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Humoral immunity in natural infection by tick-borne encephalitis virus.

Tick-borne encephalitis (TBE) virus is one of the most important flaviviruses associated with neurological disease in Europe. Cross-reactive antibodies elicited by different flaviviruses can make difficult the interpretation of ELISA and hemagglutination-inhibition (HI) tests for the diagnosis of TBE. Neutralization tests, which are more specific, are not in common use because they are difficult to perform and standardize. A plaque reduction neutralization test (PRNT), optimized previously in vaccinated children, was evaluated in sera from acute cases of TBE, collected for diagnostic purposes,

Seroepidemiology of Toxoplasma gondii infection in psychiatric inpatients in a northern Mexican city.

BACKGROUND: Patients with psychiatric disorders were found to show a high seroprevalence of Toxoplasma gondii infection. There is scarce information about the epidemiology of T. gondii infection in psychiatric patients in Mexico. Therefore, we sought to determine the prevalence of T. gondii infection and associated socio-demographic, clinical and behavioural characteristics in a population of psychiatric patients in Durango City, Mexico. Seroprevalence in patients was compared with that obtained in a control population. METHODS: One hundred and thirty seven inpatients of a public psychiatric

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… Clinical data including blood transfusion or transplant history; and behavioral data including animal contacts, cleaning up cat faeces, foreign travel, kind of meat consumption (pork, lamb, beef, goat, boar, chicken, turkey, rabbit, deer, squirrel, horse, sea food, snake and bird), raw or undercooked … Factors associated with seropositivity In the bivariate analysis, seven variables were identified as possible risk factors associated with T. gondii infection: 1) sexual promiscuity (0.04); 2) unwashed raw fruit consumption (p = 0.06); 3) deer meat consumption (p = 0.07); 4) a history of surgery ( …

A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population.

STUDY QUESTION: Is there a difference in testicular function in early adulthood between men born with cryptorchidism and men born with norma … pean Union (Contract numbers BMH4-CT96-0314, QLK4-CT-1999-01422, QLK4-CT-2002-00603. FP7/2007-2013, DEER Grant agreement no. 212844); the Danish Ministry of Health; the Danish Environmental Protection Agency; A.P. Møller and wife Chastine McKinney Møllers Foundation; and Svend Andersens Foundation. None of the founders had any role in the study design, …

Weather, host and vector--their interplay in the spread of insect-borne animal virus diseases.

The spread of insect-borne animal virus diseases is influenced by a number of factors. Hosts migrate, move or are conveyed over long distanc … nt of vectors include West Nile, Rift Valley fever, yellow fever, epizootic haemorrhagic disease of deer and Akabane viruses.In devising means of control it is essential to decide the relationship of host, vector and virus and the nature of the zone in which the area to be controlled lies. Because of the continual risk of reintroduction of infected vec …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Antler Wine | Astragali Radix, Hippophae Fructus, Lycii Frustus, Polygonati Rhizoma, Panacis Quinquefolii Radix, Cervi Cornu Pantotrichum | G20141109 Luyuanchun Brand Horse Deer Antler Soft Capsules | Cervi Cornu Pantotrichum powder (irradiated) | G20160063 Overseas Brand Ma Deer Antler and Western … Antler and Western Ginseng Tablets | Cervi Cornu Pantotrichum powder (irradiated), Panacis Quinquefolii Radix extract | G20220217 Healthy Deer Sang Brand Ma Deer Antler Tablets | Cervi Cornu Pantotrichum (irradiated) | G20230116 Royal Shop Brand Xiyangshen Ma Deer Antler Wine | Cervi Cornu Pantotrichum …

Baseline Characteristics of Participants in the Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study: A Wake-Up Call for Action.

