Результаты поиска

The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.

BACKGROUND: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. METHODS: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardi

Совпадение в полном тексте источника
… Brian Reeves, MD Nasrollah Ghahramani, MD, MS Chuntao Wu, MD, PhD Georgia Brown Faulkner, RN, BSN Steering Committee Chair University of Iowa John B. Stokes, MD The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) . Paul L. …

Isolated Lesser Trochanter Fractures in Adults: A Systematic Review of Malignant, Infectious, and Benign Etiologies.

Isolated lesser trochanter (LT) fractures are uncommon in adults and may be the first clue to an underlying pathologic process. In contrast to adolescent apophyseal avulsions, the same finding in a skeletally mature patient has been linked to metastatic disease, primary bone tumors, hematologic malignancy, infection, and, less often, benign traumatic, stress-related, osteoporotic, or metabolic causes. This review examined the malignant, infectious, and benign etiologies, diagnostic pathways, treatments, and outcomes that have been reported in adults aged 18 years or older presenting with a rad

Совпадение в полном тексте источника
… lesser trochanter fracture in adults: an early indicator of tumor infiltration Orthop Traumatol Surg Res Rouvillain JL Jawahdou R Blanco OL Benchikh-El-Fegoun A Enkaoua E Uzel M 217 220 97 2011 21354885 10.1016/j.otsr.2010.11.005 14 Non-traumatic lesser trochanter avulsion: a report of three cases Iowa …

Personalized Lifestyle Interventions for Prevention and Treatment of Obesity-Related Cancers: A Call to Action.

The increasing global burden of cancer necessitates innovative approaches to prevention and treatment. Lifestyle factors such as diet, physical activity, and smoking significantly contribute to cancer. At the same time, current guidelines are based on a one-size-fits-all approach, which limits their effectiveness across diverse populations. Obesity is a well-documented risk factor for cancer, directly affecting 13 types of cancer. The complex interplay of genetic, metabolic, hormonal, and environmental factors in obesity's etiology highlights the need for more tailored approaches to obesity-re

Совпадение в полном тексте источника
… Intentional Weight Loss and Incidence of Obesity-Related Cancers: The Iowa Women’s Health Study. Int. J. Obes. Relat. Metab. Disord. 2003;27:1447–1452. doi: 10.1038/sj.ijo.0802437. 28. Schmitz K.H., Neuhouser M.L., Agurs-Collins T., Zanetti K.A., Cadmus-Bertram L., Dean L.T., Drake B.F. …

Opportunities and Challenges in Antibody-Drug Conjugates for Cancer Therapy: A New Era for Cancer Treatment.

The antibody, linker, and payload moieties all play a significant role in giving the ADC its unique therapeutic potential. The antibody subclass employed in ADCs is determined based on relative individual receptor affinities and pharmacokinetics. Meanwhile, the linker used in an ADC can either be cleavable or non-cleavable. ADC therapy comprises antibody-dependent mechanisms in addition to the direct cytotoxic effects of the payload. These include antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and antibody-dependent cellular phagocytosis, as well as the "bystander

Совпадение в полном тексте источника
… Iowa Orthop. J. 2006;26:154–158. 3. Strebhardt K., Ullrich A. Paul Ehrlich’s magic bullet concept: 100 Years of Progress. Nat. Rev. Cancer. 2008;8:473–480. doi: 10.1038/nrc2394. 4. The Nobel Prize in Physiology or Medicine 1908 NobelPrize.org. [(accessed on 10 February 2024)]. …

Pressure injury risk assessment for palliative care patients in the acute hospital setting: a scoping review.

BackgroundHospitalised palliative care patients are at risk of pressure injury. The development of pressure injuries causes physical and psychological distress for patients. Therefore, the prevention of hospital-acquired pressure injury is a nursing priority. The first step in prevention is conducting a risk assessment, which should be population-specific. In Australia, four palliative care phases guide care planning for appropriate clinical management of palliative care patients. In phases 1-3, the palliative patient cohort is based on acute care, where patients require medical treatment and/

Совпадение в полном тексте источника
… Hunters Hill” OR Norton OR Waterlow OR Walsall OR “clinical assessment*” OR “clinical judg*” OR “nurs* assess*”) # 5 | (MH “Clinical Assessment Tools”) OR (MH “Braden Scale for Predicting Pressure Sore Risk”) OR (MH “Gosnell Pressure Score Risk Assessment Instrument”) OR (MH “Pressure Ulcer Prevention (Iowa …

