Результаты поиска

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice.

Chemotherapy is frequently accompanied by several side effects, including nausea, diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that chemotherapy can also play a major role in causing not only cachexia, but also bone loss. This complicates prognosis and survival among cancer patients, affects quality of life, and can increase morbidity and mortality rates. Recent findings suggest that soluble factors released from resorbing bone directly contribute to loss of muscle mass and function secondary to metastatic cancer. However, it remains unknown whether similar mech

Совпадение в полном тексте источника
… Samples were marked with a histology marking pen, blocked in phosphate buffered saline (PBS) containing 8% bovine serum albumin for 1 h at room temperature, and incubated at 4°C overnight with dystrophin primary antibody [Developmental Studies Hybridoma Bank, Iowa City, IA; #MANDRA1(7A10)] diluted in … Fischman at Cornell University) and the #MANDRA1(7A10) anti-Dystrophin monoclonal antibody (developed by Morris GE at NE Wales Institute) were obtained from the Developmental Studies Hybridoma Bank, created by the NICHD of the NIH and maintained at The University of Iowa, Department of Biology, Iowa …

Расположение RNA на основе RiboTag обнаруживает олигодендроглиевую воспаление в аутоиммунном энцефаломиелите: последствия для патогенеза.

Клетки олигодендроглиевой линии (ООК) необходимы для миелинирования, ремиелиции и нейронной метаболической поддержки, но недавние данные указывают на то, что они также играют активную роль в нейроинфламмации. Цель этого исследования состояла в том, чтобы выявить подстрекательский транслатом ОРЦ в начале экспериментального аутоиммунного энцефаломиэлита (EAE) - широко используемой модели множественного склероза (MS) с использованием последовательности РНК на основе RNA, основанной на RiboTag. Мы пересекли мышей Риботага Olig2-Cre Мыши для получения экспресс-выражения реберосомного белка HA-тагон

Совпадение в полном тексте источника
… All animal procedures were ethically approved by the Institutional Animal Care and Use Committee of the University of Iowa. … RNA-Seq data analysis Paired reads underwent initial processing on the University of Iowa high-performance computing cluster for sequence quality control and analysis. …

Use of Additional Doses of 2024–2025 COVID-19 Vaccine for Adults Aged ≥65 Years and Persons Aged ≥6 Months with Moderate or Severe Immunocompromise: Recommendations of the Advisory Committee on Immunization Practices — United States, 2024

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Edwin Jose Asturias, University of Colorado School of Medicine and Colorado School of Public Health; Lin Chen, Mount Auburn Travel Medicine Center; Helen Chu, University of Washington School of Medicine; Sybil Cineas, Warren Alpert Medical School of Brown University; Denise Jamieson, University of Iowa … Infectious Diseases Society of America; Preeti Mehrotra, Society for Healthcare Epidemiology of America; Sean O’Leary, American Academy of Pediatrics; Christine Oshansky, Biomedical Advanced Research and Development Authority; Stanley Perlman, Department of Microbiology and Immunology, University of Iowa …

Dental caries and beverage consumption in young children.

OBJECTIVE: Dental caries is a common, chronic disease of childhood. The impact of contemporary changes in beverage patterns, specifically decreased milk intakes and increased 100% juice and soda pop intakes, on dental caries in young children is unknown. We describe associations among caries experience and intakes of dairy foods, sugared beverages, and nutrients and overall diet quality in young children. METHODS: Subjects (n = 642) are members of the Iowa Fluoride Study, a cohort followed from birth. Food and nutrient intakes were obtained from 3-day diet records analyzed at 1 (n = 636), 2 (…

Высоконасыщенная, длинноцепная жирная кислотная кетогенная диета негативно влияет на визуальную и моторно-сенсорную функцию в предклинической модели множественного склероза.

ВВЕДЕНИЕ: Множественный склероз (MS) представляет собой нейродегенеративное состояние, приводящее к демилеляции центральной нервной системы. Визуальное расстройство, уменьшение слоя сетчатки нервно-паралитического слоя и нарушение электрической функции в клетках сетчатки на протяжении всего периода развития болезни являются полезными маркерами успеха лечения. Текущие исследования, посвященные изучению воздействия кетогенного рациона (КД) в качестве котерапии, показывают многообещающие антивоспалительные свойства, однако исследования по-прежнему ограничены различиями в экспериментальной структу

Совпадение в полном тексте источника
… Materials and methods Animals and study design All animal experiments were approved by the Iowa City IACUC and were conducted in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research. … Ethics statement The animal study was approved by the Iowa City VA IACUC # 2290402 & 2190402 and was conducted in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research. …

Библиометрический анализ кишечного микробиота и демиелионирующие заболевания, в частности множественный склероз, с тех пор 2014.

