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Cutaneous Graft-Versus-Host Disease Lichen Spinulosus-like: a New Form of Presentation of an Old Entity.

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Comparison of the long-term prognostic value of different frailty instruments in older inpatients: a 5-year prospective cohort study.

BackgroundFrailty is associated with increased mortality in older adults, but limited studies compare frailty instruments among inpatients with long-term follow-up.AimsTo evaluate five frailty scales for predicting 5-year all-cause mortality in older inpatients.MethodsThis prospective cohort study enrolled 917 inpatients aged ≥ 65 years. We used five commonly used scales [Clinical Frailty Scale (CFS), FRAIL, Fried, Edmonton, and the comprehensive geriatric assessment-frailty index (CGA-FI)] to screen or assess frailty and then conducted a 5-year telephone follow-up. The primary endpoint was 5-

The therapeutic potential of bedside art observation in hematologic cancer inpatients: a randomized controlled pilot study.

PurposePrior research has suggested that art-based interventions may reduce anxiety in cancer patients and enhance dialogue in the healthcare setting. Through implementing Art at the Bedside, an art-based hospital visitation program, we sought to examine whether dedicated art observation sessions, and varying formats (with and without guided discussion), could have therapeutic effects on cancer patients' mental wellbeing.MethodsThis randomized controlled pilot study evaluated the effects of bedside art observation on anxiety in a sample of 73 hematologic cancer inpatients. We compared state an

A phase 2, open-label, multicenter study of ixazomib plus lenalidomide and dexamethasone in adult Japanese patients with relapsed and/or refractory multiple myeloma.

BackgroundTOURMALINE-MM1 was a global study that demonstrated a significant improvement in progression-free survival with ixazomib plus lenalidomide and dexamethasone compared with placebo plus lenalidomide and dexamethasone, in patients with relapsed and/or refractory multiple myeloma. The current study was conducted to evaluate further the efficacy and safety of ixazomib plus lenalidomide and dexamethasone in Japanese patients.MethodsThis phase 2, open-label, single-arm, multicenter study enrolled patients aged ≥ 20 years with relapsed and/or refractory multiple myeloma at 16 sites in Japan.

Влияние ориентированной на семью gamification на самоуправление людьми с множественным склерозом: протокол исследования смешанных методов.

ВВЕДЕНИЕ: Множественный склероз (МС) является хроническим заболеванием центральной нервной системы, которое затрагивает миллионы людей во всем мире, в том числе людей в Иране. Она затрагивает главным образом молодежь, что приводит к возникновению биопсихосоциальных проблем с непредсказуемыми симптомами. Самоуправление имеет решающее значение, но сопряжено с трудностями из-за отсутствия окончательного лечения. Новые подходы, такие, как медико-санитарные меры, в частности gamification, направлены на более эффективное привлечение пациентов. Хорошо продуманная gamification может оказать позитивное

Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes.

BackgroundThe usefulness of non-invasive mechanical ventilation (NIMV) in oncohematological patients is still a matter of debate.AimTo analyze the rate of noninvasive ventilation failure and the main characteristics associated with this endpoint in oncohematological patients with acute respiratory failure (ARF).MethodsA ventilatory support protocol was developed and implemented before the onset of the study. According to the PaO2/FiO2 (P/F) ratio and clinical judgment, patients received supplementary oxygen therapy, NIMV, or invasive mechanical ventilation (IMV).ResultsEighty-two patients were

Ограничение способности любить и гиперсексуальное поведение в их отношениях с психотиком и паранойей.

Предпосылки к способности к любви (КТЛ) и проблематичной сексуальности можно было бы рассматривать в качестве показателей психопатологических страданий. 521 Темы390 женщин и женщин 131 мужского пола; возрастный период: 18-50) Завербованные субъекты заполнили психометрический протокол, включающий в себя следующие инструменты измерения:1) реестр возможностей любить;2) Гиперсексуальная инвентаризация поведения,3) Краткий список симптомов. Выражения указывают на значительную обратную корреляцию между CTL и как параноидальной идеей, так и психотиком, при этом гиперсексуальность положительно соотнос

Joint manifestations revealing inborn metabolic diseases in adults: a narrative review.

