Результаты поиска

Small fibre pathology in patients with fibromyalgia syndrome.

Fibromyalgia syndrome is a clinically well-characterized chronic pain condition of high socio-economic impact. Although the pathophysiology is still unclear, there is increasing evidence for nervous system dysfunction in patients with fibromyalgia syndrome. In this case-control study we investigated function and morphology of small nerve fibres in 25 patients with fibromyalgia syndrome. Patients underwent comprehensive neurological and neurophysiological assessment. We examined small fibre function by quantitative sensory testing and pain-related evoked potentials, and quantified intraepiderma

[Halitosis concomitant with chronic ENT pathology in children].

The objective of the present study was to estimate the potential of gas chromatography as a tool for diagnostics of chronic ENT pathology in the children. A total of 37 patients aged between 5 and 18 years with chronic ENT diseases and complaints of foul breath were available for the examination. Thirty one children presented with chronic tonsillitis, 3 with chronic adenoiditis, 2 with chronic rhinosinusitis, and 1 with subatrophic rhinitis. It was shown with the use of gas chromatography that the exhaled air from 34 (91.9%) patients contained cadaverin at a concentration of 0.004-0.0009 mg/ml…

Transtympanic endoscopy for diagnosis of middle ear pathology.

Office-based transtympanic endoscopy through the perforation made by laser-assisted myringotomy (LAM) has been introduced for diagnosis of ossicular interruption, stapes fixation, tympanosclerosis, congenital cholesteatoma, and perilymphatic fistula. Endoscopy of the middle ear reveals minor anomalies around the incudostapedial joint and the superstructure of the stapes. This procedure can be also applied to diagnose stapes fixation and perilymphatic fistula not diagnosed presurgically, and requires exploratory tympanotomy to make a definite diagnosis. Transtympanic endoscopy using LAM is a di

Патология трансплантации печени: обзор проблемных диагностических ситуаций.

Важную роль в лечении пациентов, прошедших трансплантацию печени, играет гистопатологическая оценка биопсии печени. В ходе этого обзора обсуждаются несколько тем, создающих проблемы с диагностикой трансплантационных патологий с уделением особого внимания патологическим характеристикам и дифференциальной диагностике. Обсуждались такие темы, как острая клеточная отторжение, поздний острый отторжение (центризональный/паренхимальный отказ), хронический отторжение, гепатит плазменных клеток, идиопатический послетрансплантационный хронический гепатит, фиброзирующий холестатический гепатит, отдельные

Совпадение в аннотации оригинала
Histopathologic assessment of allograft liver biopsies has an important role in managing patients who have undergone liver transplantation. In this review, several topics are discussed that create diagnostic problems in transplant pathology, with emphasis on pathologic features and differential diagnosis. The topics discussed are acute cellular rejection, la…

[Syphilis. Part 1: Introduction, pathology and clinical aspects].

In Germany more than 3,500 people become infected with syphilis annually. As elsewhere in Western Europe there is a low level endemicity with a concentration among population subgroups with high rates of partner exchange, such as men who have sex with other men. In Germany after initially reduced numbers of cases, the incidence rate has increased after the turn of the millennium. In 2011 the incidence reached 4.5 cases per 100,000 inhabitants, which is the highest incidence since the introduction of the Infection Protection Act of 2001. Syphilis, like other sexually transmitted infections and

Cardiac Pathology in Glycogen Storage Disease Type III.

PURPOSE: To investigate the distribution and clinical impact of glycogen accumulation on heart structure and function in individuals with GSD III. METHODS: We examined cardiac tissue and the clinical records of three individuals with GSD IIIa who died or underwent cardiac transplantation. Of the two patients that died, one was from infection and the other was from sudden cardiac death. The third patient required cardiac transplantation for end-stage heart failure with severe hypertrophic cardiomyopathy. RESULTS: Macro- and microscopic examination revealed cardiac fibrosis (n = 1), moderate t

Pathology of natural Przhevalskiana silenus infestation in goats.

Among the arthropods causing diseases to animals, myiasis causes a broad range of infestations depending on the location of larvae and its developmental stages on the body of the host. These infestations reduce host physiological functions, destroy host tissues and cause significant economic losses to livestock worldwide. This study was conducted to find out the pathological changes of goats tissue infested with Przhevalskiana silenus. Goat warble fly infestation (GWFI), improperly named goat hypodermosis, is a myiasis caused by larvae of P. silenus. Out of 16,250 goats examined in the slaught

Dendritic spine pathology in epilepsy: cause or consequence?

