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Gut immune functions and health in Atlantic salmon (Salmo salar) from late freshwater stage until one year in seawater and effects of functional ingredients: A case study from a commercial sized research site in the Arctic region.

The present study was conducted to strengthen the knowledge on gut immune functions and health in Atlantic salmon under large scale, commercial conditions in the Arctic region of Norway. Two groups of fish were monitored, one fed a series of diets without functional ingredients (Ref) and the other diets with functional ingredients (Test). The nutritional composition of the two diet series varied in parallel according to the nutrient requirements of the fish during the observation time. The content of functional ingredients in the Test diets, i.e. nucleotides, yeast cell walls, a prebiotic and

Exploring medical food supplementation as an adjunct strategy for microbiota restoration and seizure reduction in CDKL5 deficiency disorder.

OBJECTIVES: CDKL5 deficiency disorder (CDD) is a developmental and epileptic encephalopathy characterized by early-onset, treatment-resistant seizures and severe neurodevelopmental impairment. Increasing evidence suggests that alterations in the gut-brain axis may contribute to disease pathophysiology, raising interest in microbiota-targeted interventions. In this study, we evaluated the effects of a prebiotic-based nutritional intervention on clinical outcomes, gut microbiota composition, and fatty acid profiles in individuals with CDD. METHODS: Thirteen participants with drug-resistant epil

Comparative effects of mannanoligosaccharides, fructooligosaccharides, and potato resistant starch on intestinal integrity, antioxidant status, and cecal microbiota in commercial laying hens.

BACKGROUND AND AIM: Functional carbohydrates are increasingly used as alternatives to antibiotic growth promoters because of their ability to modulate intestinal health and microbial populations. However, comparative information regarding the effects of structurally different prebiotic compounds in laying hens remains limited. This study aimed to compare the effects of mannanoligosaccharides (MOS), fructooligosaccharides (FOS), and potato resistant starch (RS) on productive performance, intestinal integrity, antioxidant status, intestinal morphology, and cecal microbiota in commercial laying h

A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer.

BACKGROUND: Radiation induced proctitis is frequently encountered during the radiation therapy of cervical and prostate cancers that causes pain and occasionally with bleeding and may affect the continuity of radiation therapy. AIMS AND OBJECTIVES: The purpose of the study is to look at the benefit of administration of an oral prebiotic amylase resistant starch in reducing the incidence of acute radiation proctitis, a distressing symptom in patients receiving radiation therapy for cancer of the cervix. MATERIAL AND METHODS: The study was conducted between 2011 and 2014 in 104 patients receiv

Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT-1/Nrf-2 and Gut Microbiota in Rats.

SCOPE: Non-alcoholic fatty liver disease (NAFLD) is a common disease that is concomitant with obesity, resulting in increased mortality. To date, the efficiency of NAFLD treatment still needs to be improved. Therefore, we aimed to evaluate the effect of Lactobacillus mali APS1, which was isolated from sugary kefir, on hepatic steatosis in rats fed a high-fat diet (HFD). METHODS AND RESULTS: Sprague Dawley rats were fed a control diet, a HFD with saline, and a HFD with APS1 intervention by gavage daily for 12 weeks. The results showed that APS1 significantly reduced body weight and body weight

Management of functional constipation in children and adults.

Functional constipation is common in children and adults worldwide. Functional constipation shows similarities in children and adults, but important differences also exist regarding epidemiology, symptomatology, pathophysiology, diagnostic workup and therapeutic management. In children, the approach focuses on the behavioural nature of the disorder and the initial therapeutic steps involve toilet training and laxatives. In adults, management focuses on excluding an underlying cause and differentiating between different subtypes of functional constipation - normal transit, slow transit or an ev

Gut microbiota in necrotizing enterocolitis: a bibliometric and visualization analysis.

BACKGROUND: Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease affecting neonates, especially preterm and very low birth w … e prominently features keywords such as "premature infants," "pathogenesis," "breast milk," "NEC," "prebiotics," "probiotics," and "gut microbiota," while topics such as "inflammatory bowel disease" and "immune system" highlight a shift in research priorities, with an increasing focus on understanding pathological mechanisms and therapeutic interventions. C …

Mutation analysis of therapy-related myeloid neoplasms.

We analyzed the genetic mutation status of 13 patients with therapy-related myeloid neoplasms (t-MN). Consistent with previous reports, t-MN cells preferentially acquired mutations in TP53 and epigenetic modifying genes, instead of mutations in tyrosine kinase and spliceosome genes. Furthermore, we compared the mutation status of three t-MN cells with each of the initial lymphoid malignant cells, and identified common mutations among t-MN and the initial malignant cells in two patients. In a patient who developed chronic myelomonocytic leukemia (CMML) after follicular lymphoma (FL), TET2 mutat

Anaerobes as Sources of Bioactive Compounds and Health Promoting Tools.

