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Tabelecleucel in Post-transplant Epstein-Barr Virus-Associated Lymphoproliferative Disease: Patient and Oncologist Perspectives.

This article is coauthored by the parents of a young patient and the medical team who cared for her.Together, they recount their shared experience with tabelecleucel, a novel therapy for Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV + PTLD). The patient's parents offer a deeply personal perspective, reflecting on several years of struggle marked by unwavering hope and trust in the medical professionals who have supported their daughter throughout her journey. The pediatric hemato-oncologist who advocated for the use of tabelecleucel described the case as unique

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… It could also be explored for broader applications in immune oncology, especially through combination regimens guided by collaborative research between academia and the pharmaceutical industry. Lessons and Strategies for Future Collaboration Dr. …

Sodium and potassium content of cataractous human lenses.

The sodium and potassium content of human senile cataractous lenses was investigated by flame photometry. A parallelism was found between the severity of the senile cataractous disorder and the increase of sodium and decrease of potassium content of lenses. The changes in ion concentration were not entirely continuous; gaps were found for both cations in a certain concentration range. The involvement of lens proteins in maintaining the gradients for sodium and potassium is also discussed.

A smartphone app to improve the safety of patients undergoing treatment with oral antineoplastic agents: 4 years of experience in a university hospital.

ObjectiveThis study aims to analyze the impact of the eOncosalud app on the management and follow-up of adverse effects (AE) in patients receiving oral antineoplastic agents.Material and methodsWe performed an observational, prospective study of cancer outpatients treated with oral antineoplastic agents (OAA), monitored by the eOncosalud app between August 2017 and October 2021. Safety variables were collected from eOncosalud: the number of AE; severity of the AE according to CTCAE, version 4.03; timelapse from app installation to first recorded AE; automatic recommendations issued; and the pa

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… The results showed that the majority of apps were developed by industry (73%, 11/15), and a minority of them were developed by healthcare professionals (15%, 3/20) or academia (2.1%; 7/328). …

Phase-Specific and Lifetime Costs of Multiple Myeloma Among Older Adults in the US.

ImportanceHealth care costs associated with diagnosis and care among older adults with multiple myeloma (MM) are substantial, with cost of care and the factors involved differing across various phases of the disease care continuum, yet little is known about cost of care attributable to MM from a Medicare perspective.ObjectiveTo estimate incremental phase-specific and lifetime costs and cost drivers among older adults with MM enrolled in fee-for-service Medicare.Design, setting, and participantsA retrospective cohort study was conducted using population-based registry data from the 2007-2015 Su

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… The oncology care model: perspectives from the Centers for Medicare & Medicaid Services and participating oncology practices in academia and the community. Am Soc Clin Oncol Educ Book. 2017;37(37):460-466. doi: 10.1200/EDBK_174909 40. Theroux H, Williams A, Liu M, et al. …

Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated pract

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… Eupati: collaborating between patients, academia and industry to champion the informed patient in medicines research and development. J Med Dev Sci. 2015;1:74–80. doi: 10.18063/JMDS.2015.01.011. 12. Rashid A, Thomas V, Shaw T, et al. …

Recent advances in precision oncology research.

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… Major goals include encouraging more extensive cooperation and collaboration between researchers in academia, government and the private sector. …

PROTAC Technology as a New Tool for Modern Pharmacotherapy.

The publication focuses on the innovative applications of PROTAC (proteolysis-targeting chimera) technology in modern pharmacotherapy, with particular emphasis on cancer treatment. PROTACs represent an advanced therapeutic strategy that enables selective protein degradation, opening new possibilities in drug design. This technology shows potential in the treatment of cancers, viral infections (such as HIV and COVID-19), and chronic diseases including atherosclerosis, Alzheimer's disease, atopic dermatitis, and Huntington's disease. Promising results from clinical studies on the compound ARV-47

Ultrastructural, optical and volume changes in brain mitochondria during gramicidin-induced ion uptake.

Gramicidin-induced swelling of rat brain mitochondria was followed spectrophotometrically with a parallel analysis of changes in the ultrastructure, volume and eccentricity ratio of the mitochondria. Under the effect of gramicidin the expansion of the inner compartment occurs with an overall increase in volume. Mitochondria tend to be rounded although not entirely spherical in shape. The reversal of swelling with respiratory inhibitor (KCN, rotenone) results in a shrinkage of the inner compartment and is not accompanied by a proportional reduction of the outer compartment. Mitochondria fail to