Результаты поиска

Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection.

BACKGROUND: Infection with HIV-1 results in marked immunologic insults and structural damage to the intestinal mucosa, including compromised barrier function. While the development of highly active antiretroviral therapy (HAART) has been a major advancement in the treatment of HIV-1 infection, the need for novel complementary interventions to help restore intestinal structural and functional integrity remains unmet. Known properties of pre-, pro-, and synbiotics suggest that they may be useful tools in achieving this goal. METHODS: This was a 4-week parallel, placebo-controlled, randomized pi

Обзор гута дисбиоза и недоедания в неврологических расстройствах: последствия, признаки и перспективные терапевтические подходы.

Предыстория/цели: Неврологические заболевания растут во всем мире, однако биологические процессы, лежащие в основе этих заболеваний, по-прежнему плохо понимаются, а существующие методы лечения неэффективны при прекращении развития заболеваний. Появляющиеся данные свидетельствуют о том, что дисбиоз оси микробиота-гут-мозгов и недоедание являются сопутствующими факторами неврологической дисфункции. Методы: Была разработана расширенная стратегия поиска с использованием многопланового подхода в различных базах данных для выявления приемлемых исследований, опубликованных в период с января 2010 года

Совпадение в полном тексте источника
… Clinical and biomarker-based effects of nutritional interventions, such as probiotics, prebiotics, and more extensive dietary patterns, have shown encouraging clinical and biomarker-related responses in neurological and neurodevelopmental disorders [ 42 , 49 ]. … The clinical outcomes indicate the effectiveness of microbiome- and nutrition-based therapies, including dietary modulation strategies, probiotics, prebiotics, and ketogenic or fibre diets, when combined with conventional neurological treatments [ 6 , 17 , 18 ]. …

Microbiome and pancreatic cancer: time to think about chemotherapy.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by late diagnosis, rapid progression, and a high mortality rate. Its complex biology, characterized by a dense, stromal tumor environment with an immunosuppressive milieu, contributes to resistance against standard treatments like chemotherapy and radiation. This comprehensive review explores the dynamic role of the microbiome in modulating chemotherapy efficacy and outcomes in PDAC. It delves into the microbiome's impact on drug metabolism and resistance, and the interaction between microbial elements, drugs,

Совпадение в полном тексте источника
… Probiotics, prebiotics and synbiotics The intricate relationship between the gut microbiome and cancer has garnered significant attention in recent years, particularly regarding the roles of prebiotics, probiotics, and synbiotics. … To provide a clear understanding of these concepts, Table 2 summarizes the definitions, examples, mechanisms of action, and potential benefits of prebiotics, probiotics, and synbiotics in the cancer context. Table 2. Summary of prebiotics, probiotics, and synbiotics. …

От Мауса к разуму: Нервозность роли орального микробиома в орофациальной боли и нейродегенерации.

Человеческая пероральная полость содержит разнообразный и динамичный микробиом, состоящий более чем из двух микробиомов. 700 Микробные виды, которые играют решающую роль в поддержании перорального и системного здоровья. Оральный дисбиоз, определяемый как нарушение этого микробного баланса, все чаще проявляется не только в периодонных заболеваниях, но и в патогенезе ородовой боли и нейродегенеративных заболеваниях. Были предложены ключевые патогены, такие, как Porphyromonas gingivalis, Treponema denticola и Fusobacterium нуклеатум, для высвобождения вирулентных факторов, включая липополисакчари

Совпадение в полном тексте источника
… Prebiotics are defined, in line with the framework proposed by the International Scientific Association for Probiotics and Prebiotics in 2016, as substrates selectively metabolized by host microorganisms in ways that confer a health benefit. 6 Compounds in this category include inulin, fructooligosaccharides … Synbiotic formulations combining probiotics and prebiotics in a single regimen may yield superior outcomes; however, clinicians should be aware that high prebiotic intake requires rigorous oral hygiene to reduce associated cariogenic risks. …

Микробиота человека в области здравоохранения и отдельные раковые заболевания.

Большинство эпителиальных поверхностей нашего тела, пищеварительный тракт, дыхательные и врожденные системы, колонизируются большим количеством бактерий, археи, грибов, протозоанов и вирусов. Эти микробиота, особенно кишки, играют важную и полезную роль в пищеварении, метаболизме и синтезе витаминов. Их метаболиты стимулируют производство цитокина человеком, которое используется против потенциальных патогенов. На состав микробиоты влияет ряд внутренних и внешних факторов, включая питание, возраст, болезни и образ жизни. Такие изменения, называемые дисбиозом, могут быть связаны с развитием разл

Совпадение в полном тексте источника
… Several investigations have found prebiotics to have a beneficial role in human metabolic disorders [ 15 ]. Prebiotics have also been found to influence brain functions. … Prebiotics Prebiotics are typically substances intended as food for intestinal bacteria. Metabolized prebiotics act as tumor suppressive metabolites [ 21 ]. …

Unlocking the Microbial Symphony: The Interplay of Human Microbiota in Cancer Immunotherapy Response.

