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Изучение взаимосвязи между гутт-здоровьем и аутоиммунными заболеваниями: систематический обзор и мета-анализ.

Аутоиммунные заболевания (АИД) представляют собой многогранные хронические заболевания, характеризующиеся иммунной дисрегулированием и системным воспалением. Более свежие данные указывают пальцем на микробиоту человеческого кишечника, триллионную популяцию микроорганизмов, обитающих в человеческом тракте GI, в качестве главного влиятельного модулятора иммунной реактивности и важного фактора аутоиммунной патогенез. Цель этого систематического обзора будет заключаться в изучении вопроса о том, каким образом литература соотносится с систематическими изменениями в микробиоте кишечника в АИД, а так

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… Keywords included variations of “gut microbiota,” “dysbiosis,” “intestinal permeability,” “leaky gut,” “probiotics,” “prebiotics,” “fecal microbiota transplantation,” and specific autoimmune conditions (e.g., “Systemic Lupus Erythematosus,” “Rheumatoid Arthritis,” “Multiple Sclerosis,” “Type 1 Diabetes … For example, in PubMed, the search string used was: ("gut microbiota"[MeSH] OR "intestinal microbiota") AND ("autoimmune diseases"[MeSH] OR "SLE" OR "RA" OR "MS" OR "T1DM") AND ("probiotics" OR "prebiotics" OR "fecal microbiota transplantation"); while in Embase, the equivalent terms were searched using …

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies.

Periodontitis, a highly prevalent multicausal chronic inflammatory and destructive disease, develops as a result of complex host-parasite interactions. Dysbiotic bacterial biofilm in contact with the gingival tissues initiates a cascade of inflammatory events, mediated and modulated by the host's immune response, which is characterized by increased expression of several inflammatory mediators such as cytokines and chemokines in the connective tissue. If periodontal disease (PD) is left untreated, it results in the destruction of the supporting tissues around the teeth, including periodontal li

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… Currently, only oligosaccharides (fructooligosaccharides and galactooligosaccharides) can be called prebiotics. … Prebiotics and probiotics often work synergistically and, when combined in the same product, are known as symbiotics. Symbiotics contain both probiotic and prebiotic components. …

От генов к окружающей среде: жизненный подход к профилактике педиатрических аутоиммунных заболеваний.

Аутоиммунные заболевания у детей, включая тип 1 Все более серьезной проблемой для здоровья людей во всем мире являются диабет, болезни селиака и детский артрит. Этот всплеск, слишком быстрый для того, чтобы его можно было объяснить только генетическими изменениями, подчеркивает важнейшую роль экологических факторов и подчеркивает настоятельную необходимость принятия активных превентивных мер. Этот обзор представляет собой комплексную, основанную на фактических данных основу для профилактики педиатрических аутоиммунных заболеваний по всему спектру услуг, начиная с первичной и заканчивая третичн

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… Current data suggest that the efficacy of both probiotics and prebiotics depends on selecting the right strain, dose, and timing, reinforcing the importance of precision approaches[ 69 ]. … Beyond dietary fiber, targeted use of probiotics and prebiotics can help restore and maintain a healthy gut microbiota, promote a healthy microbial ecosystem, improve gut barrier integrity, and balance immune activity[ 9 ]. …

Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review.

Knowledge regarding the influence of the microbial community in cancer promotion or protection has expanded even more through the study of bacterial metabolic products and how they can modulate cancer risk, which represents an extremely challenging approach for the relationship between intestinal microbiota and colorectal cancer (CRC). This review discusses research progress on the effect of bacterial dysbiosis from a metabolic point of view, particularly on the biochemical mechanisms of butyrate, one of the main short chain fatty acids (SCFAs) with anti-inflammatory and anti-tumor properties

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… Increased butyrate production has often been hypothesized to be one of the beneficial effects of prebiotics and probiotics [ 29 ]. … One important prebiotic is represented by the resistant starch (the starch which escapes the digestion in the small intestine), which reduced colonic neoplasia in studies including carcinogen-treated rats but increased intestinal tumorigenesis in the genetically driven Apc1638N mouse model [ 32 ]. …

Derivation and elimination of uremic toxins from kidney-gut axis.

Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function. More than 130 uremic solutions are included in the most comprehensive reviews to date by the European Uremic Toxins Work Group, and novel investigations are ongoing to increase this number. Although approaches to remove uremic toxins have emerged, recalcitrant toxins that injure the human body remain a difficult problem. Herein, we review the derivation and elimination of uremic toxins, outline kidney-gut axis function and relati

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… For patients with stage 3–5 CKD, prebiotics significantly reduced the levels of uremic toxin of intestinal origin and favorably affected the gut microbiome ( Ebrahim et al., 2022 ). … Similar to prebiotics, fecal microbiota transplantation (FMT) is a therapeutic method that targets the restoration of intestinal flora balance and curbing diseases stemming from such imbalances. This technique offers a fresh approach to eradicating uremic toxins. …

Targeting immunosenescence for improved tumor immunotherapy.

Tumor immunotherapy has significantly transformed the field of oncology over the past decade. An optimal tumor immunotherapy would ideally elicit robust innate and adaptive immune responses within tumor immune microenvironment (TIME). Unfortunately, immune system experiences functional decline with chronological age, a process termed "immunosenescence," which contributes to impaired immune responses against pathogens, suboptimal vaccination outcomes, and heightened vulnerability to various diseases, including cancer. In this context, we will elucidate hallmarks and molecular mechanisms underly

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… They also impact adaptive immunity by modulating B and T‐cell differentiation, proliferation, activation, and antibody production. 223 Microbiome interventions : The gut's commensal microflora significantly influences immune homeostasis. 224 Thus, using probiotics, prebiotics, and their combination … These pro‐ and prebiotics also enhance innate immune responses, improving phagocytosis, cytotoxicity against bacteria such as Staphylococcus aureus , increasing NK cell activity, and reducing CD25 expression in resting T lymphocytes. 226 Exercise and physical activity Until very recently, it offered …

From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis.

Oral mucositis (OM) is a common and impactful toxicity of standard cancer therapy, affecting up to 80% of patients. Its aetiology centres on the initial destruction of epithelial cells and the increase in inflammatory signals. These changes in the oral mucosa create a hostile environment for resident microbes, with oral infections co-occurring with OM, especially at sites of ulceration. Increasing evidence suggests that oral microbiome changes occur beyond opportunistic infection, with a growing appreciation for the potential role of the microbiome in OM development and severity. This review c

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… As an alternative to direct microbial inputs, prebiotics are an alternative strategy to support commensal organisms-balancing and sustaining microbial homeostasis. … Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics J. Nutr. 1995 125 1401 1412 10.1093/jn/125.6.1401 7782892 …

Combination strategies of gut microbiota in cancer therapy through metabolic reprogramming and immune remodeling.

Over the past decade, there has been a qualitative improvement in the understanding of gut microbiota in cancer development and treatment. Gut microbiota regulates metabolic reprogramming that occurs in the competition between tumor cells and immune cells for essential nutrients in the tumor microenvironment (TME). Besides, gut microbiota dysbiosis is one of the key factors leading to the formation of aging environment, which has many similarities with the TME. Accumulating research findings have demonstrated that gut microbiota enhances the efficacy of cancer therapies by activating the immun

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… Microbiota-based therapies, including untargeted therapies (e.g., dietary intervention, probiotics and prebiotics, fecal microbiota transplantation [FMT]) and targeted techniques (e.g., phage therapy, engineered microbes, nanomedicine-based drug delivery, outer membrane vesicles [OMVs]), hold promise … Probiotics and prebiotics Probiotics are live microorganisms that have been proven to participate in cancer treatment by maintaining the gut barrier integrity and regulating the immune system. …

Causal Relationship Between Gut Microbiota and Leukemia: Future Perspectives.

