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Tolerability of obinutuzumab therapy in patients with rituximab-relapsed/refractory B-cell malignancies - a retrospective single center cohort study.

Background & aimIn randomised clinical trials, the type II anti-CD20 antibody obinutuzumab has been shown to be more effective than rituximab for therapy of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL). However, this enhanced efficacy was linked with elevated rates of high-grade adverse events. The aim of this study was to assess the tolerability and toxicity profile of obinutuzumab treatment in routine patients with CLL and FL, of whom the majority had experienced toxicity or resistance to rituximab.MethodsThis retrospective cohort study investigated fifteen obinutuzumab-tr

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… Rates and outcomes of follicular lymphoma transformation in the immunochemotherapy era: a report from the University of Iowa/MayoClinic Specialized Program of Research Excellence Molecular Epidemiology Resource. J Clin Oncol. 2013;31:3272–8. doi: 10.1200/jco.2012.48.3990. 22. …

Пищевая зависимость от поведенческих пристрастий: сетевой подход.

СПРАВОЧНАЯ ИНФОРМАЦИЯ/AIMS: Сопоставимость психических расстройств является хорошо задокументированным явлением. Вместе с тем не было проведено никакого расследования по вопросу о соучастии и механизмах, лежащих в основе пищевой зависимости и поведенческих пристрастий. Таким образом, цели этого исследования заключались в следующем: a) проведение сетевого анализа для изучения взаимосвязей между клиническим профилем пациентов, нуждающихся в лечении от игорного расстройства, навязчивым расстройством, связанным с покупкой и покупкой (CBSD), навязанным расстройством сексуального поведения, и сопутс

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… In this context, a study using the Iowa Gambling Task (IGT), one of the most widely recognized computerized neurocognitive assessments for decision-making, found that patients with BAs, such as gambling disorder, are more likely to exhibit hypersensitivity to reward rather than to punishment and that …

Расовые различия в выживании нескольких миелом: ассоциации с трансплантацией стволовых клеток, страхованием и расширением сети медицинских учреждений.

На уровне населения чернокожие пациенты с множественной миеломой (ММ) могут выжить хуже, чем белые. Авторы изучили вопрос о том, как автологическая трансплантация стволовых клеток (ASCT), страхование и расширение сети " Медикэйд " связаны с расовыми различиями в общем уровне выживания (rwOS) в реальном мире. МЕТОДЫ: Данные, полученные 4932 больные MM (MM)24% Блэк) в Флатиронской базе данных исследований в области здравоохранения анализировался с использованием моделей " Кокс регрессиал " (rwOS), " Файн энд срей " (ASCT) и " политомная регрессия " (страхо

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… Abbreviations: aOR, adjusted odds ratio; NA, not applicable. a States (including the District of Columbia) in the study that expanded Medicaid in the 2011–2021 study period: Arkansas, Arizona, California, Colorado, Connecticut, Delaware, Hawaii, Iowa, Idaho, Illinois, Indiana, Kentucky, Louisiana, Massachusetts …

Радиотерапия и повышенный риск возникновения второго первичного рака у выживших жертв рака молочной железы: эпидемиологическое и когортное исследование.

Радиотерапия (RT) рака молочной железы (BC) может повысить риск возникновения второго первичного рака (SPC) - отношения, которые недостаточно изучены. Методы: Мы проанализировали 248268 женщины - пациентки Британской Колумбии 9 Реестры СЭЭУ, 1988-2018, идентифицирующие СПК >5 через несколько лет после первоначальной обработки, сопоставления рисков СТС между когортами RT и не-RT с использованием регрессии Fin-Gray и Poisson. РЕЗУЛЬТАТЫ: Из всех участников 55.4 % получил операцию и RT. В группе РТ отмечается более высокий уровень распространенности СТС, причем избыток распространенности значител

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… Considering the typical latency period of a minimum of 5 years for radiation-induced SPCs to become clinically evident [ 9 ], these BC patients were reported between 1988 and 2013 and underwent follow-up from 1988 to 2018 at 9 registries (Atlanta, Connecticut, Detroit, Hawaii, Iowa, New Mexico, San Francisco–Oakland …

Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative.