IntroductionThe emergence of cancer immunotherapy has revolutionized cancer treatment, offering remarkable outcomes for patients across various malignancies. However, the heterogeneous response to immunotherapy underscores the necessity of understanding additional factors influencing treatment efficacy. Among these factors, the human microbiota has garnered significant attention for its potential role in modulating immune response. Body: This review explores the intricate relationship between the human microbiota and cancer immunotherapy, highlighting recent advances and potential mechanisms u

Совпадение в полном тексте источника
… Prebiotics, Probiotics, and Postbiotics in Cancer Immunotherapy Prebiotics, probiotics, and postbiotics are increasingly recognized for their pivotal roles in gut health and their potential impact on cancer immunotherapy outcomes. … Prebiotic-rich diets, particularly those high in fiber, have been linked to beneficial shifts in gut microbiota and heightened immune activity. …

Intestinal Microbes and Hematological Malignancies.

Hematological malignancies are diverse, with high malignancy characteristics, poor prognoses, and high mortality rates. The development of hematological malignancies is driven by genetic factors, tumor microenvironment factors, or metabolic factors; however, even when considering all of these factors, one still cannot fully estimate the risk of hematological malignancies. Several recent studies have demonstrated an intimate connection between intestinal microbes and the progression of hematological malignancies, and gut microbes play a primary role in the initiation and progression of hematolo

Совпадение в полном тексте источника
… The absence of probiotics and prebiotics may cause the excessive proliferation of pathogenic bacteria and intestinal microbial disorders, inflammation, and even hematological tumor development. … Therefore, functional foods such as prebiotics (e.g., SCFAs) and probiotics (e.g., Clostridium butyrate ) have beneficial influences in controlling and preventing cancer in animal and preclinical models. …

Роль кишечника микробиота-митохондрия в нейродегенерации: основополагающие механизмы и потенциальные методы лечения.

Появляющиеся данные свидетельствуют о том, что микробиота кишечника тесно связана с патологическими проявлениями множественных нейродегенеративных заболеваний через ось кишечника, которая относится к перекрестку между кишечником и центральной нервной системой. Еще важнее то, что митохондрия считается выдающимся посредником взаимодействия между кишечной микробиотой и мозгом. Кишечные микробы могут модифицировать функцию митохондриала в центральной нервной системе, чтобы повлиять на развитие нейродегенеративных заболеваний. Митохондрия необходима для удовлетворения значительных потребностей носи

Совпадение в полном тексте источника
… The existing potential strategies include the utilities of antibiotics, probiotics and prebiotics, engineered bacteria, FMT, postbiotic therapy and dietary modification. … Inulin supplements, as prebiotics, were shown to mitigate neurotoxicity by modulating the gut microbiota and by restoring mitochondrial function. …

Communication between gut microbiota-derived metabolites and the tumor microenvironment.

The gut microbiota has been increasingly recognized as a critical player in maintaining human health and influencing disease development. The tumor microenvironment (TME) is pivotal in tumor development and progression, comprising immune cells, stromal elements, extracellular matrix components, and cytokines. Recent studies have highlighted the promising potential of gut microbiota-derived metabolites (e.g., short-chain fatty acids, bile acids, polyamines, and tryptophan derivatives) to reshape the TME in various ways, generating significant interest for the development of novel therapeutic st

Совпадение в полном тексте источника
… Probiotics and prebiotics Probiotics and prebiotics represent targeted strategies to modulate the composition and function of the gut microbiota ( 98 ). … Together, prebiotics and probiotics modulate the gut microbiota to promote host health, with overlapping mechanisms such as immune regulation and gut barrier improvement ( 107 ). …

[Significance and effects of prenatal and postnatal microbiome in the period of early individual development and options for interventional treatment].

Összefoglaló. A humán mikrobiom az emberi szervezetben és az emberi testfelszínen élő mikrobaközösségek összessége, amelyek többsége a gyomor-bél rendszerben él. Ezek a mikrobaközösségek számos és sokféle baktériumot tartalmaznak, gombákat, vírusokat, archeákat és protozoonokat. Ez a mikrobiális közösség, vagy mikrobiota, a gazdaszervezetben nagyrészt egymással kölcsönösségi viszonyban tenyészik, és gondoskodik a bélben a tápanyagok anyagcseréjéről, kalibrálja az anyagcsere-működést, tanítja az immunrendszert, fenntartja a közösség integritását, és véd a kórokozók ellen. A majdan megszületendő

Gut microbiota and microbial metabolites for osteoporosis.

