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Bispecific Antibodies and CAR T in Multiple Myeloma: Appropriate Selection of Patients and Sequencing.

T-cell redirecting therapies (TCR) marked a step forward in the treatment of relapsed/refractory multiple myeloma (RRMM). These agents, represented by chimeric antigen receptor (CAR) T-cells and bispecific antibodies (BsAbs), proved to ameliorate the prognosis of difficult-to-treat patients in pivotal clinical trials, leading to their introduction into clinical practice. Both strategies rely on recruiting patients' T-cells against specific tumor antigens, with B-cell maturation antigen (BCMA) and G-protein coupled receptor group C family 5 member D (GPRC5D) being the targets most extensively s

Urine 5-HIAA and quality of life in neuroendocrine neoplasia. Is there an association?

BACKGROUND: To determine whether urine 5-HIAA (u5HIAA) concentrations correlate with health-related quality of life (HRQL) in patients with neuroendocrine neoplasms (NEN). METHODS: A retrospective single-centre cross-sectional study was conducted including 386 patients with histological or radiological diagnosis of NEN. Patients completed standardized questionnaires at clinic appointments. Spot u5HIAA concentrations were correlated with Patient Health Questionnaire-9 (PHQ-9) depression scores, Generalized Anxiety Disorder-7 (GAD-7) anxiety scores, European Organisation for Research and Treatm

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… The reporting of this study conforms to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. 21 u5HIAA analysed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the United Kingdom Accreditation Service (UKAS) accredited (ISO 15189:2012) laboratory …

A Patient-Specific Fracture Risk Assessment Tool for Femoral Bone Metastases: Using the Bone Strength (BOS) Score in Clinical Practice.

Patients with femoral metastases are at risk of fracturing bones. It is important to prevent fractures in order to maintain mobility and quality of life. The BOne Strength (BOS) score is based on a computed tomography (CT)-based patient-specific finite element (FE) computer model that objectively calculates bone strength. In this pilot study, the added clinical value of the BOS score towards treatment-related decision making was assessed. In December 2019, the BOS score was implemented in four radiotherapy centers. The BOS scores and fracture risks of individual patients were calculated and re

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge.

The general population is getting older and suffer more haematological malignancies despite being physically fit. These malignancies are mainly only curable via an alloHCT, and they are now carried out more frequently. Patients benefit from intensive rehabilitation earlier and may need it repeatedly in cases of severe side effects (e.g., graft-versus-host disease). They can suffer many problems that other cancer patients do not experience, such as severe infections, continued immunosuppression, nutritional restrictions, acute or chronic GvHD, or organ impairments (e.g., lung, eyes). They may a

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… To carry out an alloHCT, an allogeneic transplant centre requires a European Accreditation ( www.JACIE.org , accessed on 5 October 2021) from the European Society for Blood and Marrow Transplantation [ 6 ]. … JACIE Accreditation for Blood and Marrow Transplantation: Past, Present and Future Directions of an International Model for Healthcare Quality Improvement Bone Marrow Transpl. 2017 52 1367 1371 10.1038/bmt.2017.54 28346416 PMC5629362 7. Van der Lans M.C.M. Witkamp F.E. Oldenmenger W.H. …

The 2024 Saudi Pharmacotherapy Didactic Curriculum Toolkit: A Modified Delphi Study.

BACKGROUND: Several pharmacy schools in Saudi Arabia (S.A.) refer to the American College of Clinical Pharmacy (ACCP) pharmacotherapy toolkit in developing their pharmacotherapy curriculum. However, the ACCP toolkit does not specifically address the healthcare needs of the Saudi population. A tailored pharmacotherapy curriculum that offers graduates the essential competencies to better serve the nation's needs is warranted. This study aims to develop a population-centered didactic pharmacotherapy toolkit for the Saudi population to assist pharmacy schools in designing pharmacotherapy course co

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… The Accreditation Council of Pharmacy Education (ACPE) identified the essential foundational sciences that are the building blocks of any Pharm.D. program, including basic biomedical sciences, pharmaceutical sciences, social /behavioral /administrative pharmacy sciences, and clinical sciences [ 1 ]. … Guidance for the accreditation standards. 2011. https://www.acpe-accredit.org//pdf/S2007Guidelines2.0_ChangesIdentifiedInRed.pdf . Accessed 4 Aug 2021. 2. Seaton TL Bown-Luzier A Cooke CE DeConinck JF Dupuis RE Force RW Practice guidelines for pharmacotherapy specialists. …

Chimeric antigen receptor T-cell therapies related to immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome: Diagnosis, high-risk factors, and management.

