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The effects of a financial navigation intervention on financial toxicity among patients with breast cancer in China: A randomized controlled trial.

BACKGROUND: Financial toxicity (FT) is a common issue faced by breast cancer patients worldwide. Although financial navigation (FN) is a promising approach to alleviate FT, its effectiveness in China's context remains underexplored. OBJECTIVES: To evaluate the effects of a FN intervention on FT, cost-related health literacy (CRHL), shared decision-making (SDM) ability, and perceived stress of patients with breast cancer. METHODS: This was a cluster randomized controlled trial. Participants were randomized to the FN group or control group (n = 41 per group). Outcomes including FT (primary out

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… Our results suggested that financial navigation may serve as a scalable and adaptable strategy to reduce subjective FT and improve patients’ financial empowerment. …

Comprehensive analysis of plasma cell heterogeneity and immune interactions in multiple myeloma.

This study focused on the role of plasma cells in multiple myeloma (MM) and the associated potential mechanisms. Transcriptomic data of MM and various gene sets from several public databases were downloaded for subsequent analyses. Through single-cell sequencing, 10 major cell types were identified and annotated. The differential gene expression and pathway enrichment between different plasma cell subtypes as well as cell communication analysis, transcriptional regulation analysis, and enrichment analysis in conjunction with the malignant subpopulation were performed. Next, the samples were cl

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… Multiple myeloma incidence and mortality around the globe; interrelations between health access and quality, economic resources, and patient empowerment. Oncologist. (2020) 25:e1406–e13. doi: 10.1634/theoncologist.2020-0141 4. Cowan AJ, Allen C, Barac A, Basaleem H, Bensenor I, Curado MP, et al. …

Несоответствия в рецидивной или рефрактной множественной миеломе: рекомендации межпрофессиональной консенсусной группы.

Во многих исследованиях были зафиксированы расовые, социально-экономические, географические и другие различия для пациентов из Соединенных Штатов (США) с множественной миеломой, связанные с диагностикой и управлением прифронтовыми линиями. В отличие от этого, очень мало известно о различиях в регулировании рецидивов/изъятий множественной миеломы (RRMM), несмотря на множество новых вариантов лечения. В ходе этого обзора мы обсуждаем проявления неравенства в ПРМ и стратегии по смягчению их воздействия. Лекарства от иммуномодулирующих препаратов могут создавать различия по многим осям, например н

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… Multiple Myeloma Incidence and Mortality Around the Globe; Interrelations Between Health Access and Quality, Economic Resources, and Patient Empowerment. Oncologist 2020;25:e1406–e1413. 10.1634/theoncologist.2020-0141. 10.1634/theoncologist.2020-0141 125. …

'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK.

AimTo explore cancer survivors' experiences of living with chronic pain after curative cancer treatment in England, UK.MethodsA qualitative study using telephone interviews with adult cancer survivors experiencing chronic pain after curative cancer treatment. Interview data was analysed using a reflexive thematic approach [1-3].FindingsNineteen participants: 14 female, 5 male, mean age 62.4 years, 1.5-48 years since cancer diagnosis, eight tumour groups represented. Six participants (31.6%) developed chronic pain more than ten years after completing cancer treatment (range 0-25 years). Five th

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… This acknowledgement led to a sense of relief and a feeling of empowerment and strength to go on. This is reflected in a recent meta-ethnography study synthesizing 195 qualitive studies to understand the process of healing for those living in chronic pain [ 45 ]. …

Alpe d'HuZes cancer rehabilitation (A-CaRe) research: four randomized controlled exercise trials and economic evaluations in cancer patients and survivors.

BackgroundPrevious studies showed that exercise in cancer patients is feasible and may reduce fatigue and improve physical fitness and quality of life. However, many previous studies had methodological weaknesses related to trial design, sample size, comparison group, outcome measures, short follow-up durations and programme content.PurposeThis paper aims to present the rationale and design of the clinical research subprogramme of the Alpe d'HuZes Cancer Rehabilitation (A-CaRe) programme.MethodA-CaRe Clinical Research includes four randomized controlled trials in patients: (a) after chemothera

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… This Alpe d’HuZes Cancer Rehabilitation (A-CaRe) programme includes a clinical research subprogramme (A-CaRe Clinical Research) in addition to subprogrammes aiming at patient empowerment and public relations. …

2026 Приложение к резюме Международного конгресса

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Patient-reported outcomes in cancer survivorship: insights from two decades of population-based PROFILES registry research.

PurposeWhen the field of cancer survivorship research was in its infancy, the PROFILES registry was set up in 2004 to monitor patient-reported outcomes (PROs) in survivors and a normative population. This scoping review aims to summarize lessons learned from developing a population-based PRO registry, focusing on study methodologies, data collection shifts, data utilization, multidisciplinary collaboration, societal impact, and data sharing.MethodsA systematic computerized literature search through PubMed was performed to collect all publications using data from the PROFILES registry between J

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… Broadening our perspective from scientific research to patient empowerment was a relatively effortless but valuable step. Furthermore, we also share the PROFILES registry application itself. By sharing the PROFILES registry, we enable other researchers to collect their data in an efficient manner. …

Sestrin-2: a new biomarker for type 2 Diabetes Mellitus and Insulin resistance.