Ось кишечника (GBA) представляет собой сложную двунаправленную сеть связи, соединяющую центральную нервную систему (CNS) и желудочно-кишечную систему. Наше исследование было нацелено на изучение взаимосвязи между кишечной микробиотой и демиелинирующими заболеваниями с библиометрической точки зрения с уделением особого внимания исследованиям с тех пор. 2014. МЕТОДЫ: Был проведен всесторонний поиск на базе " Web of Science Core Collection " (WoSCC) с целью поиска исследований, посвященных кишечной микробиоте и демиелионирующим заболеваниям, с уделением особого внимания публикациям, под

Совпадение в полном тексте источника
… Publications Citations 1 USA 158 12,488 The University of California, San Francisco 28 2,771 2 The People’s Republic of China 54 1,760 The University of British Columbia 19 1,212 3 Italy 49 2,682 Harvard Medical School 14 1,591 4 Germany 40 3,567 Mayo Clinic 12 1,109 5 Canada 38 3,429 The University of Iowa … Half of these organizations are based in the USA, including the University of California, San Francisco, Harvard Medical School, Mayo Clinic, University of Iowa, Dartmouth College, and University of Utah. …

Integumentary System

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Burden of disease scenarios by state in the USA, 2022-50: a forecasting analysis for the Global Burden of Disease Study 2021.

BACKGROUND: The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insigh … almost no change in female life expectancy in many states, notably in Oklahoma, South Dakota, Utah, Iowa, Maine, and Wisconsin. Female HALE is projected to decline between 1990 and 2050 in 20 states and to remain unchanged in three others. Drug use disorders and low back pain are projected to be the leading Level 3 causes of age-standardised DALYs in 2 …

Tumor angiogenesis as a target for dietary cancer prevention.

Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain,

Совпадение в полном тексте источника
… With regards to epidemiologic data, a large prospective study of 41,000 women living in Iowa between the ages of 55 and 69 found a number of flavonoid-containing leafy greens, which are abundant in quercetin, was associated with a significant risk reduction for lung cancer [ 223 ]. … In a prospective cohort of 35,159 Iowa women aged 55–69 years, intake of apple juice or cider was associated with lower risk of developing non-Hodgkin's lymphoma [ 214 ]. Ellagitannins Ellagitannins are glycosides of the flavonoid ellagic acid and fall under the category of hydrolyzable tannins. …

Cement venogram as a harbinger of methacrylate embolism after kyphoplasty: A case series.

Vertebral compression fractures remain an important cause of pain and debility. Intractable pain may be approached with vertebral kyphoplasty. We herein present a case of symptomatic pulmonary cement embolism following kyphoplasty. Discovery of a paravertebral cement venogram at the time of this procedure prompted a case series review of our institutional experience with kyphoplasty. We found that cement embolization, whether symptomatic or discovered incidentally, was universally associated with a cement venogram at the site of vertebroplasty. We propose that a cement venogram be viewed as a

Совпадение в полном тексте источника
… Institutional review A retrospective case series review of University of Iowa Health Care (UIHC) records was completed by Health Center Information Services (HCIS) using institutional-specific codes for kyphoplasty. …

Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the overproduction of mature myeloid cells and are often associated with an acquired genetic mutation of Janus Kinase2V617F. Various epidemiological studies have indicated associations between environmental factors, lifestyle factors, and host characteristics with developing MPNs. This review aims to collect and summarize the existing information on these risk factors and establish their association with pathogenesis MPNs. Medline, Embase, PubMed, and grey literature were systematically searched u

Совпадение в полном тексте источника
… 1.06-13.15). 13 These findings are in line with the results from three extensive prospective cohort studies. 16 – 18 Pedersen et al. reported the risk of MPNs could be increased by 2.5-fold (95% CI: 1.3‐5.0) among daily smokers and 1.9-fold (95% CI: 1.1‐3.3) in occasional/ex-smokers. 14 Findings of Iowa … Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's health study cohort. Int J Canc. 2014;134:1741-1750. doi: 10.1002/ijc.28492. 17. Kroll ME, Murphy F, Murphy F, et al. …

Клиническое и экономическое воздействие работников, обеспечивающих уход за пациентами, страдающими множественным склерозом, в зависимости от состояния болезни.

Справочная информация: Исследования по вопросу о партнерах по уходу за пациентами с множественным склерозом (МС) являются ограниченными. Цели: Клиническое и экономическое воздействие на партнеров по уходу за работниками оценивалось с точки зрения степени заболеваемости MS. Методы: работники с супругами/домашними партнерами с НР из базы данных о партнерах по работе (Jan. 1, 2010- Декабрь. 31, 2019) имеют право на получение пособия, если: супруг/партнер имел по крайней мере 3 Связанная с НРICD-9-CM/ICD-10-CM::340xx/G35) заявления пациентов/акушеров/болезней в рамках 1 год (последняя претензия =

Совпадение в полном тексте источника
… Puerto Rico, Rhode Island, Vermont, and Virgin Islands; 1 =Delaware, New York, and Pennsylvania; 2 = District of Columbia, Maryland, North Carolina, South Carolina, Virginia, and West Virginia; 3 = Alabama, Florida, Georgia, Mississippi, and Tennessee; 4 = Indiana, Kentucky, Michigan, and Ohio; 5 = Iowa … A greater proportion of employee care partners of patients with mild vs severe MS resided in Iowa, Minnesota, Montana, North Dakota, South Dakota, and Wisconsin (9.0% vs 4.2%). …

A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum.