AbstractImmune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) is a life-threatening complication of chimeric antigen receptor T cell (CAR-T) therapy. Despite its high mortality rate, IEC-HS remains underrecognized due to overlapping clinical and laboratory features with severe cytokine release syndrome (CRS), leading to delayed diagnosis and suboptimal management. This review systematically analyzes key strategies to distinguish IEC-HS from severe CRS in the literature. The analysis focuses on temporal patterns, such as the delayed onset of IEC-HS after CAR-

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… multiple regimens, including the HLH-94 regimen, the HLH-2004 regimen, the regimen proposed by Neelapu et al , [ 25 ] and the recommended regimens formulated by the Society for Immunotherapy of Cancer (SITC), the American Society of Clinical Oncology (ASCO), the joint guideline of the EBMT and the Joint Accreditation … Cellular Therapy; CRS: Cytokine release syndrome; CYP450: Cytochrome P450; EBMT: European Society for Blood and Marrow Transplantation; EHA: European Haematology Association; HLH/MAS: Hemophagocytic lymphohistiocytosis/Macrophage activation syndrome; IL-6: Interleukin-6; i.v.: Intravenous; JACIE: Joint Accreditation …

An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties.

Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by the high-quality extra virgin olive oil (EVOO), which is produced mostly in Mediterranean countries and is directly made from olives, the fruit of the olive tree (Olea europaea L.). Preclinical evidence supports the existence of antioxidant and anti-inflammatory properties exerted by t

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… The aforementioned EVOO analytical report was issued by Chemiservice Srl (Monopoli, Italy), a laboratory specialized in chemical and microbiological analysis in the food, environmental, industrial and cosmetic sectors [laboratory recognized by the Italian Accreditation Body for Testing Laboratories ACCREDIA … The EVOO analytical report and quality certification were issued by Chemiservice Srl (Monopoli, Italy), a laboratory specialized in chemical and microbiological analysis in the food, environmental, industrial and cosmetic sectors [laboratory recognized by the Italian Accreditation Body for Testing Laboratories …

Promoting primary palliative care in Western Kenya using Project ECHO®.

Currently less than 2% of Kenyans with severe symptoms receive palliative care (PC). Moreover, PC services are concentrated in urban settings and most rural healthcare providers have limited PC expertise. Project ECHO® Palliative Care for Western Kenya was developed as part of a hub-and-spoke model for improving primary PC in rural Kenya. The programme is based at Moi University and Moi Teaching and Referral Hospital, a public, tertiary care facility with a catchment of 25 million Kenyans, the majority of whom live in rural settings. Self-reported assessments by primary care providers found th

Nephrology in Veterinary Medicine.

Veterinary nephrology is a specialized field of veterinary medicine providing a high level of care for animals with all types of kidney disease. Veterinarians complete extensive training to become board-certified in veterinary nephrology-urology. Companion animal nephrology is the most advanced field; however, all species are afflicted by a variety of renal disorders. Most naturally occurring animal kidney diseases have similar disorders found in people; where veterinary research is lacking, clinical management is often modified from standard of care in people. Veterinarians have become adept

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… Education, Training, and Ongoing Maintenance/Update of Expertise Entrance to veterinary school is competitive because there are only 33 accredited programs in the United States. … On graduation of veterinary school and passing a national accreditation examination, veterinarians are licensed to practice all aspects of veterinary medicine. …

Factors associated with palliative care symptoms in cancer patients in Palestine.

Palliative care is critical to redundancy in cancer patients seeking to improve their quality of life. Evaluation should be incorporated into clinical practice routines at all stages of cancer. The Edmonton Symptom Assessment System (ESAS) was used to rate the intensity of ten symptom evaluations designed and validated for cancer patients in various languages and cultures. Therefore, the study aims to assess the symptoms reported using ESAS scores to identify patients who would benefit from palliative care that can improve the integration of palliative care into standard cancer care at An-Naja

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… However, Jordan was among the first Arab countries to be accredited in this domain 15 . This concept had not previously been studied in Palestinian cancer patients. … Gaining palliative medicine subspecialty recognition and fellowship accreditation in Jordan. J. Pain Symptom Manage. 2020;60:1003–1011. doi: 10.1016/j.jpainsymman.2020.05.016. 16. Richardson LA, Jones GW. A review of the reliability and validity of the Edmonton symptom assessment system. Curr. …

Neurofilaments in Tears как ранние биомаркеры корнельского нейродегенерации в диабете без ретинопатии.

ПРИСУТСТВИЕ: Нейродегенерация в роговице, особенно у больных диабетом, является новой областью исследований, в которой подчеркивается потенциал слезоточивой жидкости как источника биомаркеров. В качестве перспективных кандидатов на ранние биомаркеры нейродегенерации была определена световая цепь (Nf-L), являющаяся структурными белками, обнаруженными в нейронах. ЦЕЛЬ: В этом исследовании изучается корреляция уровней Nf-L в слезах и роговио конфокальной микроскопии (ИМКМ) у пациентов с сахарным диабетом без ретинопатии с целью увязывания уровня Nf-L с кукурузным нейродедегенерацией. DESIGN: Иссл

Биотечная антителная терапия в миэломе CNS: Ранние улики из мультицентральной группы.