PurposeTo provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort of COVID-19 cases and controls.MethodsWe used the National COVID Cohort Collaborative (N3C) to identify breakthrough infections between December 1, 2020, and May 31, 2021. We included patients partially or fully vaccinated with mRNA COVID-19 vaccines with no prior SARS-CoV-2 infection record. Risks for breakthrough infection and severe outcomes were analyzed using logistic regression.ResultsA total of 6,860 breakthrough cases were

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… Carolina at Chapel Hill—UL1TR002489: North Carolina Translational and Clinical Science Institute • University of Minnesota—UL1TR002494: Clinical and Translational Science Institute • Children's Hospital Colorado—UL1TR002535: Colorado Clinical and Translational Sciences Institute • The University of Iowa—UL1TR002537 …

VTD-melphalan is well tolerated and results in very high rates of stringent CR and MRD-negative status in multiple myeloma.

The addition of cytotoxic drugs to high-dose melphalan as a preparative regimen for autologous stem cell transplantation in multiple myeloma has not resulted in superior activity. Although novel agents have significantly improved outcome in multiple myeloma, their role in preparative regimens remains largely unknown. We have evaluated the toxicity and efficacy of combining bortezomib, thalidomide, and dexamethasone with high-dose melphalan. An institutional review board-approved retrospective analysis was performed on 100 consecutive patients receiving 153 transplants; 53 had tandem transplant

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… Patients, methods, and materials Patients The University of Iowa School of Medicine institutional review board-approved retrospective analysis was performed on all MM patients receiving either single or tandem transplants in an upfront or salvage setting at our institution between February 2012 and …

Estimating cancer incidence in Uganda: a feasibility study for periodic cancer surveillance research in resource limited settings.

BackgroundPopulation based cancer registries (PBCRs) are accepted as the gold standard for estimating cancer incidence in any population. However, only 15% of the world's population is covered by high quality cancer registries with coverage as low as 1.9% in settings such as Africa. This study was conducted to assess the operational feasibility of estimating cancer incidence using a retrospective "catchment population" approach in Uganda.MethodsA retrospective population study was conducted in 2018 to identify all newly diagnosed cancer cases between 2013 and 2017 in Mbarara district. Data wer

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… Iowa model of evidence-based practice: revisions and validation. 2017. 14(3): p. 175–82. 24. Toporcov TN. and V. Wünsch Filho, Epidemiological science and cancer control. Clinics, 2018. 73. 25. Uganda Bureau of Statistics. Poverty maps of Uganda. Uganda Bureau of Statistics (UBOS); 2018. 26. …

Access to Chimeric Antigen Receptor T Cell Therapy for Diffuse Large B Cell Lymphoma.

IntroductionGeographic access to novel oncology therapies, and the extent to which it may vary by potential sites of care, regions, and population characteristics, is poorly understood. We examined how expanding access to chimeric antigen receptor (CAR) T cell therapy administration sites impacts patient travel distances and time.MethodsWe used geographic information system techniques to calculate shortest travel distance and time between patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) and the nearest CAR T cell therapy administration site in three scenarios: academic h

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… University of Iowa Hospitals and Clinics. CAR T-cell therapy. 2019. https://uihc.org/health-topics/car-t-cell-therapy . Accessed 28 May 2019. 36. Centers for Disease Control and Prevention. Cancer clusters. 2019. https://www.cdc.gov/nceh/clusters/default.htm . Accessed 28 May 2019. 37. …

Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs.

BackgroundMultiple myeloma (MM) in dogs typically is treated with melphalan. A daily melphalan dosing schedule reportedly is well tolerated and associated with favorable outcome. Although anecdotally a pulse dose regimen has resulted in successful responses, little long-term outcome and safety data is available regarding this dosing regimen for dogs with MM.Hypothesis/objectives(1) To compare outcome and adverse event profiles between pulse dose and daily dose melphalan schedules and (2) to report prognostic factors in dogs with MM treated with melphalan. We hypothesized that both protocols wo

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… Plumb's Veterinary Drug Handbook . 8th ed Ames, Iowa : Wiley‐Blackwell ; 2015 . 43 Kyle RA , Gertz MA , Witzig TE , et al. Review of 1027 patients with newly diagnosed multiple myeloma . Mayo Clin Proc. 2003 ; 78 : 21 – 33 . 12528874 10.4065/78.1.21 44 Waheed S , Mitchell A , Usmani S , et al. …

Phytochemicals in Cancer Treatment and Cancer Prevention-Review on Epidemiological Data and Clinical Trials.