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

Совпадение в полном тексте источника
… control Effect of tro19622 in the treatment of patients with chemotherapy-induced peripheral neuropathy (CIPN) | NCT00876538 | Hoffmann-La Roche | Phase 2 | Taxanes | NS | Olesoxime ( TRO19622 ) vs. placebo Niagen and persistent chemotherapy-induced peripheral neuropathy | NCT04112641 | University of Iowa …

The challenge of chemotherapy-related cognitive impairment: assessing and managing cognitive decline after cancer treatment.

Chemotherapy-related cognitive impairment (CRCI) refers to a decline in cognitive function in patients during and after cancer treatment and is mainly associated with the use of cytotoxic chemotherapy (CT). As CT is still an essential component in the treatment of many cancers and taking into account the fact that cancer survival rates are increasing, CRCI may negatively impact the quality of life and working capacity of a growing number of individuals, especially those treated with curative intent in conditions such as breast cancer. There is still a need to address several issues related to

Совпадение в полном тексте источника
… (Iowa City: AJA Associates) Multilingual Aphasia Examination. 1998. 31. Stuss DT, Stethem LL, Poirier CA. Comparison of the three tests of attention and rapid information processing across six age groups. Clin Neuropsychol. 1987;1:139–52. doi: 10.1080/13854048708520046. 32. Wechsler D. …

Тенденции в области смертности, связанной с множественной миеломой в Соединенных Штатах, 1999-2023.

Несмотря на значительные терапевтические достижения, большое число миелом (ММ) по-прежнему является важным фактором смертности от рака в Соединенных Штатах. Понимание долгосрочных моделей смертности имеет важное значение для разработки справедливых стратегий в области клинического и общественного здравоохранения. 1999-2023 для оценки связанных с MM смертей среди взрослых ≥25 Годы. Коэффициенты смертности, скорректированные с учетом возраста, рассчитывались на основе прямой стандартизации 2000 Население США. Временные тенденции были изучены с использованием регрессии " Compoint " для

Совпадение в полном тексте источника
… 73 | 1407 | 52.08 | 6.45 (4.76 to 8.56) | 4.66 (3.64 to 5.88) | -0.84 (-1.68 to 0.01) Illinois | 487 | 407 | 11712 | -16.43 | 6.36 (5.79 to 6.92) | 3.96 (3.57 to 4.35) | -1.60 (-1.81 to -1.39)* Indiana | 225 | 251 | 6234 | 11.56 | 5.85 (5.09 to 6.62) | 4.62 (4.04 to 5.20) | -1.28 (-1.71 to -0.84)* Iowa …

Телемедицина в искусстве для лечения нейроразвитых и неврологических расстройств: аналитическая оценка.

БАКГРУС: Искусственная терапия, охватывающая арттерапию, музыкальную терапию, драматическую терапию и танцевальную терапию с более широкой практикой экспрессивной терапии, продемонстрировала положительные результаты в лечении нейроразвитых и неврологических расстройств (ННД). Все более важное значение для улучшения доступа людей с нарушениями подвижности или людей, проживающих в отдаленных районах, к средствам телемедицины приобретает интеграция методов лечения искусств. Цель этого исследования состоит в том, чтобы составить карту существующей литературы, с тем чтобы дать углубленный обзор тел

Совпадение в полном тексте источника
… The feasibility of group therapeutic singing telehealth for persons with Parkinson's disease in rural Iowa. Telemed. J. e-Health. 26, 64–68. doi: 10.1089/tmj.2018.0315, PMID: Tamplin J., Haines S. J., Baker F. A., Sousa T. V., Thompson Z., Crouch H., et al. (2024). …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome.

The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches are required. Intravenous (IV) Vitamin C (Vit-C) has emerged as one of the other alternatives for this purpose. Here we review the effects of IV Vit-C on the immune system response, the antiviral properties of IV Vit-C, and finally the antioxidant properties of IV Vit-C to specificall

Совпадение в полном тексте источника
… Accordingly, 5 trials are being conducted by scientists at Iowa University, 4 phase II studies and 1 phase IB/II trial. The 4 phase II clinical trials are focused to identify the efficiency of high-dose ascorbic acid combined with common anticancer molecules. …

Изучение ацетилхолинового разнообразия рецептора в нематодном паразите приводит к характеристике чувствительных к племени и дерквантель NAChR.