The gut microbiota plays a crucial role in maintaining homeostasis in the human gastrointestinal tract. Numerous studies have shown a strong association between the gut microbiota and the emergence and progression of various diseases. Leukemia is one of the most common hematologic malignancies. Although standardized protocols and expert consensus have been developed for routine diagnosis and treatment, limitations remain due to individual differences. Nevertheless, a large number of studies have established a link between the gut microbiota and leukemia, with disturbances in the gut microbiota

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… Gut Microbiota and Probiotics/Prebiotics Probiotics are active microorganisms that stabilize the intestinal ecosystem, promote nutrient absorption, protect the intestinal mucosal barrier, and modulate immunity. … Prebiotics are found in certain foods, such as soybean extract, and have an indirect effect by altering the composition of the gut flora. …

Ось Гут-Брэйна в нейродегенерации: механистические связи между дисбиозом и нейроатологией.

& ЦЕЛЬ: Ось кишечника по сути представляет собой two- система связи, которая физически соединяет мозг с кишечным трактом. Связь поддерживается через ряд путей, включая нейронные, эндокринные и иммунные пути. Гут дисбиоз, который объясняется как дисбаланс в микробном сообществе, связан с причинно-следственной связью различных нейродегенеративных расстройств, таких, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз. Однако патологические механизмы в мозге известны лишь частично. В настоящем обзоре описывается процесс кишечного дисбиоза и нейродегенерации с подробным описанием ф

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… Probiotics and prebiotics may also help reestablish a healthy microbiome, while fecal microbiota transplantation is being explored as a potential treatment for severe dysbiosis. … Diet, probiotics, prebiotics, fecal microbiota transplantation, lifestyle modification, and anti-inflammatory bioactive molecules offer promising strategies to restore microbial equilibrium and protect neural function. …

Микробиота и почки в Камеруне работают в автосомных доминирующих полициклических болезнях почек: перекрестное исследование.

Гут дисбиоз патобионтов (Enterobacter, Eschericia и Salmonella) и симбионтов (Bifidobacterium, Lactobacillus и Prevotella) может происходить во время развития хронической болезни почек (CKD). Мы провели оценку связей между репрезентативными симбионтами (Bifidobacterium и Lactobacillus) и патобионтами (Enterobacteriaceae) с функцией почек у лиц с автосомальным доминирующим полициклическим заболеванием почек (ADPKD). МЕТОДЫ: В этом перекрестном исследовании 29 Пациенты ADPKD сравнивались с пациентами 15 контроля в районе действия 2::1 соотношение. Были собраны клинические данные и биологические

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… Subjects were excluded from the ADPKD group if they (1) had diabetes, chronic diarrhea, or chronic infections (HIV, hepatitis B or C); (2) had undergone hemodialysis; (3) were on antibiotics, prebiotics, probiotics, laxatives or NSAIDs in the last four weeks prior to enrolment, or (4) did not provide … The effect of ß-glucan prebiotic on kidney function, uremic toxins and gut microbiome in stage 3 to 5 chronic kidney disease (CKD) predialysis participants: a randomized controlled trial. Nutrients. 2022;14(4):805. 17. Hida M, Aiba Y, Sawamura S, et al. …

От профилактики к управлению: изучение воздействия рациона питания на множественный склероз.

Множественный склероз (MS) — хроническое имунное заболевание центральной нервной системы, характеризующееся нейроинфламмацией и прогрессивным нейродегенерацией. Растущие данные свидетельствуют о том, что диетическое вмешательство может влиять на прогресс и управление симптомами MS, изменяя воспаление, окислительный стресс и кишечный микробиотический состав. В настоящем описательном обзоре рассматриваются последствия средиземноморского, растительного, кетогенного, вальса, сванка, периодического постирования и без глютена наряду с такими ключевыми питательными веществами, как жирные кислоты омег

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… Dietary interventions, including prebiotics and probiotics, have shown potential in modulating gut microbiota and reducing MS-related inflammation. … Prebiotics, such as non-digestible oligosaccharides found in dairy, promote beneficial bacteria like Bifidobacteria, which enhance immune function [ 93 ]. …

Роль воспаления в нейродегенеративных болезнях: болезнь Паркинсона, болезнь Альцгеймера и множественный склероз.

