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Therapeutic potential of alpha-tocopherol in reducing oxidative stress and inflammatory damage after experimental traumatic brain injury and pentylenetetrazol-induced seizures.

The effects of alpha-tocopherol on seizure parameters, locomotor-cognitive functions, inflammatory response, oxidative stress response, histopathological changes, immunohistochemical parameters, and miRNA fold changes were investigated in rats with traumatic brain injury (TBI) and pentylenetetrazol (PTZ)-induced seizures. Sprague-Dawley male rats were randomly divided into three groups: Control (n = 8), TBI + PTZ (n = 10), and TBI + PTZ + tocopherol (n = 10). After inducing TBI in animals using the weight-drop method, increased post-injury seizure susceptibility was achieved by administering s

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… Closed head trauma was induced by dropping a 250 g stainless steel weight onto the midline of the head from a height of 100 cm through the glass tube. … The steel weight was dropped directly onto a 10 mm diameter and 3 mm thick stainless-steel disk placed on the animal’s scalp, rather than on the scalp. The weight was attached with a rope and scaled to prevent a second impact (Marmarou et al. 1994 ; Fehily et al. 2019 ; Dill et al. 2022 ). …

Carbon fibre PEEK versus titanium cephalomedullary nails for management of oncological lesions of the femur: a retrospective cohort study.

BACKGROUND: Carbon fibre reinforced polyetheretherketone (CF-PEEK) intramedullary devices have been gaining traction in the field of orthopaedic oncology. We aim to investigate the safety and efficacy of this device. METHODS: A retrospective cohort study was performed. Our primary objectives were to compare all-cause revision and the incidence of postoperative complications between CF-PEEK nails (Group 1) to titanium alloy nails (Group 2) for management of oncological lesions of the femur. Secondary objectives were to compare estimated blood loss and all-cause mortality between the two groups

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… We excluded patients who had stainless steel devices, those below the age of 18, and those who were treated for non-femoral lesions. …

Бетен смягчает недостатки в моторном поведении, нейротоксическом воздействии и нейро-воспалительной реакции в крысиной модели обезвоживания.

Множественный склероз (MS) характеризуется как хроническое воспалительное нейродегенеративное расстройство, ведущее к порче милиновой оболочки и потере аксонов. Бетане, триметилглициновое соединение, признается за его способность проникать через барьер мозга крови (ББД) и демонстрирует свойства, которые являются антиоксидантами, антивоспалительными и нейрозащитными. Модель " чапризона " (КПЗ) служит эффективным инструментом для изучения процессов обезвоживания и воспоминания, связанных с НР. В наших исследованиях мы изучили защитные и терапевтические последствия бетаина в крысиной мо

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… Rats were housed in stainless steel cages at a constant temperature (23 ± 2 °C) and under a 12 h light/dark cycle. Animals were acclimated for 1 week before starting the experiment and were provided access to rodent chow and water ad libitum. Body weight was measured weekly during the experiment. …

Assessment of evidence from teeth and the alveolar bone of skulls.

A notable lack of agreement on a standardised criterion for representing changes in alveolar bone persists, which limits its application in forensic dentistry. This study aimed to describe the data on loss of tooth substance and alveolar bone in skulls. Dental and trabecular bone information from 28 skulls from the German Helmer skull collection was collected through dental charting, intraoral photographs taken with a DSLR camera (Nikon D5600, Nikon Corporation, Japan), and small radiographs obtained using a handheld dental X-ray device (Nomad Pro 2, Kavo Kerr, Biberach, Germany). Adobe Photos

От генов к окружающей среде: жизненный подход к профилактике педиатрических аутоиммунных заболеваний.

Аутоиммунные заболевания у детей, включая тип 1 Все более серьезной проблемой для здоровья людей во всем мире являются диабет, болезни селиака и детский артрит. Этот всплеск, слишком быстрый для того, чтобы его можно было объяснить только генетическими изменениями, подчеркивает важнейшую роль экологических факторов и подчеркивает настоятельную необходимость принятия активных превентивных мер. Этот обзор представляет собой комплексную, основанную на фактических данных основу для профилактики педиатрических аутоиммунных заболеваний по всему спектру услуг, начиная с первичной и заканчивая третичн

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

Influence of anticancer agents on sexual function: An in vivo study based on the US FDA Adverse Event Reporting System.

BackgroundPatients with cancer are treated with chemotherapeutics that cause adverse effects, including erectile dysfunction (ED).ObjectivesWe investigated erectile function in rats after the administration of anticancer agents based on data retrieved through mining of the US Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database.Materials and methodsThe statistical signal strength for the association between anticancer drugs and ED was calculated using the reporting odds ratio (ROR). A drug-event combination was detected when the lower limit of the 95% confidence in

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… Stainless steel bipolar wire electrodes (Unique Medical, Osaka, Japan) and a pulse generator (Nihon Kohden, Tokyo, Japan) were used for penile stimulation under the following conditions: 1 min at 5 V, 1–16 Hz, and a square wave duration of 5 ms. …

Malignant obstruction of the inferior vena cava: clinical experience with the self-expanding Sinus-XL stent system.

