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Unique Presentation of Bortezomib-Associated Thrombotic Microangiopathy Responsive to Therapeutic Plasma Exchange and Eculizumab Therapy.

Thrombotic microangiopathies (TMA) are a rare group of life-threatening hematological conditions characterized by thrombocytopenia and microangiopathic hemolytic anemia. Although our understanding of the pathophysiology and the availability of diagnostic testing has improved for primary TMAs, such as thrombotic thrombocytopenic purpura, the pathophysiology underlying secondary TMAs, including drug-induced TMAs (DITMAs), remains less clear. In this case report, we present the unique case of a patient with a history of multiple myeloma that presented four months after the initiation of bortezomi

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… TMA functional panel ( Table 1 ) from the University of Iowa revealed low factor H level 134 mg/L (reference range: 180–420 mg/L) and mildly elevated Bb fragment level of 2.9 mg/L (reference range <2.2 mg/L). …

Indolent systemic mastocytosis limited to the bone: a case report and review of the literature.

CONTEXT Systemic mastocytosis is defined as a clonal disorder of mast cells and their precursor cells and is currently classified as a myeloproliferative neoplasm. Its clinical course has a wide spectrum, ranging from indolent disease, with normal life expectancy, to highly aggressive disease, associated with multisystemic involvement and poor overall survival. The aim of this study was to report a case of indolent systemic mastocytosis, focusing on the diagnostic challenges, with a review of the literature. CASE REPORT A 79-year-old Caucasian woman with osteoporosis was evaluated at the Emerg

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… Iowa Orthop J. 1996;16:126–134. 7. Puxeddu I, Piliponsky AM, Bachelet I, Levi-Schaffer F. Mast cells in allergy and beyond. Int J Biochem Cell Biol. 2003;35(12):1601–1607. doi: 10.1016/s1357-2725(03)00208-5. 8. Garcia-Montero AC, Jara-Acevedo M, Teodosio C, et al. …

Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare.

Vitamin D has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, infectious diseases and cardiovascular disease. The recent data on vitamin D from experimental, ecological, case-control, retrospective and prospective observational studies, as well as smaller intervention studies, are sign

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… In the Iowa womens health study of 29 368 women of ages 55–69 years without a history of rheumatoid arthritis at study baseline showed that greater intake (highest vs. lowest tertile) of vitamin D was inversely associated with the risk of rheumatoid arthritis (RR 0.67; 95% CI: 0.44–1.00; p for trend … Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG, Iowa Women’s Health Study Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women’s Health Study. Arthritis Rheum. 2004;50:72–7. doi: 10.1002/art.11434. 93. …

Результаты терапии CAR T-Cell в реанимированном/охотничьем миеломе по расовому признаку: многоцентральное исследование реального мира.

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… We conducted a retrospective analysis of consecutive patients with RRMM who received commercial cilta-cel or ide-cel between May 2022 and April 2024 across five academic centers: Levine Cancer Institute, Ohio State University, University of Kansas Cancer Center, University of Iowa, and Medical University …

From post-war reconstruction to the twenty-first century - ophthalmic pathology in Freiburg 1945-2015. Part 2: review of 43,169 histological diagnoses from 39,256 specimens collected over 71 years at a large German tertiary eye care centre.

BACKGROUND: Ophthalmic pathology is essential for diagnosing ocular diseases, correlating clinical and histopathological findings, and advancing research. The Eye Center at the University of Freiburg, Germany, has archived histopathological specimens since 1945, offering a unique resource to analyse long-term diagnostic trends. This study examines 43,169 diagnoses from 39,256 specimens over 71 years (1945–2015), providing insights into the evolution of ophthalmic pathology at a major tertiary care centre. METHODS: We performed a retrospective analysis of all archived ophthalmic pathology repor

Oral cancer therapy: policy implications for the uninsured and underinsured populations.

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… A total of 26 states have enacted oral chemotherapy access laws: Oregon (2008), Indiana (2009), Iowa (2009), Hawaii (2009), District of Columbia (2009), Vermont (2010), Connecticut (2010), Kansas (2010), Colorado (2010), Minnesota (2010), Illinois (2011), New Mexico (2011), Texas (2011), New York (2011 …

Surveillance for Violent Deaths - National Violent Death Reporting System, 34 States, Four California Counties, the District of Columbia, and Puerto Rico, 2017.

PROBLEM/CONDITION: In 2017, approximately 67,000 persons died of violence-related injuries in the United States. This report summarizes data … ected from 34 states (Alaska, Arizona, Colorado, Connecticut, Delaware, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, …

Наблюдение за финансовыми трудностями пациентов с множественной миеломой и хронической лимфоцитической лейкемией, проходящих лечение в онкологических клиниках США (Alliance A231602CD).

