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Risk factors and outcome of acute kidney injury in critically ill patients with SARS-CoV-2 pneumonia: a multicenter study.

OBJECTIVE: To assess incidence, risk factors and impact of acute kidney injury(AKI) within 48 h of intensive care unit(ICU) admission on ICU mortality in patients with SARS-CoV-2 pneumonia. To assess ICU mortality and risk factors for continuous renal replacement therapy (CRRT) in AKI I and II patients. DESIGN: Retrospective observational study. SETTING: Sixty-seven ICU from Spain, Andorra, Ireland. PATIENTS: 5399 patients March 2020 to April 2022. MAIN VARIABLES OF INTEREST: Demographic variables, comorbidities, laboratory data (worst values) during the first two days of ICU admission to …

Welfare losses from breast cancer among women in high-income regions, 1990-2050.

INTRODUCTION: Female breast cancer remains a major source of health loss in high-income settings, but its welfare-based economic burden has … ereas the highest relative burdens (VLW/GDP) were observed in Uruguay, Germany, Cyprus, Greece, and Andorra. Age-specific welfare valuation peaked among women aged 85-89 years. Under a constant 2023 valuation framework, undiscounted and discounted VLW were projected to increase to US$1.51 trillion and US$1.02 trillion, respectively, by 2050. CONCLUSIONS: …

Medicinal Plants in Traditional Herbal Wines and Liquors in the East of Spain and the Balearic Islands.

Homemade herbal preparations from the East of Spain are the witness of traditional medicine inherited from the ancient complex formulas of herbal teas and medicinal wines. In this study, we document the use of traditional alcoholic beverages, identify their ingredients, almost exclusively botanical, record the local medicinal uses of these mixtures, and discuss patterns of distribution of this knowledge in regions of eastern Spain, the Balearic Islands and Andorra. We determine marker species and relevant patterns of herbal formulas in the different regions of the territory. Homemade liquors a…

Burden of liver cancer in the European region from 1990 to 2021: a sub-analysis of the global burden of disease study.

BACKGROUND: Liver cancer is one of the leading causes of cancer-related deaths worldwide. In Europe, viral hepatitis, alcohol consumption, a … ns bore the highest burden, with deaths and DALYs peaking in the 95+ age group in 2021. Nationally, Andorra reported the highest ASIR, ASMR, and ASDR in 2021, while Ukraine had the lowest rates. Hepatitis C and alcohol-related liver cancer were the leading contributors, with NASH showing the fastest growth. Regions with higher SDI demonstrated greater bur …

Global, regional, and national burden of fracture of pelvis, 1990-2021: analysis of data from the Global Burden of Disease Study 2021.

BACKGROUND: Fractures of the pelvis are significant orthopedic injuries associated with high morbidity, mortality, and substantial economic … lowest ASPR (77.37; 70.44-86.42) and YLD rate (13.34; 9.39-18.00). Nationally, ASIR was highest in Andorra (176.62; 111.81-281.70) and lowest in Kiribati (17.96; 13.88-23.10). Projections suggest rising burden through 2046. EAPCs were inversely associated with ASRs and HDI, except for a weak, non-significant positive correlation with ASIR (ρ = 0.08; P = …

Hepatitis B: vaccination programmes in Europe--an update.

In the eight years since the Global Advisory Group of the Expanded Program on Immunisation set 1997 as the target for integrating hepatitis … WHO European Region (51 countries) have implemented a universal hepatitis B immunisation programme: Andorra, Albania, Austria, Belarus, Belgium, Bulgaria, Estonia, France, Germany, Greece, Italy, Israel, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Luxembourg, Malta, Moldova, Monaco, Poland, Portugal, parts of the Russian Federation, Romania, Slovakia, Slov …

The Global Macroeconomic Burden of Spinal Cord Injury: A Dynamic Modeling Study from 2020 to 2050.

BACKGROUND: Spinal cord injury (SCI) is a debilitating condition that imposes profound and persistent socioeconomic burdens. Despite its rel … er capita burden ranged from below INT$ 1,000 to over INT$ 350,000, highest in Ireland, Guyana, and Andorra, while China and the USA remained in the middle-to-upper range. The highest relative burdens as a share of gross domestic product occurred in Iraq (0.25%), Burundi (0.19%), and Sri Lanka (0.17%), highlighting the vulnerability of lower income econom …

Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

BACKGROUND: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer … aiwan (province of China; 62·0 [48·9-80·0] per 100 000), Monaco (60·7 [48·5-73·6] per 100 000), and Andorra (56·6 [42·8-71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0-37·1] per 100 000), Brunei (30·3 [26·6-34·1] per 100 000), and Hungary (28·6 [23·6-34·0] per 100 000) had the highest age-standardised morta …

National burden of cancer in Italy, 1990-2017: a systematic analysis for the global burden of disease study 2017.

We monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the Global Burden of Disease study 2017. An overview of mortality trends between 1990 and 2017 was also provided. In 2017, there were 254,336 new cancer cases in men and 214,994 in women, corresponding to an age-standardized incidence rate (ASIR) of 438 and 330/100,000, respectively. Between 1990 and 2017, incid

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… International Classification of Diseases 10 [ICD-10] codes C00-C96, excluding Kaposi sarcoma, ICD-10 C46), benign/in situ neoplasms (ICD-10 D00-D49), and other malignant neoplasms (ICD-10 codes C17, C30-C31, C37, C38, C40-C41, C47-C49, C4A, C51-C52, C57-C58, C60, C63, C66, C68, C69, C74-C75). b Includes Andorra … For a comparative purpose, incidence, morality, and DALYs are also presented for all Western European countries combined, as defined by GBD (i.e., Andorra, Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, Malta, Netherlands, Norway, Portugal …

Global welfare burden of hematologic malignancies from 2015 to 2023.

Hematologic malignancies cause premature mortality and disability across the life course, but their welfare burden is difficult to compare across countries. We monetized global burden of disease (GBD) 2023 disability-adjusted life years (DALYs) for major hematologic malignancies in 188 countries from 2015 to 2023 using a value of lost welfare framework incorporating purchasing power parity adjusted gross domestic product (GDP), income transfer, age-specific valuation, and discounting. Global leukemia-related value of lost welfare (VLW) increased from US$1.40 trillion to US$1.70 trillion, while

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… For multiple myeloma, the largest increases were seen in Bolivia (+3.84 percentage points), Tunisia (+0.92 percentage points), and Andorra (+0.62 percentage points), while the largest decreases occurred in Ukraine (−1.18 percentage points), Lithuania (−0.95 percentage points), and Czechia (−0.81 percentage … For non-Hodgkin lymphoma, Bolivia showed the largest increase (+6.68 percentage points), followed by Botswana (+0.66 percentage points), Turkiye (+0.64 percentage points), and Suriname (+0.61 percentage points), whereas Ukraine (−3.00 percentage points), Bulgaria (−2.38 percentage points), and Andorra …

Applications of bio-enhanced cementitious composites for sustainable building materials: emission-reduction and carbon-sequestration pathways.

Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activatin … rative agreement under which Esteve will be the sole distributor of Ampligen in Spain, Portugal and Andorra for the treatment of chronic fatigue syndrome. Under this agreement, in addition to other terms, Esteve will also collaborate in the drug product development by conducting clinical studies in Spain in patients coinfected with HIV/HCV. In July 2001 H …

Cancer burden in Europe: a systematic analysis of the GLOBOCAN database (2022).

BackgroundCancer remains a significant public health challenge in Europe, with substantial regional disparities in incidence, mortality, and access to healthcare. This study analyses cancer patterns across Eastern, Northern, Southern, and Western Europe in 2022, highlighting key public health implications and gaps in prevention and treatment.MethodsUsing data from GLOBOCAN 2022, this study assessed total new cancer cases, age-standardized incidence and mortality rates (ASRs) per 100,000, and cumulative cancer risk at age 75. The top three cancers by sex and region were also analysed to identif

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… Population(s) included: Albania, Bosnia Herzegovina, Croatia, Cyprus, Greece, Italy, North Macedonia, Malta, Montenegro, Portugal, Serbia, Slovenia, Spain, Andorra, Gibraltar, Holy See*, San Marino Fig. 8 Top 5 most frequent cancers in Southern Europe 2022, all sexes, all ages. … Population(s) included: Albania, Bosnia Herzegovina, Croatia, Cyprus, Greece, Italy, North Macedonia, Malta, Montenegro, Portugal, Serbia, Slovenia, Spain, Andorra, Gibraltar, Holy See*, San Marino Western Europe reported 1,415,827 new cases (761,463 in males, 654,364 in females). …

Survival outcomes and healthcare utilization between immigrant patients and Danish-born patients with hematological cancers: a Danish population-based study.

Overall survival (OS) for patients with a hematological cancer may differ between immigrant and Danish-born patients due to disparities in socioeconomic status, health literacy, and language proficiency. This cohort study aimed to investigate survival and hospitalization according to immigrant status while controlling for confounders. Patients with newly diagnosed hematological cancer in 2000-2020 were identified in the Danish nationwide hematological registers and stratified into Danish-born, Western, and non-Western patients. Patients were followed from diagnosis until death, 31st December 2

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… Appendix 2 Western countries include all 28 EU countries plus Andorra, Iceland, Liechtenstein, Monaco, Norway, San Marino, Switzerland, The Vatican, Canada, USA, Australia, and New Zealand. Non-Western countries include all other countries [ 53 ] . …

Прогнозирование релапирования и индивидуализированная модель лечения-воздействия при повторном склерозе: систематический обзор.

