Результаты поиска

Моногенные заболевания почек и моногенный диабет присутствуют у пациентов почечной клиники с негенетическим диагнозом.

Генетические заболевания часто не признаются. В этом исследовании изучалось, как часто пациенты клиники почечных заболеваний, с негенетическим диагнозом и без семейной истории генетических заболеваний, зарегистрированных в последний раз. three У свиданий, у них была коренная генетическая форма болезни почек или диабета. Sixty-four Не связанные друг с другом пациенты из общей нефрологической клиники ()44 мужчина, 20 (женщины), средний возраст 66 годы (дальность 26 - 87) прошел обзор карты и полный отбор последовательности (ВВЦ). Результаты WES были отфильтрованы в случае одного нуклеотида, вызы

Factors determining utilization of stem cell transplant for initial therapy of multiple myeloma by patient race: exploring intra-racial healthcare disparities.

Multiple myeloma (MM) therapeutics have evolved tremendously in recent years, with significant improvement in patient outcomes. As newer treatment options are developed, stem cell transplant (SCT) remains an important modality that provides excellent disease control and delays the progression of disease. Over the years, SCT use has increased overall in the U.S., but two distinct gaps remain, including suboptimal use overall and racial-ethnic disparities. We evaluated the National Cancer Database (NCDB) to study what sociodemographic factors might play a role within a given racial-ethnic group

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… Facility factors indicated whether the type of facility care was at an academic or a community center according to the Commission on Cancer (CoC) accreditation category as used in the NCDB. …

Fostering next generation transplant physicians.

As opposed to the rapid expansion of hematopoietic cell transplantation (HCT) and other cellular therapies (CT), we are now facing a global shortage of transplant physicians and other professionals to support the activity of HCT/CT. To overcome this obstacle, a variety of approaches are now being undertaken in four international HCT societies. This article aims to share their current attempts to foster the next generation of transplant physicians and allied professionals needed to secure the continued global growth of HCT/CT.

Ассоциация увеита с педиатрическими аутоиммунными заболеваниями на основе исследования TriNetX.

Расследовать риск увеита среди таких пациентов. В ретроспективном когортном исследовании использовалась база данных TriNetX и были приняты на работу педиатрические аутоиммунные пациенты, диагностированные в период с января 1st 2004 и декабрь 31st 2022. Неавтоиммунная группа была произвольно выбрана пациентами-контролями в разбивке по полу, возрасту и индексу года. Главным результатом этого является появление новых увеитов. 175,328 Пациенты педиатрии с аутоиммунными заболеваниями (средний возраст) 10.7 +/- 5.1 годы; 55.8% - женщины; 66.2% Белый) и 175,328 Пациенты педиатрии без аутоиммунных заб

Early Use of Corticosteroids following CAR T-Cell Therapy Correlates with Reduced Risk of High-Grade CRS without Negative Impact on Neurotoxicity or Treatment Outcome.

BackgroundChimeric antigen receptor T-cell therapy (CAR T-cell therapy) is associated with potentially life-threatening toxicities, most commonly cytokine release syndrome (CRS) and immune-effector-cell-associated neurotoxicity syndrome (ICANS). These frequent adverse events are managed with the IL-6 receptor antagonist tocilizumab and/or corticosteroids. The prophylactic and early use of corticosteroids for CRS and ICANS have previously been reported, but eventual negative impacts on CAR T-cell efficacy are feared.MethodsRetrospective comparative analysis of two patient cohorts with hematolog

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… Management of Adults and Children Receiving CAR T-Cell Therapy: 2021 Best Practice Recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) Ann. …

Socioeconomic Factors and Survival of Multiple Myeloma Patients.

BackgroundOutcome of Multiple Myeloma (MM) patients has improved as the result of the introduction of novel medications and use of autologous hematopoietic cell transplantation. However, this improvement comes at the expense of increased financial burden. It is largely unknown if socioeconomic factors influence MM survival.MethodsWe used the National Cancer Database, a database that houses data on 70% of cancer patients in the US, to evaluate the effect of socioeconomic factors on the survival of 117,926 MM patients diagnosed between 2005 and 2014.ResultsPatients aged ≥65 years who were privat

Mobilising stakeholders to improve access to state-of-the-art radiotherapy in low- and middle-income countries.

In an ongoing effort to improve access to state-of-the-art radiotherapy in low- and middle-income countries (LMICs), a joint symposium was organised by the non-governmental, non-profit organisation Medical physicists in diaspora for Africa e.V. (MephidA e.V.) in collaboration with the Germany-based Cameroon-German medical doctor's association (Camfomedics e.V.) and the Harvard-based Global Health Catalyst summit. The goal of the symposium was to discuss the technical and structural challenges faced in African LMIC settings, re-evaluate strategies to overcome the shortfall of radiotherapy servi

Individualized, Single Session Yoga Therapy to Reduce Physical and Emotional Symptoms in Hospitalized Hematological Cancer Patients.