PURPOSE: To evaluate the technical and clinical outcome of Sinus-XL stent placement in patients with malignant obstruction syndrome of the inferior vena cava. METHODS: Between October 2010 and January 2021, 21 patients with different malignant primary disease causing inferior vena cava obstruction were treated with Sinus-XL stent implantation. Procedural data, technical and clinical outcome parameters were retrospectively analyzed. RESULTS: Technical success was 100%. Analysis of available manometry data revealed a significant reduction of the mean translesional pressure gradient following t

Ameloblastoma RNA profiling uncovers a distinct non-coding RNA signature.

Ameloblastoma of the jaws remains the top difficult to treat odontogenic tumour and has a high recurrence rate. New evidence suggests that non-coding RNAs (ncRNAs) play a critical role in tumourgenesis and prognosis of cancer. However, ameloblastoma ncRNA expression data is lacking. Here we present the first report of ameloblastoma ncRNA signatures. A total of 95 ameloblastoma cases and a global array transcriptome technology covering > 285.000 full-length transcripts were used in this two-step analysis. The analysis first identified in a test cohort 31 upregulated ameloblastoma-associated ncR

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… Disruption and homogenization of the tissues was performed using Stainless Steel beads and the TissueLyser II from Qiagen. All samples were DNAse treated prior to downstream applications. …

Organic Nanoparticles in Progressing Cardiovascular Disease Treatment and Diagnosis.

Cardiovascular diseases (CVDs), the world's most prominent cause of mortality, continue to be challenging conditions for patients, physicians, and researchers alike. CVDs comprise a wide range of illnesses affecting the heart, blood vessels, and the blood that flows through and between them. Advances in nanomedicine, a discipline focused on improving patient outcomes through revolutionary treatments, imaging agents, and ex vivo diagnostics, have created enthusiasm for overcoming limitations in CVDs' therapeutic and diagnostic landscapes. Nanomedicine can be involved in clinical purposes for CV

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… Brito et al. created a gene-eluting stent with liposome/DNA complexes immobilized on the stainless steel surface to lessen coronary restenosis. … Type of Treatment | Medical Applications | References Vesicles formulated with phospholipids and PEG-HS and istaroxime | Acute and chronic heart failure | [ 47 ] Biomimetic liposomes | Anti-inflammatory treatment of MI | [ 61 ] Liposome/DNA complexes immobilized on the stainless steel surface | Coronary …

Long-term follow-up of vertebral compression fractures in inpatients treated with integrative Korean medicine: An observational study.

Conservative management is the recommended first-line treatment for thoracolumbar vertebral compression fractures (VCFs), with integrative Korean medicine (IKM) being widely used for treatment in Korea. However, evidence regarding long-term treatment outcomes is lacking. We aimed to investigate the effectiveness of IKM treatment for thoracolumbar VCFs. Data from inpatients with thoracolumbar VCFs who received IKM treatment, comprising acupuncture, pharmacopuncture, electroacupuncture, Chuna manual therapy, and herbal medicine, at 4 KM hospitals from April 1, 2016 to June 30, 2022 were analyzed

Artificial Neural Networks Coupled with MALDI-TOF MS Serum Fingerprinting To Classify and Diagnose Pathological Pain Subtypes in Preclinical Models.

Pathological pain subtypes can be classified as either neuropathic pain, caused by a somatosensory nervous system lesion or disease, or nociplastic pain, which develops without evidence of somatosensory system damage. Since there is no gold standard for the diagnosis of pathological pain subtypes, the proper classification of individual patients is currently an unmet challenge for clinicians. While the determination of specific biomarkers for each condition by current biochemical techniques is a complex task, the use of multimolecular techniques, such as matrix-assisted laser desorption/ioniza

Interventional radiology in the elderly.

Interventional radiological percutaneous procedures are becoming all the more important in the curative or palliative management of elderly frail patients with multiple underlying comorbidities. They may serve either as alternative primary minimally invasive therapies or adjuncts to traditional surgical treatments. The present report provides a concise review of the most important interventional radiological procedures with a special focus on the treatment of the primary debilitating pathologies of the elderly population. The authors elaborate on the scientific evidence and latest developments

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… Stents may be balloon-expandable or self-expanding and are manufactured from stainless steel or other alloys. Nitinol (an alloy of nickel and titanium) self-expanding stents assume a predictable shape at body temperature when deployed and are generally preferred in the gastrointestinal tract. …

An evaluation based on the analytic hierarchy process and GGEbiplot on French fry potato genotypes in Yunnan, China.

