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Editorial: Bio-Pathological Markers in the Diagnosis and Therapy of Cancer.

Identifying novel biomarkers with diagnostic, prognostic and predictive value in terms of therapeutic response is a current topic in the clinical practice of oncologists, pathologists and medical researchers in general [...].

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… immunohistochemical study by Piombino et al. showed that Wilms’ tumor 1 (WT1) immunoreactivity could represent a strong diagnostic tool to distinguish dermatofibrosarcoma protuberans from other dermal/subcutaneous bland-looking mesenchymal spindle cell lesions, such as dermatofibromas, deep fibrous histiocytomas, neurofibromas …

Multiple myeloma presenting as a cervical intraforaminal tumor: A case report and review of literature.

Multiple myeloma (MM) is a hematological malignancy with characteristic clonal plasma cell proliferation and production of monoclonal immunoglobulins. Although it can often metastasize to the bony spine, completely extravertebral and extra-/intradural manifestations are exceedingly rare. In this case report, we describe a 51-year-old male patient with cervical extradural and intraforaminal MM who was surgically treated in our department. Clinical findings and radiological images were retrieved from medical records and an imaging system. This unusual localization of MM and similar cases in the

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… The differential diagnoses for intraforaminal and spinal cord lesions usually include schwannoma, neurofibroma, hemangioblastoma, malignant peripheral nerve sheath tumor, spinal metastasis, solitary amyloidoma, and epidural abscess ( 5 ). …

Medicinal chemistry perspectives on anticancer drug design based on clinical applications (2015-2025).

Cancer therapy has undergone a remarkable evolution over the past few decades, driven largely by innovations in medicinal chemistry. This review explores the pivotal role of medicinal chemistry in designing, optimizing, and classifying anticancer agents, from traditional cytotoxics to modern targeted therapies, immunotherapies, and radiotheranostics. The article categorizes FDA-approved anticancer drugs (2015-2025), evaluates their mechanisms of action, structural features, and structure-activity relationships (SAR), and highlights both success stories and challenges in clinical translation. A

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… Mirdametinib (Gomekli) Mirdametinib is a highly selective MEK1/2 inhibitor developed for the treatment of neurofibromatosis type 1 (NF1)-associated plexiform neurofibromas. 98 These tumors arise due to mutations in the NF1 gene, leading to hyperactivation of the Ras-Raf-MEK-ERK pathway. … Approved by the FDA in 2025, mirdametinib represents a landmark therapy for patients with symptomatic, inoperable plexiform neurofibromas. Early-phase studies demonstrated durable tumor shrinkage and pain reduction, establishing MEK inhibition as a viable strategy in NF1 (ref. 100 ) ( Table 1 ). …

Спинальное внутридуральное повреждение как проявление множественной миэломы: иллюстративный случай и систематический обзор литературы.

Множественная миелома (ММ), как правило, влияет на костный мозг. Когда он распространяется на центральную нервную систему, он обычно представляет собой внутричерепный метастаз или внесудебные повреждения позвоночника. Интрадуральные метастазы спинного мозга крайне редки. ОПИСАНИЕ СЛУЧАЙ: А 53-year-old У мужчины с иммуноглобулином у каппы MM было повреждено противопоказательное повреждение T3-4 уровень, состоящий из внутридурального повреждения и экстрадурального повреждения, протянувшегося через предплечье. Характеристики повреждения указывают на шванному, но подозревается в причастности MM с

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… foramen involvement was uniquely noted in Hsu et al .[ 14 ] These imaging features align with broader literature describing plasmacytomas as solid tumors with nonspecific but enhancing characteristics on MRI, often requiring differentiation from more common intradural pathologies such as meningioma or neurofibroma …

A Comprehensive Single Institutional Review of 2 Years in a Designated Fast-Track Sarcoma Diagnostic Clinic Linked with a Sarcoma Specialist Advisory Group: Meeting the Target but Failing the Task?