Objective: Inpatient treatment of hematological cancer is among the most physically and mentally arduous cancer treatments, and it is associated with a number of common physical, emotional, and social symptoms that can negatively affect quality of life (QOL) for years following treatment. While treating symptoms during hospitalization holds promise for improving long-term QOL, successful approaches likely require multidisciplinary interventions. In this article, we describe a 4-year effort in program enhancement that incorporated an adjunctive single yoga therapy session during treatment for h

Active Mycobacterium tuberculosis infection at a comprehensive cancer center, 2006-2014.

BackgroundMorbidity and mortality from Mycobacterium tuberculosis (Mtb) infection remain significant in cancer patients. We evaluated clinical characteristics, management, and outcomes in patients with active Mtb infection at our institution who had cancer or suspicion of cancer.MethodsWe retrospectively examined medical records of all patients with laboratory-confirmed active Mtb infection diagnosed between 2006 and 2014.ResultsA total of 52 patients with laboratory-confirmed active Mtb infection were identified during the study period, resulting in an average rate of 6 new cases per year. Th

Прогнозирующие биомаркеры для общего выживания пациентов, проходящих операцию на метастазах костей: исследование пан-ракера.

Быстрое диагностирование и прогнозируемая оценка метастаза костей (БМ) по-прежнему сопряжены с трудностями, поскольку большинство исследований и перспективных моделей концентрируются на одной первичной опухоли и пренебрегают биомаркерами, связанными с принимающей страной. Таким образом, это панраковое исследование было направлено на оценку метаболизма костей, провокационных и гематологических биомаркеров у пациентов, проходящих хирургическую операцию для БМ, выявление факторов риска для развития БМ и создание прогнозной номограммы. Потенциальная группа взрослых пациентов с гистологическим подт

GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol.

Autologous Stem Cell Transplant (ASCT) is increasingly used to treat hematological malignancies. A key requisite for ASCT is mobilization of hematopoietic stem cells into peripheral blood, where they are collected by apheresis and stored for later transplantation. However, success is often hindered by poor mobilization due to factors including prior treatments. The combination of G-CSF and GPC-100, a small molecule antagonist of CXCR4, showed potential in a multiple myeloma clinical trial for sufficient and rapid collection of CD34+ stem cells, compared to the historical results from the stand

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… In vivo studies Animals Studies were performed at a facility accredited by the Association for Assessment and Accreditation of Laboratory Animal Care and in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institute of Health. …

CART-Cell Therapy: Recent Advances and New Evidence in Multiple Myeloma.

Despite the improvement in survival outcomes, multiple myeloma (MM) remains an incurable disease. Chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA) represents a new strategy for the treatment of relapsed/refractory MM (R/R). In this paper, we describe several recent advances in the field of anti-BCMA CAR T-cell therapy and MM. Currently, available data on anti-BCMA CART-cell therapy has demonstrated efficacy and manageable toxicity in heavily pretreated R/R MM patients. Despite this, the main issues remain to be addressed. First of all, a significant pro

Characteristics and predictors of mortality of patients with hematologic malignancies requiring invasive mechanical ventilation.

RationaleAcute respiratory failure (ARF) may complicate the course of hematologic malignancies (HMs). Our objective was to study the characteristics, outcomes and predictors of mortality of patients with HMs who required intubation for ARF.MethodsThis retrospective cohort study evaluated all patients with HMs who were admitted to the Intensive Care Unit (ICU) of King Abdul-Aziz Medical City-Riyadh between 2008 and 2013 and required invasive mechanical ventilation. We noted their baseline characteristics, treatments and different outcomes. Multivariable logistic regression analysis was performe

Distress prior to undergoing hematopoietic stem cell transplantation: demographic and symptom correlations and establishing a baseline.

BackgroundDistress can arise from physical and/or psychosocial impairments and has been documented in patients after hematopoietic stem cell transplantation in the outpatient setting. It has not been evaluated in inpatients admitted to undergo the transplant, nor has potential correlations with length of hospital stay, physical function, and pain after receiving the transplant.ObjectivesTo measure distress in patients admitted to the hospital to undergo hematopoietic stem cell transplantation, and to evaluate potential correlations with length of hospital stay, physical function, pain, and dep

Расположение Мелфлюфа в организме пациентов, прошедших курс интенсивной предварительной терапии: реальные данные в мире в быстро меняющемся терапевтическом ландшафте.

