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Staged Correction of Severe Thoracic Kyphosis in Patients with Multilevel Osteoporotic Vertebral Compression Fractures.

Study Design Technical report. Objective Multilevel osteoporotic vertebral compression fractures may lead to considerable thoracic deformity and sagittal imbalance, which may necessitate surgical intervention. Correction of advanced thoracic kyphosis in patients with severe osteoporosis remains challenging, with a high rate of failure. This study describes a surgical technique of staged vertebral augmentation with osteotomies for the treatment of advanced thoracic kyphosis in patients with osteoporotic multilevel vertebral compression fractures. Methods Five patients (average age 62 ± 6 years)

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… Regarding the fixation rods, we preferred to use the stiffer CoCr rods over titanium or stainless steel alloys. … Would CoCr rods provide better correctional forces than stainless steel or titanium for rigid scoliosis curves? J Spinal Disord Tech. 2013;26(2):E70–E74. doi: 10.1097/BSD.0b013e31826a0f19. 53. Lamerain M, Bachy M, Delpont M, Kabbaj R, Mary P, Vialle R. …

Carbon-Fiber-Reinforced PEEK Intramedullary Nails Defining the Niche.

BackgroundCarbon-fiber-reinforced Polyetheretherketone (CFR-PEEK) nails are gaining interest as they have biomechanical properties potentially capable of overcoming disadvantages of conventional metal nails.Case summaryThree cases are illustrated which required superior mechanical toughness, compatibility with radiotherapy, and postoperative advanced imaging.ConclusionCFR-PEEK nails seem to have a niche role in distinct groups of patients.

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… Introduction There is no doubt that metals like stainless steel, cobalt-chrome, and titanium alloys have changed the face of orthopaedics over the last decades. … Discussion For the majority of long bone fixations, titanium alloy and stainless steel nails will produce satisfactory outcomes. There are, however, specific clinical scenarios in which the biomechanical properties of CFR-PEEK nails can address the pitfalls associated with these types of nails. …

Разработка и оценка мягкой одежды для обнаружения и контроля виртуальной окружающей среды на основе SEMG.

По мере увеличения числа лиц, диагностированных нейродегенеративными расстройствами (НД), возрастает потребность в повышении как количества, так и качества подходов, используемых для лечения этих изнурительных заболеваний. Прогресс ND может вызывать мышечную слабость нижних или верхних конечностей. Мы уделяем особое внимание площади верхней конечности, в частности реабилитации сцепления, путем разработки системы (VRGrip), которая может надежно регистрировать электромиографические (EGM) события ручных мышц сгибания, чтобы контролировать адаптивную и игру с помощью хватки. Цель этого исследовани

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… Then, 2.5 cm × 2.5 cm pieces of conductive hook tape were sewn onto the scuba neoprene using silver-coated polyester conductive thread as the top thread, and stainless steel thread as the bottom thread, in a “Y” orientation [ 16 ]. … Each stem was saturated with stainless steel flux for five minutes and then covered with lead-free solder to create a wire-like connection to the circuit board (see Figure 1 ). …

COVID-19: A 2020 update

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… They should only be adjusted secondary to clinical judgment with significant regard for hemodynamic status. [ 8 ] Viable virus particles were detected at 72 h on most surfaces, with longer viability detected on stainless steel and plastic. [ 7 , 9 ] Household disinfectants, particularly those containing … Viability was detected at 72 h on most surfaces, with more favorable durability on stainless steel and plastic. [ 7 , 9 ] These data about virus viability and destruction are similar to prior knowledge of other pathogenic coronaviruses – SARS-CoV-2 and MERS-CoV. …

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

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… This is in agreement with previous studies showing superior patency outcomes with the new generation nitinol stents compared to stainless-steel stents [ 100 , 101 ]. … Primary patency of femoropopliteal arteries treated with nitinol versus stainless steel self-expanding stents: propensity score-adjusted analysis. Radiology. 2004;232:516–21. doi: 10.1148/radiol.2322031345. 101. Hayerizadeh R, Zeller T, Krankenberg H, et al. …

Флунаризин предотвращает демиелинцию и неврологические недостатки в модели мыши, вызванной купризоной, множественного склероза.

КОНТЕКСТ: Множественный склероз (MS) является наиболее распространенным демиелинизирующим заболеванием центральной нервной системы, где демиелинация происходит одновременно с аксонным и нейронным дегенерацией. Текущие методы лечения ориентированы главным образом на иммуномодуляцию и борьбу с симптомами, при этом их эффективность в том, чтобы остановить или обратить вспять демиэлизацию, невелика. Найти лекарственные средства для лечения прогрессирующего заболевания по-прежнему является самой большой неудовлетворенной потребностью людей с НР. МАТЕРИАЛЫ И МЕТОДЫ: Демиелинация вызывается у швейцар

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… These animals were housed in polypropylene cages having stainless steel lids with the provisions for keeping food and drinking water. Husk was used as bedding material, and the animals were housed for 7 days before the start of the experiment. … The procedure was done on the day before treatment and repeated on the 3 rd and 6 th week.[ 20 ] Evaluation of effect on cognition by shuttle box avoidance test The study involved training mice on a shuttle box with two compartments separated by a wooden wall and a stainless-steel grid floor. …

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions.

Percutaneous-reinforced osteoplasty is currently being investigated as a possible therapeutic procedure for fracture stabilization in high-risk patients, primarily in patients with bone metastases or osteoporosis. For these patients, a percutaneous approach, if structurally sound, can provide a viable method for treating bone fractures without the physiologic stress of anesthesia and open surgery. However, the low strength of fixation is a common limitation that requires further refinement in scaffold design and selection of materials, and may potentially benefit from tissue-engineering-based

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… To overcome this limitation, in one study, a metallic mesh containing 25 to 50 medical-grade stainless steel microneedles was inserted at the site of the metastatic lesion; this was followed by PMMA cement injection to create an overall “rebar” structure for repairing humeral head metastasis [ 21 ]. … Figure 3 Percutaneous augmented osteoplasty with a metallic mesh containing 25–50 medical-grade stainless steel microneedles and PMMA cement [ 13 , 21 ]. …

Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody.

BACKGROUND: The blood-brain barrier (BBB) presents a major challenge for the development of monoclonal antibody (mAb)-based therapies for brain disorders. To improve the likelihood of success of such therapies, Roche Brainshuttle technology utilizes a single anti-transferrin receptor 1 (TfR1)-antigen-binding antibody fragment linked to a therapeutic antibody, allowing engagement with TfR1 to transport the therapeutic antibody into the brain via receptor-mediated transcytosis. METHODS: We compared Fc-silenced and Fc-competent variants of the Brainshuttle and the parental (non-shuttled) type II

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… Animals were paired and housed in stainless steel pens containing wood chips and environmental enrichment consisting of coloured plastic tools, coloured plastic balls, and stainless‐steel mirrors. … Animals were housed in groups of 2–4 in pens containing wood shavings and environmental enrichment consisting of perches, plastic toys, balls, climbing frames, and stainless‐steel mirrors. …

Clinical performance of implanted devices used in surgical treatment of patients with spinal tumors: a systematic review.

PURPOSE: Implanted devices used in metastatic spine tumor surgery (MSTS) include pedicle screws, fixation plates, fixation rods, and interbody devices. A material to be used to fabricate any of these devices should possess an array of properties, which include biocompatibility, no toxicity, bioactivity, low wear rate, low to moderate incidence of artifacts during imaging, tensile strength and modulus that are comparable to those of cortical bone, high fatigue strength/long fatigue life, minimal or no negative impact on radiotherapy (RT) planning and delivery, and high capability for fusion to

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… Ti6Al4V has replaced stainless steel due to its higher corrosion and fatigue resistance, lower density and lower modulus of elasticity (E) [ 17 ]. However, Ti6Al4V has some shortcomings, including a larger E compared to that of cortical bone (respectively 110 GPa vs. 17–21 GPa). … steel)) OR (polyetheretherketone)) OR (hydroxyapatite)) OR (radiolucent))) AND ((((((radiotherapy) OR (magnetic resonance imaging)) OR (computed tomography)) OR (radiotherapy)) OR (magnetic resonance imaging)) OR (computed tomography)). …

Proceedings of the CIMAGO Congress - Environment, Genetics and Oncobiology in the 21st Century - Challenges and Opportunities.