Phytochemicals are a non-nutritive substances that are present in plants and contribute significantly to their flavor and color. These biologically active compounds are classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing compounds, and alkaloids, and are known for their potential health benefits in the prevention of various diseases, including cancer. The purpose of this review article is to explore the potential therapeutic benefits of the dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, carotenoids, and stilbe

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… In a large prospective study of 34,708 postmenopausal women, the Iowa Women’s Health Study looked at the relationship between total flavonoids and seven flavonoid subclasses and the risk of lung, colorectal, breast, pancreatic, and upper aerodigestive cancer. … Dietary Flavonoid Intake and Risk of Cancer in Postmenopausal Women: The Iowa Women’s Health Study. Int. J. Cancer. 2008;123:664–671. doi: 10.1002/ijc.23564. 52. Ingram D., Sanders K., Kolybaba M., Lopez D. Case-Control Study of Phyto-Oestrogens and Breast Cancer. …

The Role of Diet in Prognosis among Cancer Survivors: A Systematic Review and Meta-Analysis of Dietary Patterns and Diet Interventions.

Cancer survival continues to improve in high-income countries, partly explained by advances in screening and treatment. Previous studies have mainly examined the relationship between individual dietary components and cancer prognosis in tumours with good therapeutic response (breast, colon and prostate cancers). The aim of this review is to assess qualitatively (and quantitatively where appropriate) the associations of dietary patterns and cancer prognosis from published prospective cohort studies, as well as the effect of diet interventions by means of randomised controlled trials (RCT). A sy

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… Neck Specialised Program of Research Excellence; CPS-II, Cancer Prevention Study II; CALGB, National Cancer Institute–sponsored Cancer and Leukaemia Group B; SBCSS, Shanghai Breast Cancer Survival Study; LACE, Life After Cancer Epidemiology; NHS, Nurses’ Health Study; MEC, Multiethnic Cohort; IWHS, Iowa … The first one, from the Iowa Women’s Health Study (IWHS), examined adherence to the WCRF/AICR guidelines among older women survivors of breast cancer, colorectal cancer, gynaecologic cancers (including cervical, endometrial, ovarian and related cancers) and other cancers [ 36 ]. …

Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Guido Tricot, University of Iowa Hospital and Clinics, Iowa City, IA 346. Suzanne Trudel, University Health Network: Princess Margaret Cancer Centre, Ontario, Canada 347. Sascha A. Tuchman, University of North Carolina—Chapel Hill, Chapel Hill, NC 348. …

Leiomyosarcomas of the Great Saphenous Vein: Diagnostic and Therapeutic Strategies to Prevent Unplanned Excisions and Improve Oncologic, Functional, and Psychological Outcomes.

Background/objectivesThere are very few publications on unplanned excisions of great saphenous vein leiomyosarcomas (GSV-LMS), and their impact on the prognosis of the disease is not well known. The objective of this study is to present a series of nine new leiomyosarcomas of the great saphena vein (LMS-GSV) cases, with the aim of increasing diagnostic awareness and proposing guidelines for therapeutic management.MethodsThis is a prospective single-centre study of a series of nine GSV-LMS in thigh (stage IIIA AJCC), knee and proximal leg (IB, 1 II and 3 IIIA), and ankle (2 IIIB and 1 II). Eigh

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… Iowa Orthop. J. 2018;38:123–130. 36. Nakamura T., Hasegawa M. Unplanned excision in soft tissue sarcoma: Current knowledge and remaining gaps. Diagnostics. 2025;15:453. doi: 10.3390/diagnostics15040453. 37. Quintana J.M., Padierna A., Esteban C., Arostegui I., Bilbao A., Ruiz I. …

Средний показатель воздействия выборочной обработки на анализ обработанных веществ (САТТ) с использованием контрфактического объяснения указывает на БМТ и SARS-CoV-2 вакцинация как защитные факторы риска, связанные COVID-19 Сильность и выживаемость у пациентов с множественной миеломой.

Пациенты с множественной миеломой (ММ), возрастной неоплазмой плазменных клеток, производящих антитела, скомпрометировали иммунную систему и могут подвергаться повышенному риску сильного воздействия COVID-19 :: результаты. Это исследование характеризует факторы риска, связанные с клиническими показателями COVID-19 Суровая и всепричинная смертность у пациентов миэломы с использованием национальной базы данных по сотрудничеству в области КОВИД (N3C). Консорциум N3C представляет собой крупный централизованный ресурс данных, представляющий собой крупнейшую многоцентровую группу COVID-19 - случаи и

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… • The Ohio State University—UL1TR002733: Center for Clinical and Translational Science • The State University of New York at Buffalo—UL1TR001412: Clinical and Translational Science Institute • The University of Chicago—UL1TR002389: The Institute for Translational Medicine (ITM) • The University of Iowa—UL1TR002537 …

The role of CAR-T cell therapy as second line in diffuse large B-cell lymphoma.