Aerobic microorganisms have been sources of medicinal agents for several decades and an impressive variety of drugs have been isolated from … a is believed to alleviate some of these serious health problems. Indeed, the use of probiotics and prebiotics which favourably change the number and composition of the gut microflora is known to render a health promoting effect. Our interaction with the microbiome anaerobes is complex. In fact, not only our lives but also our identities are more closely lin …

Poria cocos polysaccharides alleviate colitis via the tryptophan metabolism-AhR-redox axis.

ETHNOPHARMACOLOGICAL RELEVANCE: Poria cocos (Fuling), a classic edible and medicinal fungus with a 2000-year clinical application history in traditional Chinese medicine, is well-documented for its core efficacies of "invigorating the spleen and relieving diarrhea", which is highly consistent with the core clinical manifestations of infectious colitis including persistent diarrhea, intestinal barrier impairment and mucosal inflammation. Poria cocos polysaccharides (PCP) are recognized as the primary bioactive component of Poria cocos, with proven anti-inflammatory and immunomodulatory activiti

A novel cholesterol-reducing mechanism of polygonati rhizoma: Dual action via Bacteroides-mediated cholesterol sulfonation and feedback inhibition of ACAT2 by sulfated metabolite.

ETHNOPHARMACOLOGICAL RELEVANCE: Polygonati Rhizoma (PR) has the function of "invigorating spleen and tonifying kidney", and is historically applied as a homology of medicine and food to prevent and treat dyslipidemia in China. However, there is limited experimental evidence to support this application, and the underlying mechanism has not been fully deciphered. AIM OF THE STUDY: To analyze the composition and illuminate the cholesterol-lowering potential and molecular mechanism of PR's aqueous extract (PRE) in high-fat emulsion (HFE)-induced hypercholesterolemia mouse model. MATERIALS AND ME

[Detection and analysis of intestinal flora diversity in patients with complex anal fistula].

Objective: To explore the possibility that the intestinal flora profile in complex anal fistula patients is different to that of healthy con … such as actinomycosis and tuberculosis) were also excluded, as were those who had used antibiotics, prebiotics, or probiotics that may affect intestinal microecology in the month prior to the study. Total bacterial genomic DNA was extracted by PCR amplification of the V4 hypervariable region of the 16S rRNA sequences. High-throughput sequencing and data anal …

MR-CISD investigation (including extensivity corrections) of Rydberg n-3 s and n-3p states of the smallest ionized HCl-water cluster.

CONTEXT: The [H3O(H2O)3]+Cl- ion-pair is the smallest cluster of ionized HCl in water. It has been demonstrated experimentally that it can be formed in conditions compatible with the interstellar medium (ISM). It is also a precursor of another ion-pair, H3O+(MetOH)3Cl-, suggested as an important prebiotic species in the ISM. Aiming to help the detection of the former ion-pair several properties of its n-3 s and n-3p singlet and triplet Rydberg states have been studied through a highly correlated ab-initio method. The vertical excitation energies (ΔEv), oscillator strengths (f), dipole moments

Роль микробиомы в множестве миелом: новые знания и терапевтические возможности.

Множественная миелома — гематологический рак, описываемый распространением плазменных клеток в костном мозге, что вызывает иммунную дисфункцию и другие аномалии. Микробиом кишечника, микробное сообщество в желудочно-кишечном тракте, было обнаружено, что он модифицирует системный иммунитет, воспаление и метаболизм. Хотя взаимосвязь между кишечным микробиомом и множеством миелома была обнаружена в недавних исследованиях, существует пробел в знаниях, связывающий воздействие микробиома на патогенез и лечение множественной миеломы. Несбалансированность в кишечном микробиоме, дисбиозе, может влиять

Совпадение в полном тексте источника
… Probiotics and Prebiotics Probiotics and prebiotics offer non-invasive alternatives to FMT for modulating the gut microbiome. … Modulation of the gut microbiome through probiotics, prebiotics, or fecal microbiota transplantation represents a promising avenue that may improve MM treatment. …

Терапия клеток CAR-T и модуляция микробиоты в мультислерозе: новые терапевтические стратегии и текущие ограничения.

