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Effect of autologous concentrated growth factor on bedsore wounds in elderly patients with diabetes: a case-control study.

BACKGROUND: Pressure ulcers, also known as bedsores, are common injuries to the skin and subcutaneous tissues in patients who are bedridden or wheelchair-bound, with a particularly high incidence among elderly patients with diabetes. These chronic wounds often lead to increased morbidity, prolonged hospitalization, and reduced quality of life. Traditional treatments for pressure ulcers have limited efficacy. In recent years, autologous concentrated growth factor (ACGF) has emerged as a promising regenerative medicine approach, showing potential in promoting wound healing through enhanced cell

Profiling the most elderly parkinson's disease patients: Does age or disease duration matter?

BACKGROUND: Despite our ageing populations, elderly patients are underrepresented in clinical research, and ageing research is often separate from that of Parkinson's disease (PD). To our knowledge, no previous study has focused on the most elderly ('old-old', age ≥ 85 years) patients with PD to reveal how age directly influences PD clinical progression. OBJECTIVE: We compared the clinical characteristics and pharmacological profiles, including complications of levodopa treatment, disease progression, disabilities, and comorbidities of the old-old with those of comparable younger ('young-old'

Pressure ulcer prevention.

The purpose of this collective review is to outline the predisposing factors in the development of pressure ulcers and to identify a pressure ulcer prevention program. The most frequent sites for pressure ulcers are areas of skin overlying bony prominences. There are four critical factors contributing to the development of pressure ulcers: pressure, shearing forces, friction, and moisture. Pressure is now viewed as the single most important etiologic factor in pressure ulcer formation. Prolonged immobilization, sensory deficit, circulatory disturbances, and poor nutrition have been identified

[Maximal exercise in spinal cord injured subjects: effects of an antigravity suit].

Paraplegics have low aerobic capacity because of the spinal cord injury. Their functional muscle mass is reduced and usually untrained. They have to use upperbody muscles for displacements and daily activities. Sympathic nervous system injury is responsible of vasomotricity disturbances in leg vessels and possible abdominal vessels, proportionally to level injury. If cord injury level is higher than T5, then sympathic cardiac efferences may be damaged. Underbody muscles atrophy and vasomotricity disturbances contribute to phlebostasis. This stasis may decrease venous return, preload and stroke

Abdominal massage plus advice, compared with advice only, for neurogenic bowel dysfunction in MS: a RCT.

BACKGROUND: Between 50% and 80% of people with multiple sclerosis (PwMS) experience neurogenic bowel dysfunction (NBD) (i.e. constipation and faecal incontinence) that affects quality of life and can lead to hospitalisation. OBJECTIVES: To determine the clinical effectiveness and cost-effectiveness of abdominal massage plus advice on bowel symptoms on PwMS compared with advice only. A process evaluation investigated the factors that affected the clinical effectiveness and possible implementation of the different treatments. DESIGN: A randomised controlled trial with process evaluation and he

Glucocorticoid corticosteroids for Duchenne muscular dystrophy.

BACKGROUND: Duchenne muscular dystrophy is the most common muscular dystrophy of childhood. This incurable disease is characterised by muscle wasting and loss of walking ability leading to complete wheelchair dependence by 13 years of age. Prolongation of walking is one of the major aims of treatment. OBJECTIVES: The aim of this review was to assess whether glucocorticoid corticosteroids stabilize or improve muscle strength and walking in boys with DMD. SEARCH STRATEGY: We searched the Cochrane Neuromuscular Disease Group specialised register (October 2003) using the term 'Duchenne muscular

General weakness as an indication for parathyroid surgery in patients with secondary hyperparathyroidism.

HYPOTHESES: There are factors that affect patients with general weakness owing to secondary hyperparathyroidism and as reported by results noted after parathyroidectomy and autotransplantation. DESIGN: Case series and consecutive samples. SETTING: Tertiary care center. PATIENTS: From July 1996 to June 1998, 56 patients with secondary hyperparathyroidism underwent total parathyroidectomy and autotransplantation. Their ages were 45 +/- 13 years (mean +/- SD) and preoperative duration of dialysis was 75 +/- 37 months. Prior to surgery the patients were divided into 2 groups: group A comprised

[The German promille law--overview and guideline for legal traffic applications].