Background: Alberta Cancer Exercise (ACE) is a hybrid effectiveness-implementation study evaluating a cancer-specific community-based exercise program across urban sites in Alberta, Canada. The purpose of this paper is to describe the baseline characteristics of participants. Methods: Adults with any type and stage of cancer, who were undergoing cancer treatment or up to three years post treatment completion, were eligible. ACE was delivered in person at 18 sites across 7 cities in Alberta, with video conferencing introduced during the COVID-19 pandemic. Participants took part in 60 min of mil

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… Prior to the coronavirus disease (COVID-19) pandemic, the exercise programming was offered in seven Alberta cities (Calgary, Edmonton, Fort McMurray, Grande Prairie, Lethbridge, Medicine Hat and Red Deer). … Official in-person classes resumed in Edmonton, Calgary, and Red Deer in September 2021, and in Lethbridge in Winter 2022. Virtual group exercise class options continued to be offered through Calgary, Edmonton, Grande Prairie, and Red Deer sites. …

The Missing Link: Integrating Interventional Pain Management in the Era of Multimodal Oncology.

Cancer-related pain (CrP) is one of the most frequent and debilitating issues that affect the quality of life of patients with cancer. Systemic analgesics, particularly opioids, have been the cornerstone of pain management. However, the following shortcomings of the mentioned therapies, such as side effects, tolerance, and inadequate relief in refractory cases, make implementing a more complete, multimodal treatment plan necessary. Interventional pain management (IPM) uses specific invasive procedures, with different degree of invasiveness, such as nerve blocks, neurolysis, neuromodulation, an

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… Narouze S, Benzon HT, Provenzano D, Buvanendran A, De Andres J, Deer T, et al. … Deer TR, Pope JE, Hanes MC, McDowell GC. Intrathecal therapy for chronic pain: a review of morphine and ziconotide as firstline options. Pain Med Malden Mass. 2019;20(4):784–98. 107. Edra DAJPF, Luciano P, PhD VV, Marcos ASJ, Gustavo FC. …

In vitro and in vivo acaricidal properties of orally delivered ivermectin against the blacklegged tick, Ixodes scapularis.

BACKGROUND: The lack of effective and affordable new environmental tick control products is one of the major challenges to the existing control strategies against the blacklegged tick (Ixodes scapularis), the vector of Lyme disease affecting public health in the United States. Ivermectin is a systemic antiparasitic pesticide that has been used successfully to control biting flies and ticks infesting livestock. Ivermectin-treated corn has also been shown to be effective against adult ticks feeding on deer. The goal of this study was to assess acaricidal properties of orally delivered ivermectin…

Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population.

STUDY QUESTION: Is anogenital distance (AGD) associated with semen quality and reproductive hormones in men from the general population? SU … pean Union (Contract numbers BMH4-CT96-0314, QLK4-CT-1999-01422, QLK4-CT-2002-00603, FP7/2007-2013, DEER Grant agreement no. 212844); the Danish Ministry of Health; the Danish Environmental Protection Agency; A.P. Møller and wife Chastine McKinney Møllers foundation; and Svend Andersens Foundation. None of the funders had any role in the study design, …

Trichinellosis surveillance--United States, 2008-2012.

PROBLEM/CONDITION: Trichinellosis is a parasitic disease caused by nematodes in the genus Trichinella, which are among the most widespread z … 45 (54%) cases, including 41 (91%) that were linked with bear meat, two (4%) that were linked with deer meat, and two (4%) that were linked with ground beef. The source for 17 (20%) cases was unknown. Of the 51 patients for whom information was reported on the manner in which the meat product was cooked, 24 (47%) reported eating raw or undercooked mea …

Nitroaromatic munition compounds: environmental effects and screening values.

Available data on the occurrence, transport, transformation, and toxicity of eight nitroaromatic munition compounds and their degradation pr … hort-tailed shrew, white-footed mouse, meadow vole, cottontail rabbit, mink, red fox, and whitetail deer--were used to calculate NOAELs for oral intake. In the case of TNB, a comparison of toxicity data from studies conducted with both the white-footed mouse and the laboratory rat indicates that the white-footed mouse may be more resistant to the toxic …

Patient-Reported Outcomes with Peripheral Nerve Stimulation for Low Back Pain from Vertebral Plana Deformities: A Case Series.

