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AL type cardiac amyloidosis: a devastating fatal disease.

IntroductionCardiac amyloidosis is a rare entity with a grave prognosis. Due to the low index of suspicion secondary to non-specific symptoms, it is often diagnosed at an advanced stage with multi-organ involvement.MethodsWe report a case of systemic AL amyloidosis with predominant cardiac and renal involvement associated with multiple myeloma.Case summaryA 60-year-old male presented with progressive anasarca, orthopnea and weight gain over 8 months. On clinical examination, 3+ pitting edema was found in bilateral extremities and scrotum. Serum N-type proBNP and troponin T were elevated, and E

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… Ann Noninvasive Electrocardiol . 2013 ; 18 ( 4 ): 157 – 162 . 23530486 10.1111/anec.12018 PMC6932432 [9] Falk RH , Plehn JF , Deering T , et al . Sensitivity and specificity of the echocardiographic features of cardiac amyloidosis . …

A Compendium Review of the Global Epidemiology of Ticks and Tick-borne Diseases: Regional Insights from Türkiye.

Vector-borne diseases have historically posed significant threats to plants, humans, domestic animals, and wildlife, with their impact being … TBDs. In particularly, closely monitoring TBPs in wildlife-such as transmissible prion proteins in deer and rickettsial pathogens identified in mountain goats and mountain sheep-and elucidating their zoonotic potential is critically important. In addition, the ecological importance of bat-associated tick species-especially those infesting cave-dwellin …

Complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors: WFNS spine committee recommendations.

ObjectiveThis review aims to formulate the most current, evidence-based recommendations regarding complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors.MethodsA systematic literature search in PubMed and MEDLINE, and was performed from 2013 to 2023 using the search terms "complications" + "spine metastases", "spine metastases" + + "rehabilitation", "spine metastases" + "pain therapy" + "palliative care". Screening criteria resulted in 35, 15 and 56 studies respectively that were analyzed. Using the Delphi method and two rounds of vot

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… Aman MM Mahmoud A Deer T Sayed D Hagedorn JM Brogan SE Singh V Gulati A Strand N Weisbein J The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the Interventional Management of Cancer-Associated Pain J Pain Res 2021 14 2139 2164 10.2147/JPR.S315585 34295184 PMC8292624 … Aman MM, Mahmoud A, Deer T, Sayed D, Hagedorn JM, Brogan SE, Singh V, Gulati A, Strand N, Weisbein J et al (2021) The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the Interventional Management of Cancer-Associated Pain. …

Многоступенчатые ассоциации патогенеза и болезней Mycobacterium avium подраздел паратуберкулез.

Mycobacterium avium subsp. паратуберкулез (MAP) является основным агентом причинно-следственной связи болезни Джона (JD) в румынках и имеет потенциальные последствия для здоровья населения. Совокупные эпидемиологические и молекулярные данные предполагают, что MAP может способствовать болезни Крона (CD), в то время как его связь с множественным склерозом (MS), тип 1 Болелезный диабет (T1DM) и амиотропический боковой склероз (ALS) остаются ассоциативными без подтвержденной причинно-следственной связи. В настоящем описательном обзоре синтезируются данные о распределении по окружающей среде, генот

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… Beyond cattle, MAP infects a broad range of domestic ruminants, notably sheep, deer, and camels. … MAP infection in wildlife species, particularly deer, bison, wild boars, and other free-ranging animals, has been reported in approximately 38% of countries worldwide, thus establishing natural reservoirs that increase the risk of interspecies transmission ( 9 ). …

The use of interventional procedures for cancer pain. A brief review.

