systematically examined empirical

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… Finally, integration efforts extend beyond curriculum design and include institutional policies, accreditation standards, and faculty development programs. … Institutions are encouraged to entrench narrative-digital competencies into core learning outcomes, faculty development programs, and accreditation standards. …

Prolonged Cytopenia with CAR-T Cell Therapy and Management Recommendations.

Chimeric antigen receptor T-cell (CAR T-cell) therapy has revolutionized the treatment of lymphoid malignancies. Prolonged cytopenias, though poorly understood, have emerged as important considerations in the treatment process. In this review, we classified cytopenias into early (< 30 days post CAR T infusion), and late-occurring (after day 30 post infusion). We identified previous chemotherapy and lymphodepletion chemotherapy as the major risk factors contributing to early cytopenia. Product characteristics, such as costimulatory domains, and side effects of therapy such as cytokine release s

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… Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) Hayden P. … Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) Yakoub-Agha I., Chabannon C., Bader P.., et al. 2020Haematologica …

Twitter Social Media is an Effective Tool for Breast Cancer Patient Education and Support: Patient-Reported Outcomes by Survey.

BackgroundDespite reported benefits, many women do not attend breast cancer support groups. Abundant online resources for support exist, but information regarding the effectiveness of participation is lacking. We report the results of a Twitter breast cancer support community participant survey.ObjectiveThe aim was to determine the effectiveness of social media as a tool for breast cancer patient education and decreasing anxiety.MethodsThe Breast Cancer Social Media Twitter support community (#BCSM) began in July 2011. Institutional review board approval with a waiver of informed consent was o

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… Traditional on-campus patient support groups are valuable and have been recommended by the National Accreditation Program for Breast Centers and other organizations in the United States [ 2 , 3 ]. However, traditional support groups may not be available for all patients. … National Accreditation Program for Breast Centers . NAPBC Standards Manual 2014 Edition. Chicago, IL: American College of Surgeons; 2014. [2015-04-28]. https://www.facs.org/~/media/files/quality%20programs/napbc/2014%20napbc%20standards%20manual.ashx . 3. …

The impact of smoking on outcomes among patients undergoing hematopoietic SCT for the treatment of acute leukemia.

A paucity of research exists examining the potential impact of tobacco use on cancer treatment outcomes, especially among patients treated with hematopoietic SCT (HSCT). A retrospective cohort study design was used to examine the impact of smoking on duration of hospitalization and overall survival among 148 consecutive patients undergoing HSCT for treatment of acute leukemia from 1999 to 2005. Of the 148 patients, 15% reported current smoking, 30% former smoking, and 55% never used tobacco. Patients were followed for a median 3.5 years (interquartile range=2.1-5.5). Compared to no history of

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… Pre-transplant variables, hospitalization days, and survival status were electronically imported from standardized forms within the medical record, which is maintained in compliance with Foundation for the Accreditation of Cellular Therapy. 16 Patients approved for transplant must meet pre-transplant … .157.2.9705072 15 Hoodin F Kalbfleisch KR Thornton J Ratanatharathorn V Psychosocial influences on 305 adults' survival after bone marrow transplantation; depression, smoking, and behavioral self-regulation J Psychosom Res 2004 57 145 154 15465068 10.1016/S0022-3999(03)00599-3 16 FACT, Foundation for the Accreditation …

GAPcare: The Geriatric Acute and Post-Acute Fall Prevention Intervention for Emergency Department Patients - A Qualitative Evaluation.