Никотинические ацетилхолинные рецепторы (NAChRs) паразитических нематод, необходимые для движения тела, являются объектами важных "классических" антеллиментов, таких как левамизол и пирантель, а также "новых" антеллиментов, таких как племянник и дерквантель. Four Биофизические подтипы NAChR наблюдались электрофизиологически в мышцах тела нематодового паразита Оэзофагостома, но их молекулярная основа не была понята. Кроме того, потери one подтипов (G) 35 PS) было установлено, что оно связано с сопротивлением левамизолу. В настоящем исследовании мы выявили и выразили в Ксенопус-оцитах: four О. г

Совпадение в полном тексте источника
… Jeff Beetham, Department of Vet Pathology, Iowa State University for assistance cloning the receptor subunits. References 1 Hotez PJ , Brindley PJ , Bethony JM , King CH , Pearce EJ , et al ( 2008 ) Helminth infections: the great neglected tropical diseases . …

Assisted reproductive technology surveillance--United States, 2011.

PROBLEM/CONDITION: Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of advan … ange: 46% in the District of Columbia to 82.7% in Oklahoma) among twins, and 97.1% (range: 76.9% in Iowa to 100% in several states) among triplets or higher-order multiples; comparable percentages for all infants were 10.1% (range:7.5% in Oregon to 16.6% in Puerto Rico), 57.3% (range: 46.8% in New Hampshire to 68.8% in Louisiana), and 93.4% (range: 73. …

Giant Cell Tumor of the Sacrum: A Narrative Review of Management Challenges and Modalities.

Background/Objectives: Sacral giant cell tumor of bone (GCTB) is a rare, mostly benign but locally aggressive neoplasm that carries significant diagnostic and treatment challenges due to its anatomic complexity, proximity to sacral nerve roots as well as the blood vessels, and potential impact on bowel, bladder, sexual, and lumbopelvic function and stability. This narrative review aimed to synthesize current evidence on the epidemiology, clinical presentation, diagnostic evaluation, classification, management strategies, outcomes, and surveillance of sacral GCTB. Methods: A focused literature

Совпадение в полном тексте источника
… Iowa Orthop. J. 2010;30:69–75. 3. Wang J., Li D., Yang R., Tang X., Yan T., Guo W. Epidemiological characteristics of 1385 primary sacral tumors in one institution in China. World J. Surg. Oncol. 2020;18:297. doi: 10.1186/s12957-020-02045-w. 4. Kalwaghe A., Phatak S., Mitra K., Onkar P., Gund S. …

RNA therapeutics in targeting G protein-coupled receptors: Recent advances and challenges.

G protein-coupled receptors (GPCRs) are the major targets of existing drugs for a plethora of human diseases and dominate the pharmaceutical market. However, over 50% of the GPCRs remain undruggable. To pursue a breakthrough and overcome this situation, there is significant clinical research for developing RNA-based drugs specifically targeting GPCRs, but none has been approved so far. RNA therapeutics represent a unique and promising approach to selectively targeting previously undruggable targets, including undruggable GPCRs. However, the development of RNA therapeutics faces significant cha

Совпадение в полном тексте источника
… ) miR-21 Alport syndrome Sanofi NCT03373786 (phase II) MRG-106 (Cobomarsen) miR-155 cutaneous T cell lymphoma/mycosis fungoides Fungoides miRagen Discontinued RG-101 miR-122 chronic hepatitis C Regulus Therapeutics Discontinued pSil-miR200c and PMIS miR-200a/c miR200a tooth extraction University of Iowa … Sanofi | NCT03373786 (phase II) MRG-106 (Cobomarsen) | miR-155 | cutaneous T cell lymphoma/mycosis fungoides | Fungoides miRagen | Discontinued RG-101 | miR-122 | chronic hepatitis C | Regulus Therapeutics | Discontinued pSil-miR200c and PMIS miR-200a/c | miR200a | tooth extraction | University of Iowa …

Полиморфизм HLA в нейроиммунных болезнях: увязка представления антигенов с нейроинфламматическими программами.

