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Contextual analysis of hematopoietic stem cell transplantation in outpatients.

Objectivesto analyze and map the contextual aspects of hematopoietic stem cell transplantation in outpatients in the literature.Methodsa scoping review was conducted from October 2023 to June 2024 in databases, portals, and thesis and dissertation libraries. Data collection and analysis were based on the framework proposed by Hinds, Chaves, and Cypress, according to the contextual layers: metacontext, general, specific, and immediate.Resultsthe final sample consisted of 30 studies. Regarding the contextual layers, metacontext addressed outpatient hematopoietic stem cell transplantation worldwi

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… Still within the European context, for the performance of allogeneic HSCT in outpatient centers, accreditation by the European Society for Blood and Marrow Transplantation is necessary as a way to establish professional responsibility towards patients and public healthcare services ( 45 ) . … EBMT JACIE accreditation Activity Report 2024. 2024. [cited 2025 Apr 2]. [Internet] https://www.ebmt.org/annual-report-2024/jacie-activity-report-2024 . 46. Iida M, Kodera Y, Dodds A, Ho AYL, Nivison-Smith I, Akter MR, et al. …

Access to Chimeric Antigen Receptor T Cell Therapy for Diffuse Large B Cell Lymphoma.

IntroductionGeographic access to novel oncology therapies, and the extent to which it may vary by potential sites of care, regions, and population characteristics, is poorly understood. We examined how expanding access to chimeric antigen receptor (CAR) T cell therapy administration sites impacts patient travel distances and time.MethodsWe used geographic information system techniques to calculate shortest travel distance and time between patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) and the nearest CAR T cell therapy administration site in three scenarios: academic h

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… It is also critical to note that there are additional costs required to expand CAR T cell therapy to nonacademic hospitals and treatment settings to meet requirements consistent with the Foundation for the Accreditation of Cellular Therapy (FACT) [ 48 , 49 ]. … Inpatient units are more likely to have FACT accreditation at the time they establish a CAR T cell therapy program [ 49 ], and outpatient facilities must also coordinate with inpatient providers for possible admission to manage adverse events [ 48 ]. …

Temporary halo fixation and radiotherapy as alternative to long-construct spondylodesis in patients with multiple unstable cervical metastases.

Background and purposeCurrently no minimally invasive surgical treatment exists to provide immediate stability for unstable cervical/cervicothoracic metastases. Long-construct spondylodesis carries a high complication risk and has severe impact on residual range of motion. This study explores temporary halo fixation and radiotherapy as an alternative to long-construct cervical spondylodesis.Materials and methodsThis retrospective cohort study included twenty patients with multiple unstable cervical metastases treated between 2013-2023. All patients underwent halo fixation for an intended durat

Validation of an Instrument for Measuring Adherence to Treatment With Immunomodulators in Patients With Multiple Myeloma.

Background: Validate the Treatment Adherence Measure (TAM) instrument in outpatients with MM concerning construct validity, reliability and the ceiling and floor effects. Methods: This cross-sectional study included patients diagnosed with MM previously treated with an immunomodulator for at least one month, aged 18 or over, and followed-up in the investigated outpatient clinics. Adherence to immunomodulators was measured by TAM. The TAM's reliability was assessed using Cronbach's alpha; The association between adherence and health-related quality of life was investigated to analyze the diverg

Cancer immunotherapy insights: key takeaways from the ADSCC bone marrow and cellular therapy congress 2024.

The rising global cancer burden underscores the urgent need for innovative and effective therapies. Molecular and cellular immunology advances have revolutionized cancer immunotherapy, transforming laboratory discoveries into clinical breakthroughs. The Second Bone Marrow Transplant and Cellular Therapy Congress, held in Abu Dhabi, United Arab Emirates (UAE), on October 26th - 27th, 2024, and sponsored by the Abu Dhabi Stem Cells Center (ADSCC), convened global experts to discuss cutting-edge developments in adoptive cell transfer (ACT); chimeric antigen receptor T-cell (CAR-T) therapy, tumor-

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… Observational analyses have shown that many patients who ultimately receive CAR-T treatment reside in proximity to accredited treatment centers, whereas patients living farther away are less likely to receive therapy. … In Europe, although CAR-T therapies are approved and incorporated into clinical guidelines, access remains uneven across countries, reflecting differences in national reimbursement policies, center accreditation requirements, and the concentration of treatment delivery within EBMT/JACIE-accredited cellular …

Bispecific antibody targets and therapies in multiple myeloma.