BackgroundThree million US emergency department (ED) visits occur for falls each year. The mortality of falls is increasing and only one fourth of older adults report their fall to their primary care provider, suggesting that valuable preventative opportunities are missed. A fall prevention intervention initiated in the ED immediately after a fall has the potential to reduce subsequent falls, but ED providers lack the time and resources to complete fall risk assessments on their patients. GAPcare, the Geriatric Acute and Post-Acute Fall Prevention Intervention, was developed to address this ne

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… Although an interdisciplinary team that includes pharmacists and physical therapists (PTs) who perform standardized fall assessments is a key criterion for US geriatric ED accreditation [ 4 ], currently no applicable model exists to guide this care [ 5 ]. … ACEP accredits geriatric emergency care for emergency departments . ACEP Now . 2017 . Available from: http://www.acepnow.com/article/acep-accredits-geriatric-emergency-care-emergency-departments/ . 5. Carpenter CR , Cameron A , Ganz DA , Liu S . …

Little Patients, Big Tasks - A Pediatric Emergency Medicine Escape Room.

AUDIENCE: The target audience for this small group session is post-graduate year (PGY) 1-4 emergency medicine (EM) residents, pediatric EM (PEM) fellows, and medical students. INTRODUCTION: Pediatric emergency department visits have been declining since the start of the COVID-19 pandemic, leading to decreased exposure to pediatric emergency care for EM residents and other learners in the ED.1 This is a major problem, given that the Accreditation Council for Graduate Medical Education (ACGME) mandates that a minimum of 20% of patient encounters or five months of training time for EM residents …

Trauma intensive care unit (TICU) at Hamad General Hospital.

Trauma is a leading cause of mortality and morbidity worldwide, and thus represents a great global health challenge. The World Health Organi … o start rotating in the TICU soon. The Trauma Critical Care Fellowship Program (TCCFP) is an ACGME (Accreditation Council for Graduate Medical Education) fellowship that was established over seven years ago. To date, over 40 physicians from both within, and out of, the trauma department have completed the program. Up to seven fellows, including international ca …

Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.

Most breast cancers at an advanced stage exhibit an aggressive nature, and there is a lack of effective anticancer options. Herein, the development of patient-derived organoids (PDOs) is described as a real-time platform to explore the feasibility of tailored treatment for refractory breast cancers. PDOs are successfully generated from breast cancer tissues, including heavily treated specimens. The microtubule-targeting drug-sensitive response signatures of PDOs predict improved distant relapse-free survival for invasive breast cancers treated with adjuvant chemotherapy. It is further demonstr

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… (Accreditation number: 308‐2015‐001), Centro Hospitalar Conde de S. … Januário (Accreditation number: BSERE16‐APP010‐FHS), and Zhuhai People's Hospital (Accreditation number: ZH2019‐03) (data file S1, Supporting Information). Informed consent was obtained prior to acquisition of samples from all donors. …

Regulatory Convergence in Cell and Gene Therapy: Harmonizing Quality, CMC, and Approval Pathways Across the FDA, EMA, PMDA, and Emerging Markets.

Cell and gene therapies (CGTs) have progressed from proof of concept to an established commercial pipeline, yet global translation remains constrained by fragmented regulatory frameworks; heterogeneous Chemistry, Manufacturing, and Controls (CMC) requirements; and divergent approval pathways. This narrative review compares CGT quality, CMC, and approval-pathway regulation across the US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Japan's Pharmaceuticals and Medical Devices Agency (PMDA), together with five emerging-market agencies: Brazil, Russia, India, China, and

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… A 2025 review of CAR-T-cell manufacturing across Latin America found that Brazil has paired its regulatory pathway with accredited treatment centers and an emerging national platform for viral vector and plasmid production, positioning it, alongside Colombia and Mexico, among the region’s more advanced … BCP trials must occur at Minzdrav-accredited institutions [ 79 ], narrowing the eligible site pool relative to jurisdictions without such accreditation requirements. …

Coronary lesions in patients with COPD (Global Initiative for Obstructive Lung Disease stages I-III) and suspected or confirmed coronary arterial disease.

