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References

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Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets.

The onerous health and economic burden associated with head and neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of novel surgical techniques and therapeutic protocols, there is an incessant need for efficacious diagnostic and therapeutic targets to monitor the invasion, metastasis and recurrence of HNSCC due to its substantial morbidity and mortality. The differential expression patterns of histone deacetylases (HDACs), a group of enzymes responsible for modifying histones and regulating gene expression, have been demonstrated in neoplastic tissues. However, th

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… Another compound that shows promise is Apicidin, which is a fungal metabolite derived from Fusarium fermentation [ 156 ]. It has been found to selectively reduce HDAC8 expression in OSCC AT-84 cells, leading to significant growth inhibition. …

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016.

Infectious complications after allogeneic haematopoietic stem cell transplantation (allo-HCT) remain a clinical challenge. This is a guideline provided by the AGIHO (Infectious Diseases Working Group) of the DGHO (German Society for Hematology and Medical Oncology). A core group of experts prepared a preliminary guideline, which was discussed, reviewed, and approved by the entire working group. The guideline provides clinical recommendations for the preventive management including prophylactic treatment of viral, bacterial, parasitic, and fungal diseases. The guideline focuses on antimicrobial

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… The share of rare IFDs like those caused by the order of Mucorales or Fusarium spp. appear to be increasing [ 94 , 109 ]. Newer agents like isavuconazole demonstrated favorable response rates in primary treatment against moulds; however, larger prophylaxis studies are still needed [ 110 – 112 ]. …

Biomaterials from the sea: Future building blocks for biomedical applications.

Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in t

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… YS-80-122 Hydrolase Degrade carrageenans [ [172] , [173] , [174] , [175] ] Cellulose and hemicellulose hydrolase Cytophaga, Cellulomonas, Vibrio, Clostridium, Streptomyces Fusarium, Chaetomium, Phoma, Sporotrichum, Glaciecola sp. strain 4H-3–7+YE-5 Hydrolase Break down cellulose [ [176] , [177] , [178 … YS-80-122 | Hydrolase | Degrade carrageenans | [ [172] , [173] , [174] , [175] ] Cellulose and hemicellulose hydrolase | Cytophaga, Cellulomonas, Vibrio, Clostridium, Streptomyces Fusarium, Chaetomium, Phoma, Sporotrichum, Glaciecola sp. strain 4H-3–7+YE-5 | Hydrolase | Break down cellulose | [ [176] …

Advances in MALDI Mass Spectrometry Imaging Single Cell and Tissues.

Compared with conventional optical microscopy techniques, mass spectrometry imaging (MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique, which can sensitively and simultaneously detect, quantify, and map hundreds of biomolecules, such as peptides, proteins, lipid, and other organic compounds in cells and tissues. So far, although several soft ionization techniques, such as desorption electrospray ionization (DESI) and secondary ion mass spectrometry (SIMS) have been used for imaging biomolecules, matrix-assisted laser desorption/ionization (MALDI) is still t

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… Histology-guided High-Resolution AP-SMALDI Mass Spectrometry Imaging of Wheat-fusarium Graminearum Interaction at the Root-Shoot junction. Plant Methods 14, 103. 10.1186/s13007-018-0368-6 Bien T., Bessler S., Dreisewerd K., Soltwisch J. (2021a). …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

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… Ether, chloroform, and ethanol extracts of C. longa along with its oil possess antifungal effect against Aspergillus flavus , Aspergillus parasiticus, Fusarium moniliforme , and Penicillium digitatum , as suggested by several authors ( Wuthi-Udomlert et al., 2000 ; Jayaprakasha et al., 2001 ). …

Critically Ill Immunosuppressed Host

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Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… It was reported that vincristine is produced by Fusarium oxysporum , an endophyte of Catharanthus roseus [ 317 ]. Additionally, biosynthesis of the anticancer vincristine in callus cultures of Catharanthus roseus is one of the promising alternatives [ 314 ]. …

Естественные и синтетические АМП из Латинской Америки по всему спектру технологий и приложений в области разнообразия.

Биоразнообразие в Латинской Америке примерно 60% в целом по миру, подпитывая научные исследования в области природных продуктов, весьма значимой области открытия наркотиков по сей день. Это сопровождается увеличением числа антимикробных пептидов (АМП), полученных из натуральных продуктов в регионе, которые за последнее десятилетие были переработаны путем модификации, усовершенствования и уточнения их физико-химических свойств и антимикробной эффективности с использованием подходов, которые варьируются от изучения рациональной конструкции и соотношения структуры-активности (САР) до методов иску

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… This peptide also exhibited antifungal activity, completely inhibiting spore germination of Fusarium oxysporum MUCL 909, Rhizopus sp. LAMPB-UFSC, and Penicillium sp. LIAA-UFSC (a strain associated with the shrimp midgut). …

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian

Monoclonal Antibodies Approved for Cancer Therapy

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… Thirteen infections (sepsis 6, pneumonia 5, Fusarium infection 1, and PML 1) led to death. …

Pleuropulmonary Changes Induced by Drugs in Patients with Hematologic Diseases

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… Careful exclusion of malignancy and an infection is required in all cases, for infection due to Pneumocystis jiroveci , Aspergillus sp. and other fungi, HSP, Rhodococcus , Mucor , Cryptococcus, Fusarium and tuberculosis can manifest with lung nodules. …

Diseases of the Nervous System

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Биология и болезни крыс

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ISEV2020 Резюме

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The use of RNA-based treatments in the field of cancer immunotherapy.

Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a clinical reality. These vaccines offer several advantages over traditional vaccine techniques, including their high potency, rapid development, low-cost manufacturing, and safe administration. However, until recently, concerns over the instability and inefficient distribution of mRNA in vivo have limited their utility. Fortunately, recent technological advancements have mostly resolved these concerns, resulting in the development of numerous mRNA vaccination platforms for infectious diseases and various t

In vitro расширила человека CD4+CD25+ регуляционные T клетки, подавляющие распространение Т клеток.

Регулирующие Т клетки (Tregs) оказались критически важными в балансе между автоиммунизацией и терпимостью и были связаны с несколькими аутоиммунными заболеваниями человека. Однако небольшое число трегов в периферии крови ограничивает их терапевтический потенциал. Поэтому мы разработали протокол, который позволит расширить "Трегз" при сохранении их подавляющей активности. Мы изолировали клетки CD4+CD25 hi от человеческой периферической крови и расширили их in vitro в присутствии anti-CD3 и anti-CD28 Магнитные кситы и высокие концентрации внешнего интерлейкина (IL) -2. Траги были эффективно расш

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Sessions (O009-O155).

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference.

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