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Malignant otitis externa: experience with hyperbaric oxygen therapy.

With the low incidence of malignant otitis externa (MOE) and its variable manifestations, it is not possible to perform relevant prospective controlled studies in this condition. Therefore, the best evidence on which to base therapeutic decisions is likely to remain retrospective reviews of case series. Even though our knowledge in regard to MOE is not greatly increased by the retrospective case series by Saxby et al in this issue, nevertheless it has value.1 The larger number of cases here confirms that multimodal therapy, with the inclusion of hyperbaric oxygen therapy (HBOT), enables a redu

Hyperbaric oxygen therapy in the treatment of skin ulcers due to calcific uraemic arteriolopathy: experience from an Australian hyperbaric unit.

INTRODUCTION: Calcific uraemic arteriolopathy (CUA), also known as 'calciphylaxis', is a syndrome of ischaemic necrotic ulcers occurring in uraemic patients with end-stage renal failure. It is a debilitating condition with a high morbidity and mortality. Hyperbaric oxygen (HBO) has been used to treat such wounds for many years but evidence of its efficacy is limited. AIM: We aimed to study the efficacy of HBO on the healing of problem ulcers secondary to CUA. METHOD: A retrospective case review of all patients with chronic skin ulcers secondary to CUA treated at the Alfred Hospital Hyperbari

Fifty years of decompression sickness research at Brooks AFB, TX: 1960-2010.

UNLABELLED: INTRODUCTION, FACILITIES, AND METHODS: Decompression sickness (DCS) occurring in hypobaric environments related to aviation or spaceflight was a major focus of research at Brooks AFB/City-Base, TX, throughout the period 1960-2010. Multiple hypobaric chambers and extensive support facilities were built for research on altitude DCS using both human subjects and animal models. Areas of study included symptomatology, incidence, prediction, and prevention of DCS. High-altitude aviation, spacecraft atmospheres, and pressure suits were evaluated with various decompression and prebreathing

[Pre-hospital management of adults with life-threatening emergencies].

In France, acute life-threatening situations are handled by the French Secours a Personne (assistance to persons) and emergency medical faci … ing, drug overdose, certain forms of poisoning, and conditions requiring initial hyperbaric oxygen (diving accidents, acute carbon monoxide and smoke poisoning). The reasons for suboptimal emergency care in life-threatening situations are currently a major issue, with medical facilities being reduced in some areas, fewer voluntary firemen, hospital reorg …

Adaptive prosthetics for the lower extremity.

The potential for lifestyle recovery is tremendous for most lower extremity amputees. The amazing and ever-expanding array of adaptive prost … er it is they like to do. I was told I would never be able to wear two dynamic feet and that my sky diving days were over. I said, "Well how do you know? Can't I try?" It took years to find out what I could have and then to find people to help me get it. The prosthetic prescription the physician writes is the patient's gateway to the kind of prosthetics …

Sea-dumped chemical weapons: environmental risk, occupational hazard.

INTRODUCTION: Chemical weapons dumped into the ocean for disposal in the twentieth century pose a continuing environmental and human health … disturbing munitions lying on or buried in the seabed. Pipe laying, cable burying, drilling, scuba diving, trawling, and undersea scientific research are the activities posing the most risk. The long-term threat to the benthic habitat via increased arsenic concentrations, shifts in microbiota speciation, and chronic toxicity to vertebrates and invertebr …

Neurological and functional outcome after unstable cervicothoracic junction injury treated by posterior reduction and synthesis.

BACKGROUND CONTEXT: Unstable lesions of the cervicothoracic junction present a severe clinical problem for diagnosis, treatment, and prognos … hicle accident, 5 who had fallen from a height, 1 case of ballistic trauma, and 1 person injured by diving in shallow water. There were 22 male and 8 female patients aged between 18 and 80, with an average age of 49. In 18 cases the lesion level was vertebra C7, in 5 cases vertebra T1, in 2 cases vertebra T2, and in 5 cases vertebra T3. Neurologically, o …

Technical and Clinical Outcomes at a Thrombectomy-Capable Stroke Center in Poland in the Context of the Center's Growing Experience, Expanding Treatment Guidelines and the Rise in Acute Ischemic Stroke Patient Volume: A Comparative Analysis of Initial and Subsequent Endovascular Procedures.

