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Pyoderma gangrenosum у пациента с множественным склерозом при лечении в ходе родовспоможения: отчет по делу.

Пёдерма Гангреносум (PG) часто рассматривается в качестве иммунной болезни. До 50% случаев ПГ - редкое, неинфекционное воспалительное заболевание кожи, характеризующееся болезненными некротическими язвами, - связано с такими основополагающими системными заболеваниями, как ремуматуидный артрит (RA) и инфламматический болезень Боулинга (IDB), а также с моноклональной антителной терапией. Мы описали 38-летнюю пациентку с множественным склерозом (MS), которая три года лечилась от Натализумаба. Myalgia, лихорадка и эритимные доски, сопровождаемые болезненными повреждениями в обеих верхних конечност

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… Additionally, Daclizumab may induce skin reactions, such as psoriasis, alopecia, pruritus, pityriasis roses, exfoliated dermatitis, seborrheic dermatitis, eczema, urticaria, contact dermatitis, folliculitis and erythema nodosum [ 31 ]. …

Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses.

The bis triazole agent fluconazole is used widely in the treatment of superficial and deep mycoses. A single oral dose of fluconazole 150 mg … s or months results in over 90% clinical cure or improvement for cutaneous mycosis including tinea, pityriasis, cryptococcosis and candidiasis. Prolonged (6 to 12 months) fluconazole 150 mg once a week is needed to treat onychomycosis successfully. Higher oral doses (200 to 400 mg daily) for long periods are generally used to treat deep mycoses such as menin …

Coexistence of Anogenital Psoriasis and Genital Warts - Is There an Optimal Treatment?

The prevalence of psoriasis is 2% of the world's population (1). Inverse psoriasis is characterized by the development of erythematous shiny … oebner phenomenon can be found in other skin diseases like vitiligo, lichen planus, lichen nitidus, pityriasis rubra pilaris, flat warts, and keratosis follicularis (Darier disease) (5). According to Eyre at al., about 67% patients with psoriasis (4) present with clearing of psoriatic lesions following skin injury (positive "reverse" Koebner reaction) (4). T …

Семья " Interleukin-17 " в области здравоохранения и иммунных заболеваний: от происхождения до клинических последствий.

Семья интерлейкин-17 является ключевой группой цитокинов и демонстрирует широкий спектр биологических функций, включая регулирование подстрекательского каскада в различных аутоиммунных и подстрекательских болезнях, таких, как множественный склероз, оптический спектр нейромилита, миастения гравис, синдром Гильен-Барре, острый распределенный энцфаломиэлит, диабет, воспалительные кожные заболевания, суставное воспаление и рак. Хотя функция семьи интерлейкин-17 привлекает все большее внимание к исследованиям на протяжении многих лет, выражение, функции и механизмы регулирования различных членов се

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… A rise in Th17 and Th1 Inflammatory mediators (including IL-17A and IL-17F) was observed within the diseased skin of patients with pityriasis rubra pilaris. … Treatment with drugs targeting IL12/23 and IL-17A—examples of which include Ustekinumab, Secukinumab, and Ixekizumab—resulted in clinical and histopathological improvement in pityriasis rubra pilaris patients (Feldmeyer et al., 2017). …

Diabetes mellitus and the skin.

Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

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… Disappeared lesions have about 40% chance to reappear. 63 The lack of symptoms, scaling or blistering associated to GA helps to differentiate it from other skin diseases such as tinea corporis, pityriasis rosea, psoriasis, or annular erythema. … other common superficial mycoses in diabetics are extensive pityriasis versicolor and dermatophytoses Which disease is not associated with diabetes mellitus? …

Hereditary epidermolysis bullosa: clinical-epidemiological profile of 278 patients at a tertiary hospital in São Paulo, Brazil.

BACKGROUND: Epidermolysis bullosa (EB) is a group of rare hereditary diseases, characterized by fragility of the skin and mucous membranes. Epidemiological data on EB in Brazil are scarce. OBJECTIVES: To describe epidemiological aspects of patients with EB diagnosed in the Dermatology Department of a tertiary hospital, from 2000 to 2022. METHODS: An observational and retrospective study was conducted through the analysis of medical records. The evaluated data included clinical form, sex, family history, consanguinity, age at diagnosis, current age, time of follow-up, comorbidities, histopath

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… Dermatological findings unrelated to EB included seborrheic dermatitis (1), atopic dermatitis (1), and pityriasis amiantacea (1). Folliculitis decalvans was identified in two individuals, both with dystrophic EB. Cicatricial alopecia affected two JEB patients. …

What's New in Genetic Skin Diseases.

The discoveries of new genes underlying genetic skin diseases have occurred at a rapid pace, supported by advances in DNA sequencing technologies. These discoveries have translated to an improved understanding of disease mechanisms at a molecular level and identified new therapeutic options based on molecular targets. This article highlights just a few of these recent discoveries for a diverse group of skin diseases, including tuberous sclerosis complex, ichthyoses, overgrowth syndromes, interferonopathies, and basal cell nevus syndrome, and how this has translated into novel targeted therapie

Integrating personalized gene expression profiles into predictive disease-associated gene pools.