BackgroundSystemic inflammation is the pathophysiological link between coronary artery disease (CAD) and COPD. However, the influence of subclinical COPD on patients with suspected or diagnosed CAD is largely unknown. Thus, this study was designed to evaluate the degree of coronary involvement in patients with COPD and suspected or confirmed CAD.MethodsIn this cross-sectional study, carried out between March 2015 and June 2017, 210 outpatients with suspected or confirmed CAD were examined by both spirometry and coronary angiography or multidetector computed tomography. These patients were divi

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… The investigation was carried out in the cardiology laboratories of the University Hospital of the Federal University of Sergipe (FUS), in addition to the Echocardiography Laboratory (ECOLAB) of the Clínica e Hospital São Lucas, Aracaju, Sergipe, Brazil, a cardiology referral center, with Accreditation … with Excellence (Instituto Qualisa de Gestão) and Qmentum International Diamond (Accreditation Canada). …

Автономная трансплантация стволовых клеток с помощью гематопоиетической гематомии для множественных склерозов в Соединенном Королевстве: A 20-year Ретроспективный анализ деятельности и гематологических результатов Британского общества трансплантации крови и мозга и клеточной терапии (BSBMTCT).

Автологическая трансплантация стволовых клеток (AHSCT) была разработана в качестве средства лечения множественных склерозов (MS) с тех пор. 1995. Соединенное Королевство one :: из наиболее активных стран Европы, осуществляющих АХСХТ для НР. Мы сообщаем об опыте Соединенного Королевства в области AHSCT для MS 364 :: пациенты, имеющие MS, которые лечатся AHSCT между 2002 и 2023. Мы представляем данные о смертности, связанной с трансплантацией (ТМР), осложнениях и эффективности АХСПП, определяемых расширенной шкалой показателей инвалидности (ЭДСС) в условиях бесперебойного выживания (ПФС) 2 годы

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… All centres were accredited by JACIE (Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and European society for Blood and Marrow Transplantation (EBMT)). Statistical analysis Data were analysed in Stata 18 (StataCorp. 2023. …

Сопоставление 4 Методы скрининга для выявления риска токсичности флуоропиримидина: выявление наиболее эффективного и рентабельного метода спасения жизни.

ПРИСУТСТВИЕ: Флуоропиримидины (ФЛ) носят вокруг 20% риск G3-5 токсичность и 0.2-1% Риск смерти из-за недостатка дигидропиримидина дегидрогеназы (ДХД). Для прогнозирования токсичности существует несколько подходов к отбору, однако в настоящее время обсуждается вопрос о том, какой метод является наиболее оптимальным. В настоящем исследовании сопоставляются 4 Подходы к отбору. МЕТОД: 472 Проверки пациентов, прошедших лечение раком цветной, головной и поджелудочной кости, груди или поджелудочной кости, которые не прошли предварительную обработку на риск токсичности ИП, проводились с использованием

Abstracts From JADPRO Live at APSHO 2017.

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Материалы ежегодной конференции Канадского общества респираторных терапевтов, май 8-10, 2025.

Мы рады представить ряд выдержек из работы ежегодной Конференции по ТРСК. состоявшемся в Оттаве, Онтарио, в мае 8 в адрес 10, 2025, эта конференция включала в себя темы, подготовленные отдельными лицами, имеющими опыт работы в различных областях практики дыхательной терапии. Как видно из следующих резюме, работа наших коллег 2025 :: акцентировали внимание на текущих исследовательских и практических нововведениях, осуществляемых РТ. Мы приложили все усилия для того, чтобы включить все выдержки, принятые Комитетом по программе до предельного срока публикации; вместе с тем просьба иметь в виду, ч

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… Respiratory therapy program curricula, like other medical education programs, are complex and must meet accreditation standards while deployed in unique local and regional contexts. … Regional contexts were considered when accreditation standards were applied. Data captured for each step came from multiple sources including existing program meetings, program performance results, stakeholder surveys, rotationalevaluations, and accreditation documents. …

Diagnosis of CCSVI in Meniere syndrome.