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… Management of adults and children undergoing chimeric antigen receptor T‐cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Haematologica. 2020;105(2):297–316. 14. …

Целая Боди Криотерапия воздействует на уровень D витамина крови у людей с множественным склерозом.

Цель этого исследования заключалась в изучении и оценке воздействия серии из 20 методов криотерапии на уровень витамина D в крови женщин с множественным склерозом и здоровыми женщинами. Методы: Это исследование проводилось с участием трех групп участников. Экспериментальная группа состояла из 15 женщин в возрасте от 34 до 55 лет, у которых был диагностирован множественный склероз (МС), которые прошли криотерапию всего тела. Первая контрольная группа состояла из 20 женщин с РС, которые не проходили криотерапию. Вторая контрольная группа состояла из 15 женщин в возрасте от 30 до 49 лет, которые

Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results.

There is a critical need for effective treatments for leptomeningeal disease (LMD). Here, we report the interim analysis results of an ongoing single-arm, first-in-human phase 1/1b study of concurrent intrathecal (IT) and intravenous (IV) nivolumab in patients with melanoma and LMD. The primary endpoints are determination of safety and the recommended IT nivolumab dose. The secondary endpoint is overall survival (OS). Patients are treated with IT nivolumab alone in cycle 1 and IV nivolumab is included in subsequent cycles. We treated 25 patients with metastatic melanoma using 5, 10, 20 and 50

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… Department of Veterinary Medicine and Surgery provided veterinary care, including routine husbandry and health monitoring, facilities and services in support of the Institutional Animal Care and Use Program, in keeping with all applicable laws, regulations, guidelines and the Association for Assessment and Accreditation … of Laboratory Animal Care accreditation standards. …

International Congress on Academic Medicine: 2025 medical education abstracts.

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Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis.

Diffusion MRI (dMRI) is a growing imaging technique with the potential to provide biomarkers of tissue variation, such as cellular density, tissue anisotropy, and microvascular perfusion. However, the role of dMRI in characterizing different aspects of bone quality, especially in aging and osteoporosis, has not yet been fully established, particularly in clinical applications. The reason lies in the complications accompanied with implementation of dMRI in assessment of human bone structure, in terms of acquisition and quantification. Bone is a composite tissue comprising different elements, ea

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… Accreditation John Wiley and Sons, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. John Wiley and Sons, Inc. designates this journal‐based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™ . …

CD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist?

CD19-directed chimeric antigen receptor (CAR) T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases. By selectively depleting CD19-positive B-cells, this therapy brings a new approach in resetting immune dysregulation and potentially providing long-term remission for patients with a refractory disease. Recent reports have highlighted its effectiveness in conditions such as SLE, systemic sclerosis and myositis. However, while these early results are encouraging, questions remain regarding strategie

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… The European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) have summarised recommendations, also for the autoimmune disease setting. 18 19 Patients should have a good performance status … Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) Ann Oncol. 2022;33:259–75 …

Cardiovascular disease and chimeric antigen receptor cellular therapy.

Chimeric antigen receptor T-cell (CAR T) therapy is a revolutionary personalized therapy that has significantly impacted the treatment of patients with hematologic malignancies refractory to other therapies. Cytokine release syndrome (CRS) is a major side effect of CAR T therapy that can occur in 70-90% of patients, with roughly 40% of patients at grade 2 or higher. CRS can cause an intense inflammatory state leading to cardiovascular complications, including troponin elevation, arrhythmias, hemodynamic instability, and depressed left ventricular systolic function. There are currently no stand

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… Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the european society for blood and marrow transplantation (EBMT) and the joint accreditation committee of ISCT and EBMT (JACIE) . … Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the european society for blood and marrow transplantation (EBMT) and the joint accreditation committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) . …

A scoping review examining the integration of exercise services in clinical oncology settings.

BackgroundAddressing questions surrounding the feasibility of embedding exercise service units in clinical oncology settings is imperative for developing a sustainable exercise-oncology clinical pathway. We examined available literature and offered practical recommendations to support evidence-based practice, policymaking, and further investigations.MethodsFour thousand eight hundred sixty-three unique records identified in Embase, CINAHL, MEDLINE, Web of Science Core Collection, and ProQuest (Health and Medicine) were screened for studies that recruited cancer patients, assessed the co-locati

Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations.

For over two decades, the EBMT has updated recommendations on indications for haematopoietic cell transplantation (HCT) practice based on clinical and scientific developments in the field. This is the ninth special EBMT report on indications for HCT for haematological diseases, solid tumours and immune disorders. Our aim is to provide guidance on HCT indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered with the risk of the disease, risk of HCT procedure and non-HCT strategies, includi