Результаты поиска

Сердечные аритмии, связанные с S1PRM: фармакологическое исследование, основанное на реальных данных.

ИСТОРИЯ ВОПРОСА: Sphingosine-1-phosphate Рецепторные модуляторы (S1PRM) представляют собой эффективный класс методов лечения, позволяющих модифицировать заболевания (DMT) для лечения множественных склерозов (MS). В то время как сердечные аритмии, такие, как брадикардия и атриовентрикулярный блок (AV), являются признанными классовыми эффектами S1PRM, сравнительными реальными характеристиками безопасности по всему миру four Недостаточным образом характеризуются утвержденные агенты, особенно новые агенты, имеющие ограниченное количество данных после реализации. МЕТОДЫ: Мы провели ретроспективный

The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.

Cardiac amyloidosis (CA) represents a growing etiology of heart failure (HF) and arrhythmogenesis, driven by the intramyocardial deposition of aberrantly folded proteins, notably immunoglobulin light chains (AL) and transthyretin (ATTR). This infiltrative process compromises myocardial compliance and disrupts the cardiac conduction system, leading to a diverse spectrum of dysrhythmias. The escalating prevalence of CA, particularly within geriatric demographics and individuals with plasma cell dyscrasias, underscores the imperative for refined diagnostic and therapeutic paradigms. The considera

Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Age at session was 4‐39 years; arrhythmias were atrioventricular reentrant tachycardia (AVNRT) in 6 cases, intraatrial reentrant tachycardia in 5 cases, premature ventricular contractions/ ventricular tachycarida in 2 cases, tachycardia involving twin atrioventricular nodes (TAVN) in 2 cases, atrioventricular …

Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma.

Background: Arrhythmias are common cardiovascular complications in multiple myeloma (MM) patients and are related to a poor prognosis. Objective: This study aimed to assess the burden of arrhythmias and their prognostic value in patients with MM. Methods: This was a retrospective study of patients with MM between January 2015 and April 2020 at the First Affiliated Hospital of Xi'an Jiaotong University. The incidence of arrhythmia and associated risk factors were evaluated. The relationship between the type of arrhythmia and survival was analyzed. Results: A total of 319 patients with MM were i

3rd-Degree Atrioventricular Block.

AUDIENCE: This oral boards case is appropriate for emergency medicine residents and medical students on emergency medicine rotations. INTRODUCTION/BACKGROUND: Third-degree heart block (also known as complete heart block) is a cardiovascular emergency that requires prompt recognition. Complete heart block is a type of atrioventricular (AV) block whereby no atrial impulses reach the ventricular conduction system. The most common etiology of AV block is ischemic heart disease, with up to 1 in 5 patients developing some type of conduction disturbance after an MI.1 Complete heart block is seen in

State of the Art of Cardiac Amyloidosis.

Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic stenosis, arrythmia, and conductive disorder. Innovative, specific therapeutic approa

ANMCO position paper 'Hypertrophic cardiomyopathy: from diagnosis to treatment'.

Hypertrophic cardiomyopathy (HCM) is a non-rare genetic cardiomyopathy, with an estimated prevalence of 1:500, characterized by an increase in the left ventricular wall thickness in the absence of increased loading conditions. The hypertrophy is mostly asymmetric and predominantly affects the basal septum and anterior wall. Left ventricular outflow tract obstruction, at rest or after provocative tests, is detected in many patients and represents the primary cause of reduced functional capacity, as well as an independent predictor of sudden cardiac death and advanced heart failure. Until ∼1 yea

Совпадение в полном тексте источника
… Diltiazem or verapamil also reduces atrioventricular conduction and prolongs atrioventricular delay (negative dromotropic effect), through lengthening the refractory period in the atrioventricular node. …

Нетипичные неблагоприятные явления в реальном мире в исследовании долгосрочной иммуномодуляции в связи с множественным склерозом и расстройством спектра нейромилита.