ВВЕДЕНИЕ: Индивидуальное прогнозирование результатов, связанных с рецидивом, может способствовать отбору и мониторингу лечения при повторном склерозе. Однако существующие исследования существенно отличаются друг от друга по клиническим целям, целевым результатам, подходам к моделированию и стратегиям проверки. МЕТОДЫ: Мы провели систематический обзор в соответствии с ПРИСМА 2020. Пубмед, Web of Science, IEEE Xplore и Scopus были найдены записи на английском языке, опубликованные на английском языке. 1 Январь 2010 в адрес 14 Январь 2026. Были включены исследования по разработке или оценке модел

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… Andorra M Freire A Zubizarreta I De Rosbo NK Bos SD Rinas M . Predicting disease severity in multiple sclerosis using multimodal data and machine learning . J Neurol. ( 2024 ) 271 : 1133 – 49 . doi: 10.1007/s00415-023-12132-z 38133801 PMC10896787 49. Yousef H Malagurski Tortei B Castiglione F . …

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 20

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… Regional and country-specific HALE HALE at birth was highest for men in Singapore (72·3 years [95% UI 70·1–74·2]) and for women in Andorra (76·3 years [72·8–79·4]) in 2015. It was lowest in Lesotho for both men (39·1 years [34·3–44·7]) and women (43·8 years [37·9–49·8]; table 2 ; appendix p 12 ). … HALE at age 65 years was highest in Andorra for both men (15·2 years [UI 13·9–16·3]) and women (19·4 years [17·8–20·8]) in 2015, whereas the lowest HALE for men was in Lesotho (6·9 years [5·2–9·4]) and for women in Afghanistan (6·9 years [5·8–8·2]). …

Cancer burden and risk in the Chinese population aged 55 years and above: A systematic analysis and comparison with the USA and Western Europe.

BackgroundWe analysed the cancer burden among elderly Chinese people over the age of 55 years and compared them to USA and Western Europe to explore the cancer model in China.MethodsWe retrieved data on 29 cancers with 34 risk factors from the 2019 Global Burden of Disease database to evaluate the cancer burden in Chinese elderly individuals aged 55 years and older. We then used the age-standardised incidence rate (ASIR), age-standardised death rate (ASDR), age-standardised disability-adjusted life year (DALY) rate, and average annual percentage change (AAPC) to compare the characteristics and

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… In the GBD 2019 study, Western Europe comprised Switzerland, Finland, San Marino, UK, Germany, France, Ireland, Greece, Luxembourg, Iceland, Monaco, Andorra, Belgium, Israel, Austria, Italy, Denmark, Malta, Cyprus, Netherlands, Spain, Portugal, Norway, and Sweden. …

Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications.

Background: Since the 1990s, transplantations of hematopoietic and mesenchymal stem cells (HSCT and MSCT) and dendritic cell (DCT) have been investigated for the treatment of neurological autoimmune disorders (NADs). With the growing number of transplanted patients, awareness of neuroimmunolgical complications has increased. Therefore, an overview of SCT for the most common NADs and reports of secondary immunity after SCT is provided. Methods: For this narrative review, a literature search of the PubMed database was performed. A total of 86 articles reporting on different SCTs in NADs and 61 a

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… Zubizarreta I., Flórez-Grau G., Vila G., Cabezón R., España C., Andorra M., Saiz A., Llufriu S., Sepulveda M., Sola-Valls N., et al. Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial. Proc. Natl. Acad. Sci. …

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with e

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

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… | 80·4 (79·0–81·9) | 69·4 (69·2–69·5) | 73·5 (72·1–75·0) | 66·6 (63·7–69·2) | 69·5 (66·4–72·4) | 61·5 (59·2–63·5) | 64·8 (62·2–67·4) Western Europe | 79·5 (79·5–79·5) | 84·2 (83·9–84·5) | 73·0 (73·0–73·0) | 79·5 (79·2–79·8) | 68·2 (65·0–71·0) | 71·8 (68·3–74·8) | 64·3 (61·8–66·5) | 69·4 (66·5–71·9) Andorra … | 19·8 (18·9–20·8) | 13·9 (13·8–14·0) | 15·8 (14·9–16·7) | 13·5 (12·3–14·6) | 15·0 (13·5–16·4) | 10·5 (9·6–11·4) | 11·9 (10·7–13·1) Western Europe | 18·5 (18·5–18·5) | 21·9 (21·6–22·1) | 14·7 (14·7–14·7) | 18·7 (18·5–18·9) | 13·9 (12·7–15·0) | 16·4 (14·9–17·7) | 11·2 (10·3–12·1) | 14·1 (12·9–15·2) Andorra …

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… A prospective case-series study Christian Morgenstern 1 , Rudolf Morgenstern 2 1 Centro Medico Teknon, Morgenstern Institute of Spine, Barcelona, Spain 2 Endospine SLU, El Tarter, Canillo, Andorra Introduction: Endoscopic/percutaneous transforaminal lumbar interbody fusion (TLIF) is a relatively …