Полиморфизм человека антигена лейкоцита (HLA) формирует антигенное представление и подверженность иммунизированным заболеваниям. В нейроиммунных расстройствах главный вопрос заключается в том, как зависимость от HLA антигенная видимость превращается в специфический иммунитет от болезней и повреждение тканей. В этом Обзоре мы интегрируем генетические, молекулярные, клеточные и клинические данные по множеству склерозов (MS), расстройству спектра нейромиелитов, синдрому Гильен-Барре, нарколепсии, аутоиммунальному энцефалиту и миастении гравис. :: HLA-DR15-MS Ось является наиболее механистически р

Совпадение в полном тексте источника
… Mangalam , University of Iowa Carver College of Medicine, United States Reviewed by: Belinda Kaskow , Perron Institute for Neurological and Translational Science, Australia Michael R. …

Engineering Next-Generation CAR-T Cells for Better Toxicity Management.

Immunoadoptive therapy with genetically modified T lymphocytes expressing chimeric antigen receptors (CARs) has revolutionized the treatment of patients with hematologic cancers. Although clinical outcomes in B-cell malignancies are impressive, researchers are seeking to enhance the activity, persistence, and also safety of CAR-T cell therapy-notably with a view to mitigating potentially serious or even life-threatening adverse events like on-target/off-tumor toxicity and (in particular) cytokine release syndrome. A variety of safety strategies have been developed by replacing or adding variou

Совпадение в полном тексте источника
… Coley and the Treatment of Bone and Soft-Tissue Sarcomas Iowa Orthop. J. 2006 26 154 158 16789469 PMC1888599 2. Köhler G. Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity Nature 1975 256 495 10.1038/256495a0 1172191 3. Mach J.-P. …

Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function.

Estrogens exert their physiological and pathophysiological effects via cellular receptors, named ERα, ERβ, and G-protein coupled estrogen receptor (GPER). Estrogen-regulated physiology is tightly controlled by factors that regulate estrogen bioavailability and receptor sensitivity, while disruption of these control mechanisms can result in loss of reproductive function, cancer, cardiovascular and neurodegenerative disease, obesity, insulin resistance, endometriosis, and systemic lupus erythematosus. Restoration of estrogen physiology by modulating estrogen bioavailability or receptor activity

Совпадение в полном тексте источника
… EJF acknowledges funds from the Department of Surgery at the University of Iowa. AKS is the Lyle and Sharon Bighley Chair in Pharmaceutical Sciences. …

Нейропсихологические аспекты расстройств контроля импульсов в болезни Паркинсона.

Синдромы импульсного контроля (ИДД), такие, как чрезмерные азартные игры, навязчивое сексуальное поведение, поедание бингов, навязчивые покупки, а также синдром регулирования дофамина, могут возникать как изнурительное нервно-психическое осложнение болезни Паркинсона (PD). Хотя патофизиология не в полной мере понятна, она, вероятно, включает мезолимбичную допаминергическую чрезмерную оптимизацию в сочетании с факторами уязвимости, связанными с заболеваниями, в плане поощрения, мотивации и ингибиционных сетей контроля. В настоящем описательном обзоре резюмируются данные о нейропсихологических,

Совпадение в полном тексте источника
… One widely used paradigm to assess it is the Iowa Gambling Task (IGT), which requires considering immediate rewards against long-term losses ( Antonelli et al., 2011 ). …

Более широкие соображения в отношении интеграции медицинских и стоматологических данных

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… (Wolfe et al. 2006 ) reported that 76% of licensed general dentists in Iowa were familiar with the AAPD age 1 dental visit recommendation and that most obtained the information through continuing education; 11% believed that the first dental visit should occur between 0 and 11 months of age. …

Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations.

Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA damage and other effects important in cancer transformation. Dietary vitamin C from natural sources is taken with other compounds affecting its bioavailability and biological effects. High pharmacological doses of vitamin C may induce prooxidant effects, detrimental for cancer cells. An oxidized form of vitamin C, dehydroascorbate, is transported through glucose transporters, and cancer cells switch from oxidative phosphorylation to glycolysis in energy production so an excess of vitamin C may limit glucose tr

Совпадение в полном тексте источника
… The Iowa Women's Health Study. American journal of epidemiology. 1996;144(2):165–174. doi: 10.1093/oxfordjournals.aje.a008904. 53. Lin J., Cook N. R., Albert C., et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. …