КОЛИЧЕСТВО: Иммунотерапии являются неотъемлемой частью борьбы с множественным склерозом (МС) и связанными с ним демиелиническими заболеваниями, однако негативные реакции на наркотики существенно сказываются на терпимости методов лечения, позволяющих регулировать заболевания (ДМТ). ЦЕЛИ: Цель настоящего исследования заключается в оценке характеристик безопасности ДМТ в рамках реальной группы населения, затронутой МЗ и связанными с ними заболеваниями, и в выявлении нетипичных неблагоприятных явлений (АЭ) и явлений исключительной тяжести. МЕТОДЫ: Был проведен ретроспективный анализ 3850 больные с

Совпадение в полном тексте источника
… node; CD20, cluster of differentiation 20; CR, case report; dB, decibel; DMF, dimethyl fumarate; F, female; GA, glatiramer acetate; IFN-β1a/b, interferon beta 1a/b; IgE, immunoglobulin E; i.m., intramuscular; IU, international unit; M, male; MS, multiple sclerosis; NAT, natalizumab; n.d., not determined … aCD20, anti-CD20-antibodies; AVN, atrioventricular node; CD20, cluster of differentiation 20; CR, case report; dB, decibel; DMF, dimethyl fumarate; F, female; GA, glatiramer acetate; IFN-β1a/b, interferon beta 1a/b; IgE, immunoglobulin E; i.m., intramuscular; IU, international unit; M, male; MS, multiple …

From Clinical Clues to Final Diagnosis: The Return of Detective Work to Clinical Medicine in Cardiac Amyloidosis.

Cardiac amyloidosis is frequently misdiagnosed, denying patients the opportunity for timely and appropriate management of the disease. The purpose of this review and case studies is to raise awareness of the diagnostic "red flags" associated with cardiac amyloidosis and the currently available non-invasive strategies for diagnosis. The review focuses on the identification of one of the two main types of cardiac amyloidosis, transthyretin amyloid cardiomyopathy, and non-invasive tools to distinguish this from light-chain amyloidosis. A diagnostic algorithm centered around the use of non-invasiv

Diagnosis and treatment of cardiac amyloidosis: an interdisciplinary consensus statement.

The prevalence and significance of cardiac amyloidosis have been considerably underestimated in the past; however, the number of patients diagnosed with cardiac amyloidosis has increased significantly recently due to growing awareness of the disease, improved diagnostic capabilities and demographic trends. Specific therapies that improve patient prognosis have become available for certain types of cardiac amyloidosis. Thus, the earliest possible referral of patients with suspicion of cardiac amyloidosis to an experienced center is crucial to ensure rapid diagnosis, early initiation of treatmen

A case report of fludarabine associated ectopic atrial bradycardia and literature review of fludarabine induced bradycardia.

BACKGROUND: Fludarabine is a chemotherapeutic agent with lymphodepleting effects that is increasingly used as part of a conditioning regimen prior to allogeneic stem cell transplantation. Fludarabine is generally considered a relatively safe medication with only rare cases of cardiotoxic side effects. CASE PRESENTATION: Here, we present a case of a 30-year-old woman who was undergoing conditioning for a haploidentical cell transplantation for treatment of Fanconi anemia with a 5-day course of daily fludarabine infusion. After her second fludarabine infusion, she was noted to have ectopic atri

Arrhythmias and Device Therapies in Cardiac Amyloidosis.

Cardiac amyloidosis is caused by amyloid fibrils that deposit in the myocardial interstitium, causing restrictive cardiomyopathy and eventually death. The electromechanical, inflammatory, and autonomic changes due to amyloid deposition result in arrhythmias. Atrial fibrillation is by far the most common arrhythmia. The rate control strategy is generally poorly tolerated due to restrictive filling physiology and heart rate dependance, favoring adoption of the rhythm control strategy. Anticoagulation for stroke prophylaxis is warranted, irrespective of CHA2DS2-VASc score in patients with a favor

Storage diseases with hypertrophic cardiomyopathy phenotype.

Never judge a book by its cover, nor assume hypertrophic cardiomyopathy (HCM) as sarcomeric, as appearances can deceive. HCM phenocopies account for a 5-10% of the cases, mainly represented by storage diseases, flagged by the increasing prevalence of senile cardiac amyloid in developing countries. Multisystemic and heterogeneous presentation of these entities is a challenge for clinicians, and time delay in diagnosis is a major concern. Promising drugs and gene-specific tailored therapies are under development, therefore, more than ever, appropriate understanding of these conditions is mandato

Совпадение в полном тексте источника
… Interestingly, it is not due to an accessory pathway but to an accelerated conduction of the atrioventricular node (AVN). Some studies report 17% incidence of AF on ambulatory monitoring. …

Oral ixazomib, lenalidomide, and dexamethasone for transplant-ineligible patients with newly diagnosed multiple myeloma.

