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Recurrent dislocation of the shoulder joint.

[Figure: see text] Dr. DePalma was the first editor of Clinical Orthopaedics and Related Research, established by the recently formed Associ … ment age of 65. He closed his practice and moved briefly to Pompano Beach, Florida, but the lure of academia proved too powerful, and in January, 1971, he accepted the offer to develop a Division of Orthopaedics at the New Jersey College of Medicine and became their Chair. He committed to a five-year period, and then again moved to Pompano Beach, only to t …

From virtual to reality: innovative practices of digital twins in tumor therapy.

BackgroundAs global cancer incidence and mortality rise, digital twin technology in precision medicine offers new opportunities for cancer treatment.ObjectiveThis study aims to systematically analyze the current applications, research trends, and challenges of digital twin technology in tumor therapy, while exploring future directions.MethodsRelevant literature up to 2024 was retrieved from PubMed, Web of Science, and other databases. Data visualization was performed using R and VOSviewer software. The analysis includes the research initiation and trends, funding models, global research distri

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… Future progress may depend on fostering international collaboration, integrating academia and industry, and establishing dedicated funds to accelerate the global development and clinical translation of digital twin technology. … In the near future, global digital twin alliances—bringing together industry, government, academia, and practitioners—will be essential for standardizing digital twin methodologies and establishing interoperability protocols. …

A new era in myeloma: the advent of chimeric antigen receptor-T (CAR-T) cells and bispecific antibodies.

T-cell re-directional therapies, including chimeric antigen receptor (CAR)-T cell and bispecific antibodies (BsA), have transformed the treatment landscape to benefit patients with multiple myeloma. A number of these novel therapies has been approved internationally, with CAR-T therapy recently approved in Australia. In this clinical perspective, we describe the development of CAR-T and BsA therapies, highlighting the clinical benefits and risks, together with the significant costs and infrastructure support required for the provision of these therapies to myeloma patients.

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… This requires the concerted efforts of all stakeholders – government, biotechnological industry, physicians and academia, to ensure efficient and equitable access in the community. Despite the optimism, a ‘cure’ – the ultimate goal – remains on the horizon as relapses continue to occur. …

Наркотики, основанные на сходстве генных экспрессионных сигнатур, чтобы исследовать потенциальные признаки кексетина: тематическое исследование множественных склерозов.

Quercetin (QR) — природный флавонол, широко распространенный в королевстве растений с обширными фармакологическими последствиями. Чтобы найти потенциальные клинические показатели QR, 156 Дифференциально выраженные гены (DEG), регулируемые QR, были получены из базы данных Gene Express Omnibus, и новые потенциальные фармакологические эффекты и клинические показатели QR были перенаправлены путем интегрирования соединений с аналогичными генными сигнатурами возмущения и соответствующими сигнатурами болезни QR на основе карты связи и платформ Coexedia. Предлагаемые результаты QR оказывают главным об

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… At present, the method of drug repurposing has been successfully applied to developing new drugs and the repurposing of old drugs has achieved a series of successful cases, which has attracted wide attention from academia and pharmaceutical companies ( Parvathaneni et al., 2019 ). …

Structured benefit-risk evaluation for medicinal products: review of quantitative benefit-risk assessment findings in the literature.

A favorable benefit-risk profile remains an essential requirement for marketing authorization of medicinal drugs and devices. Furthermore, prior subjective, implicit and inconsistent ad hoc benefit-risk assessment methods have rightly evolved towards more systematic, explicit or "structured" approaches. Contemporary structured benefit-risk evaluation aims at providing an objective assessment of the benefit-risk profile of medicinal products and a higher transparency for decision making purposes. The use of a descriptive framework should be the preferred starting point for a structured benefit-

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… there is still a lack of a clear guidance and understanding on how regulatory bodies expect structured benefit–risk to be conducted, on how to integrate patients’ preferences and when to use quantitative methods. 35 Regulatory bodies should continue to collaborate with multiple stakeholders, including academia …

Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence.

On 4 September 2024, the Reagan-Udall Foundation for the FDA (FDA Foundation) in collaboration with the Food and Drug Administration (FDA) and the Gates Foundation hosted a workshop titled "Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence". The event brought together a diverse group of experts, including international regulatory bodies, regulated industries, healthcare professionals, patients, academic researchers and global health advocates, to discuss the rapid advancements in gene therapy and the pressing need for equitable access in low-and middle-

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… Early and Frequent Interaction with Developers: Ongoing engagement with developers from industry (both for-profit and not-for-profit) and academia is vital for regulatory success. …

Карта знаний об искусственном интеллекте в нейродегенеративных болезнях: исследование библиометрии и визуализации на протяжении десяти лет.