Osteoporosis is an age-related bone metabolic disease. As an essential endocrine organ, the skeletal system is intricately connected with extraosseous organs. The crosstalk between bones and other organs supports this view. In recent years, the link between the gut microecology and bone metabolism has become an important research topic, both in preclinical studies and in clinical trials. Many studies have shown that skeletal changes are accompanied by changes in the composition and structure of the gut microbiota (GM). At the same time, natural or artificial interventions targeting the GM can

Совпадение в полном тексте источника
… Probiotics and prebiotics According to the latest International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement, probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. 80 Prebiotics are substrates … Compared with young mice, old mice presented the most significant reduction in the abundance of Akkermansia . 26 Although several animal studies of probiotics and prebiotics for bone health have been conducted, clinical trials examining individual probiotics/prebiotics are rare. …

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.

Medicinal mushrooms are widely used in East Asia for the treatment of various diseases, especially in complementary cancer care. While there is a growing interest in medicinal mushrooms in Western countries and an increasing number of pre-clinical studies indicate distinct anti-cancer and regenerative properties, little is known about their potential relevance for clinical practice. This review aims to provide an overview of the clinical evidence, significance and potential role of medicinal mushrooms in complementary cancer care. Scientific databases for (randomized) controlled clinical trial

Совпадение в полном тексте источника
… Medicinal mushrooms could act as prebiotics that can stimulate the growth of beneficial microbiota. Prebiotics can modulate the human intestinal microbiota and can attenuate various disease such as diabetes, obesity and cancer ( Rossi et al., 2018 ). … Their prebiotic effects pose a possible explanation, as do other, yet unknown effects. …

Ось Гут-Брэйна и взаимодействие мозга с помощью микробиома с медицинской точки зрения.

Фон: кишечный микробиом непосредственно влияет на здоровье и активность мозга, что означает, что они тесно связаны между собой. Эта взаимосвязь предполагает наличие связи между микробными диспропорциями и болезнями, такими, как болезнь Альцгеймера, хотя здесь также играют свою роль и многочисленные другие факторы, способствующие этому, такие, как генетика. Кроме того, недавние исследования показали, что цереброспинальная жидкость содержит микробную дезоксирибонуклеиновую кислоту (ДНК), которая может быть истолкована как означающая наличие микробиома в мозгу. Вагустный нерв и центральная нервна

Совпадение в полном тексте источника
… The current theme sets the pace for exploring gut-based therapies such as probiotics and prebiotics alongside other interventions to restore microbial balance. … The gut microbiome in depression and potential benefit of prebiotics, probiotics, and synbiotics: A systematic review of clinical trials and observational studies Int. J. Mol. Sci. 2022 23 4494 10.3390/ijms23094494 35562885 PMC9101152 14. McGuinness A.J. Davis J.A. Dawson S.L. Loughman A. …

From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease.

The skeletal system is an extraordinary structure that serves multiple purposes within the body, including providing support, facilitating movement, and safeguarding vital organs. Moreover, it acts as a reservoir for essential minerals crucial for overall bodily function. The intricate interplay of bone cells plays a critical role in maintaining bone homeostasis, ensuring a delicate balance. However, various factors, both intrinsic and extrinsic, can disrupt this vital physiological process. These factors encompass genetics, aging, dietary and lifestyle choices, the gut microbiome, environment

Совпадение в полном тексте источника
… Prebiotics support the nourishment of beneficial bacteria, aiding in the restoration of a balanced and healthy oral microbiota [ 94 ]. … Prebiotics, Bone and Mineral Metabolism. Calcif. Tissue Int. 2018;102:443–479. doi: 10.1007/s00223-017-0339-3. 44. Guo D., Liu W., Zhang X., Zhao M., Zhu B., Hou T., He H. …

Effects of Saccharomyces boulardii cell wall polysaccharide supplementation on growth performance, serum immunity, and fecal microorganisms in newborn calves.

BACKGROUND: Xinjiang is characterized by extremely cold weather and significant seasonal temperature variations, and these harsh climatic conditions have led to a high incidence of diarrhea and increased mortality rates among newborn calves, resulting in substantial economic losses for the local cattle industry. Saccharomyces boulardii cell wall polysaccharide (SBWP) is a natural prebiotic that has emerged as a promising alternative to conventional antibiotics for the mitigation of systemic inflammation, diarrhea, and mortality in livestock production. Therefore, this study aimed to investigat

Гут Микробиом и мальгический энцефаломилит/хронический синдром утомления (ME/CFS): Понимание механизмов борьбы с заболеваниями.