Множественный склероз (MS) — хроническое аутоиммунное воспалительное заболевание центральной нервной системы (CNS), характеризующееся разрушением миелиновой оболочки вокруг нервных клеток. Широкое распространение и серьезные последствия НР свидетельствуют о недостатках существующих методов лечения и о важности разработки новаторских терапевтических подходов. На основе успешных экспериментальных исследований среди пациентов и экспериментальной модели мышью аутоиммунного энцефаломиелита (EAE) клетки CAR-T предлагают новый терапевтический механизм путем непосредственной адресации и ликвидации кле

Совпадение в полном тексте источника
… The Immune-Enhancing Effects of Dietary Fibres and Prebiotics. Br. J. Nutr. 2002;87:221–230. doi: 10.1079/BJNBJN/2002541. 115. Yoo S., Jung S.-C., Kwak K., Kim J.-S. The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health. Int. J. Mol. … Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9:1021. doi: 10.3390/nu9091021. 117. Andersson H., Asp N.-G., Bruce Å., Roos S., Wadström T., Wold A.E. Health Effects of Probiotics and Prebiotics A Literature Review on Human Studies. …

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation.

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective treatment for patients with high-risk hematologic malignancies. Over the last decade, gut microbiota composition during allo-HCT has been associated with patients' outcomes. Treatment-related factors, in particular the use of broad-spectrum antibiotics and the conditioning regimen, frequently induce gut dysbiosis, which is associated with immune dysregulation, toxicity, and adverse outcomes, particularly after allo-HCT. Microbial metabolites further modulate immune responses and therapeutic efficacy. Emerging microbiota-t

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… Prebiotics, and Nutrition Support Prebiotics are substrates that resist digestion by the host but can be metabolized by beneficial gut bacteria. The primary prebiotics are resistant starches, fructooligosaccharides (including inulin), and galactooligosaccharides. … Finally, a pilot study compared outcomes between patients who received standard EN ( n = 10) versus prebiotic fiber EN ( n = 20) after allo‐HCT. …

Sheep Milk Symbiotic Ice Cream: Effect of Inulin and Apple Fiber on the Survival of Five Probiotic Bacterial Strains during Simulated In Vitro Digestion Conditions.

We conducted a study to determine the survival of bacterial cells under in vitro digestion. For this purpose, ice cream mixes were prepared: … icated that sheep milk ice cream could provide a suitable matrix for the delivery of probiotics and prebiotics and contribute to intestinal homeostasis. The obtained results have an applicative character and may play an essential role in developing new functional sheep milk ice cream.

Gut microbiota shapes cancer immunotherapy responses.

The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.

Совпадение в полном тексте источника
… Diet and prebiotics, such as inulin gel, pectin, high-fiber diets, fasting-mimicking diets, and ketogenic diets, contribute to microbiota modulation and immune system support. … Prebiotics improve epithelial integrity, enhance mucosal barrier function, and activate innate immune cells, contributing to improved immunotherapy outcomes 345 – 348 . …

Влияние жизненных поступков, способствующих укреплению здоровья, на микробиоту у выживших жертв гематологического рака: обзор скопирования.

Целью этого аналитического обзора является изучение взаимосвязи между поведением, способствующим здоровому образу жизни, и микробиотой кишечника у выживших жертв гематологического рака, включая лейкемию, лимфому и множественную миелому. С учетом растущего числа таких случаев и связанных с этим проблем с лечением понимание того, как факторы образа жизни влияют на состояние здоровья, может дать представление о том, как улучшиться состояние выживших жертв. МЕТОДЫ: Мы провели всеобъемлющий поиск по нескольким базам данных, включая PubMed/Medline, CINAHL и Scopus, вслед за предпочтительными элемент

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… Fecal butyrate concentration was maintained or increased more frequently in the prebiotics group. | Prebiotic intake mitigated oral mucositis and reduced the duration of diarrhea in the early phase after allo‐HCT. … The incidence of all grades of acute GvHD and Grades 2–4 acute GvHD was significantly lower in the prebiotics group compared to the control group. The cumulative incidence of acute skin GvHD was markedly decreased in the prebiotic group compared to controls. …

Обнаружить важную роль гута микробиота и диета в многоразовом склерозе.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы (CNS), характеризующееся нейродегенерацией, повреждением аксона, обезвоживанием и воспалением. В последнее время кишечный дисбиоз связан с MS и другими аутоиммунными условиями. А именно, кишечная микробиота играет жизненно важную роль в регулировании иммунной функции, оказывая влияние на развитие иммунных клеток, производство цитокина и целостность кишечника. В то время как сбалансированная микробиота способствует иммунной терпимости, дисбиоз нарушает иммунное регулирование, наносит ущерб проницаемо

Совпадение в полном тексте источника
… Prebiotics Prebiotics are products that intestinal bacteria in hosts use to support the survival and activity of particular bacterial genera and species [ 164 , 165 ]. They are mostly galactans and inulin [ 165 ]. … prebiotics as promising therapeutic candidates for further research on EAE and MS [ 170 ]. 4.3. …