Нейродегенеративные заболевания представляют собой группу заболеваний, которые, как правило, характеризуются постепенным повреждением и дегенерацией нейронов в центральной нервной системе. В эту группу входят болезнь Паркинсона, болезнь Альцгеймера и множественный склероз. В последние годы все больше фактов указывает на важную роль воспаления в патогенезе этих условий. Происхождение воспаления в мозге, которое часто вызывается провоспалительной активацией микроглий или астроцитов, может, следовательно, привести к хронической провокационной реакции, способствующей развитию нейродегенеративных п

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… Experimental studies using prebiotics have shown that fermentation of small fecal matter in patients with Parkinson’s disease increases SCFA production and alters the gut microbiota, suggesting that the patients’ microbiota responds positively to prebiotics. … In an intervention study involving patients with newly diagnosed ( n = 10) and treated Parkinson’s disease ( n = 10), 10-day prebiotic therapy was associated with favorable changes in microbiota, SCFA production, inflammation, and neurofilament levels [ 66 ]. …

S3 guideline Allergy Prevention.

BACKGROUND: The persistently high prevalence of allergic diseases in Western industrial nations and the limited possibilities of causal ther … h moderate to severe AD. There is still insufficient evidence for an allergy-preventive efficacy of prebiotics or probiotics, vitamin D, or other vitamins in the form of supplements so that recommendations against their supplementation were adopted for the first time in the current guideline. Biodiversity plays an important role in the development of immunol …

Leveraging Dietary Interventions to Benefit Patients with Hematologic Malignancies and Clonal Hematopoiesis.

Diet is a modifiable factor that influences multiple pathways relevant to hematologic malignancy, including systemic inflammation, immune cell activity, gut microbiota composition, and cancer cell metabolism. Translation of preclinical findings into clinical practice for hematologic malignancies remains nascent, although momentum is building to evaluate dietary interventions as a component of supportive and disease-modifying care. This review examines the mechanistic rationale for dietary interventions across the spectrum of clonal hematologic disorders and synthesizes current clinical evidenc

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… Dietary Strategies to Restore and Maintain a Healthy Microbiome: Prebiotics and Probiotics Addressing gut dysbiosis in patients with hematologic malignancies may require a two-pronged approach encompassing both prebiotics and probiotics. … Prebiotics are fermentable dietary fibers and substrates that selectively nourish beneficial gut bacteria. …

Targeting the gut microbiota to enhance the antitumor efficacy and attenuate the toxicity of CAR-T cell therapy: a new hope?

Chimeric antigen receptor (CAR) -T cell therapy has achieved tremendous efficacy in the treatment of hematologic malignancies and represents a promising treatment regimen for cancer. Despite the striking response in patients with hematologic malignancies, most patients with solid tumors treated with CAR-T cells have a low response rate and experience major adverse effects, which indicates the need for biomarkers that can predict and improve clinical outcomes with future CAR-T cell treatments. Recently, the role of the gut microbiota in cancer therapy has been established, and growing evidence

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… Diet, prebiotics and probiotics In addition to antibiotics and FMT, which can directly modulate the gut microbiota, diet is a critical means of regulating microbial composition and function. … These fibers are called prebiotics and cannot be digested by gastrointestinal enzymes but can be fermented by bacteria ( 129 , 130 ). Recently, prebiotics have been shown to affect the functional status of the gut microbiota in preclinical models. …

Dietary fungi in cancer immunotherapy: From the perspective of gut microbiota.