Continuous lenalidomide-dexamethasone (Rd)-based regimens are among the standards of care in transplant-ineligible newly diagnosed multiple myeloma (NDMM) patients. The oral proteasome inhibitor ixazomib is suitable for continuous dosing, with predictable, manageable toxicities. In the double-blind, placebo-controlled TOURMALINE-MM2 trial, transplant-ineligible NDMM patients were randomized to ixazomib 4 mg (n = 351) or placebo (n = 354) plus Rd. After 18 cycles, dexamethasone was discontinued and treatment was continued using reduced-dose ixazomib (3 mg) and lenalidomide (10 mg) until progres

Cardiotoxicity of Biological Therapies in Cancer Patients: An In-depth Review.

Cardiotoxicity from chemotherapy regimens has been long reported. However, the understanding of cardiac side effects of biological therapies is rapidly evolving. With cancer patients achieving higher life expectancy due to the use of personalized medicine and novel targeted anticancer agents, the occurrence of cardiotoxicity is becoming more significant. Novel biological therapies include anti-HER2 antibodies, tyrosine kinase inhibitors, bruton kinase inhibitors, antivascular endothelial growth factors, proteasome inhibitors, immunomodulator drugs, and immune checkpoint inhibitors. Potential c

Сравнительная эффективность и терпимость Sphingosine-1-Phosphate Рецептор-модуляторы в пациентах с множественным склерозом: сетевая мета-анализа случайных контролируемых испытаний.

ИСТОРИЯ ВОПРОСА: Sphingosine-1-phosphate Рецепторные модуляторы (S1PRM) используются для лечения повторного множественных склерозов (MS). Каждый наркотик имеет разный S1PR-subtype избирательный подход. Они нацелены на G-протеиновые рецепторы, сцепленные с S1P, и оказывают значительное иммунодуляционное воздействие, например предотвращая появление новых CNS-повреждений и возобновление ранее существовавших повреждений. ЦЕЛЬ: Настоящее исследование направлено на изучение эффективности и безопасности S1PRM при обработке MS. МЕТОДЫ: В августе был проведен систематический поиск литературы в базах да

Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review.

Cancer is the abnormal proliferation of physiologically inadequate cells. Studies have identified the cardiac pacemaker pocket as a site of rare neoplasms. To evaluate the clinical outcomes, treatment, prognosis, and individualized management of tumors originating in the cardiac pacemaker pocket, a systematic review was conducted using case reports and case series available in the PubMed/Medline, Science Direct, Cochrane Central, LILACS, and Scientific Electronic Library Online (Scielo) databases. Pacemaker pocket tumors affected patients with a mean age of 72.9 years, with a higher incidence

T-Type Calcium Channels: A Mixed Blessing.

The role of T-type calcium channels is well established in excitable cells, where they preside over action potential generation, automaticity, and firing. They also contribute to intracellular calcium signaling, cell cycle progression, and cell fate; and, in this sense, they emerge as key regulators also in non-excitable cells. In particular, their expression may be considered a prognostic factor in cancer. Almost all cancer cells express T-type calcium channels to the point that it has been considered a pharmacological target; but, as the drugs used to reduce their expression are not complete

Совпадение в полном тексте источника
… However, later reports showed that mibefradil can inhibit other ion channels, including the voltage-gated sodium, Ca 2+ - and volume-activated chloride channels, and potassium (inward rectifier, delayed rectifier, and hERG) channels in the sinus and atrioventricular nodes, slowing conduction velocity …

Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management.

Livedoid vasculopathy (LV) is a rare, chronic, and occlusive disease of the veins supplying the upper parts of the skin. The pathogenesis of the disease is not precisely understood, and its attacks are often unpredictable but tend to worsen during the summer. LV affects women more often. This increased risk for LV in women might be related to sex-specific physiological conditions, such as pregnancy, or a higher incidence of LV-associated conditions, such as connective tissue diseases, hypercoagulable states, and venous stasis in women. The typical clinical appearance of LV consists of three ma

C

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Called also thyrocalcitonin. c. gene-related peptides potent vasodilators widely distributed in periadventitial nerves of blood vessels, sinoatrial and atrioventricular nodes, sensory neurons, and the central nervous system generally. … Calcium channel blockers act to control arrhythmias by slowing the rate of sinoatrial node discharge and the conduction velocity through the atrioventricular node. Examples include nifedipine and verapamil. Also called calcium blocker, calcium antagonist. …