Recently, several bispecific antibodies (BsAbs) have been approved for the treatment of relapsed multiple myeloma (MM) after early phase trials in heavily pre-treated patients demonstrated high response rates and impressive progression-free survival with monotherapy. These BsAbs provide crucial treatment options for relapsed patients and challenging decisions for clinicians. Evidence on the optimal patient population, treatment sequence, and duration of these therapeutics is unknown and subject to active investigation. While rates of cytokine release syndrome and neurotoxicity appear to be low

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… Additionally, CAR T access is hampered by manufacturing constraints, a limited number of accredited centers, and socioeconomic barriers ( 7 – 9 , 31 , 83 ). The frequency and severity of CRS and neurological toxicity are increased with CAR T compared to BsAb therapy ( 7 – 9 , 11 ). … The requirement for accreditation from the Foundation for the Accreditation of Cellular Therapy (FACT) in North America or the Joint Accreditation Committee ISCT-Europe & EBMT (JACIE) in Europe limits CAR T delivery to large academic centers with the necessary staff and budget. …

Оказание высококачественной комплексной помощи в области склероза в Германии: проблемы и региональные модели.

Множественная склерозовая (МС) помощь в Германии вступила в стадию, когда терапевтический прогресс все больше сдерживается возможностями родовспоможения. Более ранняя диагностика, более широкий доступ к высокоэффективным методам лечения заболеваний (ДМТ) и более совершенные стратегии мониторинга расширили возможности для достижения благоприятных долгосрочных результатов. В то же время эти достижения усилили потребность в специализированных экспертных знаниях, инфильтрации и инфраструктуре мониторинга, оперативном доступе к изображениям, структурированных процедурах обеспечения безопасности и м

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… Physicians must meet defined qualification requirements and apply for ASV accreditation; patients and referring physicians can use ASV directories to identify authorised providers [ 38 ]. … Scalable models require explicitly defined competencies, structured supervision, and accredited training pathways for MS nurses, advanced medical assistants, and physician assistants [ 35 , 49 ]. …

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events.

Immune effector cell (IEC) therapies offer durable and sustained remissions in significant numbers of patients with hematological cancers. While these unique immunotherapies have improved outcomes for pediatric and adult patients in a number of disease states, as 'living drugs,' their toxicity profiles, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), differ markedly from conventional cancer therapeutics. At the time of article preparation, the US Food and Drug Administration (FDA) has approved tisagenlecleucel, axicabtagene ciloleuc

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… Note that familiarity and adherence to these guidelines do not replace formal accreditation by the Foundation for the Accreditation of Cellular Therapy (FACT) or similar regulatory bodies; formal IEC accreditation is strongly recommended by the authors to any clinical center that plans to offer these …

Hypercalcemia of Malignancy: An Incidental Finding in Carcinoma Cervix.

Hypercalcemia occurs in 30% of patients of cancer at either as apart of paraneoplastic process or due to bone metastases. It is an uncommon finding in gynecological cancers. Most common in ovarian cancers and till date very few cancer cervix with hypercalcemia have been reported. We, hereby, report patient of carcinoma cervix who was found to have incidental hypercalcemia without any associated clinical symptoms.

Longitudinal Cognitive Assessment After CAR-T Cell Immunotherapy: A Prospective Cohort Study.