ContextPain is a common experience in people living with cancer. Concerns around opioid prescribing have seen a move toward a multi-modality management approach, which includes interventional pain procedures.PurposeIn this paper we discuss the interventional pain procedures used to treat cancer pain at two major tertiary centers in Australia.Methods and resultsThis expert review provides practical insights on cancer pain management from healthcare providers in different specialties. These insights can be used to guide the management of a wide range of cancer pain types.ConclusionsFurthermore,

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… Aman MM, Mahmoud A, Deer T, Sayed D, Hagedorn JM, Brogan SE, et al. The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the interventional management of cancer-associated pain. J Pain Res. 2021;14:2139–2164. doi: 10.2147/jpr.S315585. 22. …

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… Called also deer fly. Do not suck blood but will mop up spilled blood. … P. fasciolaemorpha found in the digestive tract and gallbladder of the elk and deer. paraffin [ par′ -fin ] 1. kerosene. 2. petrolatum. 3. a purified hydrocarbonwax used for embedding histological specimens. …

Occupational risk factors among Iranian farmworkers: a review of the available evidence.

Farming is one of the most important components of most economies. No comprehensive picture exists of the health status of Iranian farmers and the work-related hazards that affect them. We aimed to determine the gaps in the current knowledge regarding the occupational health of Iranian farmworkers. Electronic databases including Medline, Web of Science, Scopus, and Embase, as well as national databases including the Scientific Information Database, MagIran, and Barakat Knowledge System, were searched for articles published through March 2017. All epidemiologic studies regarding the occupationa

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… behaviors for skin cancer were associated with perceived susceptibility, severity, response efficacy, and self-efficacy Aliabadi (2012) [ 18 ] | Hamadan | M | NR | cs | Physical: noise | Noise pollution | The highest and the lowest noise level around the tractors were 83.8 dB(A) and 73.9 dB(A) for the John Deere …

Integumentary System

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Poor Applicability of Currently Available Prognostic Scoring Systems for Prediction of Outcome in KIT D816V-Negative Advanced Systemic Mastocytosis.

Within our nationwide registry, we identified a KIT D816V mutation (KIT D816Vpos.) in 280/299 (94%) patients with advanced systemic mastocytosis (AdvSM). Age, cytopenias and the presence of additional somatic mutations confer inferior overall survival (OS). However, little is known about the characteristics of KIT D816V-negative (D816Vneg.) AdvSM. In 19 D816Vneg. patients, a combination of clinical, morphological and genetic features revealed three subgroups: (a) KIT D816H- or Y-positive SM (KIT D816H/Ypos., n = 7), predominantly presenting as mast cell leukemia (MCL; 6/7 patients), (b) MCL wi

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… The following antibodies were used: CD117 (Agilent, Santa Clara, CA, USA), CD25 (Leica, Deer Park, TX, USA), CD2 (Leica), MZT (Zytomed, Berlin, Germany), CD30 (Thermo Fisher Scientific, Waltham, MA, USA), CD20 (Agilent, Santa Clara, CA, USA), CD138 (Zytomed, Berlin, Germany), Kappa (Agilent, Santa Clara …

A Scalable Radiomics- and Natural Language Processing-Based Machine Learning Pipeline to Distinguish Between Painful and Painless Thoracic Spinal Bone Metastases: Retrospective Algorithm Development and Validation Study.

BackgroundThe identification of objective pain biomarkers can contribute to an improved understanding of pain, as well as its prognosis and better management. Hence, it has the potential to improve the quality of life of patients with cancer. Artificial intelligence can aid in the extraction of objective pain biomarkers for patients with cancer with bone metastases (BMs).ObjectiveThis study aimed to develop and evaluate a scalable natural language processing (NLP)- and radiomics-based machine learning pipeline to differentiate between painless and painful BM lesions in simulation computed tomo

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… GS Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases Ann Palliat Med 2017 12 6 Suppl 2 S240 S247 10.21037/apm.2017.09.04 29156912 apm.2017.09.04 29156912 10 Gunn Joshua Hill Melissa M Cotten Bradley M Deer …

A Systematic Review of Decision Aids in Hematologic Malignancies: What Are Currently Available and What Are We Missing?

BackgroundPatient decision aids (PDAs) are tools designed to facilitate decision-making. In this systematic review, we summarized existing studies on the development and evaluation of PDAs for patients with hematologic malignancies.Patients and methodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched for articles in PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. We included studies, abstracts, and clinical trial protocols available in English involving PDAs for patients ag

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… Leblanc TW , Rizzieri D , Martin P , Mayorga V , Deering K , Schenkel B. Shared decision-making tools for patients with hematologic malignancies . J Clin Oncol. 2016 ; 34 ( Suppl 15 ): e19007 . 33. Miller M , Belkora J , Coyne K , et al . …

Patients' perspectives on the derivation and use of organoids.

