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A multicenter, randomized, double-blind trial comparing LY01011, a biosimilar, with denosumab (Xgeva®) in patients with bone metastasis from solid tumors.

IntroductionDenosumab (Xgeva®) is a standard treatment for the prevention of skeletal-related events (SREs) in patients with bone metastases (BM). This trial was designed to assess the equivalence of LY01011 to denosumab in terms of efficacy and safety.Materials and methodsEligible patients with BM from solid tumors were randomized at a 1:1 ratio to receive 120 mg of LY01011 or 120 mg of denosumab subcutaneously every four weeks during a 12-week double-blind treatment period, and then all enrolled patients continued to receive LY01011 until week 53. The primary endpoint was the natural logarit

Developing and validating a nomogram prediction model for osteoporosis risk in the UK biobank: a national prospective cohort.

BACKGROUND: Osteoporosis is a prevalent bone disease that increases frailty. Developing a nomogram prediction model to predict osteoporosis risk at multiple time points using bone mineral densities, behavioral habits, and clinical risk factors would be essential to identify individual risk and guide prevention. METHODS: The study population from the UK Biobank was followed from 2014 to December 31st, 2022. The study outcome was identified as the first occurrence of osteoporosis in the UK Biobank during the follow-up period. After rebalancing with the synthetic minority over-sampling technique

Многомерное пространственное воздействие на толщину сетчатки АИ с высоким разрешением.

Толщина сетчатки является показателем здоровья сетчатки и в более широком плане рассматривается как перспективный биомаркер многих системных заболеваний. Измерения толщины сетчатки производятся на основе оптической последовательности томографии (OCT) в рамках плановой клинической офтальмологии. Мы обработали снимки Biobank OCT в Великобритании с помощью нервной сети для проведения мелких измерений толщины сетчатки по всей стране. > 29,000 Очки в макуле, часть сетчатки, ответственная за центральное зрение человека. Макула в непропорционально большой степени страдает от таких серьезных заболеван

Relevant parameters for recommendations of physical activity in patients suffering from multiple myeloma : A pilot study.

PURPOSE: This pilot study aimed to describe physical performance, self-reported physical activity, health-related quality of life, anxiety and depression in patients who were assigned from Austrian self-help groups for multiple myeloma patients. These parameters were then discussed in the context of clinical decision-making concerning the recommended type of regular physical activity and exercise. METHODS: Members of the self-help groups were invited to participate. Physical performance and physical activity were assessed with the 6 min walk test (6MWT), handgrip strength test, timed up and g

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… The questionnaire was scored in terms of estimated metabolic equivalent task minutes per week (MET-min/week) [ 24 ]. … assessment, TUG timed up and go test, FES falls efficacy scale, HADS hospital anxiety and depression scale, MET metabolic equivalent of task, EORTC QLQ-C30 European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 Parameter | Total ( n = 40) mean ± SD | Median …

Lifestyle Factors and Cancer: A Narrative Review.

Lifestyle factors and their impact on cancer prevention, prognosis, and survivorship are increasingly recognized in the medical literature. Lifestyle factors are primarily defined here as diet and physical activity. We conducted a narrative review of the primary published data, including randomized controlled trials and prospective studies, on the impact of primary lifestyle factors on oncogenesis and clinical outcomes in the preventative and survivorship setting. First, we discuss the oncogenic mechanisms behind primary lifestyle factors (diet, physical activity and, within these 2, obesity).

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… Patel et al, 2005 | Prospective | 72,174 | Prostate | The incidence of aggressive prostate cancer was inversely associated with >35 metabolic equivalent-h/wk of recreational physical activity compared with that in men who reported no recreational physical activity. … Meyerhardt et al, 2006 | Prospective cohort | 832 | Colon | Disease-free survival was better for high levels of physical activity (metabolic equivalent task hours per week). Postdiagnostic activity was associated with improvement in recurrence-free survival. …

Opioid Use at End-Of-Life Among Nova Scotia Patients With Cancer.

Purpose: To determine the factors associated with opioid analgesic prescriptions as measured by community pharmacy dispensations to all Nova Scotia (NS) patients with cancer at end-of-life from 2005 to 2009. Methods: The NS Cancer Registry and the NS Prescription Monitoring Program (NSPMP) were used to link Nova Scotians who had a cancer diagnosis and received a prescription for opioids in their last year of life (n = 6,186) from 2005 to 2009. The association of factors with opioid dispensations at end-of-life were determined (e.g., patient demographics, type of prescriber, type of cancer, and

The impact of a hospital-based exercise oncology program on cancer treatment-related side effects among rural cancer survivors.