For approximately three decades, autologous hematopoietic cell transplantation (auto-HCT) has been the standard of care for patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) after frontline therapy. This approach is limited due to the intensity of chemotherapy and the proportion of patients who relapse after auto-HCT. Since the approval of anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy and novel agents, the treatment paradigm for DLBCL has changed remarkably. Anti-CD19 CAR-T therapy was first approved for relapsed DLBCL after two or more previous lines o

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… The SCHOLAR-1 study was an observational cohort study that evaluated the outcome for patients who had refractory DLBCL from four sources (MD Anderson Cancer Center, Molecular Epidemiology Resource of the University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellence, the NCIC CTG …

Study Design and Rationale for The Breathe Easier With Tadalafil Therapy for Exercise-Related Dyspnea in COPD-PH (BETTER COPD-PH).

Dyspnea, a debilitating symptom of COPD, worsens health-related quality of life (HRQL), reduces daily physical activity, increases health care utilization, and is more closely associated with survival than airflow limitation. Thus, having treatments that reduce dyspnea in COPD is important. Pulmonary hypertension (PH) is a common complication of COPD that is associated with severe dyspnea, more frequent COPD exacerbations, and increased mortality. Multiple causes of PH, including a reduction in bioavailable vasodilator nitric oxide (NO), are associated with COPD (COPD-PH). Phosphodiesterase ty

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… One hundred twenty‐six Veterans will be randomized in a 1:1 ratio to treatment with once‐daily tadalafil or oral placebo stratified across 5 VA sites (VA Boston Health Care, VA Providence Health Care, VA Atlanta Health Care, VA Nebraska‐Western Iowa Health Care in Omaha, and Rocky Mountain Regional VAMC …

Molecular events in the jaw vascular unit: A traditional review of the mechanisms involved in inflammatory jaw bone diseases.

Inflammatory jaw bone diseases are common in stomatology, including periodontitis, peri-implantitis, medication-related osteonecrosis of the jaw, radiation osteomyelitis of the jaw, age-related osteoporosis, and other specific infections. These diseases may lead to tooth loss and maxillofacial deformities, severely affecting patients' quality of life. Over the years, the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic challenge. Therefore, exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial fo

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… vesicles from human periodontal-ligament stem cells increase VEGF/VEGFR2 expression during bone regeneration Front Physiol 2019 10 512 10.3389/fphys.2019.00512 31114512 PMC6503111 94 Ogilvie CM, Lu C, Marcucio R, et al Vascular endothelial growth factor improves bone repair in a murine nonunion model Iowa …

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 20

Резюме книги: Тема: 13th Международный симпозиум на тему &quot; Ходжкин лимфома &quot; ; октябрь 2024

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… , Nice, Italy, 5 University of Modena and Reggio Emilia, Modena, Italy, 6 Department of Clinical Haematology and Medical Oncology, Austin Health, Heidelberg, Australia, 7 Princess Margaret Hospital, Toronto, Canada, 8 Southampton General Hospital School of Medicine, Southampton, UK, 9 University of Iowa … Hospitals and Clinics, Iowa City, Iowa, 10 BC Cancer, Vancouver, Canada, 11 Instituto di Ematologia Seràgnoli, Bologna, Italy, 12 Rutgers Cancer Institute, New Brunswick, New Jersey, USA Table 1: Risk groups based on “ranking” of AS‐HL pts vis‐a‐vis the A‐HIPI predictive model. …

Упражнения и питание в гематологических заболеваниях: свидетельства перевода и новые меры вмешательства.

Пациенты, страдающие гематологическими микроорганизмами, включая лейкемию, лимфому и миелому, живут дольше из - за прогресса в лечении. Тем не менее такое лечение часто приводит к токсичным последствиям, влияющим на качество жизни пациентов (QoL). Хотя мероприятия, связанные с образом жизни, такие, как упражнение и питание, приносят пользу, снижая риск заболевания раком и улучшая результаты лечения твердых опухолей, их применение в гематологических опухолей по-прежнему недостаточно изучено. В настоящем описательном обзоре рассматриваются текущие данные о роли физических упражнений и питания в

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… Diet and risk of leukemia in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2002;11(8):777–781. 25. Ma X, Park Y, Mayne ST, et al. Diet, lifestyle, and acute myeloid leukemia in the NIH–AARP cohort. Am J Epidemiol. 2010;171(3):312–322. doi: 10.1093/aje/kwp371. 26. …