По мере увеличения заболеваемости нейродегенеративными заболеваниями соответствующие исследования ИИ становятся все более и более передовыми. В этом исследовании мы анализируем литературу в этой области за последнее десятилетие с помощью методов библиометрии и визуализации с целью разработки известных журналов, институтов, авторов и стран в этой области и анализа ключевых слов, с тем чтобы предположить возможные будущие тенденции в области исследований. МЕТОДЫ: Извлечено наше исследование 1,921 соответствующие публикации, охватывающие 2015-2025 из базы данных " Web of Science Core Collect

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… The commonality of these institutions lies in the fact that through infrastructure sharing, interdisciplinary team establishment and industry-academia-research linkage, the barriers to technological translation are systematically lowered, thus creating sustainable research outputs in the niche areas. …

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

Clinical development of chimeric antigen receptor (CAR)-T-cell therapy has been enabled by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and complex logistics to distribute the drug product to treatment sites. A key ambition of the CARAMBA project is to provide clinical proof-of-concept for virus-free CAR gene transfer using advanced Sleeping Beauty (SB) transposon technology. SB transposition in CAR-T engineering is attractive due to the high rate of stable CAR gene transfer enabled by optimized hyperactive SB100X transposase and transposon combinations, en

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… Given the financially very significant engagement of major pharmaceutical companies in the fields of cell and gene therapy and immuno-oncology with genetically modified (typically autologous) immune effector cells, the question why academia remains active in this highly competitive field is often posed …

Gene Expression Profiling and Pathway Network Analysis Predicts a Novel Antitumor Function for a Botanical-Derived Drug, PG2.

PG2 is a botanical drug that is mostly composed of Astragalus polysaccharides (APS). Its role in hematopoiesis and relieving cancer-related fatigue has recently been clinically investigated in cancer patients. However, systematic analyses of its functions are still limited. The aim of this study was to use microarray-based expression profiling to evaluate the quality and consistency of PG2 from three different product batches and to study biological mechanisms of PG2. An integrative molecular analysis approach has been designed to examine significant PG2-induced signatures in HL-60 leukemia ce

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… Huang), the Industrial-Academia Collaboration Project from PhytoHealth Corporation, and Chang Gung Memorial Hospital (CGMH-NYMU Joint Research, CMRPG2D0091 to Chi-Ying F. Huang and Tse-Hung Huang). …

An expanding horizon of complex injectable products: development and regulatory considerations.

There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various indications. This is either market-driven or technology-driven to improve the overall therapeutic efficacy and patients' quality of life. The pharmaceutical industry has experienced rapid growth in the area of complex injectable products because of their effectiveness in the unmet market. These novel parenteral products, viz, the nanoparticles, liposomes, microspheres, suspensions, and emulsions, have proven their worth as "Safe and Effective" produ

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… Regulatory bodies are putting efforts to promote more generic product competition and emphasizing excessively on collaborating with the government, academia, and industry. In comparison to the pharmaceutical industries, academic research focuses more into the advanced drug delivery systems. … In the future, such collaborative efforts by the regulatory bodies would help in translating the scientific knowledge from the academia to the industries resulting in the fruition of the products from the pipeline. …

[AORTIC ANEURYSMS. THE SILENT ENEMIES].

Aortic aneurysms are caused by a localized degeneration of the middle layer, which promotes the formation and progressive expansion of the aneurysm. In ascending thoracic aorta, usually have genetic cause, and intervene when they reach 5 to 5.5 cm in diameter. The downlink and abdominal aorta are associated with cardiovascular risk factors, especially age, smoking and hypertension. They are usually asymptomatic until rupture and diagnosis or is incidental or required before rupture performing an ultrasound scan in males over 65 who have been smokers. The alternative treatment to surgery in thi

[Polycystic kidney disease: from genetics to dialysis].

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end stage renal disease. In addition, end-stage renal disease is complicated by acquired polycystic kidney disease. Recent advances in our understanding of the pathogenesis of ADPKD have identified the primary cilium as key to cystogenesis, and have defined the molecular, cellular and tissue pathogenesis of the disease, leading to the design of clinical trials that may ultimately lead to effective therapy of the disease. In 2012 a key trial has shown that blockade of vasopressin receptors with tolvaptan sl

[A new prevention strategy against meningococcal disease: the menigococcus B vaccine].

The new anti-meningococcal vaccine contributes not only to fight against a severe condition like the meningococcal disease caused by meningococcus B, but also gives us a new tool: inverse vaccinology. This technique parts from the bases of the virtual knowledge of the microorganism's genome, knowing all the proteins that the pathogen is able to express on its surface. This allows us to predict the candidate antigens which are most likely to be used in a potential vaccine. After the selection of these candidates, the vaccines are studied first in animals and later in humans. All this research w

[Splenic-thoracic transit: a rare evolution of hydatid disease].

We report a case of splenic hydatid cyst, an unfrequent localization of hydatid disease that usually presents with hydatid cysts in other organs (but not in this case). Primary spleen infestation generally occurs trough arterial blood supply, after the oncosphere of Echinococcus granulosus travels from host's digestive tube to the left atrium, passing trhough hepatic and pulmonar filters; other routes are also possible. Migration of an abdominal hydatid cyst into the thoracic cavity (phenomena called abdominal thoracic hydatid transit) occurs in 3.5% to 5% of liver cysts, and is quite exceptio

[Where does Parkinson's disease start?].

Parkinson's disease concept is classically restricted to a rigid-akinetic syndrome due to a nigro-striatal dopaminergic depletion. This concept ignored the widespread extension of neuropathologic findings across the CNS. Moreover detailed clinical studies showed that patients suffer a constellation of other symptoms and signs such as anosmia, constipation, cardiovascular disautonomia, neuropsychologic and neuropsychiatric disorders, dementia and sleep changes. Taken together these evidences have lead to the idea that Parkinson's disease is a multisystemic disease of the nervous system. Braak e