ЦЕЛИ: Оценка доли и корреляции финансовых трудностей, о которых сообщают сами пациенты с множественной миеломой (ММ) или хронической лимфоцитической лейкемией (КЛ). Вечеринка: Sixty-six Общинная практика США и практики меньшинств в области онкологии связана с Программой общинных онкологических исследований Национального института раковых заболеваний (НКОРП). Участники: в целом 521 (больные)≥18 С согласия MM или CLL и 416 :: ответы на опрос (процент завершения)79.8%). Респонденты имели диагноз MM (MM-диагностика)74.0%), степень бакалавра или выше (53.4%), белые (или белые).89.2%), застрахованны

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… . § Geographic Regions were divided according to the United States census divisions and regions: Northeast: Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, Connecticut, New York, New Jersey and Pennsylvania; Midwest : Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa, Missouri … Not reported. § Geographic Regions were divided according to the United States census divisions and regions: Northeast: Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, Connecticut, New York, New Jersey and Pennsylvania; Midwest : Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa …

Viewing the US presidential electoral map through the lens of public health.

Health, disease, and mortality vary greatly at the county level, and there are strong geographical trends of disease in the United States. Healthcare is and has been a top priority for voters in the U.S., and an important political issue. Consequently, it is important to determine what relationship voting patterns have with health, disease, and mortality, as doing so may help guide appropriate policy. We performed a comprehensive analysis of the relationship between voting patterns and over 150 different public health and wellbeing variables at the county level, comparing all states, including

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… "Battleground states” are the tightly contested states of the 2016 Presidential election: Nevada, Colorado, Virginia, Florida, Michigan, Minnesota, Wisconsin, Iowa, New Hampshire, Ohio, and Pennsylvania. … The battleground states are: Nevada, Colorado, Virginia, Florida, Michigan, Minnesota, Wisconsin, Iowa, New Hampshire, Ohio, and Pennsylvania. The flipped states are: Michigan, Pennsylvania, Wisconsin and Maine. …

2020 ACVIM Forum On Demand Research Abstract Program.

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… ABSTRACT C10 Diagnostic utility of caudal vena cava measurements in dogs with cavitary effusions or heart failure Yen Yu Chou 1 ; Jessica Ward 2 ; Lara Barron 3 ; Melissa Tropf 2 ; Shane Murphy 2 ; Gregory Lisciandro 4 ; John Bonagura 3 ; Anna McManamey 3 ; Teresa DeFrancesco 3 1 Iowa State University … ; 2 College of Veterinary Medicine, Iowa State University; 3 College of Veterinary Medicine, North Carolina State University; 4 Hill Country Veterinary Specialists Thoracic ultrasound has proven effective for the diagnosis of left‐sided congestive heart failure (L‐CHF) dogs and cats with respiratory …

Cost Implications of Comorbidity for Autologous Stem Cell Transplantation in Elderly Patients with Multiple Myeloma Using SEER-Medicare.

Comorbidity is more common in older patients and can increase the cost of care by increasing toxicity. Using the SEER-Medicare database from 2000 to 2007, we examined the costs and life-year benefit of Auto-HSCT for MM patients over the age of 65 by evaluating the difference over time relative to comorbidity burden. One hundred ten patients had an Auto-HSCT in the early time period (2000-2003) and 160 in the late time period (2004-2007). Patients were divided by a Charlson Comorbidity Index (CCI) of 0 or greater than 1 (CCI1+). Median overall survival was 53.5 months for the late time period p

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… Data Source SEER registries include the Alaska Native Tumor Registry, Arizona Indians, Cherokee Nation, Connecticut, Detroit, Georgia (Atlanta, Greater Georgia, and Rural Georgia), California (Greater Bay Area Cancer Registry, Los Angeles, and Greater California), Hawaii, Iowa, Kentucky, Louisiana, …

Myohythmia: Количественное исследование синхронии и ритмичности между головой и верхним лимбом.

Мьоритмия — это расстройство осцилляционного движения <4 Гц, которое было в разной степени охарактеризовано как синхронное или асинхронное между частями тела и как вялое или ритмичное по внешнему виду, но никакого доклада о количественном анализе движения не опубликовано. МЕТОДЫ: 51-летняя женщина развила недееспособную миоритмию в голове и верхних конечностях (право) (слева) примерно через три месяца после рецидива множественных склерозов в ее мозговой стебле и мозжечке. Движение головы и двусторонних рук было зафиксировано в состоянии покоя и в позе с трехосными акселерометрами и гироскопиче

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… Funding Statement This study was funded by a grant from the Kiwanis Neuroscience Research Foundation, Illinois-Eastern Iowa District. …

Comorbidities in Black South Africans with established rheumatoid arthritis.