The main question to ask himself when preparing to write an article is "why publish a scientific paper?" First of all to publish an own article qualifies his author - or authors - as "scientist". Because the surgery is a mixture of art and knowledge, which coexist and interreact mutually increasing each other, scientific publications are the world where ideas are shared. Secondly, to an academic career is essential to be Author of scientific publications; but also for those who follow an hospital career or simply exercise the surgical profession in other contexts it represents the opportunity

A SWOT-Consensus for CAR-T in Follicular Lymphoma: Fine Tuning of Patient Journey and Selection.

Over the past 2 decades, advancements in follicular lymphoma (FL) treatment, particularly with anti-CD20 antibodies, have significantly improved patient survival. However, a subset of FL patients experiences early relapse and progression within 24 months (POD24) after first line treatment, which is a sign of poor prognosis. Current guidelines recommend various second-line treatments, but there is no consensus on an optimal treatment sequence for relapsed/refractory (r/r) FL. Moreover, despite available treatments, reduced survival after second-line therapies and diminishing responses with each

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… The Foundation for the Accreditation of Cellular Therapy (FACT) has established standards for IEC use, including CAR‐T cells, covering patient selection, cell collection, therapy, toxicity management, and long‐term follow‐up. … FACT accreditation improves program quality, ensuring compliance and enabling clinical trial participation and certification for administering commercial IEC therapies [ 61 ]. …

Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor.

Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have been approved with, or are under clinical development with, other targeted therapies including proteasome inhibitors, αCD38 monoclonal antibodies, as well as histone deacetylase (HDAC) inhibitors for combination therapy. HDAC inhibitors broadly targeting Class I and IIb HDACs have shown potent preclinical efficacy but have frequently demonstrated an undesirable safety profile in combination therapy approaches in clinical studies. Therefo

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… This site has an approved Assurance Statement (A4358-01) on file with the Office of Laboratory Animal Welfare (OLAW), National Institutes of Health (NIH) and is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). …

Регулирование заразительных осложнений в создании химической антигенной приемной клетки (CAR-T)

Химерическая антигенная рецепторная T-клетка (CAR T-клетка) изменила парадигму управления лимфомой не Ходжкина (NHL) и множественной миеломой. Осложнения, связанные с инфекцией, стали предметом озабоченности, которая может возникнуть в процессе лечения и привести к заболеваемости и смертности. В ходе этого обзора мы классифицировали осложнения, связанные с инфекцией, в three Категория, этап предварительного вливания с момента предварительного лимфодерации (LD) до дня zero, ранний этап от дня вливания до дня 30 после введения в эксплуатацию и с запозданием изо дня в день 30 и дальше. Инфекции,

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… The recommendations for vaccinations after CD19 and BCMA CAR-T, based on the European Society for Blood and Marrow Transplantation ( EBMT), the Joint Accreditation Committee of ISCT and EBMT (JACIE), and the European Hematology Association ( EHA) consensus are shown in Table 3 and Figure 3 . 65 It is … Wiley 29 7 2023 25 S1 e14109 1398-2273 10.1111/tid.14109 10.1111/tid.14109 37515788 PMC10909447 Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee …

Connect MM Registry as a national reference for United States multiple myeloma patients.

BackgroundThe Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community-based Connect MM Registry as a national reference for MM.MethodsBaseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified.ResultsAs of Fe

Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain.

This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal nanoparticle spray of a cannabis-based medicine (MDCNS-01) in patients with advanced incurable malignancy with unrelieved pain from opioid analgesic. The study was a non-blinded single arm 2 stage study. Stage I was a single escalating dose (n = 5) [2.5 mg Δ9-THC and 2.5 mg CBD) versus a 3-fold escalated dose. Stage II was an up-titrated dose in patients with advanced cancers and intractable pain (n = 25). During Stage I with an increased cannabis-bas

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… Oro-buccal (inside of the cheek) dosing Medlab Clinical formulated the investigational product (MDCNB-01) which was manufactured by PCI Pharma Services (Melbourne, Australia) in a GMP accredited facility. … Adverse events were documented as per the criteria used for the AEs as ascertained from the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) Patient Safety Event Taxonomy [ 20 ] that facilitated a common approach for patient safety information in this pilot study. …