Systemic mastocytosis (SM) is a heterogeneous group of disorders caused by mast cell proliferation. SM often presents with non-specific symptoms making it a diagnostic challenge. Moreover, presentation with bone involvement is highly uncommon. Here, we report a rare case of SM in a 68-year-old female who initially presented with gastrointestinal symptoms and was later found to have sclerotic bone lesions on imaging. This case highlights an unusual presentation of SM, informing clinicians of the importance of keeping this disease process on the differential list of diagnostic conundrums.

Совпадение в полном тексте источника
… Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2378151/ Iowa Orthop J. 1996;16:126–134. 5. Mast cell: a multi-functional master cell. Krystel-Whittemore M, Dileepan KN, Wood JG. …

Transplant conditioning with bortezomib, thalidomide, and melphalan and intensive 2 year post-transplant therapy for multiple myeloma in older patients.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The study was approved by the Institutional Review Board of the University of Iowa and performed in accordance with the principles of the Declaration of Helsinki. …

Thrombotic microangiopathy following chimeric antigen receptor T-cell therapy.

INTRODUCTION: Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia and is associated with a variety of conditions and following hematopoietic stem cell transplantation. Chimeric antigen receptor T-cell (CAR-T) therapy is a novel immunotherapeutic approach using genetically modified autologous T cells. CAR-T therapy has been linked with injuries to vascular endothelium, but a direct association between CAR-T and TMA has not been reported. CASE REPORTS: Two cases of TMAs following CAR-T treatment are reported here. In each case, clinical evidence of kidney inju

Совпадение в полном тексте источника
… A send out Genetic and Complement Renal Panel to the University of Iowa, which tests for 13 genes implicated in hereditary disorders associated with atypical HUS and TMA, returned negative. All viral studies were negative. Patient remained normotensive. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 32 States, 2016.

PROBLEM/CONDITION: In 2016, approximately 65,000 persons died in the United States as a result of violence-related injuries. This report sum … rom 32 states for 2016 (Alaska, Arizona, Colorado, Connecticut, Georgia, Hawaii, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, and Wis …

Восприятие и использование зарегистрированных диетологов в области многоклерозового ухода: экспериментальное обследование многодисциплинарных поставщиков.

Зарегистрированные диетологи (ДНД) являются смежными специалистами в области здравоохранения, которые могут помочь людям с множественным склерозом (МС) включить здоровое питание, но мало что известно об их участии в уходе за НР. Таким образом, цель этого обследования заключалась в изучении восприятия и использования РНО в системе ухода за НР среди междисциплинарных поставщиков НР в Соединенных Штатах и Канаде. МЕТОДЫ: Онлайновое обследование было распространено через консорциум центров по электронной почте и научные конференции по конкретным НР. В ходе обследования был задан вопрос о типе прак

Совпадение в полном тексте источника
… The survey was determined as ‘not human subjects research’ by the University of Iowa Institutional Review Board (#202304271), as no identifiable information was collected. …

MOG35 - 55 модель зрительного нерва EAE по сравнению с MS, MOGAD и NMOSD подтипов человеческого оптического неврата.

Оптический неврит (ON) или воспаление зрительного нерва является распространенным симптомом демиелинации нервно-воспалительных заболеваний, которые приводят к значительной потере негативного зрения. С учетом его связи с нарушениями зрения и различными масштабами визуального восстановления " ОН " была признана серьезным бременем для здоровья и потребность в новых терапевтических стратегиях для улучшения долгосрочных визуальных результатов. Среди ресурсов, используемых для проведения исследований, в качестве мощного инструмента изучения основ патофизиологии и эффективности предлагаемых

Совпадение в полном тексте источника
… Animals: Data from animals shown in Fig. 3 were obtained from animal experiments that were approved by the University of Iowa and Iowa City Veterans Affairs IACUC and were conducted in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research. …

Abstracts of the Cell Therapy Transplant Canada 2022 Annual Conference.

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2022 Annual Conference. The conference was held in-person 15-18 June 2022, in Niagara Falls, Ontario. Poster authors presented their work during a lively and engaging welcome reception on Thursday, 16 June, and oral abstract authors were featured during the oral abstract session in the afternoon on Friday, 17 June 2022. Thirty-three (33) abstracts were selected for presentation as posters and six (6) as oral presentations. The top abstracts in each of four (4) categories, (1) Basic/Translati

Совпадение в полном тексте источника
… , Iowa City, IA, United States 13 University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 14 University of Rochester School of Medicine, University of Rochester, Rochester, NY, United States 15 Hematology Department, Institut Català d’Oncologia-Hospitalet, IDIBELL, … , Iowa City, IA, United States Background: ELARA is an ongoing, single-arm, global, multicenter, phase II trial evaluating efficacy and safety of tisagenlecleucel (tisacel) in adult patients (pts) with relapsed/refractory follicular lymphoma (r/r FL). …