Objectives: This study evaluated peripheral nerve stimulation (PNS) as a treatment for vertebra plana fractures, focusing on its impact on pain intensity, physical function, anxiety, depression, fatigue, social role participation, and pain interference. The goal was to assess whether PNS could serve as a minimally invasive alternative for managing pain in patients with severe vertebral fractures. Methods: Four patients with lumbar vertebra plana fractures received PNS implants for 60 days. Pain scores and PROMIS-29 domains (physical function, anxiety, depression, fatigue, social participation,

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… Deer T.R. Gilmore C.A. Desai M.J. Li S.C. DePalma M.J. Hopkins T.J. Burgher A.H. Spinner D.A. Cohen S.P. McGee M.J. Percutaneous Peripheral Nerve Stimulation of the Medial Branch Nerves for the Treatment of Chronic Axial Back Pain in Patients After Radiofrequency Ablation Pain. … Deer T.R. Grace W. Burgher A.H. Sayal P.K. Amirdelfan K. Treatment of chronic axial back pain with 60-day percutaneous medial branch PNS: Primary end point results from a prospective, multicenter study Pain. Pract. 2021 21 877 889 10.1111/papr.13055 34216103 PMC9290596 31. Abd-Elsayed A. …

Recent Advances in the Development and Utilization of Nanoparticles for the Management of Malignant Solid Tumors.

The purpose of nanotechnology-based drug delivery systems or novel drug delivery systems is to improve the effectiveness of therapy, and their promising properties have led to their increasing significance in the management of cancer. The researchers have primarily focused on designing novel nanocarriers, like nanoparticles (NPs), that can effectively deliver drugs to target cells and respond specifically to conditions particular to cancer. Whether passive or active targeting, these nanocarriers can deliver therapeutic cargoes to the tumor site to release the drug from the drug delivery system

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… antler extract NPs | Deer antler water extract | Prostate cancer | Nazarbek et al. [ 110 ] PLGA NPs | Brusatol and docetaxel | Prostate cancer | Adekiya et al. [ 111 ] AgCa-NPs | Carnosine | Colorectal cancer | Hsieh et al. [ 112 ] mPEG-PLA-NPs | Epirubicin | Colorectal cancer | Khan et al. [ 113 ] … Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells. Nazarbek G, Mu C, Shaimoldina A. J Funct Foods. 2024;115:106089. 111. PSMA-targeted combination brusatol and docetaxel nanotherapeutics for the treatment of prostate cancer. …

Early Interventional Treatments for Patients with Cancer Pain: A Narrative Review.

Between 10% and 20% of patients with cancer-related pain cannot achieve adequate control following the three-step ladder guidelines by the World Health Organization. Therefore, a "fourth step", including interventional approaches, has been suggested for those cases. Systematic reviews support the early use of interventional procedures to treat refractory cancer pain, control symptoms and prevent opioid dose escalation. There is strong evidence of the efficacy of celiac plexus or splanchnic neurolysis, vertebroplasty, kyphoplasty and intrathecal drug delivery. Those procedures have been found t

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… Smith TJ, Staats PS, Deer T, et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. … Deer TR, Pope JE, Hayek SM, et al. The Polyanalgesic Consensus Conference (PACC): recommendations on intrathecal drug infusion systems best practices and guidelines. Neuromodulation . 2017;20(2):96–132. doi: 10.1111/ner.12538 34. Dupoiron D, Duarte R, Carvajal G, Aubrun F, Eldabe S. …

Baseline Characteristics of Individuals with Metastatic Cancer Enrolled in the Alberta Cancer Exercise Study and 12-Week Findings for Symptom-Related and Physical Fitness Measures.

Exercise has been found to be safe and beneficial for people with advanced cancers, but more research is needed to understand how best to design and implement exercise programming. The Alberta Cancer Exercise (ACE) study examines the effectiveness and implementation of a 12-week community-based exercise program in Alberta, Canada, for people diagnosed with cancer. Here, we describe the characteristics of individuals with metastatic cancer enrolled in the ACE program and report 12-week changes in self-reported and objective outcomes. Of 306 participants, 274 (89.5%) completed the 12-week study.

