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Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.

The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical

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… Moreover, the role of iPSCs in the study is particularly highlighted in Fig. 3 , which shows the differentiation of pluripotent iPSCs into embryoid bodies (EB), representing the potential of these cells to give rise to various tissue types. … The telomerase activity is represented by the value in amole, which indicates the number of extended primers containing telomeric repeats. 5 The process of differentiating piPSC (pluripotent induced pluripotent stem cells) into embryoid bodies (EB). …

From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies.

Background and objectiveTumor therapy is still a tough clinical challenge, and cancer immunotherapy has drawn increasing attention. T cells and natural killer (NK) cells play crucial roles in the immune response. Induced pluripotent stem cell (iPSC) technology opens up a new way to produce functionally improved universal iPSC-derived chimeric antigen receptor (CAR) T (CAR-iT) and iPSC-derived CAR-NK (CAR-iNK) cells. This study aims to comprehensively review the generation and clinical applications of iPSC-derived universal CAR-iT and CAR-iNK cells to explore their potential and future directio

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… In addition, the “spin Embryoid Bodies” (spin EB) method ( 42 ) can optimize the production of iNK cells, generate more HPCs, and differentiate into phenotypically mature NK cells ( 15 ). …

Определение деятельности одноклеточных и пространственных микроРНК на основе транскриптомных данных.

Деятельность МИРНА варьируется в зависимости от различных популяций и систем клеток в рамках механизмов, которые проводят различие между типами клеток и ролью в живых организмах, а также в здоровье человека и болезнях. Как правило, регулирование miRNA стимулирует изменения в составе и уровнях белковой кодировки RNA и INCRNA, при этом целевые показатели регулируются понижательно, когда miRNA являются активными. Термин " деятельность МИРНК " используется для обозначения такого транскрипционного эффекта МИРНК. В этом исследовании предлагается метод miTEA-HiRes, призванный облегчить оцен

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… The datasets consist of RNAome data from human primary fibroblasts, from HEK293T and MCF7 cells (which were treated as a single multi-cell type dataset consisting of 633 cells), as well as from induced murine embryonic stem cells differentiated into embryoid bodies (2167 cells) 45 . …

Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies.

Treatment of myelofibrosis (MF), a BCR-ABL-negative myeloproliferative neoplasm, is challenging. The only current potentially curative option, allogeneic hematopoietic stem cell transplant, is recommended for few patients. The remaining patients are treated with palliative therapies to manage MF-related anemia and splenomegaly. Identification of a mutation in the Janus kinase 2 (JAK2) gene (JAK2 V617F) in more than half of all patients with MF has prompted the discovery and clinical development of inhibitors that target JAK2. Although treatment with JAK2 inhibitors has been shown to improve sy

Пространственное картирование оси AA-PGE2-EP при множественных повреждениях склероза.

Биоактивные липидные посредники (ДМ), получаемые из полиненасыщенных жирных кислот (ПУФА), являются ключевыми молекулами как инициирования, так и разрешения подстрекательских реакций. Предыдущие выводы свидетельствуют о том, что дисрегулируемый баланс LM, особенно в рамках арахидонической кислоты (АА), может способствовать реакции на нарушение разрешения и последующей хронической нейроинфламмации при множественном склерозе (МС). Однако на сегодняшний день местный биосинтез и сигнализация ММ в мозге людей с MS (PwMS) остаются неисследованными. Поэтому в этом исследовании мы впервые наметили рас

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… In short, iPSCs (cell line 114-1, female, 49 years) were used to develop mesodermal embryoid bodies, which were plated and supplemented with medium containing macrophage colony-stimulating factor (rhM-CSF, 100 µg/ml; 300-25, Peprotech) and Interleukin 3 (25 µg/ml; #200-03-B, Peprotech). …

Human-Induced Pluripotent Stem Cell Models for Amyloid Cardiomyopathy: From Mechanistic Insights to Therapeutic Discovery.

Amyloid cardiomyopathy (ACM), driven by transthyretin (TTR) and immunoglobulin light chain (LC) amyloid fibrils, remains a major clinical challenge due to limited mechanistic understanding and insufficient preclinical models. Human-induced pluripotent stem cells (iPSCs) have emerged as a transformative platform to model ACM, offering patient-specific and genetically controlled systems. In this review, we summarize recent advances in the use of iPSC-derived cardiomyocytes (iPSC-CMs) in both two-dimensional (2D) monolayer cultures and three-dimensional (3D) constructs-including spheroids, organo

S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction.