1. The alcohol level regulation affects everyone who participates in public road, rail, shipping and air traffic. In legal terms a person participating in traffic is anyone who has a direct, physical influence on the traffic flow i.e. as a pedestrian, a vehicle driver, an aircraft captain or a train driver. Participation in any kind of traffic requires a physical, mental and psychological joint effort which is controlled by the central nervous system. The influence of alcohol drastically deteriorates driver performance to the detritment of traffic safety. In cases of traffic law determination

Deciphering the role of glial cell-specific metabolites as biomarkers in early cervical myelopathy-insights from in vivo MRS study.

BACKGROUND: Early degenerative cervical myelopathy (DCM) presents a diagnostic dilemma due to its variability in presentation, overlap with other clinical conditions, and lack of specific clinical tests. Although magnetic resonance imaging (MRI) is the preferred imaging modality, its ability to detect early cervical myelopathy remains uncertain due to its inability to detect microstructural changes at an early spondylotic stage. Magnetic Resonance Spectroscopy (MRS) is a novel, noninvasive spinal imaging technique that provides metabolic and biochemical information regarding spinal cord functi

[A study on fall accident].

The study was conducted from November 1995 to May 1996 at the one general hospital in Seoul. The total subjects of this study were 412 patients who have the experience of fall accident, among them 31 was who have fallen during hospitalization and 381 was who visited emergency room and out patient clinic. The purposes of this study were to determine the characteristics, risk factors and results of fall accident and to suggest the nursing strategies for prevention of fall. Data were collected by reviewing the medical records and interviewing with the fallers and their family members. For data an

Assessing Skin Blood Flow and Interface Pressure in Patients With Spinal Cord Injury Provided an Alternating Pressure Overlay: A Cross-sectional Study.

UNLABELLED: The effects of an alternating pressure (AP) overlay on the skin are not fully understood. PURPOSE: This study was conducted among persons with spinal cord injury (SCI) to examine skin blood flow (SBF) and interface pressure (IP) during and after AP overlay use. METHODS: In this cross-sectional, repeated measures study, persons eligible for participation were clinic outpatients from a large metropolitan area in the midwest United States who were 18 to 65 years old with a SCI with a neurologic level of injury at T10 or above for more than 1 year and used a wheelchair for primary mo

Glucocorticoid corticosteroids for Duchenne muscular dystrophy.

BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy of childhood. This incurable disease is characterised by muscle wasting and loss of walking ability leading to complete wheelchair dependence by 13 years of age. Prolongation of walking is one of the major aims of treatment. OBJECTIVES: The aim of this review was to assess whether glucocorticoid corticosteroids stabilize or improve muscle strength and walking in boys with DMD. SEARCH STRATEGY: This is an update of the Cochrane systematic review first published in 2004 (Manzur 2004). We searched the Cochrane N

Risk Factors for Poor Outcome after Palliative Surgery for Metastatic Spinal Tumors.

Palliative surgery is performed to improve the quality of life of patients with spinal metastases. However, it is sometimes difficult to achieve the expected results because the patient's condition, and risk factors related to poor outcomes have not been well elucidated. This study aimed to evaluate the functional outcomes and investigate the risk factors for poor outcomes after palliative surgery for spinal metastasis. We retrospectively reviewed the records of 117 consecutive patients who underwent palliative surgery for spinal metastases. Neurological and ambulatory statuses were evaluated

Powered mobility interventions for very young children with mobility limitations to aid participation and positive development: the EMPoWER evidence synthesis.

BACKGROUND: One-fifth of all disabled children have mobility limitations. Early provision of powered mobility for very young children (aged < 5 years) is hypothesised to trigger positive developmental changes. However, the optimum age at which to introduce powered mobility is unknown. OBJECTIVE: The aim of this project was to synthesise existing evidence regarding the effectiveness and cost-effectiveness of powered mobility for very young children, compared with the more common practice of powered mobility provision from the age of 5 years. REVIEW METHODS: The study was planned as a mixed-me

Обследование на предмет выявления рака груди у женщин с множественным склерозом: исследование смешанных методов.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Имеется мало информации о практике обследования на предмет выявления рака молочной железы у женщин с множественным склерозом. ЦЕЛЬ: Оценка и сопоставление показателей УХУ в УВМС и среди населения в целом и выявление барьеров и посредников. МЕТОДЫ: 2012-2020 Мы идентифицировали когортное исследование 47,166 WWMS без истории рака и совпадали с ними (до 1::4) к 184,124 контроль из французской национальной медико-административной базы данных. Показатели маммографии были сопоставлены в зависимости от возраста, социально-экономического положения на уровне городов, периода и ис

Совпадение в полном тексте источника
… Twelve of these women reported walking limitations, including needing a cane ( n  = 4) and using a wheelchair ( n  = 4) (Table  S3 ). Seventeen (85%) reported undergoing BCS and following the national BCS recommendations. … (3) “I have to drive 50 km to and from because I live in the countryside… I am tired from the trips” (Marjorie) (1) “The machine is not adapted for wheelchairs” “It will take 15 min for someone who can stand up, but for me it takes an hour… there had to be two persons to hold me … At some point I …

Artificial intelligence assisted preoperative planning and 3D-printing guiding frame for percutaneous screw reconstruction in periacetabular metastatic cancer patients.

