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Потенциальное терапевтическое воздействие ибудиластной и ретиновой кислоты на поведенческие и биохимические изменения в мышечном мозге.

Ibudilast (IBD) — новый препарат, выпущенный в качестве лекарства от множественных склерозов (MS). Ретиноиновая кислота (RA), являющаяся метаболитом витамина А, известна своими прорегенеративными и антивоспалительными свойствами, поэтому она была предложена в качестве дополнительного метода лечения для MS. Цель этого исследования заключается в изучении терапевтического воздействия RA и IBD на модели мышей, вызываемые кухонной зоной (CPZ). Seventy-two Швейцарские мыши-альбино (SWR/J) были разделены на two контроль за основными группами (n = 18); нормальная чау и CPZ (n = 54); 0.25% CPZ, смешанн

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Ibudilast (IBD) is a new drug that has been released as treatment for multiple sclerosis (MS). Retinoic acid (RA), a metabolite of vitamin A, is known for its pro-regenerative and anti-inflammatory properties, therefore, it has been suggested as a supplementary treatment for MS. The objective of this study is to investigate the therapeutic effects of RA and …

Нынешний подход к решению проблемы вторичного недоедания у пациентов с гематологическими отклонениями: рекомендации в отношении консенсуса экспертов Испании.

Для оценки мнений клинических гематологов было проведено обследование на базе Делфи (n = 17) и клинических иммунологов (n = 18) по всей Испании о вторичных иммунодефицитах (СИД) в области лечения онкогематологических пациентов. Там было 100% :: согласие с необходимостью наличия руководящих принципов в отношении лечения иммунодефицита у пациентов, страдающих гематологией; проведение базовой иммунологической оценки у пациентов с хронической лимфоцитной лейкемией (КЛЛ), множественной миеломой (ММ), лимфомой и гематопоиетической трансплантацией стволовых клеток (ХСБТ); и количественная оценка уров

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… Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis. New Engl. J. Med. 2017;376:209–220. doi: 10.1056/NEJMoa1606468. 21. Viardot A., Goebeler M.-E., Hess G., Neumann S., Pfreundschuh M., Adrian N., Zettl F., Libicher M., Sayehli C., Stieglmaier J., et al. …

Искусственные разведывательные методологии для ранней диагностики точности и индивидуализированных терапевтических стратегий в нейро-офтальмических и нейродегенеративных патологиях.

Совершенствование нейроимации, в частности методов диффузной магнитной резонансной съемки (MRI) и молекулярной съемки с помощью позитронной томографии (ПТЭ), значительно повысило раннее обнаружение биомаркеров в нейродегенеративных и нейро-офтальмических расстройствах. К ним относятся болезнь Альцгеймера, болезнь Паркинсона, множественный склероз, оптика нейромиелита и болезнь антител миэлина олигодендроцита гликопротеина. В настоящем обзоре подчеркивается преобразующая роль современных методов диффузии MRI - Неевритная ориентация - диспергация и интерпретация плотности и дифлюстрация Куртоза

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Advancements in neuroimaging, particularly diffusion magnetic resonance imaging (MRI) techniques and molecular imaging with positron emission tomography (PET), have significantly enhanced the early detection of biomarkers in neurodegenerative and neuro-ophthalmic disorders. These include Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuromyel…

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments.

Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an accumulation of its substrate, glucosylceramide, in macrophages. In the general population, its incidence is approximately 1/40,000 to 1/60,000 births, rising to 1/800 in Ashkenazi Jews. The main cause of the cytopenia, splenomegaly, hepatomegaly, and bone lesions associated with the disease is considered to be the infiltration of the bone marrow, spleen, and liver by Gaucher cells. Type-1 Gaucher disease, which affects the

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… An insufficiency of PGRN has also been associated with many types of neurodegenerative disease, including frontotemporal dementia, Parkinson’s disease (PD), Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis [ 36 ]. … Increased chitotriosidase levels are also observed, but to a lesser extent, in certain other lysosomal storage diseases (e.g., Niemann–Pick diseases) and a variety of non-LSD disorders (sarcoidosis [ 138 ], β-thalassemia, multiple sclerosis, Alzheimer’s disease, or visceral leishmaniasis [ 139 ]). …

Терапевтический потенциал зубных мезенхимальных стволовых клеток в сравнении с мезенхимальными стволовыми клетками из других источников: систематический обзор исследований животных.