(1) Background: Cognitive dysfunction represents an emerging concern in chimeric antigen receptor T-cell (CAR-T) therapy recipients, yet longitudinal data using simple, clinically applicable tools are lacking. (2) Methods: We conducted a single-center prospective cohort study of consecutive adults with hematologic malignancies treated with commercially available CAR-T cell products between May 2023 and November 2025 at our center. Cognitive function was evaluated with the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) at baseline (before the administration of lym

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… Patients treated between May 2023 and November 2025 at our Joint Accreditation Committee International Society for Cell and Gene Therapy–European Society for Blood and Marrow Transplantation (EBMT)-accredited center were considered eligible and were consecutively enrolled after providing written informed …

Chimeric antigen receptor T cell therapy: a new emerging landscape in autoimmune rheumatic diseases.

Chimeric antigen receptor T cell (CAR-T) therapy, an innovative immune cell therapy, has revolutionized the treatment landscape of haematological malignancies. The past 2 years has witnessed the successful application of CD19-targeting CAR constructs in refractory cases of autoimmune rheumatic diseases, including systemic lupus erythematosus, systemic sclerosis and anti-synthetase syndrome. In comparison with existing B cell depletion therapies, targeting CD19 has demonstrated a more rapid and profound therapeutic effect, enabling drug-free remission with manageable adverse events. These promi

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… Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA). … Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Haematologica 2020;105:297–316. 10. …

A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.

We previously demonstrated that a subset of acute myeloid leukemia (AML) patients with concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that most of these TP53 mutations are missense mutations. Here, we report that, in contrast to the mixed AML and T cell malignancy that developed in NrasG12D/+ p53-/- (NP-/-) mice, NrasG12D/+ p53R172H/+ (NPmut) mice rapidly developed inflammation-associated AML. Under the inflammatory conditions, NPmut hematopoietic stem and progenitor cells (HSPCs) displayed imbalanced myelopoiesis and lymphopoiesis and mostly normal cell prolife

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… The program is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (protocol M005328). All human samples were obtained from the University of Wisconsin Hospitals and Clinics with IRB approval (protocol 2014-0904). Data availability. …

How do Internal Medicine Residents from Different Backgrounds Make Subspecialty Career Choices? A Qualitative Analysis.

PurposeMedical career decisions are complex. Gender and racial disparities remain among internal medicine (IM) subspecialty fellows, particularly in procedural subspecialties. This qualitative study aims to thematically explore factors that influence IM resident subspecialty career choice, with a focus on factors specific to women and UIM trainees to better understand existing disparities. This is the first study to explore IM residents own stated reasons to subspecialize into various fields.MethodsWe conducted virtual focus groups with 37 IM residents from multiple institutions, organized by

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… productivity and performance, 8 the quality of healthcare delivered, 8 health disparities, 9 and the clinical learning environment. 10 Despite this, women and underrepresented in medicine (UIM) physicians remain underrepresented across all internal medicine (IM) subspecialties. 11 Enrollment data from the Accreditation … This was valuable given the current state of disparities in representation across all IM subspecialties. 11 Study Participants and Recruitment Using convenience sampling, we recruited third-year IM residents or fourth-year chief residents from US-based, ACGME-accredited, IM residency programs who were …

Управление терапией клеток CAR-T в Германии.

ВВЕДЕНИЕ: химическая антигенная рецепторная Т-клетка (CAR-T-клетка) стала стандартной терапией для рецидивов или рефрактальных гематологов, таких, как лимфома не Ходжкина и множественная миелома. Ввиду быстрого прогресса в области клеточной терапии CAR-T и отсутствия общепринятых руководящих принципов лечения мы гипотезуем значительные различия между центрами в профилактике, диагностике и лечении краткосрочных и долгосрочных осложнений.МЕТОДЫ: Для того чтобы отразить нынешнее управление ячейками ЦАР-Т в германских центрах в целях определения медицинских потребностей и конкретных областей для б

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… After hospital discharge, accreditation requirements necessitate providing care for patients exclusively at the CAR-T centers during the first months after CAR-T cell treatment. … Management of adults and children receiving CAR-T cell therapy: 2021 best practice recommendations of the European society for blood and marrow transplantation (EBMT) and the joint accreditation committee of ISCT and EBMT (JACIE) and the European haematology association (EHA). …

Population-Based Clinical Cancer Registration in Germany.