OBJECTIVE: Comorbidities contribute both to morbidity and mortality in rheumatoid arthritis (RA). The aim of the current study was to investigate the prevalence and spectrum of comorbidities in South Africans with established RA. METHODS: A retrospective, consecutive case record review of 500 Black South African patients with established disease of ≥5 years attending a tertiary rheumatology service was performed. Common comorbidities including those listed in the Charlson Comorbidity Score (CCS) were documented. RESULTS: Most patients, 463 known alive (AG) and 37 known deceased (DG), were fe

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… Mortality risk associated with rheumatoid arthritis in a prospective cohort of older women: results from the Iowa Women's Health Study. Ann Rheum Dis. 2002;61(11):994‐999. 26. Zumla A, George A, Sharma V, Herbert N. Baroness Masham of I. …

ICIMH 2022 Abstracts

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… Dusek 1 1 Connor Integrative Health Network, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States 2 Palmer Center for Chiropractic Research, Palmer College of Chiropractic, Davenport, Iowa, United States 3 Connor Integrative Health Network, Cleveland Medical Center, Cleveland … , California, United States 3 VHA, Iowa City, Iowa, United States 4 VHA, Washington, District of Columbia, United States 5 VHA, New York City, New York, United States Contact: Alison Whitehead, alison.whitehead@va.gov Abstract Background: The Veterans Health Administration (VHA) Directive 1137: …

Surveillance for Violent Deaths - National Violent Death Reporting System, 39 States, the District of Columbia, and Puerto Rico, 2018.

PROBLEM/CONDITION: In 2018, approximately 68,000 persons died of violence-related injuries in the United States. This report summarizes data … s with statewide data (Alabama, Alaska, Arizona, Colorado, Connecticut, Delaware, Georgia, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virg …

Surveillance for Violent Deaths - National Violent Death Reporting System, 42 States, the District of Columbia, and Puerto Rico, 2019.

PROBLEM/CONDITION: In 2019, approximately 67,000 persons died of violence-related injuries in the United States. This report summarizes data … tatewide data (Alabama, Alaska, Arizona, Colorado, Connecticut, Delaware, Georgia, Hawaii, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, …

Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.

UnlabelledDrugs used for the prevention and the treatment of osteoporosis exert various favourable and unfavourable extra-skeletal effects whose importance is increasingly recognized notably for treatment selection.IntroductionThe therapeutic armamentarium for the prevention and the treatment of osteoporosis is increasingly large, and possible extra-skeletal effects of available drugs could influence the choice of a particular compound.MethodsThe present document is the result of a national consensus, based on a systematic and critical review of the literature.ResultsObservational research has

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… In the Iowa Women’s Health Study in 34,486 postmenopausal women aged 55 to 69 years, Bostick and colleagues found that the highest quartile of total calcium intake (>1,425 mg/day), when compared to the lowest quartile (<696 calcium/day), was associated with a 33% reduction in ischaemic heart disease … Furthermore, an inverse association between higher intake of vitamin D and risk of rheumatoid arthritis was demonstrated in the Iowa Women’s Health Study [ 105 ]. …

Neurology

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Renal impairment and use of nephrotoxic agents in patients with multiple myeloma in the clinical practice setting in the United States.

Renal impairment is a common complication of multiple myeloma and deterioration in renal function or renal failure may complicate clinical management. This retrospective study in patients with multiple myeloma using an electronic medical records database was designed to estimate the prevalence of renal impairment (single occurrence of estimated glomerular filtration rate [eGFR] 2 on or after multiple myeloma diagnosis) and chronic kidney disease (at least two eGFR values 2 after multiple myeloma diagnosis that had been measured at least 90 days apart), and to describe the use of nephrotoxic ag

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… All geographic regions of the United States were represented in the sample, although patients were concentrated in the West North Central region (Iowa, Kansas, Minnesota, Missouri, North Dakota, Nebraska, South Dakota; 39% of patients), reflecting the distribution of OSCER sites across the nation. …

Связанный с K27 ROR__t Уничтожение Nedd4 потенциалами Th17-посредованная автонепроницаемость.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Было продемонстрировано, что THCT E3 Ubriquitin ligase Nedd4 позитивно регулирует реакцию клеток Т, однако его роль в дифференциации клеток и автономном иммунитете Т неизвестна. Считается, что 17 клеток играют ключевую роль в развитии и патогенезе аутоиммунных заболеваний. Тем не менее, правила, регулирующие активацию РОРТ в ходе дифференциации клеток TH17 с помощью сигнала TCR, пока еще не уточнены. Эти неизведанные аспекты вдохновляют нас на изучение потенциальной роли Nedd4 в автоматическом иммунитете Th17.МЕТОДЫ: Мы провели оценку воздействия дефицита Nedd4 на развит

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… Human specimens MS patients (treatment-naïve and in remission) and healthy controls were recruited from the Ohio State University Wexner Medical Center and the University of Iowa Hospitals and Clinics. … The two customized synthetic single strand oligo donor DNAs (ssODNs) bearing the desired mutations were purchased from Integrated DNA Technologies (IDT, Coralville, Iowa, USA). …