BACKGROUND: The percutaneous screw reconstruction technique, known as the "Tripod Technique," has demonstrated favorable clinical outcomes in the management of metastatic periacetabular lesions, as evidenced by our prior investigations and corroborated by independent studies. Nevertheless, there is a steep learning curve in handling this technique, with possible complications such as intraarticular screw placement. METHODS: Preoperative pelvic CT scans were acquired before surgery and utilized for the guiding frame design. A convolutional neural network model was trained with annotated data t

A Multidisciplinary Rehabilitation Approach for a Patient With Diffuse Large B-cell Lymphoma and Bone Metastasis: A Case Report.

Cancer is often accompanied by bone metastasis, which may lead to skeletal-related events (SREs), such as pain, hypercalcemia, pathological fractures, spinal cord compression, orthopedic surgical intervention, and palliative radiation directed at the bone. Herein, we report the case of a 75-year-old female patient diagnosed with diffuse large B-cell lymphoma (DLBCL) with bone metastasis and a pathological fracture of the right iliac bone. The management strategy and follow-up were determined by a multidisciplinary cancer board comprising physicians, physiatrists, orthopedic surgeons, radiologi

Leukoencephalopathy During Daratumumab-Based Therapy: A Case Series of Two Patients with Multiple Myeloma.

Leukoencephalopathy in the setting of multiple myeloma (MM) is a rare demyelinating condition, with few reported cases in literature. Daratumumab is a CD38 targeted monoclonal antibody that has been widely used for the management of MM. In the absence of central nervous system (CNS) disease, many medication-induced leukoencephalopathy cases reported with MM, including daratumumab-induced, are associated with progressive multifocal leukoencephalopathy (PML) and John Cunningham (JC) virus. Currently, there are no reported cases of daratumumab-induced leukoencephalopathy among patients without CN

Подтверждение того, что качество жизни, связанное со здоровьем, ухудшается для мониторинга долгосрочного прогресса в борьбе с заболеваниями, связанными с MS: продольный анализ из швейцарского регистра множественного склероза.

Мониторинг развития склероза (MS) традиционно опирается на клинические меры, которые могут игнорировать симптомы, влияющие на качество жизни. Включение результатов, сообщаемых пациентами, могло бы улучшить понимание ухудшения состояния заболеваний. ЦЕЛЬ: Оценить алгоритм на основе EQ-5D для обнаружения ухудшения болезни и сравнить его с ухудшением EDS. Мы проанализировали продольные данные EQ-5D и EDS из швейцарского регистра MS. Ухудшение состояния системы EQ-5D было определено как устойчивое сокращение по сравнению с двумя оценками; ухудшение состояния системы EDS осуществлялось в соответств

Приемлемость и пригодность ассистивных средств и технологий для лиц с множественным склерозом: качественное исследование с участием профессиональных терапевтов.

ВВЕДЕНИЕ: Вспомогательное оборудование и технология (АЭ и Т) часто являются частью практики профессиональной терапии для лиц с множественным склерозом (МС). Мы стремимся изучить приемлемость и удобство использования ЭИ и Т людьми, имеющими НР, с точки зрения профессиональных терапевтов. МЕТОДЫ: В нашем исследовании использовался качественный описательный дизайн с использованием полуструктурированных опросов, проведенных с пятью квалифицированными профессиональными терапевтами, имеющими по меньшей мере 6-месячный опыт в деле обеспечения профессиональной терапии взрослых, имеющих MS. Для анализа

Совпадение в полном тексте источника
… This also includes a process of fear around dependence on assistive technology, such as wheelchair, which can progress to acceptance once individuals with MS experience how AE&T enables participation in certain occupations ( Desborough et al., 2020 ). … Furthermore, mobility aids such as scooters, manual and powered wheelchairs, walking frames, hoists, banana boards, sara steadies, electric mini lifts, stairlifts, profiling beds and chairs. …