PurposeTo assess the impact of the Personal Optimism With Exercise Recovery (POWER) program on cancer treatment-related side effects among rural cancer survivors.MethodsIn this retrospective study of data collected between 2016 and 2019, we assessed change in cardiorespiratory fitness, whole-body muscular endurance, physical function and strength, anthropometrics, fatigue, and quality of life (QoL), after participation in POWER. Descriptive statistics were calculated for demographic and clinical variables. Univariate analysis of variance was carried out with age and BMI at initial assessment a

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… Cardiorespiratory fitness Cardiorespiratory fitness variables, relative peak aerobic capacity (ml/kg/min) and peak metabolic equivalents (METs), were estimated using a modified Bruce protocol and the American College of Sports Medicine’s metabolic calculations for the estimation of energy expenditure … Table 1 Characteristics of survivors who completed an initial assessment and participated in POWER ( n = 849) BMI body mass index, Peak VO 2 peak oxygen consumption, METs metabolic equivalents, FACIT Functional Assessment of Chronic Illness Therapy, FACT Functional Assessment of Cancer Therapy Variable …

National guidelines for diagnosis and treatment of osteoporosis in Slovakia.

BACKGROUND: Osteoporosis is a chronic, systemic skeletal disease characterized by decreased bone mass and microarchitectural deterioration, leading to increased fracture risk. In Slovakia, its prevalence is estimated at 6%, with substantial health, social, and economic burdens. OBJECTIVE: The Slovak national guideline provides an overview for the diagnosis, prevention, and treatment of osteoporosis in Slovakia, reflecting recent scientific advances and recommendations from international bodies. METHODS: The guidelines were developed by a multidisciplinary expert panel and officially adopted

Association of Physical Activity with Dementia Risk in Cancer Survivors: A Korean Nationwide Cohort Study.

PURPOSE: This study aimed to investigate the impact of physical activity on dementia risk among cancer survivors in South Korea. MATERIALS AND METHODS: This retrospective, population-based cohort study included 344,152 cancer survivors identified from the National Health Insurance Service database in South Korea. The mean follow-up time was 5.81 years. Different levels of physical activity post-cancer diagnosis, ranging from inactive to highly active, were assessed. The primary outcome was the incidence of overall dementia, Alzheimer's disease, and vascular dementia. Secondary outcomes includ

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… Metabolic equivalents of task (MET) values of 2.9, 4.0, and 7.0 were assigned to light, moderate, and vigorous PA, respectively, based on prior research [ 19 , 20 ]. The aggregate weekly energy expenditure was then estimated by summing these values across all levels of PA intensity. … BMI, body mass index; CCI, Charlson comorbidity index; FBS, fasting blood glucose; MET, metabolic equivalents of task; SBP, systolic blood pressure; SD, standard deviation. …

Обзор " Метформин " и " нейродегенерация: всеобъемлющий обзор " .

В рамках этого всеобъемлющего обзора изучается терапевтический потенциал метаформина, хорошо зарекомендовавшего себя лекарство от диабета, при лечении нейродегенеративных расстройств. Первоначально использованная в качестве первой линии обработки для типа 2 диабет, недавние исследования начали изучать эффекты метаформина, выходящие за рамки метаболических расстройств, особенно его нейрозащитные способности против таких заболеваний, как болезнь Паркинсона, болезнь Альцгеймера, болезнь Хантингтона и множественный склероз. Ключевые выводы показывают, что нейрозащитный эффект метформина действует

Sheng-Jiang Powder Alleviates Th17/Treg Immune Imadium of Experimental Autoimune Encephalomyelitis путем регулирования метаболизма жирных кислот.

Множественный склероз (MS) является одной из главных причин инвалидности среди молодежи, и иммунный дисбаланс между клеткой Т 17 (Th17) и клетками регулирования Т (Tregs) играет решающую роль в ее патогенезе. В настоящее время лечение MS в значительной степени зависит от иммунодепрессивных препаратов или глюкокортикоидов, которые часто имеют побочные эффекты и недостатки в эффективности. Порошок Шэн Цзян (SJP) — традиционная китайская медицина — продемонстрировал антивоспалительные эффекты и может предложить новый терапевтический вариант для MS.АИМ: Цель этого исследования заключалась в изучен

2,4 Dinitrophenol as Medicine.

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950's to suggest that warfarin, a rat poison, could be repositioned into a breakthrough drug in humans to protect against strokes as a blood thinner. Yet it was approved in 1954 as Coumadin® and has been prescribed to billions of patients as a standard of care. Similarly, no one can forget the horrific effects of thalidomide, prescribed or available without a prescri

Efficacy, Safety, and Population Pharmacokinetics of MW032 Compared With Denosumab for Solid Tumor-Related Bone Metastases: A Randomized, Double-Blind, Phase 3 Equivalence Trial.

ImportanceThe bioequivalence of denosumab biosimilar has yet to be studied in a 53-week, multicenter, large-scale, and head-to-head trial. A clinically effective biosimilar may help increase access to denosumab in patients with solid tumor-related bone metastases.ObjectivesTo establish the biosimilarity of MW032 to denosumab in patients with solid tumor-related bone metastases based on a large-scale head-to-head study.Design, setting, and participantsIn this 53-week, randomized, double-blind, phase 3 equivalence trial, patients with solid tumors with bone metastasis were recruited from 46 clin

Rotating Nightshift Work and Hematopoietic Cancer Risk in US Female Nurses.

