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INTERNATIONAL REFERENCE PREPARATIONS OF TYPHOID VACCINE. A REPORT ON INTERNATIONAL COLLABORATIVE LABORATORY STUDIES.

Before their establishment as International Reference Preparations of Typhoid Vaccine, an acetone-inactivated vaccine (vaccine K) and a heat-phenol-inactivated vaccine (vaccine L) were tested on man in large-scale controlled field trials and simultaneously subjected to extensive collaborative laboratory studies on their relative potencies. Some 20 laboratories in 12 countries took part in these collaborative studies. This paper describes in detail the results of the investigation of 14 different assay procedures.One of the main objects of these studies was to determine whether one or more of t