Background. National guidelines prompted the implementation of a designated two-week wait referral pathway to facilitate the early diagnosis of sarcomas, to improve treatment outcomes. Methods. Patients referred to the Cambridge Sarcoma Diagnostic Clinic between January 2013 and December 2014 were identified through the electronic appointments system. Information was retrospectively retrieved about patient characteristics and details of the diagnostic pathway. Results. 17.3% of patients referred (69/397) were diagnosed with a malignancy. Of these, 59.3% (41/69) had primary sarcomas, 17.4% (12/

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… | 6 Lipoma (spindle cell) | 8 Lipoma with fat necrosis | 1 Lipomatosis | 1 Angiomyolipoma | 1 Fibrolipoma | 1 Bone tumours | Benign giant cell tumour | 1 Cystic medullary bone tumour | 1 Enchondroma | 3 Exostosis | 1 Intraosseous ganglion | 1 Osteochondroma | 2 Neural tumours | Neural tumour | 1 Neurofibroma …

Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study.

BACKGROUND & AIMS: Brown adipose tissue (BAT) has been mainly investigated as a potential target against cardiometabolic disease, but it has also been linked to cancer-related outcomes. Although preclinical data support that BAT and the thermogenic adipocytes in white adipose tissue may play an adverse role in the pathogenesis of cancer cachexia, results from studies in patients have reported inconsistent results. The purpose of this study was to examine the interrelationship between presence of detectable BAT, changes in body weight, and cachexia in patients with cancer. We hypothesized that

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… neuroendocrine); 6) breast (lobular carcinoma, any breast tissue malignancy, in situ/ invasive ductal carcinoma); 7) head and neck (squamous cell carcinoma with origin in the head or neck region, basaloid squamous cell carcinoma, adenoid cystic carcinoma); and 8) other cancer types of various origins (neurofibroma …

Сердечно-сосудистые заболевания

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… Neurofibroma, although uncommon, frequently causes arrhythmia and variable intensity of heart sounds in affected cattle and bulls. Furthermore, the cardiac arrhythmia may coexist with paresis or paralysis caused by neurofibroma masses in the spinal canal. … Although perhaps a moot point because both diseases are fatal, further medical workup of patients with neurofibroma fails to provide confirmation of lymphosarcoma. To date, postmortem examination has been the only means of definitive diagnosis for cardiac neurofibroma. …

2022 NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF HYPERTENSION (SIIA)

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… Two of the following 7 diagnostic criteria are required for diagnosis: at least 6 café-au-lait spots or hyperpigmented macules greater than 5 mm, axillary or inguinal freckles, 2 or more neurofibromas or at least one plexiform neurofibroma, optic nerve glioma, at least 2 Lisch nodules, pseudarthrosis … Type II is characterized by a lower prevalence of skin manifestations with a greater tendency to develop multiple neoplasms (neurofibromas, schwannomas, gliomas, meningiomas), hearing loss, cranial nerve palsy. …

Использование реальных доказательств в США. Управление по контролю за продуктами питания и лекарственными препаратами и Европейское агентство по лекарственным препаратам утверждают онкологические продукты, поддерживаемые односторонними испытаниями (Advisory and Drug Argency and the European Medicals Agency (European Medicals Agency)2022-2025).

ВВЕДЕНИЕ: Усилился интерес регулирующих органов к реальным доказательствам (РВЭ) в дополнение к односторонним испытаниям (САТ) в области онкологии, однако по-прежнему отсутствует полное понимание того, как Управление по контролю за продуктами питания и лекарствами (ДПП) и Европейское агентство по медицине (ЕМА) оценивают такие доказательства. ЦЕЛЬ: Всеобъемлющая оценка недавних решений по онкологии, в которых СТА поддерживаются РВЭ, с описанием обратной связи по вопросам нормативного регулирования, методологических подходов, роли РВЭ в процессе принятия решений. Мы рассмотрели новые прикладные

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… March 14, 2024 (EMA) | Adults | Multiple myeloma | GPRC5D × CD3 bispecific T-cell engager | MonumenTAL-1 | Phase 1/2 Mirdametinib | EMA & FDA | Priority review; fast track; orphan drug (FDA); | orphan drug; CMA (EMA) | February 11, 2025 (FDA); July 17, 2025 (EMA) | Adults and pediatric | NF1 plexiform neurofibroma …

The potential of oral healthcare providers to recognise early systemic disease.