Multiple myeloma (MM) is the second most common haematological malignancy characterised by clonal proliferation of plasma cells within the bone marrow. Despite advances in treatment options, myeloma remains incurable. Relapsed MM poses significant challenges due to clonal evolution, drug resistance, patient comorbidities and therefore complexities of therapeutic decision-making. A critical question in managing relapsed MM is whether to switch drug classes or retreat with agents within the same class. The question is present with the recent addition of three new drug classes (XPO1 inhibitors, B

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… Ludwig H, Durie SN, Meckl A, Hinke A, Durie B Multiple Myeloma Incidence and Mortality Around the Globe; Interrelations Between Health Access and Quality, Economic Resources, and Patient Empowerment. Oncologist [Internet]. 2020 Sep 1 [cited 2025 Jan 24];25(9):e1406. …

Применение цифровых технологий для лечения хронических заболеваний: систематический обзор.

С учетом того, что на хронические заболевания приходится значительная доля предотвратимых смертей во всем мире, решающее значение имеет внедрение новаторских технологий для лечения и профилактики заболеваний. Цифровые близнецы (ДТ), представляющие one Наиболее передовые технологические решения позволяют в реальном масштабе времени осуществлять моделирование и мониторинг развития хронических заболеваний, облегчая индивидуализированные стратегии лечения и раннее вмешательство. В рамках этого систематического обзора изучаются текущие исследования по применению DT в области борьбы с хроническими з

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… This distribution may reflect the current emphasis on clinician‐facing decision support, although the presence of patient‐oriented implementations suggests growing interest in DT‐enabled approaches for patient empowerment and self‐management. …

Нацеливание moTOR сигнализирующих путей в нескольких миеломах: биология и последствия для терапии.

Множественная миелома (ММ), рак неизлечимо дифференцированных плазменных клеток, является вторым по распространенности гематологической злокачественности и неизлечимо из-за неизбежного развития лекарственной устойчивости. Интенсивный синтез белка является отличительной чертой клеток MM, поддерживающей массовое производство клональных иммуноглобулинов или свободных световых цепей. Млекопитающая цель рэпамицин (mTR) киназы ценится как главный регулятор жизненно важных клеточных процессов, включая регулирование метаболизма и синтеза белка, и может быть найдена в two Мультипротеиновые комплексы, M

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… Multiple Myeloma Incidence and Mortality Around the Globe; Interrelations Between Health Access and Quality, Economic Resources, and Patient Empowerment. Oncologist. 2020;25(9):e1406–e1413. doi: 10.1634/theoncologist.2020-0141. 4. Schurch CM, et al. …

Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.

BACKGROUND: Comprehensive next-generation sequencing is widely used for precision oncology and precision prevention approaches. We aimed to determine the yield of actionable gene variants, the capacity to uncover hereditary predisposition and liquid biopsy appropriateness instead of, or in addition to, tumor tissue analysis, in a real-world cohort of cancer patients, who may benefit the most from comprehensive genomic profiling. METHODS: Seventy-eight matched germline/tumor tissue/liquid biopsy DNA and RNA samples were profiled using the Hereditary Cancer Panel (germline) and the TruSight Onc

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… Russo A Incorvaia L Capoluongo E Tagliaferri P Galvano A Del Re M The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies Crit Rev Oncol Hematol 2022 169 103567 10.1016 …

Emerging Immunotherapy for Acute Myeloid Leukemia.

Several immune checkpoint molecules and immune targets in leukemic cells have been investigated. Recent studies have suggested the potential clinical benefits of immuno-oncology (IO) therapy against acute myeloid leukemia (AML), especially targeting CD33, CD123, and CLL-1, as well as immune checkpoint inhibitors (e.g., anti-PD (programmed cell death)-1 and anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4) antibodies) with or without conventional chemotherapy. Early-phase clinical trials of chimeric antigen receptor (CAR)-T or natural killer (NK) cells for relapsed/refractory AML showed

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… It contributes to the stabilization/empowerment of induced Tregs [ 27 ], helps mesenchymal stromal cells in suppressing T cells [ 28 ], and inhibits NK cell activity [ 29 ]. …

Effectiveness of and implementation requirements for telehealth in palliative care patients with advanced cancer: A systematic review and meta-analysis.

BackgroundTelehealth is being integrated with palliative care for patients with advanced cancer to improve access to specialized palliative care. However, its effectiveness and implementation requirements in palliative care remain unclear.AimThis study evaluates the effectiveness of and implementation requirements for telehealth in palliative care patients with advanced cancer.DesignThis was designed as a systematic review and meta-analysis with narrative synthesis (registered; CRD42024581786). The effects on patients' quality of life, symptom burden, and depression were analyzed using a rando

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… Telemedically augmented palliative care : empowerment for patients with advanced cancer and their family caregivers . Wien Klin Wochenschr 2019 ; 131 ( 23-24 ): 620 – 626 . 31667588 10.1007/s00508-019-01562-3 56 Oelschlägel L Christensen VL Moen A , et al . …

Форимтамиг, роман GPRC5D-targeting Антитела с клеточными клетками 2+1 Формат для лечения множественной миеломы.