ЦЕНТРАЛЬНАЯ терапия на основе стволовых клеток, являющаяся одной из важнейших областей регенеративной медицины, направлена на совершенствование механизмов ремонта тела (d) путем стимулирования, модуляции и регулирования внутренних стволовых клеток или пополнения пулов клеток, способствуя тем самым развитию гомеостаза и регенерации тканей и предлагая перспективное лечение многочисленных системных заболеваний. В настоящем систематическом обзоре содержится всеобъемлющее резюме исследований животных, в ходе которых изучается эффективность зубоврачебных мезенхимальных стволовых клеток (НКЦ) в лечен

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… Finally, while KA mice showed reduced self-grooming—a marker of stress and depression—DPSCs significantly increased grooming frequency, indicating stronger anti-depressive effects compared to BMMSCs, although both improved stress-related behaviors. | DPSCs Krakenes et al. | 2023 | Multiple sclerosis … In multiple sclerosis (MS) models, Krakenes et al. [ 28 ] reported that BMMSCs significantly increased myelination and reduced microglial activation. SHEDs also reduced microglial activation and more strongly suppressed astrocytic activation, but had no significant effect on myelination. …

NEK2 регулирует функцию клеток B и остроту экспериментального аутоиммунного энцефаломиелита.

Никогда в гене митоза А (NIMA) 2 (NEK2) член семьи сереново-триониновая киназа принимает активное участие в регулировании клеточного цикла. Регулирование NEK2 связано с аномальным распространением клеток B, которое потенциально вызвано NEK2-mediated нарушение равновесия PKM1/PKM2. Чрезмерное выражение NEK2 в линии клеток B может облегчить процесс созревания клеток B. Тем не менее, точная роль НКЭК2 в модуляции иммунитета от аутоиммунных расстройств с помощью клеток В еще не полностью разъяснена. В этом исследовании мы продемонстрировали, что НКЭК2 была значительно усилена в отношении пациентов

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Never in mitosis gene A (NIMA)-related kinase 2 (NEK2), a member of the serine-threonine kinase family, is critically involved in the regula … ns to be fully elucidated. In this study, we demonstrate that NEK2 was significantly upregulated in multiple sclerosis (MS) patients. Pharmacological inhibition of NEK2 resulted in a marked reduction in the expression of co-stimulatory molecules CD80 and CD86 on B cells, concomitant with a suppression of their proliferation and differentiation into antibody-secretin …

The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session.

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… sclerosis (MS) proved effectiveness and safety. … We aimed to create a model of organization of help for children with severe refractory multiple sclerosis based on multidisciplinary and multicenter approach. Methods: Fifteen children with MS received autologous HSCT (aHSCT) from January 2010 to May 2018. Gender: females - 11, males - 4. …

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients tre

Микробные профили пациентов с оптическим неуритом или миастенией гравис.

ЦЕЛЬ: Характеристика кишечного микробного состава пациентов с оптическим невритом (ON) или миастенией грависа (MG). МЕТОДЫ: Пробы стула были собраны у 45 пациентов с НО, 13 пациентов с MG и 20 здоровых методов контроля. Микробиальная геномная ДНК была извлечена, и V3-V4 области бактериальных генов 16S rRNA были расширены и секвенированы. Для сопоставления альфа-разнообразия, бета-разнообразия, таксономических задач и бактериального богатства групп был проведен биоинформатический анализ. Различия в изобилии микробных таксов были выявлены с использованием линейного анализа эффекта дискриминантов

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… Patients often present with partial or complete acute vision loss and eye pain within a few days of onset. 1 ON can be categorized into multiple subtypes according to its association with specific underlying conditions. 2 Multiple sclerosis-associated optic neuritis (MS-ON) is linked to multiple … sclerosis (MS) and typically presents with features of demyelination. …

Выявление биомаркеров для ремилеляции и восстановления при многоразовом склерозе: показатель прогресса.

Фон: Множественная патология склероза (MS) характеризуется острым и хроническим воспалением, обезвоживанием, аксоновой травмой и нейродегенерацией. После десятилетий исследований по проблеме дегенерации, связанной с НР, недавние усилия сместились в направлении восстановления и предотвращения дальнейшего ущерба. Одним из ключевых направлений деятельности является процесс ремиэлизации, в рамках которого исследователи изучают воздействие фармакотерапии на механизмы ремонта миелина. Множественные соединения испытываются на предмет их способности содействовать воссоединению в различных клинических

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Background: Multiple sclerosis (MS) pathology is characterized by acute and chronic inflammation, demyelination, axonal injury, and neurodegeneration. After decades of research into MS-related degeneration, recent efforts have shifted toward recovery and the prevention of further damage. A key area of focus is the remyelination process, where researchers are…

Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?