Like many other body structures, the mouth is often affected by disease that principally arises from, or targets, several tissue sites. Indeed, systemic disorders can manifest on the oral mucosa as the first, only, or become the most severe manifestation of a systemic disease and/or become the most significant factor to adversely affect an individual's quality of life. Oral healthcare providers (dentists, therapists and hygienists) may be the first to observe an abnormality in the mouth which sometimes indicates a significant systemic disease unknown to the patient or their general medical pra

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… Sometimes, however, symptoms identical to trigeminal neuralgia can be an early presentation of other causes of such demyelination, including multiple sclerosis and rarely, tumour (e.g, schwannoma, neurofibroma), inflammation (e.g., systemic lupus erythematosus), arterial aneurysms, arteriovenous malformations …

Posterior minimally invasive percutaneous short-segment fixation combined with mini-open anterior L5 corpectomy for metastatic tumor: a case report and literature review.

BACKGROUND: Metastatic tumors of the lumbar spine are a common complication of advanced malignancies. They often present with severe pain, neurological deficits, and spinal instability. Surgical removal of L5 vertebral body metastases is challenging due to the complex anatomy and biomechanical characteristics of the lumbosacral junction. Corpectomy using a combined approach is a common surgical strategy for achieving pain relief, adequate tumor resection, spinal cord and root decompression, and spinal stabilization. However, this approach may be associated with significant surgical trauma and

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… . | Posterior column was resected | 9000 mL | 10 h | Death of another disease Yang, 2019 ( 21 ) | Case series | 7 | 3 giant cell tumor, 1 gastrointestinal metastasis, 1 thyroid cancer metastasis, 1 neurofibroma, 1 chondrosarcoma | L5 | Posterior –only approach | Midline incision from L3 to S2, placement …

The Musculoskeletal Tumor Society Scoring system is a valid subjective and objective tool to evaluate outcomes of surgical treatment of patients affected by upper and lower extremity tumors.

PURPOSE: The main purpose of the present study was to evaluate if there is a difference between objective or subjective administration of the MSTS score in a cohort of patients affected by musculoskeletal oncological diseases. MATERIALS AND METHODS: All patients who underwent surgery for bone or soft tissue localization of neoplastic disease in lower or upper limb from June 2015 to June 2020 were considered eligible. In order to administer the score as a PROM, the MSTS was first translated and cross-culturally adapted in Italian. During follow up visits, all patients filled out Italian versio

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… 6 (12) Sarcomas | 9 (18) Osteosarcoma | 2 (4) Chondrosarcoma | 1 (2) Liposarcoma | 2 (4) Other soft tissue sarcomas | 4 (8) Lipoma | 7 (14) Fibrolipoma | 5 (10) Enchondroma | 3 (6) Schwannoma | 5 (10) Angiolipoma | 2 (4) Well differentiated liposarcoma | 1 (2) Cyst | 1 (2) Giant cell tumor | 8 (16) Neurofibroma …

SEDCYDO - SGER - SEMO ConГРЕСС МАДРИД 2025, 8-10 Возможно. Ход работы и резюме.

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Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Ensuring the Safety of Yellow Fever Vaccination in Travelers-The Experience at a Large U.S. Academic Medical Center in Colorado.