BACKGROUND: Nightshift work is a plausible risk factor for hematologic cancer, but epidemiological evidence remains sparse, especially for individual subtypes. We prospectively examined the association of rotating nightshift work with hematopoietic cancer risk. METHODS: This cohort study included US women from the Nurses' Health Study (NHS: n = 76 846, 1988-2012) and Nurses' Health Study II (NHSII: n = 113 087, 1989-2013). Rotating nightshift work duration was assessed at baseline (both cohorts) and cumulatively updated (NHSII). Cox regression was used to estimate hazard ratios (HRs) and 95%

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… CI = confidence interval; HR = hazard ratio; MET = metabolic equivalent task; MV = multivariable; NHS = Nurses’ Health Study. † Adjusted for age (continuous, months) and follow-up cycle (each 2-year interval). ‡ Adjusted for age (continuous, months), follow-up cycle (each 2-year interval), race (white … CI = confidence interval; HR = hazard ratio; MET = metabolic equivalent task; MV = multivariable; NHSII = Nurses’ Health Study II. † Adjusted for age (continuous, months) and follow-up cycle (each 2-year interval). ‡ Adjusted for age (continuous, months), follow-up cycle (each 2-year interval), race …

Feasibility and safety of exercise training and nutritional support prior to haematopoietic stem cell transplantation in patients with haematologic malignancies.

BackgroundPrehabilitation with regular exercise and nutritional care for patients undergoing surgeries for malignant disease was recently introduced to increase physiologic reserve prior to the procedure, accelerate recovery and improve outcomes. This study aimed to investigate the feasibility and safety of combined exercise training and nutritional support in patients with haematologic malignancies prior to haematopoietic stem cell transplantation (HSCT).MethodsIn this single-arm pilot study, 34 HSCT candidates were enrolled at least two weeks before admission for the procedure. Patients perf

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… We recorded the number of daily steps and the duration of physical activity above 3 metabolic equivalents of task (METs). The heart rate reserve (HRR) was calculated using the equation HRR (min − 1 ) = 220 - age (years) - pulse at rest (min − 1 ). … METs, metabolic equivalents of task Table 2 Physical activity and nutrition Values are presented as the mean (SD). …

Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases.

Purpose(153)Sm-ethylenediaminetetramethylenephosphonic acid (EDTMP; Quadramet) is indicated for the treatment of painful bone metastases, whereas zoledronic acid (Zometa) is indicated for the prevention of skeletal complications. Because of the different therapeutic effects, combining the treatments may be beneficial. Both, however, accumulate in areas with increased osteoblastic activity. Possible drug interactions were investigated.MethodsPatients with hormone-refractory prostate cancer were treated with 18.5 MBq/kg (153)Sm-EDTMP in weeks 1 and 3 and with 37 MBq/kg in week 15. Treatment with

Guidelines for the management of osteoporosis and fragility fractures.

The purpose of this document, a result of the harmonisation and revision of Guidelines published separately by the SIMFER, SIOMMMS/SIR, and SIOT associations, is to provide practical indications based on specific levels of evidence and various grades of recommendations, drawn from available literature, for the management of osteoporosis and for the diagnosis, prevention, and treatment of fragility fractures. These indications were discussed and formally approved by the delegates of the Italian Scientific Associations involved in the project (SIE, SIGG, SIMFER, SIMG, SIMI, SIOMMMS, SIR, and SIO

Role of physical activity in cancer prevention: An update.

Cancer prevention via regular physical activity has been studied across the world. This minireview aimed to present the latest updates in research in the context of the role of physical activity in the cancer prevention. The various mechanisms at the molecular level were studied in depth. The essential processes at play involving hormonal balance, weight reduction, adiposity, inflammation, immunity, sunlight exposure and vitamin D levels and insulin resistance were critically analyzed here. The dose response of exercise with respect to cancer prevention was appraised. Strong evidence supports

The Global Obesity Epidemic: Epidemiology, Health Burden and Policy Priorities.

The global prevalence of obesity has more than tripled since 1975, now affecting nearly one billion adults and over 170 million children and adolescents. In 2025, The Lancet Diabetes & Endocrinology Commission on Clinical Obesity redefined obesity as a chronic, multisystem disease characterised by excess adiposity leading to organ dysfunction, distinguishing between preclinical obesity (excess adiposity without end-organ injury) and clinical obesity (manifest metabolic or structural complications). This framework moves beyond reliance on BMI, acknowledging that ectopic fat deposition in the li

Cancer Pain Is Not One-Size-Fits-All: Evolving from Tradition to Precision.

Cancer pain remains a significant challenge in oncology, profoundly affecting patients' quality of life, function, and prognosis. Historically under-recognized and managed with a uniform, opioid-centric approach, cancer pain was often inadequately treated. Advances in pain assessment, multimodal analgesia, and supportive care have improved outcomes, yet traditional algorithms frequently fail to address the complex, heterogeneous nature of cancer pain. Contemporary management is shifting toward precision and personalized medicine, integrating genetic, molecular, and biomarker data with individu