Sertaconazole (Dermofix, Ertaczo, Ginedermofix, Monazol, Mykosert or Zalain), an imidazole antifungal agent, inhibits the synthesis of ergosterol, an essential cell wall component of fungi. It is indicated in the EU for the treatment of superficial skin mycoses such as dermatophytosis (including tinea corporis, tinea cruris, tinea manus, tinea barbae and tinea pedis), cutaneous candidiasis, pityriasis versicolor and seborrhoeic dermatitis of the scalp, and in the US for tinea pedis only. Sertaconazole has broad-spectrum antifungal activity against dermatophytes of the Trichophyton, Epidermophy…

Liver Disease Associated with Non-Hepatitis Viruses

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… Pityriasis rosea reflects primary infection with HHV-7. HVV-6 also integrates into the host's genome and is transmitted via the germline. …

Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans.

Glycosphingolipids (GSLs) are composed of hydrophobic ceramide and hydrophilic sugar chains. GSLs cluster to form membrane microdomains (lipid rafts) on plasma membranes, along with several kinds of transducer molecules, including Src family kinases and small G proteins. However, GSL-mediated biological functions remain unclear. Lactosylceramide (LacCer, CDw17) is highly expressed on the plasma membranes of human phagocytes and mediates several immunological and inflammatory reactions, including phagocytosis, chemotaxis, and superoxide generation. LacCer forms membrane microdomains with the Sr

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… The effects of infliximab have also been evaluated in other inflammatory dermatoses and in systemic diseases involving the skin, pityriasis rubra pilaris, pyoderma gangrenosum, and cutaneous sarcoidosis [ 73 ]. …

Реальное воздействие NVX-CoV2373 COVID-19 вакцина для иммунокомпромиссных людей в Южной Корее.

BackgroundNVX-CoV2373 - наночастица, белковая COVID-19 вакцина. Лица, страдающие от иммунокомпрометированных заболеваний, подвергаются высокому риску инфицирования и серьезных заболеваний; однако в реальном мире NVX-CoV2373 Цель настоящего исследования состояла в том, чтобы оценить, являются ли данные о воздействии в МКС ограниченными. NVX-CoV2373 снижение риска SARS-CoV-2 :: инфекция и серьезные заболевания в ИМС по сравнению с лицами, не имеющими иммунокомпромиссных свойств (не связанными с ИС). Южнокорейский МКС в возрасте ≥12 лет, которые получили первичную серию, третью дозу или четвертую

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… Table 1 Types of Immunocompromising conditions included in this study Condition category | Condition name (ICD-10 code) | Study participants, n (%) Rheumatologic/inflammatory disorder | Psoriasis (L40) Parapsoriasis (L41) Pityriasis rosea (L42) Lichen planus (L43) Other papulosquamous disorders (L44) …

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

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… Pityriasis rotunda seems to be a variant of ichthyosis acquisita and is correlated with hepatocarcinoma. …

Re-estimation of the burden of serious fungal diseases in Uganda.

BACKGROUND: It is of utmost importance to monitor any change in the epidemiology of fungal diseases that may arise from a change in the number of the at-risk population or the availability of local data. OBJECTIVE: We sought to update the 2015 publication on the incidence and prevalence of serious fungal diseases in Uganda. METHODS: Using the Leading International Fungal Education methodology, we reviewed published data on fungal diseases and drivers of fungal diseases in Uganda. Regional or global data were used where there were no Ugandan data. RESULTS: With a population of ~45 million, w

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… Superficial and implantation mycoses Superficial fungal diseases contribute to over 1 billion cases annually. 54 However, most superficial fungal infections such as pityriasis versicolor and tinea corporis are mainly asymptomatic and not life-threatening. …

Mucosal-Associated Invariant T Cells in Health and Disease.

Mucosal-associated invariant T (MAIT) cells are a population of evolutionarily conserved, unconventional innate-like T lymphocytes that are restricted by major histocompatibility complex Class I-related (MR1) molecules. They can be activated either in a T-cell receptor-MR1- or cytokine-dependent manner. Activated MAIT cells play crucial roles in maintaining homeostasis and the fine regulation of the immune system. This review presents a systematic exploration of the development, biological characteristics, and multiple effects of MAIT cells in health and various diseases. In healthy individual

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… Another report indicated that a SARS‐CoV‐2‐infected woman diagnosed with pityriasis rubra pilaris may have been mediated by a SAg of SARS‐CoV‐2, given the clinical similarity of the prodromic scarlatiniform phase with other skin disorders mediated by the SAgs; although the superantigenic nature of SARS‐CoV …

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.

The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interac

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… This is an interesting finding as Malassezia is among the most abundant members of the skin mycobiota and has been documented to play important roles in the development of skin diseases such as atopic dermatitis, pityriasis versicolor, and psoriasis. …

P941 – P1197

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How does academia respond to the burden of infectious and parasitic disease?

BackgroundAcademic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there have been concerns regarding whether the academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies.MethodsWith a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to

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… OR "Cradle cap" OR "Dermatitis" OR "Dermatophytosis" OR "Diaper rash" OR "Eczema" OR "Erythema multiforme" OR "Erythema nodosum" OR "Hidradenitis suppurativa" OR "Hirsutism" OR "Impetigo" OR "Ingrown nail" OR "Keloid scar" OR "Lichen planus" OR "Lymphadenitis" OR "Onychomycosis" OR "Paronychia" OR "Pityriasis …

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