Multiple system atrophy is a rapidly progressive and fatal neurodegenerative disorder. While numerous preclinical studies suggested efficacy of potentially disease modifying agents, none of those were proven to be effective in large-scale clinical trials. Three major strategies are currently pursued in preclinical and clinical studies attempting to slow down disease progression. These target α-synuclein, neuroinflammation, and restoration of neurotrophic support. This review provides a comprehensive overview on ongoing preclinical and clinical developments of disease modifying therapies. Furth

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… The immunomodulatory drug Fingolimod, currently marketed for treating multiple sclerosis, shows neuroprotective effects in different animal models by increasing brain-derived neurotrophic factors. … [117] Gray E, Thomas TL, Betmouni S, Scolding N, Love S (2008) Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathol 18, 86–95. …

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

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… CERTAIN ACUTE SENSORY-MOTOR PRESENTATIONS CONSIDERED AS “MEDICALLY UNEXPLAINED” [TABLES 1 AND 2 ] Table 1 Assessment of acute onset motor disturbances TIA – Transient ischemic attack; RLS – Restless leg syndrome; NMS – Neuroleptic malignant syndrome; MS – multiple sclerosis; CBG – Capillary blood glucose … sclerosis; NOVL – Nonorganic visual loss | Organic | Psychogenic Visual loss | Detailed ophthalmological and neurological workup (visual evoked potential) is a must | NOVL[ 23 ]–in either visual acuity or field loss – should be a diagnosis of exclusion after detailed ophthalmological evaluation | …

Surgical techniques for patients with cancer-related neuropathic pain.

In this manuscript, we discuss the use of neuromodulatory techniques such as intrathecal therapy (IT) and spinal cord stimulation (SCS) for cancer pain in neuro-oncology patients. Currently, cancer pain management relies on oral opioids, which have a number of systemic side effects particularly in a chronic setting. An escalation of pain therapy for pain relief, such as neuromodulation, is necessary to improve neuro-oncology patients' quality of life. The paper highlights the need for more comprehensive pain management for patients during and after receiving cancer therapies. IT allows analges

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… Motor conduction velocity in the human spinal cord: Slowed conduction in multiple sclerosis and radiation myelopathy. J Neurol Neurosurg Psychiatry. 1985;48(11):1135–1139. 13. Yakovlev AE, Ellias Y. Spinal cord stimulation as a treatment option for intractable neuropathic cancer pain. …

Nephrology's Next Frontier: Expanding the Reach of CAR T-Cell Therapy for Refractory Lupus Nephritis and Beyond.

Chimeric antigen receptor (CAR) T-cell therapy has recently evolved beyond cancer therapy's boundary to treating autoimmune diseases such as lupus nephritis. In CAR T-cell therapy, the genetically engineered patient's T cells express a receptor specifically targeting antigens such as CD19, a protein found on the surface of B cells. By directing the immune system to eliminate B cells, which play a central role in the pathogenesis of systemic lupus erythematosus, CAR T-cell therapy offers a novel and potent approach to resetting the immune system and achieving remission in difficult-to-treat lup

Морфологические изменения в сетчатке при расстройствах, связанных с употреблением алкоголя: систематический обзор и метаанализ исследований с использованием технологии оптической согласованности.

Цель обзора - использование чреонического алкоголя связано с различными структурными и функциональными изменениями в мозге. Скринальная морфология, оцениваемая с помощью оптической последовательности томографии (OCT), неинвазивно выявляет повреждения мозга, связанные с алкоголем, и может быть маркером болезней. 15/ Апрель/2025). Метаанализы случайного воздействия проводились по толщине параметров сетчатки как на диске, так и на макуле: слой волокна сетчатки (RNFL), слой ячеек ганглиона (GCL), внутренний плексиформный слой (IPL), плексиформальный слой с ганглионными клетками (GCIPL), толщина хо

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… Prolonged alcohol use tends to provoke or exacerbate both psychiatric disorders and neurological disorders such as stroke, multiple sclerosis and dementia. 1 Structural changes such as global cerebral, cerebellar atrophy and central pontine myelinolysis are known to be caused by chronic alcohol use. …

Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities.

Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are primary brain tumors that account for ~80% of all malignant brain tumors. Glioblastoma multiforme (GBM) is the most common, invasive, and lethal subtype of glioma. Therapy resistance and intra-GBM tumoral heterogeneity are promoted by subpopulations of glioma stem cells (GSCs). Cannabis sativa produces hundreds of secondary metabolites, such as flavonoids, terpenes, and phytocannabinoids. Around 160 phytocannabinoids have been identified in C. sativa. Cannabis is commonly used to treat various medical co

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… These include Nabiximols, which is a whole-plant prescription cannabinoid used in the management of patients with multiple sclerosis, chronic neuropathic pain, and cancer-related pain [ 13 ]. … Dysregulation of the ECS is associated with different diseases, including obesity, diabetes, anxiety and depression, inflammation, neurodegenerative disorders, multiple sclerosis, schizophrenia, glaucoma, cardiovascular diseases, obesity, and cancer [ 48 , 49 ]. …

Hematopoietic stem cell transplantation therapy for refractory' Crohn disease: A systematic review and meta-analysis.

BackgroundDespite the availability of numerous treatments for Crohn disease, there are patients who do not respond to any therapy, thereby diminishing their quality of life. The aim of this review is to analyze the efficacy and safety of autologous hematopoietic stem cell transplantation therapy for refractory Crohn disease.MethodsThis work is a systematic review with meta-analysis conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses. Electronic databases such as PubMed, Scopus, Web of Science, and ClinicalTrials were consulted. T

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… Articles Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol. 2009;8:244–53. [57] Krasulová E, Trněný M, Kozák T, et al. … High-dose immunoablation with autologous haematopoietic stem cell transplantation in aggressive multiple sclerosis: a single centre 10-year experience. Mult Scler. 2010;16:685–93. [58] Brinkman DMC, De Kleer IM, Ten Cate R, et al. …

Unraveling the Role of Allo-Antibodies and Transplant Injury.

Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled grafts. Acute TCMR can generally be well controlled by the establishment of effective immunosuppression (1, 2). Acute ABMR is a low frequency finding in the current era of blood group and HLA donor/recipient matching and the avoidance of engraftment in the context of high-titer, pref

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… Finally, alemtuzumab is a recombinant DNA-derived humanized IgG1 kappa mAb that is directed toward CD52 and is used is used to treat B-cell chronic lymphocytic leukemia (B-CLL) and multiple sclerosis patients, warranting consideration for the treatment of ABMR. … Pediatr Nephrol ( 2011 ) 26 ( 10 ): 1919 – 20 . 10.1007/s00467-011-1929-3 21643943 PMC3163808 91 Caon C Namey M Meyer C Mayer L Oyuela P Margolin DH Prevention and management of infusion-associated reactions in the comparison of alemtuzumab and rebif( ® ) efficacy in multiple sclerosis (CARE-MS) program …

Cancer Immunotherapies: What the Perioperative Physician Needs to Know.

Purpose of reviewFor patients with cancer, treatment may include combination therapy, including surgery and immunotherapy. Here, we review perioperative considerations for the patient prescribed immunotherapeutic agents.Recent findingsThe perioperative period is a poignant moment in the journey of a patient with cancer, potentially deemed most influential compared to other moments in the care continuum. Several immunotherapeutic medications have been employed near the time of surgery to potentially increase effectiveness. Of the various drug classes, including immune checkpoint inhibitors, cyt

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… Individual case reports of rare adverse effects like multiple sclerosis and optic neuritis have been described although a causal association has not been established [ 112 ]. There was no significant difference in the side effect profile between the HepB-CpG and Engerix-B vaccines [ 113 ]. … Hepatitis B vaccine and risk of multiple sclerosis. Pharmacoepidemiol Drug Saf. 2007;16(6):705–7. doi: 10.1002/pds.1408. 113. Schillie S, Harris A, Link-Gelles R, Romero J, Ward J, Nelson N. …

The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

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… Not included in the PSR but presented for completeness is an systematic review of MRI LM enhancement (LME) of the brain in multiple sclerosis and other neuroinflammatory diseases e-published prior to print January 2022 [ 945 ]. DLMs were not specifically included. …