Несмотря на несколько утвержденных методов лечения, миелома (ММ) остается неизлечимым заболеванием с высоким уровнем неудовлетворенных медицинских потребностей. 5 Член D (GPRC5D) продемонстрировал высокий уровень объективной реакции у пациентов, прошедших тщательное предварительное лечение, с MM; однако часто происходят первичное сопротивление, непродолжительная продолжительность реагирования и рецидив, вызванный сменой антигена. Хотя GPRC5D представляет собой наиболее избирательный целевой показатель в MM, недавние выводы показывают, что потери антигенов происходят чаще, чем в BCMA. Так, anti

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… References 1 Ludwig H Durie SN Meckl A Hinke A Durie B Multiple myeloma incidence and mortality around the globe; interrelations between health access and quality, economic resources, and patient empowerment Oncol 25 9 2020 e1406 e1413 10.1634/theoncologist.2020-0141 PMC7485361 32335971 2 Berdeja JG …

The Role of DNA Repair in Genomic Instability of Multiple Myeloma.

Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance in MM. The dysregulation of DNA repair function may provide an alternative explanation for genomic instability observed in MM cells and in cells derived from MM patients. This review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role th

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… Multiple Myeloma Incidence and Mortality Around the Globe; Interrelations Between Health Access and Quality, Economic Resources, and Patient Empowerment Oncologist 2020 25 e1406 e1413 10.1634/theoncologist.2020-0141 32335971 PMC7485361 4. Albagoush S.A. Azevedo A.M. …

Оценка медицинских препаратов с учетом интересов пациентов: разработка, совершенствование и проверка стратегии поиска материалов для получения результатов соответствующих исследований.

ВВЕДЕНИЕ: Плохое индексирование и непоследовательное использование терминов и ключевых слов могут помешать эффективному поиску результатов исследований по оценке рисков, связанных с получением лекарств, с учетом интересов пациентов. Мы стремились разработать и утвердить объективно разработанную стратегию поиска контента, содержащую общие термины поиска, которые могут быть адаптированы для любого поиска доказательств наличия у пациентов БРА лекарств в любой области лечения.Мы использовали мощный многоэтапный процесс для разработки и подтверждения стратегии поиска контента: (1) мы разработали ба

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… Patient-centered care encompasses shared decision-making, support for self-management, patient information, patient empowerment, care planning, the integration of medical and nonmedical care, and good communication between clinicians and patients [ 46 ]. …

Abstracts From JADPRO Live at APSHO 2017.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Patient empowerment and education is at the heart of ACP. Monthly review of progress and continual quality improvement of the program process will help increase program access to every patient. JL502. …

Poster Presentation

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… Tanvi Shinde Tata Memorial Hospital Introduction: Our hospital’s Respite Palliative Care Unit [RPCU] is the first of its kind in India where patients are admitted briefly for symptom control, psychosocial support, and empowerment of caregivers. …

The Role of Response-Shift in Studies Assessing Quality of Life Outcomes Among Cancer Patients: A Systematic Review.

Objective: Response-shift has been cited as an important measurement consideration when assessing patient reported quality of life (QoL) outcomes over time among patients with severe chronic conditions. Here we report the results of a systematic review of response shift in studies assessing QoL among cancer patients. Methods: A systematic review using MEDLINE, EMBASE, and PsychINFO along with a manual search of the cited references of the articles selected, was conducted. A quality review was performed using STROBE criteria and reported according to PRISMA guidelines. Results: A systematic rev

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… Detecting unbiased or “real” cancer treatment effects is crucial not only to help fine-tune interventions, their administered length of time and intensity dosages, to inform patient education and empowerment programs in order to reduce negative side effects and improve patients' quality of life, but …

Engineering TCR-directed T-cells for the treatment of multiple myeloma.

Multiple myeloma (MM) is a virtually incurable plasma cell malignancy characterized by malignant cells that expand within the tumor-permissive bone marrow (BM) microenvironment. Novel strategies are urgently needed to improve the outcomes of patients with difficult-to-treat and therapy-refractory disease. The ability to genetically manipulate T-cells and the introduction of adoptive cellular therapies (ACTs) has improved the treatment of relapsed and/or refractory (RR)MM. Emerging evidence supports the efficacy of ACTs as early lines of cancer treatment, potentially even as an alternative to a

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… Multiple myeloma incidence and mortality around the globe; interrelations between health access and quality, economic resources, and patient empowerment . Oncologist . ( 2020 ) 25 : e1406 – e1413 . doi: 10.1634/theoncologist.2020-0141 , PMID: 32335971 PMC7485361 3 van de Donk N Pawlyn C Yong KL . …