Myalgic Encephalomyelitis/Chronic Fatige (ME/CFS) — клиническая болезнь, характерная особенность которой заключается в постэкспертальной болезни (PEM). Она может влиять на многие органы и системы, что приводит к серьезному ухудшению качества жизни пациентов. Несмотря на многочисленные постинфекционные, иммунологические, неврологические, метаболические и эндокринные изменения, не существует ни окончательного диагностического маркера, ни утвержденного лечения. Этиология и патофизиология по-прежнему не до конца понимаются; однако появляющиеся данные свидетельствуют о том, что кишечная микробиомия

Совпадение в полном тексте источника
… Prebiotics Prebiotics such as fructo-oligosaccharides and galacto-oligosaccharides serve as nutrients for gut bacteria. They can enhance the growth of some beneficial bacterial populations like Bifidobacterium spp., consequently correcting microbiota imbalance [ 121 ]. … Prebiotics seem a reasonable treatment opportunity in ME/CFS, as studies with rodents fed with prebiotics show reduced gut inflammation with a presence of lower levels of LPS and pro-inflammatory cytokines in the serum [ 124 , 125 ]. 5.3. …

Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms.

Cancer is the leading cause of mortality worldwide. Various chemotherapeutic drugs have been extensively used for cancer treatment. However, current anticancer drugs cause severe side effects and induce resistance. Therefore, the development of novel and effective anticancer agents with minimal or no side effects is important. Notably, natural compounds have been highlighted as anticancer drugs. Among them, many researchers have focused on mushrooms that have biological activities, including antitumor activity. The aim of this review is to discuss the anticancer potential of different mushroom

Совпадение в полном тексте источника
… Prebiotic Properties of Medicinal Mushrooms in Cancer Several groups have reported that medicinal mushrooms can act as prebiotics, and thus enhance the growth of beneficial microbiota. … Prebiotics can affect the human intestinal microbial population and suppress various diseases such as diabetes, obesity, and cancer [ 77 ]. …

The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies.

Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and preclinical experimental evidence has shown that the efficacy of immunotherapy in tumor treatment varies markedly among individuals. The commensal microbiome mainly colonizes the intestinal lumen in humans, is affected by a variety of factors and exhibits individual variation. Moreover, the gut is considered the largest immune organ of the body due to its influence on the immune system. In t

Совпадение в полном тексте источника
… Table 4 Studies on improving the effect of antitumor immunotherapy by prebiotics Tumor type | Immunotherapy treatment | Prebiotic | Overview of mechanism | References CRC (CT26); breast cancer (4T1); melanoma (B16-F10) | αCTLA-4 mAb; αPD-1 mAb | Exopolysaccharide (EPS-R1) | Dietary intake of EPS-R1 induces … Prebiotic usage to promote antitumor immunotherapy has attracted increasing attention in recent years [ 211 , 212 ]. …

Развитие микробиотерапии: роль синтетической биологии в инженерных микробных сообществах для точной медицины.

В последние годы исследования в области микробиотических исследований и синтетической биологии были посвящены изучению новых подходов к микробным манипуляциям в терапевтических целях. Тем не менее, по этому аспекту имеется фрагментированная информация с ключевыми идеями, разбросанными по различным дисциплинам, таким, как молекулярная биология, генетика, биоинженерия и медицина. Цель этого обзора заключается в создании преобразующего потенциала синтетической биологии в плане развития исследований и лечения микробиоме, что имеет значительные последствия для здравоохранения, сельского хозяйства и

Совпадение в полном тексте источника
… Probiotics, prebiotics, and postbiotics in health and disease. MedComm 4, e420. 10.1002/mco2.420 Kalidasan V., Theva Das K. (2021). Is Malaysia ready for human gene editing: a regulatory, biosafety and biosecurity perspective. Front. Bioeng. … Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony. Front. Nutr. 11, 1355542. 10.3389/fnut.2024.1355542 Zhou Z., Chen X., Sheng H., Shen X., Sun X., Yan Y., et al. (2020). …

Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy.

BACKGROUND: Across the developed world, an estimated 150,000 to 300,000 people are treated annually with pelvic radiotherapy and 80% will de … been added; enteral tube feeds; or parenteral nutrition (partial or total). We excluded probiotics, prebiotics and synbiotics. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. We contacted study authors to obtain missing data. We assessed bias for each of the included studies using the bias assessment …