Organoid research is enhancing understanding of human development and diseases as well as aiding in medication development and selection, raising hopes for even more future therapeutic options. Nevertheless, this work raises important ethical issues and there is a paucity of data regarding patients' perspectives on them. We report on 60 interviews with adult patients or parents of pediatric patients from diverse disease populations who receive medical care at a major academic research institution in the United States. Interviewees expressed broad support for organoid development and use. Howev

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… Hyun I., Scharf-Deering J.C., Lunshof J.E. Ethical issues related to brain organoid research. Brain Res. 2020;1732:146653. doi: 10.1016/j.brainres.2020.146653. …

Immunomodulatory drugs in multiple myeloma: Impact of the SCARMET (Self CARe and MEdication Toxicity) educational intervention on outpatients' knowledge to manage adverse effects.

Long-term multiple myeloma therapy by immunomodulatory drugs (IMiDs) raises the question of management of adverse effects. The aim of this study is to assess the impact of an educational session for patients on the acquisition of knowledge to manage hematologic and thromboembolic adverse effects of IMiDs. In this prospective single-center study, patients attended an educational session with a hospital clinical pharmacist and a nurse. The primary endpoint was the patient's level of knowledge for the management of IMiDs adverse effects, assess with a dedicated questionnaire administered before t

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… Morrow DG, Weiner M, Young J, Steinley D, Deer M, Murray MD. Improving medication knowledge among older adults with heart failure: a patient-centered approach to instruction design. The Gerontologist 2005;45:545–52. 10.1093/geront/45.4.545 28. Yardley SJ, Davis CL, Sheldon F. …

Sarcopenia Diagnosis and Management in Hematological Malignancies and Differences with Cachexia and Frailty.

Sarcopenia is a geriatric syndrome characterized by a progressive loss of systemic muscle mass and decreased muscle strength or physical function. Several conditions have a role in its pathogenesis, significantly impacting adverse outcomes such as falls, functional decline, frailty, disability, multiple hospitalizations, and mortality. In the oncological setting, sarcopenia is associated with an increased risk of treatment toxicity, postoperative complications, and a higher mortality rate related to other causes (e.g., pneumonia). In the hematological field, even more so, sarcopenia predicts t

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… Deer R.R. Volpi E. Protein intake and muscle function in older adults Curr. Opin. Clin. Nutr. Metab. Care 2015 18 248 253 10.1097/MCO.0000000000000162 25807346 PMC4394186 68. Landi F. Calvani R. Tosato M. Martone A.M. Ortolani E. Savera G. D’angelo E. Sisto A. Marzetti E. …

Knockdown of LINC00963 targets miR-1252-5p to reduce inflammatory levels and ECM degradation in nucleus pulposus cells of IDD.

BACKGROUND: In middle-aged and older adults, intervertebral disc degeneration (IDD) is a major cause of chronic low back pain and disability. This pathological process is closely linked to the activation of inflammatory factors resulting from an imbalance in extracellular matrix (ECM) metabolism and abnormalities in Nucleus pulposus cells (NPCs). This study aims to clarify the functional importance of LINC00963 in IDD and its potential molecular mechanisms. METHODS: 102 IDD patients and 88 scoliosis controls were enrolled. IL-1β-stimulated NPCs modeled IDD in vitro. RT-qPCR detected LINC00963,

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… Mechanisms of Intervertebral Disc Degeneration Treatment with Deer Antlers Based on Network Pharmacology and Molecular Docking. Evidence-based complementary and alternative medicine: eCAM. 2022;2022:8092848. 7. Ohnishi T, Iwasaki N, Sudo H. …

Immunotherapy for Cutaneous Squamous Cell Carcinoma: Results and Perspectives.