Современная терапия явно ознаменовала историю множественной миэломы (ММ), что привело к неоспоримым преимуществам с точки зрения устойчивых мер реагирования и продолжительного выживания при постепенном повышении качества жизни пациентов. Тем не менее повторение заболеваний и устойчивость к имеющимся методам лечения подчеркивают важность выявления дополнительных вариантов лечения, особенно у пациентов с тяжелыми условиями лечения или в тех случаях, когда доступ к современной иммунотерапии ограничен. Мелфлюфен (мельфалан-флюфенамид) плюс дексаметасон были утверждены Европейским агентством по мед

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… However, while an increasing number of patients are able to access these advanced therapies, their use in clinical practice may still be influenced by factors such as eligibility criteria, logistical challenges, center accreditation requirements (for CAR‐Ts) and costs [ 25 , 26 , 27 ]. …

Early intrathecal dexamethasone and methotrexate as an effective approach for immune effector cell-associated neurotoxicity syndrome after CAR-T cell therapies.

INTRODUCTION: Chimeric antigen receptor T (CAR-T) cell therapies have demonstrated remarkable success in treating relapsed and refractory (R/R) B-cell hematological malignancies. Although the application of CAR-T therapy in acute myeloid leukemia (AML) is still restricted, we and other institutions have also demonstrated high complete remission rate of CAR-T targeting C-type lectin-like molecule 1 (CLL1) for R/R AML. However, CAR-T cell related toxicities such as steroid-refractory and severe immune effector cell-associated neurotoxicity syndrome (ICANS) can be life-threatening. Previous cases

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… Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA). …

Расширенный полиглутамин в ATAXIN1 приводит к потере функции, которая усугубляет остроту множественного склероза в модели мыши EAE.

Ataxin-1 (ATXN1) — белок, в котором расширение его полиглутаминового тракта вызывает нервно-дегенеративное расстройство спинномозговой системы 1 (SCA1) в результате повышения функциональности. Недавно было продемонстрировано, что АТXN1 дикая порода играет защитную роль в регулировании жесткости экспериментального аутоиммунного энцефаломиелита (EAE) — хорошо зарекомендовавшей себя модели мыши для мультиклероза (MS). В этом исследовании дополнительно изучается роль ATXN1 с расширенным полиглутаминым трактом в контексте MS с использованием модели мыши EAE.МЕТОДЫ: Гемизигиозные мыши Atxn1 (Atxn12Q

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… Mice were housed and managed by Research Animal Resources under specific pathogen-free conditions in an Association for Assessment and Accreditation of Laboratory Animal Care International approved facility. Food and water were provided ad libitum . …

A smartphone app to improve the safety of patients undergoing treatment with oral antineoplastic agents: 4 years of experience in a university hospital.

ObjectiveThis study aims to analyze the impact of the eOncosalud app on the management and follow-up of adverse effects (AE) in patients receiving oral antineoplastic agents.Material and methodsWe performed an observational, prospective study of cancer outpatients treated with oral antineoplastic agents (OAA), monitored by the eOncosalud app between August 2017 and October 2021. Safety variables were collected from eOncosalud: the number of AE; severity of the AE according to CTCAE, version 4.03; timelapse from app installation to first recorded AE; automatic recommendations issued; and the pa

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… International organizations such as the Institute for Safe Medication Practices (ISMP) ( 19 ) and the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) consider that OAA are high-risk drugs ( 20 ). OAA can produce AE with severe consequences, although half are preventable. …

Current and Future Role of Medical Imaging in Guiding the Management of Patients With Relapsed and Refractory Non-Hodgkin Lymphoma Treated With CAR T-Cell Therapy.

Chimeric antigen receptor (CAR) T-cells are a novel immunotherapy available for patients with refractory/relapsed non-Hodgkin lymphoma. In this indication, clinical trials have demonstrated that CAR T-cells achieve high rates of response, complete response, and long-term response (up to 80%, 60%, and 40%, respectively). Nonetheless, the majority of patients ultimately relapsed. This review provides an overview about the current and future role of medical imaging in guiding the management of non-Hodgkin lymphoma patients treated with CAR T-cells. It discusses the value of predictive and prognos

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… Management of Adults and Children Undergoing Chimeric Antigen Receptor T-Cell Therapy: Best Practice Recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (Jacie). …

Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer.

AimSSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.ResultsHigh levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.ConclusionIncreases in SSAT-1 contents in tumor tissue could be of value in targeting cancers with high SSAT-1 expression for confirmati