Background: Yellow fever (YF) virus has the potential to cause fatal outcomes among at-risk individuals visiting endemic areas. Vaccinating travelers who are at risk is necessary to prevent virus-related life-threatening complications. We lack data on the clinical features of persons seeking YF vaccination. We aim to describe the characteristics of a cohort of persons receiving the YF vaccine before travel. Methods: A retrospective analysis of 964 travelers receiving the YF vaccine (Stamaril®) from Oct 2016 to Jul 2019 was performed at the University of Colorado Hospital, U.S. Percentages, mea

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… Neoplasms ICD-10-CM | D23.4 | Other benign neoplasm of skin of scalp and neck | Neoplasms ICD-10-CM | D23.71 | Other benign neoplasm of skin of right lower limb, including hip | Neoplasms ICD-10-CM | D23.62 | Other benign neoplasm of skin of left upper limb, including shoulder | Neoplasms ICD-9-CM | 210 | Neurofibroma …

Medium to long term follow-up of survival and quality of life in patients with primary tumors of the cervical spine: Experience From a large single center.

ObjectivesTo evaluate the survival and medium to long term health-related quality of life (HRQoL) of patients with primary cervical spinal tumors in a cross-sectional study and to identify any significant associations with demographic or clinical characteristics.MethodsPatients diagnosed with primary cervical spinal tumors were retrospectively enrolled and their clinical, radiologic, and follow-up data (specifically the EQ-5D questionnaire) were collected. Univariate and multivariate Cox time-dependent regression analyses were performed to examine the significance of certain variables on overa

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… 15 | 20/24 | 14.2 GCT | 35 | 10.3 | 15/20 | 11/24 | 31.9 Osteoblastoma | 19 | 5.6 | 15/4 | 4/15 | 22.8 ABC | 15 | 4.4 | 9/6 | 6/9 | 26.8 Osteoid osteoma | 14 | 4.1 | 8/6 | 6/8 | 23.8 Osteochondroma | 12 | 3.5 | 5/7 | 3/9 | 25.3 FD | 9 | 2.6 | 8/1 | 6/3 | 34.3 Hemangioma | 8 | 2.3 | 4/4 | 2/6 | 46.9 Neurofibroma …

Presenting characteristics, histological subtypes and outcomes of adult central nervous system tumours: retrospective review of a surgical cohort.

IntroductionThe most recent local study on the incidence of histological subtypes of all brain and spinal tumours treated surgically was published in 2000. In view of the outdated data, we investigated the presenting characteristics, histological subtypes and outcomes of adult patients who underwent surgery for brain or spinal tumours at our institution.MethodsA single-centre retrospective review of 501 patients who underwent surgery for brain or spinal tumours from 2016 to 2020 was conducted. The inclusion criteria were (a) patients who had a brain or spinal tumour that was histologically ver

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… 0 (0.0) | 6 (1.2) FSH-positive | 3 (0.7) | 0 (0.0) | 3 (0.6) LH-positive | 2(0.5) | 0 (0.0) | 2 (0.4) TSH-positive | 1 (0.2) | 0 (0.0) | 1 (0.2) Craniopharyngioma | 2(0.5) | 0 (0.0) | 2 (0.4) Nerve sheath tumors; n (%) | 32 (7.4) | 31 (47.0) | 63 (12.6) Schwannoma | 30 (6.9) | 29 (43.9) | 59 (11.8) Neurofibroma …

Hospital Use, Morbidity, and Cancer Risk by Age Group in Neurofibromatosis Type 1: A Nationwide Retrospective Cohort Study.

Neurofibromatosis type 1 (NF1) affects multiple organs progressively, leading to a shortened life expectancy. This study aimed to identify the complications that are prominent in each age group by comparing 28,082 patients with NF1 and 84,246 matched controls. Benign and malignant neoplasms along with neurological complications were the primary contributors to hospital use across most age groups. Respiratory and circulatory disorders were a common cause of hospital use in children and older adults, respectively. Except for soft tissue and central nervous system-originated malignancies, which a…

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

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… Mast cells found in neurofibromas account for the release of histamine, which leads to itching. …