Inborn metabolic diseases (IMD) are rare conditions that can be diagnosed during adulthood. Patients with IMD may have joint symptoms and the challenge is to establish an early diagnosis in order to institute appropriate treatment and prevent irreversible damage. This review describes the joint manifestations of IMD that may be encountered in adults. The clinical settings considered were arthralgia and joint stiffness as well as arthritis. Unspecific arthralgias are often the first symptoms of hereditary hemochromatosis, chronic low back pain may reveal an intervertebral disc calcification in

Content validation of the EORTC QLQ-C15-PAL with advanced cancer patients and health care professionals from palliative care services in Chile.

BackgroundThe assessment of patients' quality of life (QOL) is essential when evaluating the outcome of palliative care; however, no instruments have been validated for measuring symptoms and QOL in patients receiving palliative care in Chile. We aimed to investigate the content validity of the EORTC Quality of Life Questionnaire Core 15 Palliative Care (QLQ-C15-PAL), replicating the methods used previously to shorten the EORTC Quality of Life Questionnaire Core 30 (QLQ-C30) for use among patients in palliative care.MethodsThis cross-sectional study was conducted from October to November 2017

Плазмоцитома в эксклюзивном манифестации Множественной миеломы: доклад по делу.

Внешняя плазменная цитома является необычным проявлением множественной миэломы (ММ) и может включать в себя широкий круг участков с мягкими тканями. Поверхностное участие спины является особенно редким и может быть ошибочно истолковано как доброкачественное повреждение мягких тканей. Мы сообщаем о случае 59-летнего мужчины с диагнозом MM, поставленным в апреле 2024 года, который лечился четырьмя циклами бортезомида, циклофосфамида и дексаметасона (ВЦД), достиг ремиссии с исчезновением сыворотки и мочи М-протеина на иммунофиксе. В октябре 2025 года, несмотря на лечение даратумумаба, болезнь вно

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Prevalence and Mortality-Related Factors of Multiple Myeloma in Taiwan.

In this retrospective cohort study based in Taiwan, we reported the current epidemiology of patients with multiple myeloma and analyzed the factors affecting mortality. We identified 7285 patients with newly diagnosed multiple myeloma (MM) between 1997 and 2013 in Taiwan. Privileges data from the National Health Institute Research Database was used, as it is made readily available to the public in electronic format for research purposes. From 1997 to 2013, the average incidence of MM per 100,000 people was 1.83. The mortality accounted for an average of 0.44 per 100,000 deaths. In all 7285 inp

Use of complementary and alternative medicine by patients with hematological diseases experience at a university hospital in northeast Mexico.

BackgroundComplementary and alternative medicine includes a diverse group of medical and healthcare systems, practices and products not considered part of conventional medicine. Although there is information on unconventional practices in oncological diseases, specific data regarding the use of complementary and alternative medicine by hematology patients is scarce.ObjectiveThe aim of this study is to document the prevalence of this modality of unconventional therapy in patients with malignant and benign hematological diseases, particularly children with acute lymphoblastic leukemia.MethodsAn

Cancer during a pandemic: A psychosocial telehealth intervention for young adults.

The SARS-II COVID-19 pandemic has posed pronounced global health threats and prompted assorted transformations in societal engagement and clinical service delivery. For cancer survivors, many of whom are immune-compromised, these pandemic-related health threats pose greater challenges, warranting extra precautions within everyday living. Young adult (YA) cancer survivors already confront many unique physical and emotional challenges specific to their demographic. Already comfortable with assorted technologies, the pandemic presented an opportunity to provide telehealth intervention that target

Feasibility of a tailored and virtually supported home exercise program for people with multiple myeloma using a novel eHealth application.