The aberrant activity of Wnt signaling is an early step in the transformation of normal intestinal cells to malignant tissue, leading to more aggressive tumors, and eventually metastases. In colorectal cancer (CRC), metastasis accounts for about 90% of patient deaths, representing the most lethal event during the course of the disease and is directly linked to patient survival, critically limiting successful therapy. This review focuses on our studies of the metastasis-inducing gene S100A4, which we identified as transcriptional target of β-catenin. S100A4 increased migration and invasion in v

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… Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies Biochem. Biophys. Res. Commun. 2006 343 555 563 10.1016/j.bbrc.2006.02.161 16554030 38. Boye K. Maelandsmo G.M. S100A4 and metastasis: a small actor playing many roles Am. J. …

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application.

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase signaling pathway that has a fundamental role in many biologic processes including embryonic development, tissue regeneration, and angiogenesis. Increasing evidence indicates that this pathway plays a critical role in oncogenesis via gene amplification, activating mutations, or translocation in tumors of various histologies. With multiplex sequencing technology, the detection of FGFR aberrations has become more common and is tied to cancer cell proliferation, resistance to anticancer therapies, and n

Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy.

Gamma delta (γδ) T cells are a minor population of T cells that share adaptive and innate immune properties. In contrast to MHC-restricted alpha beta (αβ) T cells, γδ T cells are activated in an MHC-independent manner, making them ideal candidates for developing allogeneic, off-the-shelf cell-based immunotherapies. As the field of cancer immunotherapy progresses rapidly, different subsets of γδ T cells have been explored. In addition, γδ T cells can be engineered using different gene editing technologies that augment their tumor recognition abilities and antitumor functions. In this review, we

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… They successfully reprogrammed the cells into iPSC lines that were pluripotent and capable of differentiating into embryoid bodies (EB) and hematopoietic progenitor cells. However, they did not continue to differentiate the cells into fully mature γδT cells. …

Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications.

The peripheral nervous system undergoes sufficient stress when affected by diabetic conditions, chemotherapeutic drugs, and personal injury. Consequently, peripheral neuropathy arises as the most common complication, leading to debilitating symptoms that significantly alter the quality and way of life. The resulting chronic pain requires a treatment approach that does not simply mask the accompanying symptoms but provides the necessary external environment and neurotrophic factors that will effectively facilitate nerve regeneration. Under normal conditions, the peripheral nervous system self-r

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects.

With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift in the concept of neoangiogenesis occurred. The identification of circulating EPCs in peripheral blood marked the beginning of a new era with enormous potential in the rapidly transforming regenerative field. Overwhelmed with the revelation, researchers across the globe focused on isolating, defining, and interpreting the role of EPCs in various physiological and pathological conditions. Consequently, controversies emerged regarding the isolation techniques and classification of EPCs. Nevertheless, th

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… Additionally, embryoid bodies (EBs), which are differentiated ESCs, have also indicated that multiple haematopoietic lineages can originate from ESCs in culture [ 20 ]. …

Revolutionizing the treatment for nasopharyngeal cancer: the impact, challenges and strategies of stem cell and genetically engineered cell therapies.

Nasopharyngeal carcinoma (NPC) is a distinct malignancy of the nasopharynx and is consistently associated with the Epstein-Barr virus (EBV) infection. Its unique anatomical location and complex aetiology often result in advanced-stage disease at first diagnosis. While radiotherapy (RT) and chemotherapy have been the mainstays of treatment, they often fail to prevent tumour recurrence and metastasis, leading to high rates of treatment failure and mortality. Recent advancement in cell-based therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown great promise in hematologic

Tumor-derived systems as novel biomedical tools-turning the enemy into an ally.

Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body," fails to convey the intricate interaction between the many entities involved in cancer. Recent advancements in the field of cancer research have shed light on the role played by individual cancer cells and the tumor microenvironment as a whole in tumor development and progression. This breakthrough enables the utilization of the tumor and its components as biological

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

Премии победителей и резюме 32nd Ежегодный симпозиум Общества протеинов; Бостон, ОЭТ, июль 9-12, 2018.

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АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

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:: 45th Ежегодное совещание Европейского общества по трансплантации крови и костного мозга: Врачи - сессия плаката.

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Резюме докладов 53rd Конференция Европейского общества генетики человека: интерактивные электронные постеры.

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Abstract

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