Immunotherapies are recently emerged as a new strategy in treating various kinds of cancers which are insensitive to standard therapies, while the clinical application of immunotherapy is largely compromised by the low efficiency and serious side effects. Gut microbiota has been shown critical for the development of different cancer types, and the potential of gut microbiota manipulation through direct implantation or antibiotic-based depletion in regulating the overall efficacy of cancer immunotherapies has also been evaluated. However, the role of dietary supplementations, especially fungal

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… Along with the assessment of the role of animal or plant-based diets on gut microbiota, modulating activity of phytochemicals as well as prebiotics on gut microbiota was also evaluated. … Prebiotic inulin-type fructans induce specific changes in the human gut microbiota . Gut ( 2017 ) 66 ( 11 ): 1968 . doi: 10.1136/gutjnl-2016-313271 28213610 PMC5739857 114 Wang H Chen G Li X Zheng F Zeng X . Yeast β-glucan, a potential prebiotic, showed a similar probiotic activity to inulin . …

Механизмы и новые регулирующие органы нейроинфламмации: изучение новых терапевтических стратегий в отношении неврологических расстройств.

Нейроинфламмация представляет собой сложную и динамичную реакцию центральной нервной системы (КНС) на травмы, инфекцию и болезни. В то время как острая нейроинфламмация играет защитную роль, облегчая расчистку патогенов и восстановление тканей, хроническая и дисрегулированная воспаление в значительной степени способствует развитию таких нейродегенеративных расстройств, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз. В рамках этого обзора изучаются клеточные и молекулярные механизмы, лежащие в основе нейроинфламмации, с уделением особого внимания роли микроглий, астроцитов

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… Preclinical models have demonstrated promise in restoring microbial balance with therapies such fecal microbiota transplantation (FMT), probiotics, and prebiotics. … Manipulating gut microbiota through probiotics, prebiotics, or fecal microbiota transplantation could potentially modulate systemic and CNS-specific immune responses. …

Cellular and Molecular Mechanisms Associating Obesity to Bone Loss.

Obesity is an alarming disease that favors the upset of other illnesses and enhances mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The imbalance between excessive food ingestion and less energy expenditure leads to pathological adipose tissue expansion, characterized by increased production of proinflammatory mediators with harmful interferences in the whole organism. Bone tissue is one of those target tissues in obesity. Bone is a mineralized connective tissue that is constantly renewed to maintain its mechanical properties. Osteoblasts are responsib

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… Due to obesity-induced dysbiosis, prebiotics have become an alternative therapy to revert the prejudicial impacts of imbalanced microbiota on different systems. … The prebiotics also ameliorates gut dysbiosis by reducing the Firmicutes/Bacteroidetes ratio, normalizing intestinal permeability [ 159 ]. Combined with exercise, fiber prebiotics prevented knee joint damage, insulin resistance, and endotoxemia in high-fat and high-sucrose diet (HFS) mice [ 160 ]. …

Probiotics: Potential Benefits and Safety in Hematological Malignancies.

Cancer remains one of the most significant global health challenges, with increasing incidence and mortality rates and a substantial socioeconomic burden. Traditional cancer treatments such as chemotherapeutic drugs and radiation therapies, while effective, have significant adverse effects on the body, prompting the search for less invasive treatment options. In recent years, probiotics have emerged as a promising alternative in the prevention and treatment of cancer and its associated complications, especially in gastrointestinal malignancies. Probiotics have been found to have several benefi

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… Several definitions for probiotics, prebiotics, and synbiotics have been proposed in scientific literature. … Probiotics and prebiotics in intestinal health and disease: from biology to the clinic . Nat Rev Gastroenterol Hepatol. 2019;10(16):605–16. doi: 10.1038/s41575-019-0173-3. Hrdý J, Alard J, Couturier-Maillard A, Boulard O, Boutillier D, Delacre M, et al. …