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… Program Feasibility and Safety Exercise location and type: The ACE participants included in this analysis enrolled in exercise classes at the following study locations: Edmonton (n = 130, 42.5%), Calgary (n = 140, 45.8%), North Zone (Fort McMurray: n = 2, 0.7%; Grand Prairie: n = 8, 2.6%; Red Deer, … By location, the 12-week program attendance rates were 71.0% for Calgary, 76.5% for Edmonton, 71.6% for the North Zone (Fort McMurray: N/A; missing data for 2 participants; Grand Prairie: 78.8%; missing data for 3 participants; Red Deer: 68.3%), and 75.8% for the South Zone (Lethbridge: 81.8%; Medicine …

Surgical techniques for patients with cancer-related neuropathic pain.

In this manuscript, we discuss the use of neuromodulatory techniques such as intrathecal therapy (IT) and spinal cord stimulation (SCS) for cancer pain in neuro-oncology patients. Currently, cancer pain management relies on oral opioids, which have a number of systemic side effects particularly in a chronic setting. An escalation of pain therapy for pain relief, such as neuromodulation, is necessary to improve neuro-oncology patients' quality of life. The paper highlights the need for more comprehensive pain management for patients during and after receiving cancer therapies. IT allows analges

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… Deer TR, Pope JE, Hayek SM, et al. The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines. Neuromodulation. 2017;20(2):96–132. 17. Lamer TJ. Treatment of cancer-related pain: When orally administered medications fail. … Deer TR, Smith HS, Burton AW, et al. ; Center For Pain Relief, Inc. Center For Pain Relief, Inc. Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain. Pain Physician. 2011;14(3):E283–E312. 21. …

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… calf [ kaf ] 1. bovine young less than 1 year old. 2. young of other species including elephant, larger deer, e.g., red, Japanese sika, wapiti, elk, moose, reindeer, and also pinnipeds and cetaceans. 3. in dogs, refers to the region of the hindlimb between the stifle and the hock. bull c. male intact … campylognathia curved jaw, a rare congenital defect in Vorderwald calves in Europe and red deer in South America. Canaan dog a medium-sized (35–55 lb), spitz-type dog with a short, sandy to red brown, white or black coat, with white markings. …

Painful boney metastases.

Boney metastasis may lead to terrible suffering from debilitating pain. The most likely malignancies that spread to bone are prostate, breast, and lung. Painful osseous metastases are typically associated with multiple episodes of breakthrough pain which may occur with activities of daily living, weight bearing, lifting, coughing, and sneezing. Almost half of these breakthrough pain episodes are rapid in onset and short in duration and 44% of episodes are unpredictable. Treatment strategies include: analgesic approaches with "triple opioid therapy", bisphosphonates, chemotherapeutic agents, ho

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… Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. … Deer T, Krames ES, Hassenbusch SJ, Burton A, Caraway D, Dupen S, et al. Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. …

Diseases of the Nervous System

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Clinical Trials of Liposomes in Children's Anticancer Therapy: A Comprehensive Analysis of Trials Registered on ClinicalTrials.gov.

ObjectiveClinical trials have become essential for driving the development of medicine. However, little is known about the current status of clinical trials on liposomes in children's anticancer therapy (LCAT). This study aimed to synthesize current finding from clinical trials of LCAT in ClinicalTrials.gov.MethodsA cross-sectional descriptive study of clinical trials on LCAT was conducted, using studies registered on ClinicalTrials.gov through December 30, 2021.ResultsA total of 74 eligible trials were identified, accounting for 4.8% (74/1552) of all trials on liposomes for cancer therapy. Am

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… Nicholl A, Evelegh K, Deering KE, et al. Using a Respectful Approach to Child-centred Healthcare (ReACH) in a paediatric clinical trial: a feasibility study. PLoS One . 2020;15(11):e0241764. doi: 10.1371/journal.pone.0241764 23. Nik ME, Malaekeh-Nikouei B, Amin M, et al. …