(1) Introduction. To improve access times and provide effective treatment to the growing patient population with acute stroke due to large vessel occlusion (LVO), thrombectomy-capable stroke centers (TCSCs) should be made an integral part of hospital infrastructure in Poland. The geographical proximity of thrombectomy-capable centers and recently extended treatment time windows will considerably increase patient numbers, decrease patient disability, and reduce the costs of long-term care. (2) Aim of the study. This study investigates the clinical outcomes, time metrics, and angiographic data o

India's medical devices policy: exploring determinants in business ecosystem for export excellence.

PURPOSE: This paper attempts to elucidate the fundamental determinants-both enablers and impediments-that shape a resilient business ecosystem for the medical devices sector in India, with a particular emphasis on sustainable export endeavours under the ambit of the Medical Devices Policy 2023. DESIGN/METHODOLOGY/APPROACH: This study dives into India's medical device export firms, analysing factors influencing their performance. By reviewing relevant literature, it identifies regulatory, manufacturing, marketing, distribution and import-related factors. A Likert scale questionnaire was design

Assessment of bleeding risk of interventional techniques: a best evidence synthesis of practice patterns and perioperative management of anticoagulant and antithrombotic therapy.

BACKGROUND: Interventional pain management is a specialty that utilizes invasive procedures to diagnose and treat chronic pain. Patients und … with or without anticoagulant therapy associated with stressors such as chiropractic manipulation, diving, and anatomic abnormalities such as ankylosing spondylitis, and the lack of necessity of discontinuation of nonsteroidal anti-inflammatory drugs (NSAIDs), including low dose aspirin prior to performing interventional techniques. There is fair eviden …

Utilisation of the support workforce in diagnostic imaging: a mixed-methods investigation.

BACKGROUND: Demand for imaging in England massively outstrips supply in terms of workforce capacity, with well-documented shortages of both radiographers and radiologists. The COVID-19 pandemic exacerbated already stretched services, which have remained 'in crisis'. Three high profile national reports highlighted the urgent need to develop the capacity and capability of the imaging support workforce, yet it is unclear how this vital workforce is utilised. AIM: To investigate the development, deployment and contribution of the support workforce to diagnostic imaging activity across England to

Aspects of constitutive and acquired antibioresistance in Aeromonas hydrophila strains isolated from water sources.

Over the last three decades, the literature pointed out the implications of Aeromonas species in human pathology. These species were describ … infections in man related to different professional activities such as fishing, surfing, swimming, diving, etc.). The purpose of this work was to determine the aspects related to constitutive and acquired antibioresistance in 35 A. hydrophila strains isolated in aquatic environment of Danube Delta (10 salmaster waters, 5 aquatic plants, 5 fish intestina …

Pituitary apoplexy can mimic acute meningoencephalitis or subarachnoid haemorrhage.

Pituitary apoplexy is an uncommon but life-threatening condition that is often overlooked and underdiagnosed. We report a 45-year-old man wh … ecent travel abroad, exposure to sick contacts, involvement in outdoor pursuits such as hiking/cave diving, or trauma. He worked in a bank and had been well until 24 h prior to the onset of sudden headache, which was gradually worsening in nature and associated with increasing confusion. The patient's wife reported that he had neither experienced any fev …

Family caregiver roles and challenges in assisting patients with cancer treatment decision-making: Analysis of data from a national survey.

BackgroundWe aimed to describe the roles and challenges of family caregivers involved in patients' cancer treatment decision-making.MethodsFamily caregiver-reported data were analyzed from a national survey conducted in the United States by CancerCare® (2/2021-7/2021). Four select-all-that-apply caregiver roles were explored: (1) observer (patient as primary decision-maker); (2) primary decision-maker; (3) shared decision-maker with patient and (4) decision delegated to healthcare team. Roles were compared across five treatment decisions: where to get treatment, the treatment plan, second opin

Prediction, prognosis and monitoring of neurodegeneration at biobank-scale via machine learning and imaging.

