Результаты поиска

Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects.

Determination of sarcopenia is crucial in identifying patients at high risk of adverse health outcomes. Recent studies reported a significan … predicting sarcopenia. The masseter and lateral pterygoid CSA can be used to predict sarcopenia in healthy aging subjects with a high accuracy.

"Think positive and don't die alone" - Foreign-born, South Asian older adults' perceptions on healthy aging.

South Asians are the largest and fastest-growing racialized group in Canada, yet there are limited data on various aspects of health and well-being within this population. This includes the South Asian older adults' ethnoculturally informed perceptions of ageing. The study aimed to understand how social and cultural forces impact the meaning assigned to healthy ageing amongst older South Asians in Canada. We recruited with purposeful and snowball sampling strategies in Southern Ontario. We conducted in-depth focus group and individual interviews (n = 19) in five South Asian languages, employin

Prevalence of healthy aging among community dwelling adults age 70 and older from five European countries.

BACKGROUND: To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for the DO-HEALTH clinical trial. Participants were selected for absence of prior major health events. METHODS: Cross-sectional analysis of DO-HEALTH baseline data. All 2,157 participants (mean age 74.9, SD 4.4; 61.7% women) were included and 2,123 had data for all domains of the healthy aging status (HA) definition. HA was assessed based on the Nurses` Health Study (NHS) definition requiring four domains: no major chronic diseases, no disabilities, no cognitive impairment …

Aging and entheses: An ultrasonographic probing of degenerative enthesopathy in a cohort of 147 healthy subjects.

AIM: To investigate the prevalence and features of degenerative enthesopathic changes in a large cohort of healthy individuals by musculoskeletal ultrasound (MSUS) and their relation to age and other demographic features. METHODS: In this cross-sectional study, 147 healthy subjects (1470 entheses) were examined by MSUS according to the Outcome Measures in Rheumatology guidelines: Achilles tendon, plantar fascia, patellar, and quadriceps insertions of both lower limbs. RESULTS: The mean age (±SD) of the participants was 43.68 (±14.53) years and 57.1% were female. Enthesopathy has been detecte

Simultaneous Assessment of Electroencephalography Microstates and Resting State Intrinsic Networks in Alzheimer's Disease and Healthy Aging.

Electroencephalography (EEG) microstate topologies may serve as building blocks of functional brain activity in humans. Here, we studied the spatial and temporal correspondences between simultaneously acquired EEG microstate topologies and resting state functional MRI (rs-fMRI) intrinsic networks in 14 patients with Alzheimer's disease (AD) and 14 healthy age and sex matched controls. We found an anteriorisation of EEG microstates' topologies in AD patients compared with controls; this corresponded with reduced spatial expression of default mode and increased expression of frontal lobe network

Towards Healthy Aging: Influence of the Built Environment on Elderly Pedestrian Safety at the Micro-Level.

As vulnerable road users, elderly pedestrians are more likely to be injured in road crashes due to declining physical and perceptual capabilities. Most previous studies on the influence of the built environment on elderly pedestrian safety focused on intersections or areal units. Using a district of Shanghai as the study area, this research investigated the effects of the built environment at the road segment level with elderly pedestrian collision, taxi tracking point, point of interest, street view image, open street map, land use, housing price, and elderly population datasets. In particula

Improving Healthy Aging by Monitoring Patients' Lifestyle through a Wearable Device: Results of a Feasibility Study.

Population aging is related to a huge growth in healthcare and welfare costs. Therefore, wearable devices could be strategic for minimizing years of disability in old age and monitoring patients' lifestyles and health. The purpose of this study was to assess the feasibility of using smart devices to monitor patients' physical activity in a primary care setting. To assess the acceptance of this novel technology from the point of view of both patients and healthcare professionals, two questionnaires (one paper-based and one ex-novo developed) were administered to 11 patients with type 2 diabetes

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.

To date, microglia subsets in the healthy CNS have not been identified. Utilizing autofluorescence (AF) as a discriminating parameter, we identified two novel microglia subsets in both mice and non-human primates, termed autofluorescence-positive (AF+) and negative (AF-). While their proportion remained constant throughout most adult life, the AF signal linearly and specifically increased in AF+ microglia with age and correlated with a commensurate increase in size and complexity of lysosomal storage bodies, as detected by transmission electron microscopy and LAMP1 levels. Post-depletion repop

Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis.

Diffusion MRI (dMRI) is a growing imaging technique with the potential to provide biomarkers of tissue variation, such as cellular density, tissue anisotropy, and microvascular perfusion. However, the role of dMRI in characterizing different aspects of bone quality, especially in aging and osteoporosis, has not yet been fully established, particularly in clinical applications. The reason lies in the complications accompanied with implementation of dMRI in assessment of human bone structure, in terms of acquisition and quantification. Bone is a composite tissue comprising different elements, ea

Совпадение в полном тексте источника
… , participants will be better able to: Describe the key factors contributing to variations in diffusion process in bone during healthy aging and osteoporosis Describe the potential role of diffusion MRI for assessment of bone quality in healthy aging and osteoporosis Activity Disclosures No commercial … Osteoclast cells resorb the bone and osteoblast cells form new bone. 12 Three main mechanisms contribute to pathophysiology of healthy aging and osteoporosis: 1) during healthy aging, the number and function of osteoblasts reduce significantly, leading to decreased bone formation; 2) with age, and particularly …

Aging of the cervical spine in healthy volunteers: a 10-year longitudinal magnetic resonance imaging study.