A total of 33 potato (Solanum tuberosum L.) cultivars and breeding clones imported from the United States and two local cultivars (Yunshu 401 and Cooperation 88, CK) were planted and evaluated. To determine their suitability for processing into French fries at five locations (e1-e5) in Yunnan Province, China, we developed a comprehensive evaluation system using the analytical hierarchy process (AHP). Eleven evaluation indicators for French fry quality, yield, and agronomic characteristics with a relative importance (weight coefficients) of 0.483, 0.301 and 0.216, respectively, were used to ana

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… They were hand-peeled starting at the stem-end (basal) side of all 10 potato tubers using stainless steel knives, and the peeled tubers were cut along the long axis with an automatic French fry cutter machine into 7 mm × 7 mm rectangular strips; the central four strips of each tuber were collected ( …

Exosomal AFAP1-AS1 binds to microRNA-15a-5p to promote the proliferation, migration, and invasion of ectopic endometrial stromal cells in endometriosis.

BackgroundEndometriosis (EMS) remains a major challenge to reproductive health due to multifactorial etiology, disease heterogeneity, and the lack of appropriate diagnostic markers and treatment. Eexosome (Exo) has become a major factor in progression of a variety of diseases. However, the mechanisms directing their role in the pathophysiology of EMS are ill-defined. Here, we aimed to investigate the clinical implications of actin filament associated protein 1-Antisense RNA 1 (AFAP1-AS1) in EMS.MethodsBioinformatics analysis was used to predict the expression and interaction of AFAP1-AS1, miR-

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… After digestion, the tissue solutions were filtered through 150 μm and 74 μm stainless steel cell filters (GongLu; Hangzhou, China) to obtain cells, respectively. …

FmocFF Peptide Hydrogel Is a Promising Matrix for Encapsulation and Controlled Release of the Anticancer Peptide Drug Bortezomib.

One major public health issue is cancer chemotherapy; despite constant progress in the area, administration of anticancer drugs to patients is often associated with serious side effects. It is therefore imperative to develop vehicles for encapsulation and controlled delivery of such drugs. Anticancer drugs include small peptide drugs, such as Bortezomib (BTZ). Self-assembling peptides have been recently reported as promising drug delivery agents. The research reported here proposes the encapsulation of BTZ into peptide hydrogels formed by the self-assembling FmocFF dipeptide as delivery vehicl

Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases.

Bone marrow is vital for hematopoiesis, producing blood cells essential for oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, and myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy and stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects and limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising a

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… Metal biomaterials, such as cobalt-based alloys, titanium, and stainless steel, are commonly used for implants due to their durability. …

Characterization of a rat model of bortezomib-induced painful neuropathy.

Background and purposeBortezomib (Velcade®) is a breakthrough treatment for multiple myeloma, significantly improving patient survival. However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first-line treatment due to lack of treatment. The aim of this study was to characterize a clinically relevant rat model of bortezomib-induced painful neuropathy, using established evoked measures and novel ethological techniques, to aid drug discovery.Experimental approachAdult male Sprague-Dawley rats were injected i.p. with 0.1 and 0.2 mg·kg-1 bortezomib, or its

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… Cages were Type III polycarbonate, and wheels were made of stainless steel. Animals had access to food and water ad libitum and free access to the wheel. Activity wheel cages contained sawdust only and were kept within the room that the rats were normally housed. …

Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory disease that leads to myelin loss and neurological dysfunction. Clinical studies show increased anti-Kir4.1 antibody levels in MS patients' serum, indicating its diagnostic potential. However, the specific mechanism has remained elusive. In a mouse model of experimental autoimmune encephalomyelitis (EAE), it is found that impaired Kir4.1 channels in oligodendrocyte precursor cells (OPCs) hindered myelin repair in the spinal cord. Using a thermal shift assay (TSA), the small molecule 2-D08 is identified, which effectively activated Kir4.1 channe

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… Responses of the gastrocnemius muscle were recorded using a 250 µm diameter 304 stainless steel electrode (Kedou Brain Computer Technology Co. Ltd., Suzhou, China). Date were acquired using an electrophysiology data acquisition system (Medusa, Bio‐Signal Technologies, USA) and digitized at 1 kHz. …

Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration.

Bone regeneration is a complex biological process that relies on the orchestrated interplay of various cellular and molecular events. Bone tissue engineering is currently the most promising method for treating bone regeneration. However, the immunogenicity, stable and cell quantity of seed cells limited their application. Recently, exosomes, which are small extracellular vesicles released by cells, have been found to effectively address these problems and better induce bone regeneration. Meanwhile, a growing line of research has shown the cargos of exosomes may provide effective therapeutic an

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… Typical metal scaffolds utilized in bone tissue engineering consist of titanium alloy,metal–organic frameworks, stainless steel scaffolds, etc. …