INTRODUCTION: eHealth exercise interventions have the unique ability to leverage the benefits of in-person programming (tailoring and supervision) with the benefits of home programming (flexibility). There may be a role for eHealth-delivered exercise for people with multiple myeloma (MM), as exercise tailoring and supervision are critical for successful outcomes due to the significant impacts/risks of myeloma-related side effects. The purpose of this study was to determine the safety, feasibility, and preliminary efficacy of a 12-week virtually supported eHealth exercise program. METHODS: Par

Ключевые результаты мероприятий по профессиональной реабилитации лиц с множественным склерозом: Номинальное техническое исследование группы.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Мероприятия по профессиональной реабилитации лиц с множественным склерозом (МС) в целях удержания рабочих мест могут оказать позитивное воздействие на независимость человека и непосредственно повлиять на результаты в области здравоохранения и занятости. Вместе с тем оценка эффективности мероприятий в области ПР может быть сопряжена с трудностями в силу их весьма индивидуализированного характера и разнообразных потенциальных последствий для здоровья и занятости, которые могут быть затронуты. AIM: Определение наиболее важных результатов деятельности по сохранению рабочих м

Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report.

A 55-year-old male was admitted to the hospital with pneumonia. During an intubation procedure, the patient received an application of endobronchial lidocaine (4% gel). Within 2 h of intubation, the patient developed worsening hypoxia, and investigation of arterial blood gasses revealed a pH of 7.21, carbon dioxide partial pressure (PaCO2) of 3.3 kPa, oxygen partial pressure (PaO2) of 55.1 kPa, and measured oxygen saturation of 49%. Co-oximetry of this sample returned a methemoglobin level of 53%. Intravenous methylthioninium chloride (1% solution at 1 mg/kg) was delivered, and subsequent arte

The use of cortical heterologous sheets for sinus lift bone grafting: a modification of Tulasne's technique with 7-year follow-up.

PLAIN ENGLISH SUMMARY: (Please see www.Toolsfortalking.co.uk for an easy read summary of the project.) The Tools for Talking are a set of resources that were developed through collaboration between Black, Asian and minority ethnic people with learning disabilities and researchers at the University of Birmingham. The resources were designed to be used by people with learning disabilities and service providers to facilitate culturally-sensitive communication and information sharing, service planning and delivery. They comprise illustrative videos and exploratory activities relating to five topic

< < Холистическое управление множественной миеломой > > : доклад по делу < < Терапия Сидды > > как дополнение к режиму Бортезомиба-Леналидомида-Дексаметасона (БЛД).

Множественная миелома (ММ) — сложная гематология, характеризующаяся клональным распространением плазменных клеток в костном мозге. Это вторая по распространенности гематологическая халатность, которая проявляется у пожилых пациентов. Инкорпорирование дополнительной медицины в обычные методы лечения рака все чаще наблюдается среди пациентов, что обусловлено такими факторами, как управление симптомами, целостное благосостояние и культурная увязка. В настоящем докладе представлена информация о комплексном управлении деятельностью 65-year-old Пациент мужского пола диагностировал ММ, который получа

Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists.

Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As part of the disease, proteins that were originally soluble misfold and acquire a fibrillar conformation that renders them insoluble and resistant to proteolysis. Systemic amyloidosis is a rare, often underdiagnosed condition. In recent years, the incidence of newly diagnosed cases of amyloidosis has been increasing in association with the aging of the population and greater access to diagnostic tests. From a clinical perspective, systemic amyloidosis is f

Vitamin D levels and their associations with survival and major disease outcomes in a large cohort of patients with chronic graft-vs-host disease.

AimTo identify the factors associated with vitamin D status in patients with chronic graft-vs-host disease (cGVHD) and evaluate the association between serum vitamin D (25(OH)D) levels and cGVHD characteristics and clinical outcomes defined by the National Institutes of Health (NIH) criteria.Methods310 cGVHD patients enrolled in the NIH cGVHD natural history study (clinicaltrials.gov: NCT00092235) were analyzed. Univariate analysis and multiple logistic regression were used to determine the associations between various parameters and 25(OH)D levels, dichotomized into categorical variables: ≤20