IntroductionIn 2013, a new federal law obligated all German federal states to collect additional clinical data in population-based cancer registries as an active tool for monitoring and improving the quality of cancer care, increasing transparency and promoting health research. Now, 10 years later, the current status of the expanded cancer registration is presented, including current figures on cancer in Germany.MethodsReporting of cancer is mandatory for physicians, and about 5 to 10 reports from different healthcare providers are expected for each case. A uniform national dataset of about 13

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… As this type of cancer registration has been successfully used for the quality assessment of oncological care, hospital benchmarking and accreditation, the 2008 German National Cancer Plan recommended the implementation of additional population-based registration of clinical data as an active tool to … There are several publications comparing accredited hospitals on the basis of quality indicators, for example for breast cancer [ 27 ] or renal cancer [ 28 ], but these reports are based on specific hospital-based data collection and not on routine cancer registration. …

Pursuing equity in cancer care: implementation, challenges and preliminary findings of a public cancer referral center in rural Rwanda.

BackgroundCancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro Cancer Center of Excellence (BCCOE) to expand cancer services nationally. In hopes of informing cancer care delivery in similar settings, we describe program-level experience implementing BCCOE, patient characteristics, and challenges encountered.MethodsButaro Cancer Center of Excellence was founded on diverse partnerships that emphasize capacity building. Services available incl

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… However, strategies for compensation and professional accreditation for nurses and doctors will be necessary to sustain a cadre of oncology-skilled clinicians [ 8 ]. … Medications were sourced from accredited India-based generic drug companies whose prices were three to five times cheaper than European counterparts [ 21 ]. …

Expedited drug review process: Fast, but flawed.

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The Multidisciplinary Heart Team in Cardiovascular Medicine: Current Role and Future Challenges.

Cardiovascular multidisciplinary heart teams (MDHTs) have evolved significantly over the past decade. These teams play a central role in the treatment of a wide array of cardiovascular diseases affecting interventional cardiology, cardiac surgery, interventional imaging, advanced heart failure, adult congenital heart disease, cardio-oncology, and cardio-obstetrics. To meet the specific needs of both patients and heart programs, the composition and function of cardiovascular MDHTs have had to adapt and evolve. Although lessons have been learned from multidisciplinary cancer care, best practices

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… In 2017, the Adult Congenital Heart Association launched an accreditation system that defined the resources, staff, and processes necessary for the optimal care, clinical outcomes, and safety of ACHD patients. Two levels of programs were identified: care centers and comprehensive care centers. … Currently, there are 43 accredited CHD programs in the United States; the MDHT is a critical component in each of these programs. …

Integrating Palliative Care into Oncology Care Worldwide: The Right Care in the Right Place at the Right Time.

Opinion statementWhile the benefits of early palliative care are indisputable, most of the current evidence has emerged from resource-rich settings in urban areas of high-income countries, with an emphasis on solid tumors in outpatient settings; this model of palliative care integration is not currently scalable internationally. A shortage of specialist palliative care clinicians means that in order to meet the needs of all patients who require support at any point along their advanced cancer trajectory, palliative care must also be provided by family physicians and oncology clinicians who req

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… This not-for-profit organization is committed to expanding primary palliative care capacity nationally through its accredited “Learning Essential Approaches to Palliative Care” program, and has trained over 28,000 professionals through 1600 courses from 2015 to 2019. … Through universal health coverage that includes palliative care, and the integration of health networks across all clinical settings, successful milestones have been possible; these include the accreditation of a specialist palliative medicine program and an amendment to the “Controlled Substances Act …

Current state and future opportunities in granulocyte colony-stimulating factor (G-CSF).

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… The 2021 guidelines of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) recommend the following G-CSF prophylaxis [ 106 ]: G-CSF to shorten duration of neutropenia can be used … Hayden PJ Roddie C Bader P Basak GW Bonig H Bonini C Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology …