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High prevalence of cardiovascular and respiratory abnormalities in advanced, intensively treated (transplanted) myeloma: The case for 'late effects' screening and preventive strategies.

OBJECTIVES: Modern management of myeloma has significantly improved survival, with increasing numbers of patients living beyond a decade. However, little is known about the long-term cardiovascular and respiratory status of intensively treated and multiply relapsed survivors. METHODS: We performed detailed cardiovascular and respiratory evaluations in patients with intensively treated, advanced but stable myeloma. All patients had received at least two lines of treatment, including at least one haematopoietic stem cell transplantation procedure, but had stable, controlled disease and were off

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… Echocardiography was performed by sonographers trained to UK national accreditation standards and echocardiograms were reported by the reviewing echosonographer according to British Society of Echocardiography criteria. 11 Serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) was measured and …

A brief clinical genetics review: stepwise diagnostic processes of a monogenic disorder-hypertriglyceridemia.

The completion of the Human Genome Project and tremendous advances in automated high-throughput genetic analysis technologies have enabled explosive progress in the field of genetics, which resulted in countless discoveries of novel genes and pathways. Many phenotype- or disease-associated single nucleotide polymorphisms (SNPs) with a high statistical significance have been identified through numerous genome-wide association studies (GWAS), and various polygenic risk scoring (PRS) schemes have been proposed to identify individuals with a high risk for a certain trait or disorder. Meanwhile, me

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… In addition, the College of American Pathologists (CAP) Laboratory Accreditation Program (LAP) monitors to ensure that accredited clinical laboratories are conforming to certain standards. …

Clinical Posters From JADPRO Live 2023.

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… Current challenges in cancer care include shortages of oncologists, nurses, and other allied staff, increase administrative burden, accreditation, and regulatory requirements, and more. … The education criteria put forth by the accrediting bodies for both nurse practitioner and physician assistant degree programs do not require didactic or clinical rotations in oncology (ARC-PA, 2022)(APRN Consensus Work Group, 2008). …

Clinical Posters From JADPRO Live 2025

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Факторы риска и результаты новой инфекции моноцитогенов листерии в Пакистане: понимание из больницы третичной медицинской помощи.

Listeria monocitogenes — грэм-положительный стержень, ответственный за листериоз. Она стала одним из основных патогенов, передающихся через пищевые продукты, и была причастна к многочисленным вспышкам во всем мире, часто встречающимся с бактерией, и может привести к серьезным проявлениям, таким, как менингоэнцефалит, особенно у лиц с иммунокомпромиссом и у пожилых людей. Инфекция материнства связана с худшими последствиями беременности. Цель этого исследования заключается в оценке факторов риска, клинических особенностей и результатов лечения пациентов, инфицированных моноцитогенами Листерии,

Расширенный полиглутамин в ATAXIN1 приводит к потере функции, которая усугубляет остроту множественного склероза в модели мыши EAE.

Ataxin-1 (ATXN1) — белок, в котором расширение его полиглутаминового тракта вызывает нервно-дегенеративное расстройство спинномозговой системы 1 (SCA1) в результате повышения функциональности. Недавно было продемонстрировано, что АТXN1 дикая порода играет защитную роль в регулировании жесткости экспериментального аутоиммунного энцефаломиелита (EAE) — хорошо зарекомендовавшей себя модели мыши для мультиклероза (MS). В этом исследовании дополнительно изучается роль ATXN1 с расширенным полиглутаминым трактом в контексте MS с использованием модели мыши EAE.МЕТОДЫ: Гемизиговые атксны1 (Atxn1 2Q/-)

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… Mice were housed and managed by Research Animal Resources under specific pathogen-free conditions in an Association for Assessment and Accreditation of Laboratory Animal Care International approved facility. Food and water were provided ad libitum . …

CAR T-cell therapy and the onco-nephrologist.

Cell therapy, specifically the revolutionary chimeric antigen receptor (CAR) T-cell therapy, has transformed the landscape of oncology, making substantial strides in practical treatment approaches. Today, established guidelines for diseases such as lymphomas, myelomas, and leukemias actively advocate the utilization of these once-unconventional therapies. The practical impact of these therapies is underscored by their unparalleled efficacy, reshaping the way we approach and implement treatments in the realm of oncology. However, CAR T-cell therapy, with its performance in anti-tumor aggression

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… Quality and accreditation in cellular therapy. J Bone MARROW Transplant Cell Ther. (2022) 3:153. 5. Alencar AJ, Hirayama AV, Clé DV, Salvino MA, Perini G, Arrais C, et al. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. …

Насколько общим является гиперкортизолизм у пациентов с гипертензией? Факторы риска, эпидемиология и диагностика.

Эндогенный гиперкортизолизм (ЭГК) является недооцененным и клинически значительным фактором гипертонии, особенно резистентной гипертонии. После того, как EHC считается редким субъектом, он теперь воспринимается как спектр избытка кортизола, связанного с неблагоприятными кардиометаболическими результатами и ущербом, причиненным мишени. Недавно проведенные широкомасштабные исследования свидетельствуют о значительном увеличении распространенности ЭГК среди пациентов с устойчивой гипертонией и трудноконтролируемым диабетом, зачастую в отсутствие классических особенностей кушингоида. В настоящем об

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… ABILITY‐DM trial, funded by Concept Medical; for ALLAY‐HF, funded by Alleviant Medical), Novartis, Population Health Research Institute; Rutgers University (for the NIH‐funded MINT Trial); Honoraria: American College of Cardiology (Senior Associate Editor, Clinical Trials and News, ACC.org ; Chair, ACC Accreditation …

Development and Implementation of an Advanced Practitioner-Led Survivorship Clinic for Patients Status Post Allogeneic Transplant.

BackgroundSurvivor recovery from hematopoietic cell transplantation (HCT) is long term, with significant physical and psychological morbidities that impact quality of life and reentry into personal and social lives. The optimal timing of when and how to deliver comprehensive HCT survivorship care is not well defined.PurposeThe purpose of this study was to design, implement, and evaluate an advanced practitioner (AP)-led pilot survivorship clinic incorporating an individual and group format for patients post HCT at the 1-year transition period.MethodsA survey assessing physical, social, emotion

Use of epidemiological data as the basis for developing a medical curriculum.

Context and objectiveEpidemiology may help educators to face the challenge of establishing content guidelines for the curricula in medical schools. The aim was to develop learning objectives for a medical curriculum from an epidemiology database.Design and settingDescriptive study assessing morbidity and mortality data, conducted in a private university in São Paulo.MethodsAn epidemiology database was used, with mortality and morbidity recorded as summaries of deaths and the World Health Organization's Disability-Adjusted Life Year (DALY). The scoring took into consideration probabilities for

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… Sources of funding: None REFERENCES 1 Physicians for the twenty-first century Report of the Project Panel on the General Professional Education of the Physician and College Preparation for Medicine J Med Educ 1984 59 11 Pt 2 1 208 6492116 2 International standards in medical education: assessment and accreditation …

2021 International Cancer Education Conference Program and Abstracts.

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… ACCREDITATIONS In support of improving patient care, this activity has been planned and implemented by Amedco LLC and the American Association for Cancer Education. … Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. …

Emerging Trends in Diagnostic Radiology: Integrating Advanced Imaging Modalities for Early Detection, Clinical Monitoring, and Prognostic Evaluation of Multisystem Internal Medicine Disorders.

Diagnostic radiology has progressed from basic X-ray imaging to a highly advanced, multimodality discipline that integrates high-resolution structural techniques, functional and molecular imaging, and computational analytics. This review synthesizes emerging trends in diagnostic radiology with a particular focus on their relevance to multisystem internal medicine disorders. The historical evolution of imaging is outlined, from early radiographs to computed tomography (CT), magnetic resonance imaging (MRI), and hybrid platforms such as positron emission tomography-computed tomography (PET-CT) a

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… Accreditation programs and regulatory bodies, including the American College of Radiology (ACR), have established quality assurance frameworks, dose benchmarks, and continuing education requirements to standardize safety practices across imaging centers. …

A pilot randomized clinical trial of a peer support intervention for hematopoietic stem cell transplantation.

AbstractPeer support has been associated with improved patient-reported outcomes (PROs), including reduced psychological distress, among patients undergoing hematopoietic stem cell transplantation (HSCT), but structured interventions are limited. This study assessed the feasibility, acceptability, and preliminary effects of a scalable peer support intervention to reduce psychological distress and enhance quality of life (QOL) post-HSCT. We conducted a pilot randomized clinical trial evaluating the Supporting Transplant Experiences with Peer Program (STEPP), a 5-session, telephone-based interve

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… Gratwohl A, Baldomero H, Frauendorfer K, Urbano-Ispizua A, Joint Accreditation Committee, International Society for Cellular Therapy. European Group for Blood and Marrow Transplantation EBMT activity survey 2004 and changes in disease indication over the past 15 years. …

Real-World Dermatologic Adverse Events of CAR T-Cell Therapy: A Decade-Wide Disproportionality Analysis of the FDA Adverse Event Reporting System.

Background: Chimeric antigen receptor (CAR) T-cell therapy has transformed haematological-malignancy care, but its dermatologic safety profile remains incompletely characterised across products and indications. Methods: We analysed 8,431,841 deduplicated FDA Adverse Event Reporting System reports from 2016 Q3 to 2026 Q1. Seven approved CAR T-cell products were identified. The primary outcome was any dermatologic adverse event, defined using the MedDRA Skin and subcutaneous tissue disorders system organ class. Secondary outcomes included broad severe cutaneous adverse reactions, narrow Stevens-

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… Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) Ann. …

Оптимизация COVID-19 Записи вакцин для иммунокомпромиссированных групп населения (BOOST-IC): протокол исследования для адаптационного случайного контролируемого клинического испытания.

КОЛИЧЕСТВО: Иммунокомпромированные носители (МГХ) сталкиваются с более интенсивными инфекциями и более тяжелыми клиническими результатами после заражения COVID-19 чем иммунокомпетентные люди. Профилактическая моноклональная терапия антител может быть труднодоступной, и быстро появляются варианты выхода. Иммунитет, предоставляемый путем вакцинации, по-прежнему является одной из центральных стратегий профилактики COVID-19. COVID-19 Прививки не обеспечивают оптимальный иммунитет в ICH, а повышаются благодаря дополнительным дозам вакцины, что улучшает юморальную и клеточную иммунную реакцию. Этот

Optimizing the post-CAR T monitoring period in recipients of axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel.

AbstractCD19-directed chimeric antigen receptor T-cell (CAR T) therapies, including axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel), have transformed the treatment landscape for B-cell non-Hodgkin lymphoma, showcasing significant efficacy but also highlighting toxicity risks such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). The US Food and Drug Administration has mandated patients remain close to the treatment center for 4 weeks as part of a Risk Evaluation and Mitigation Strategy

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… Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA) Ann Oncol. 2022;33(3):259 …

Cytopenia after CAR-T Cell Therapy-A Brief Review of a Complex Problem.

Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has emerged as an efficacious and life extending treatment modality with high response rates and durable remissions in patients with relapsed and refractory non-Hodgkin lymphoma (NHL), follicular lymphoma, and B-cell acute lymphoblastic leukemia (B-ALL) as well as in other diseases. Prolonged or recurrent cytopenias after CAR-T therapy have increasingly been reported at varying rates, and the pathogenesis of this complication is not yet well-understood but is likely contributed to by multiple factors. Current studies reported are primarily

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… Management of adults and children receiving CAR-T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Trasnplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EA) Ann. …

A Novel Hydroxamic Acid-Based Curcumin Derivative as Potent Histone Deacetylase Inhibitor for the Treatment of Glioblastoma.

Glioblastoma (GBM) is one of the most common primary and deadliest malignant brain tumor with chemoresistance and poor prognosis. There is a lack of effective chemotherapeutic drug for the treatment of GBM. In this work, we reported the preparation of a histone deacetylase (HDAC) inhibitor, DMC-HA, from the structural modification of natural product curcumin. DMC-HAs were tested in an HDAC inhibition assay and an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for cytotoxicity. It showed potent inhibition of HDAC1-2 and HDAC6 with IC50 values in the submicromolar conce

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… All animal protocols were implemented according to the guidelines of the Association for Assessment and Accreditation of Laboratory Animal Care. U87 cells (3 × 10 6 ) were subcutaneously implanted into the right flank of mice. …

Disparities in the enrollment to systemic therapy and survival for patients with multiple myeloma.

BackgroundDisparities driven by socioeconomic factors have been shown to impact outcomes for cancer patients. We sought to explore this relationship among patients with multiple myeloma (MM) who were not considered for hematopoietic stem cell transplant in the first-line setting and how it varied over time.MethodsWe queried the National Cancer Database for patients diagnosed with MM between 2004 and 2016 and included only those who received systemic therapy as the first-line treatment. Enrollment rates for therapy were calculated as receipt of systemic therapy as the incident event of interest

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… The facility type was assigned according to the Commission on Cancer accreditation category as used in the NCDB. Locations were assigned based on data provided by the US Department of Agriculture Economic Research Service. …

The potential impact of exercise upon symptom burden in adolescents and young adults undergoing cancer treatment

Abstract Purpose Adolescents and young adults (AYAs) experience vast symptom burden resulting from cancer treatment-related toxicities (TRTs). Evidence supports integrated exercise to mitigate several TRTs in other cohorts; however, evidence in AYAs is lacking. Conventional reporting of TRTs adopts a maximum grade approach failing to recognise the trajectory over time, of persistent, or lower grade toxicities. Alternatively, longitudinal analysis of toxicities over time (ToxT) may provide clinically meaningful summaries of this data. We evaluated the longitudinal impact of an exercise interven