Abnormalities in dendritic spines have commonly been observed in brain specimens from epilepsy patients and animal models of epilepsy. However, the functional implications and clinical consequences of this dendritic pathology for epilepsy are uncertain. Dendritic spine abnormalities may promote hyperexcitable circuits and seizures in some types of epilepsy, especially in specific genetic syndromes with documented dendritic pathology, but in these cases it is difficult to differentiate their effects on seizures versus other comorbidities, such as cognitive deficits and autism. In other situatio…

Surgical treatment approaches to second metatarsophalangeal joint pathology.

The second metatarsophalangeal joint is prone to specific and varied pathology that is well understood and may exist in isolation or in combination with other forefoot abnormality. Surgical treatment options for managing end-stage second metatarsophalangeal abnormalities have been minimally studied and exist primarily in case studies and series in the literature. As a result, surgical approaches remain controversial and warrant further discussion.

Craniovertebral junction pathology in high cervical disc disease.

OBJECTIVE: To establish predisposing factors of high cervical disc degeneration (HCDD) with an emphasis on the presence or absence of craniovertebral junction (CVJ) pathology by a retrospective analysis of clinical and radiologic parameters of patients operated at our institute. METHODS: Thirty-seven patients of C3-4 prolapsed intervertebral disc (PIVD) were compared with 45 patients of C5-6 PIVD. Nurick's grade was used for clinical assessment. Radiological parameters like congenital and osteoarthritic changes at CVJ along with measurement of stress levels in flexion and extension on X-rays …

Analysis of demographic data obtained from pathology records.

INTRODUCTION: Pathologists commonly analyse patient data obtained from pathology records. Such information is useful in that it might provide an indication of changing patterns of disease, or of the aetio-pathogenesis of a disease process, but such data is seldom standardised. AIM: To determine to what extent the lack of standardisation may influence the resultant data and the conclusions drawn. MATERIALS AND METHODS: Pathology reports of all cysts diagnosed from 1994 to 2004 were retrieved. The diagnosis and site of the cyst, and the age, gender and race of patient were analysed. Comparativ…

[Genetic diagnosis and molecular pathology of inherited neuropathy].

Recent advances in genetic analysis technology have enabled a surprising progress in genetic diagnosis in the field of neurological disease research. High-throughput molecular biology techniques, such as microarrays and next-generation sequencing, are the major contributors to this progress and to new discoveries. Charcot-Marie-Tooth disease (CMT), a known hereditary motor and sensory neuropathy, is clinically and genetically heterogeneous. Genetic studies have revealed at least 35 disease causing-genes responsible for Charcot-Marie-Tooth disease. Genetic studies have revealed that abnormaliti

Pathology and biology of peripheral T-cell lymphomas.

Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of more than 20 neoplastic entities derived from mature T cells and natural killer (NK) cells involved in innate and adaptive immunity. With few exceptions these malignancies, which may present as disseminated, predominantly extranodal or cutaneous, or predominantly nodal diseases, are clinically aggressive and have a dismal prognosis. Their diagnosis and classification is hampered by several difficulties, including a significant morphological and immunophenotypic overlap across different entities, and the lack of characterist

Role of serotonin in gastrointestinal physiology and pathology.

Serotonin is one of the most abundant molecules in the gastrointestinal tract and it plays a crucial role in the regulation of several physiological functions, such as motility, secretion and visceral sensitivity. Besides this well documented physiological role, increasing evidence supports the concept that 5-HT is directly involved in pathological mechanisms, as well as the modulation of immune/inflammatory responses within the gut. The wide range of pathophysiological actions exerted by 5-HT are mediated by several different serotonergic receptor types and subtypes. Depending on the receptor

Inflammation in the early stages of neurodegenerative pathology.

Inflammation is secondary to protein accumulation in neurodegenerative diseases, including Alzheimer's, Parkinson's and Amyotrophic Lateral Sclerosis. Emerging evidence indicate sustained inflammatory responses, involving microglia and astrocytes in animal models of neurodegeneration. It is unknown whether inflammation is beneficial or detrimental to disease progression and how inflammatory responses are induced within the CNS. Persistence of an inflammatory stimulus or failure to resolve sustained inflammation can result in pathology, thus, mechanisms that counteract inflammation are indispen…