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… Nitinol, Ti-based alloys, and several stainless steel (SS) grades are widely used for manufacturing fixed appliances that will remain inside the oral cavity for approximately 2 years. …

What Are the Challenges and Complications of Sterilizing Autografts with Liquid Nitrogen for Malignant Bone Tumors? A Preliminary Report.

BACKGROUND: Reconstruction of defects after resection of malignant bone tumors with liquid nitrogen-sterilized recycled autografts is an alternative to bone allografts and endoprostheses in resource-constrained environments. Most studies reporting favorable outcomes with liquid nitrogen-sterilized autografts for bone reconstruction are geographically restricted to a few countries, and the technical challenges of routinely using liquid nitrogen intraoperatively, especially when using the pedicle freezing technique, has not been documented. QUESTIONS/PURPOSES: (1) What are the technical challen

Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population.

Several clinical examinations have shown the essential impact of monitoring (de)hydration (fluid and electrolyte imbalance) in cancer patients. There are multiple risk factors associated with (de)hydration, including aging, excessive or lack of fluid consumption in sports, alcohol consumption, hot weather, diabetes insipidus, vomiting, diarrhea, cancer, radiation, chemotherapy, and use of diuretics. Fluid and electrolyte imbalance mainly involves alterations in the levels of sodium, potassium, calcium, and magnesium in extracellular fluids. Hyponatremia is a common condition among individuals

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… Illustration for the working electrode (WE): 1, stainless steel; 2, carbon covering; 3, f‐MWCNTs; 4, K + sensitive layer. … Most recently, Parrilla et al. developed a wearable microneedle patch for intradermal potentiometric detection of K + in ISF using a K + selective sensor (Figure 7I ), which allows for continuous and real‐time intradermal monitoring of K + in individuals. 22 Stainless steel microneedles supported on …

Influence of oral health on mucositis in patients undergoing hematopoietic progenitor cell transplantation (HPCT).

AimsTo establish whether or not the state of patient oral health can influence the occurrence and/or severity of oral mucositis during hematopoietic progenitor cell transplantation (HPCT).Materials and methodsThe study included 72 patients awaiting HPCT. Prior to transplantation, clinical exploration and radiology were carried out and oral photographs were taken. This evaluated the extent of caries present, the number of missing teeth and the number of dental fillings in each patient; CAO (Caries and Obturations Index) DMFS (Decayed, Missing, and Filled Surfaces) and Restoration Indices were c

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… The exploration kit consisted of: two dental mirrors with stainless steel handles (Roeko®) and Nº 5 mirror (Actual®), dental tweezers 2885 (Martin®), a 17-22 (Hu-Friedy®) exploratory probe and a PCP 11 5B (Hu-Friedy®) periodontal exploratory probe. …

Balloon kyphoplasty in the treatment of metastatic disease of the spine: a 2-year prospective evaluation.

There is currently little data on the longer term efficacy and safety of balloon kyphoplasty (BKP) in patients with metastatic vertebral compression fractures (VCFs). To prospectively assess the long-term efficacy and safety of BKP in treating thoracic and lumbar spinal metastatic fractures that result in pain or instability. Sixty-five patients (37 men, mean age: 66 years) underwent 99 BKP procedures. Patient-related outcomes of pain visual analogue scale (VAS) and Oswestry Disability Index were assessed pre- and post-operatively and after 3, 6, 12 and 24 months. Correction of vertebral heigh

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… The KyphX ® Bone Filler Device, which was filled before with 1.5 ml of polymethylmethacrylate (PMMA), was then advanced through the working cannula towards the anterior part of the cavity and cement was slowly extruded by a stainless steel stylet, acting as a plunger. …

Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in the treatment of CIPN, but at present there have been no randomized clinical research studies to analyze the effectiveness of acupuncture for the treatment of CIPN, particularly in MM patients. METHODS: The MM patients (104 individuals) who met the inclusion criteria were randomly assigned into a solely methylcobalamin therapy group (500 μg intramuscular methylcobalamin injec

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… An aseptic procedure was executed with disposable, stainless steel 30–32 gauge needles, which were implanted to a depth of 0.3–1.0 in. into the acupoints until the patient felt dull pain or de qi [ 26 ], and were left in place for 30 min. …

Biomechanical effects of osteoplasty with or without Kirschner wire augmentation on long bone diaphyses undergoing bending stress: implications for percutaneous imaging-guided consolidation in cancer patients.

BackgroundOsteoplasty has been discouraged in long bones. However, despite a substantial lack of pre-clinical biomechanical tests, multiple clinical studies have implemented a wide range of techniques to optimise long bone osteoplasty. The aim of the present study is to evaluate the biomechanical properties of osteoplasty alone and in combination with Kirschner wires (K-wires) in a cadaveric human diaphyseal model undergoing 3-point bending stress.MethodsThirty unpaired human cadaveric hemi-tibia specimens were randomly assigned to receive no consolidation (group 1, n = 10), osteoplasty alone

The complex regulation of TGF-β in cardiovascular disease.

Transforming growth factor β (TGF-β1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood-vessel interface. In accordance with this, the TGF-β1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount

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… Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis. J Vasc Res. 2010;47(4):309–322. doi: 10.1159/000265565. 65. Kieć-Wilk B, Stolarz-Skrzypek K, Sliwa A, Zdienicka A, Kawecka-Jaszcz K. …

Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model.

Muscle weakness and cachexia are significant paraneoplastic syndromes of many advanced cancers. Osteolytic bone metastases are common in advanced breast cancer and are a major contributor to decreased survival, performance, and quality of life for patients. Pathologic fracture caused by osteolytic cancer in bone (OCIB) leads to a significant (32%) increased risk of death compared to patients without fracture. Since muscle weakness is linked to risk of falls which are a major cause of fracture, we have investigated skeletal muscle response to OCIB. Here, we show that a syngeneic mouse model of

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… EDL was dissected from hind limbs, and stainless steel hooks were tied to the tendons of the muscles using 4-0 silk sutures, and the muscles were mounted between a force transducer (Aurora Scientific, Aurora, ON, Canada) and an adjustable hook. …

Multiple Myeloma (Part 2) - Update on The Approach to Bone Disease.

The increase in life expectancy of the world population has led to a concomitant increase in the prevalence of multiple myeloma (MM), a disease that usually affects the elderly population. Bone lesions are frequent in patients with this condition, demanding an early approach, from drug treatment, through radiotherapy to orthopedic surgery (prophylactic or therapeutic) with the objective of preventing or delaying the occurrence of fracture, or, when this event has already occurred, treat it through stabilization or replacement (lesions located in the appendicular skeleton) and/or promote stabil

Разработка и оценка [11С]DPA-813 и [18F]DPA-814: новые индикаторы PET, не чувствительные к единому нуклеотидному полиморфизму человека, Rs6971.

P ЦЕЛЬ: Протеин транслокатора 18 кДа (TSPO) — широко используемый маркер для визуализации нейроинфламмации через Томографию позитронных выбросов (PET). Однако подавляющее большинство сообщаемых индикаторов PET TSPO демонстрируют низкую связь с общей изоформой человека TSPO (rs6971; A147T), что делает их непригодными для всеобщего использования среди населения в целом. В этом исследовании мы разработали и проконтролировали два новых индикатора, предназначенных для изображения TSPO у пациентов всех генотипов.МЕТОДЫ: Новые аналоги известных лигандов TSPO были синтезированы, оценены с точки зрения

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… Radiolabelling Synthesis of [ 11 C]DPA-813 [ 11 C]CO 2 produced by a cyclotron (Cyclone 18/9, IBA, Louvain-la-Neuve, Belgium) was trapped in a stainless steel coil cooled with liquid nitrogen. …