Although initial surgical excision cures 95% of patients, a minority of cutaneous squamous cell carcinomas (cSCCs) are judged to be unresectable, either locally advanced or with unresectable regional lymph nodes or distant metastases. These patients are offered systemic treatments. Response rate to chemotherapy is relatively low and not durable, as well as the results obtained with epidermal growth factor inhibitors (EGFRi). Like other cutaneous tumors, cSCCs have high immunogenicity, driven by the high mutational burden, the ultraviolet signature, and the overexpressed tumor antigens. Two che

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… Proc Am Soc Clin Oncol ( 2019 ) 37 : e21033 . doi: 10.1200/JCO.2019.37.15_suppl.e21033 14 Ruiz E Chen CI Deering K . Treatment Patterns and Costs in Cutaneous Squamous Cell Carcinoma (CSCC) Patients With Nodal Dissection, Chemotherapy, and/or Radiation Therapy . …

Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening.

Notch signaling plays an important role in several cellular functions including growth, differentiation, cell fate determination and stemness. Increased Notch activity has been linked to several types of cancers. Activation of Notch signaling is triggered by the interaction of Notch receptors (Notch1-4) with 5 different ligands (Jagged1-2 and Dll1-3-4) expressed on the neighbouring cells. Currently, indirect approaches to inhibit Notch signalling are based on the inhibition of the key step of Notch activation catalyzed by the γ-Secretase and thereby affect several different γ-Secretase substra

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… Residues involved in Notch2::Jagged2 contacts are highlighted by shells rendered according to van deer Waals distance. Conserved residues at the interface of the complex are shown in stick representation. (A’) Notch2::Jagged2 detailed view. …

Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state.

Neurodegeneration in glaucoma patients is clinically identified through longitudinal assessment of structure-function changes, including intraocular pressure, cup-to-disc ratios from fundus images, and optical coherence tomography imaging of the retinal nerve fiber layer. Use of human post-mortem ocular tissue for basic research is rising in the glaucoma field, yet there are challenges in assessing disease stage and severity, since tissue donations with informed consent are often unaccompanied by detailed pre-mortem clinical information. Further, the interpretation of disease severity based so

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… IHC was performed with antibodies (Table 2 ) against RBPMS (RGC soma marker), NEFL (RGC axon marker), GFAP (astrocyte marker) and IBA1 (microglia/macrophage marker) using a LeicaBond RX stainer (Leica Biosystems, Deer Park, IL, USA). …

Меры по оказанию помощи в случае хронических заболеваний, основанные на группировании: систематический обзор случайных контролируемых испытаний.

Растущее глобальное бремя хронических заболеваний требует новых и интерактивных и устойчивых мер. Гамификация стала новаторской стратегией, направленной на более активное вовлечение пациентов в лечение хронических заболеваний и их самостоятельное лечение. Хотя gamification широко используется в сфере здравоохранения, анализ данных о ее эффективности в различных клинических условиях остается непоследовательным. three основные базы данных: EBSCOhost, PubMed и Scopus вместе с two поисковые системы, включая Google Scientific and Sage Journal, без ограничений по годам, после PRISMA 2020 и методолог

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… Swartz MC, Lewis ZH, Deer RR, et al. Feasibility and acceptability of an active video game–based physical activity support group (Pink warrior) for survivors of breast cancer: randomized controlled pilot trial. JMIR Cancer . 2022;8(3):1–18. doi: 10.2196/36889 27. …

Combination radiofrequency ablation and vertebral cement augmentation for spinal metastatic tumors: A systematic review and meta-analysis of safety and treatment outcomes.

BACKGROUND: The treatment of spine metastases continues to pose a significant clinical challenge, requiring the integration of multiple therapeutic modalities to address the multifactorial aspects of this disease process. Radiofrequency ablation (RFA) and vertebral cement augmentation (VCA) are 2 less invasive modalities compared to open surgery that have emerged as promising strategies, offering the potential for both pain relief and preservation of vertebral stability. The utility of these approaches, however, remains uncertain and subject to ongoing investigation.This systematic review and

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… Aman MM, Mahmoud A, Deer T, et al. The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the interventional management of cancer-associated pain. J Pain Res. 2021;14:2139–2164. doi: 10.2147/JPR.S315585. 13. Yevich S, Chen S, Metwalli Z, et al. …