STUDY DESIGN: Prospective longitudinal study, mean follow-up period; 11.7 +/- 0.8 years was conducted from 1995 to 2007. OBJECTIVE: To clarify normal aging process of cervical spine and correlation between progression of disc degeneration and development of clinical symptoms. SUMMARY OF BACKGROUND DATA: Aging of the cervical spine can inevitably occur in anyone. Long-term longitudinal studies following the same individuals are necessary to elucidate the accurate aging processes of the cervical spine. METHODS: Two hundred twenty-three subjects of 497 original cohorts (123 men, 100 women, mea

The UN Decade of healthy ageing in practice: A qualitative case study on perspectives of healthy ageing among older adults, healthcare professionals, and decision-makers in Norway.

BACKGROUND: Global populations are ageing, making healthy ageing an increasingly important priority. In Norway, the number of people aged 70 and above is expected to double by 2050. The UN Decade of Healthy Ageing (2021-2030) guides Norway's national programs on healthy ageing through its four action areas: combating ageism, age-friendly environments, integrated care and long-term care. The aim of this study is to explore how healthy ageing is understood and interpreted in Norway in light of the four action areas of UN's Decade of Healthy Ageing and the enabler listening to diverse voices and

CD8+ effector memory and regulatory T cell dynamics predict subclinical atherosclerotic plaque formation in healthy aging.

BACKGROUND: Subclinical atherosclerotic plaque (SAP) develops silently in older adults. Biological changes that predict plaque formation are not well defined. We examined whether circulating immunological, metabolic, and functional measures identify vascular vulnerability before clinical disease. METHODS: In a three-year longitudinal study, 49 healthy older adults (63.8 ± 3.8 years) underwent carotid ultrasound, T cell phenotyping, serum protein profiling, body composition assessment, and fitness testing at baseline and follow-up. At follow-up, participants were classified as no SAP, new SAP

Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure in Drosophila melanogaster.

INTRODUCTION: Luteolin is a dietary flavonoid widely distributed in fruits, vegetables, and medicinal plants and is recognized for its antio … importance of developmental stage and biological sex when evaluating nutritional interventions for healthy aging.

Integrated arts engagement as preventive infrastructure for active and healthy aging: a conceptual and policy framework.

Population aging is changing the work of public health. Longer lives require not only medical treatment, but also support for functional ability, social connection, meaning, participation, and everyday wellbeing. Arts engagement is increasingly discussed in relation to health, yet arts activities often remain treated as cultural or recreational provision rather than as part of preventive public health systems. This conceptual article develops the idea of integrated community arts engagement as a framework for understanding how arts participation can contribute to healthy aging. The framework d…

Healthy diet and slower biological aging as protective factors against microvascular complications in type 2 diabetes.

This study aimed to evaluate the independent and joint effects of adherence to healthy dietary patterns and slower biological aging on the incidence of diabetic microvascular complications in individuals with type 2 diabetes mellitus (T2DM), and to assess the mediating role of biological aging. In a prospective cohort of 13,294 T2DM participants without baseline DMCs, dietary quality was assessed using a validated 10-point score, while biological aging was calculated from nine biomarkers and chronological age. Cox regression models were used to assess associations, and mediation analysis was p

Healthy Aging in Subsidized Housing in the United States: Exploring Older Adults' Views of Service Coordination.

BACKGROUND AND OBJECTIVES: Low-income older adults face many barriers to healthy aging, including housing cost burden. Publicly subsidized rental units for older adults are one affordable housing option; these typically have a service coordinator who helps tenants access community resources. Previous research has indicated that service coordinators can support resident health. However, little is known about older adults' perspectives on service coordination. Our study aimed to explore how older adults living in subsidized housing perceive the relationship between service coordinators and healt…

Sex differences in healthy brain aging are unlikely to explain higher Alzheimer's disease prevalence in women.

As Alzheimer's disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However, despite aging being the primary risk factor for AD, it remains unclear whether men and women differ in the extent of brain decline with age. Using 12,638 longitudinal brain MRIs from 4,726 participants aged 17 to 95 y across 14 cohorts, we examined sex differences in structural brain changes over time, controlling for differences in head size. Men showed greater cortical thickness (CT) decline in the cuneus, lingual, parahippocampal, and pericalcar

Implementing ICOPE in New Mexico: A process-oriented approach to promoting healthy aging in older adults.

The New Mexico Health Care Authority, the University of New Mexico Hospital, and the School of Medicine partnered in 2024 to implement the World Health Organization's Independent Care for Older People (ICOPE) program. The program's mission is to "empower New Mexico's seniors through prevention and person-centered care, enhancing health, independence, and quality of life by improving services, resources, and community support for healthy aging." Using the 2025 second edition of the ICOPE manual, the New Mexico ICOPE team has developed a strategic plan, an organizational structure reliant on com…

Association between sarcopenia and healthy aging patterns among Chinese older adults: A latent class analysis approach.

BACKGROUND: From the perspective of active aging, understanding the relationship between sarcopenia and multidimensional health status among older adults is crucial for developing targeted interventions and health policies. METHODS: Data were derived from the China Health and Retirement Longitudinal Study (CHARLS) 2018 survey. In total, 3392 older adults (aged ≥60 years) were included in the analysis. Healthy aging was assessed using 38 items across seven domains: cognition, psychological symptoms, vitality, sensory function, mobility, activities of daily living (ADLs), and instrumental activ…

The Interplay between Gut Microbiota and Cognitive Functioning in the Healthy Aging Population: A Systematic Review.

BACKGROUND: The gut microbiota in healthy older individuals typically show a decrease in beneficial bacteria like Bifidobacterium and Lactobacillus, alongside an increase in pro-inflammatory microbes such as Enterobacteriaceae and Clostridia. These changes contrast with younger and middle-aged individuals and appear to correlate with cognitive status. Although there is extensive research on gut microbiota and cognitive functions in cognitively impaired elderly individuals, its impact on cognitively healthy elderly populations has not been extensively studied. METHOD: A comprehensive literatur