BACKGROUND: Alzheimer's disease and related dementias (ADRD) and Parkinson's disease (PD) are the most common neurodegenerative conditions. These central nervous system disorders impact both the structure and function of the brain and may lead to imaging changes that precede symptoms. Patients with ADRD or PD have long asymptomatic phases that exhibit significant heterogeneity. Hence, quantitative measures that can provide early disease indicators are necessary to improve patient stratification, clinical care, and clinical trial design. This work uses machine learning techniques to derive such

[Injuries to the lower cervical spine].

PURPOSE OF THE STUDY: The authors present a retrospective evaluation of a group of patients with injury to the lower cervical spine. The aim of the study is to show current trends in the diagnosis and treatment of this trauma. MATERIAL: Between 1995 and 2003, 363 patients with trauma to the lower cervical spine were treated in our clinic. They included 63 women and 300 men, who fell into age categories as follows:14-19 years, 52 patients; 20-29, 108 patients; 30-39, 76 patients; 40-49, 57 patients; 50-59, 40 patients; 60-69, 22 patients; over 70, 8 patients. Neurological findings were classif

Hyperbaric oxygen therapy in the treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

INTRODUCTION: Hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (HSCT), characterized by inflammation and bleeding of the bladder. Hyperbaric oxygen therapy (HBOT) has been shown to be effective in the treatment of radiation-induced HC. However, the optimal treatment for HC after allogeneic HSCT has not yet been established. Furthermore, limited research has been conducted on the use of HBOT in this setting. This study aimed to evaluate the effectiveness and safety of HBOT in patients with late-onset HC after allogeneic HSCT. METHODS:

Совпадение в полном тексте источника
… Louge P Pignel R Serratrice J Stirnemann J Validation of Sham Treatment in Hyperbaric Medicine: a Randomised Trial Diving Hyperb Med. 2023 53 1 51 54 10.28920/dhm53.1.51-54 36966522 PMC10318180 Louge, P., Pignel, R., Serratrice, J. & Stirnemann, J. … Diving Hyperb Med. 53 (1), 51–54 (2023). 36966522 10.28920/dhm53.1.51-54 PMC10318180 …

Diffuse Large B-Cell Lymphoma Presenting as an Unusual Paraneoplastic Neurologic Syndrome Affecting the Central and Peripheral Nervous Systems.

A 68-year-old man presented with a two-week history of ascending, symmetric, sensory neuropathy concerning an acute inflammatory demyelinating polyneuropathy that briefly responded to intravenous immunoglobulin (IVIg) therapy. The initial workup was negative for acquired causes. After three months of poor response to standard therapies, he was hospitalized for severe disability, unintentional weight loss, and additional, unexplained neurologic symptoms including cerebellar ataxia, dysarthria, and muscle twitching. Positron emission tomography revealed hypermetabolism isolated to the bone marro

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… Prior to the onset of his neurologic symptoms, he was healthy and active, and was working as a scuba diving instructor. Over the course of three months, he had become progressively reliant on his wife for assistance with his activities of daily living. … He recently resumed scuba diving instruction and deep-sea diving per his preference. We plan to follow the patient with repeat PET/CT imaging and bone marrow biopsy at two years, after which point he will be followed by labs and exams in conjunction with his primary care physician. …

Challenges and opportunities in cancer immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision.

Cancer immunotherapy has flourished over the last 10-15 years, transforming the practice of oncology and providing long-term clinical benefit to some patients. During this time, three distinct classes of immune checkpoint inhibitors, chimeric antigen receptor-T cell therapies specific for two targets, and two distinct classes of bispecific T cell engagers, a vaccine, and an oncolytic virus have joined cytokines as a standard of cancer care. At the same time, scientific progress has delivered vast amounts of new knowledge. For example, advances in technologies such as single-cell sequencing and