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Eye movements and binocular function in low birthweight teenagers.

PURPOSE: To assess eye movements and binocular function in 14-year-olds with very low birthweight (VLBW: birthweight </= 1500 g) and 14-year-olds born at term but small for gestational age (SGA: birthweight < 10th percentile) in a population-based study. METHODS: Ophthalmological examinations including measurements of heterophoria/tropia, near point of convergence, accommodative amplitude, stereopsis, nystagmus, saccades and smooth pursuit were performed in 51 adolescents with VLBW, 58 adolescents born SGA and in a control group consisting of 75 subjects of the same age. RESULTS: Latent or m

Correction of large amblyopiogenic refractive errors in children using the excimer laser.

PURPOSE: We sought to determine whether laser subepithelial keratomileusis (LASEK) and photorefractive keratectomy (PRK) are effective methods for correcting amblyopiogenic refractive errors in children. METHODS: Thirty-six eyes in 35 amblyopic children, who ranged in age from 4 to 16 years (mean, 8.4 years), received treatment for large magnitude ametropia. Seventy-two percent (25/35) of the children had a neurobehavioral disorder and/or were noncompliant with spectacle or contact lens wear. Myopia ranged from -3.25 to -24.25 D (mean, -11.48 D); one patient had hyperopia of +5.87 D. Correcti

The outcomes of paediatric cataract surgery with intraocular lens insertion in sub-Saharan Africa: a systematic review.

IMPORTANCE: Cataract is one of the leading causes of childhood blindness in Africa. The management of this condition requires timely surgica … t there is a high proportion of patients lost to follow-up and suboptimal refractive correction and amblyopia treatment after paediatric cataract surgery.

The natural history and ophthalmic involvement in childhood myasthenia gravis at the hospital for sick children.

OBJECTIVE: To characterize signs, symptoms, and the natural history of myasthenic syndromes in pediatric patients. DESIGN: Retrospective no … Many of these patients are first seen by the ophthalmologist who can aid the diagnosis, screen for amblyopia, and monitor the patient's response to therapy.

Vision Screening and Vision Loss-Related Conditions Among American Indian or Alaska Native Children.

IMPORTANCE: Early vision screening plays a critical role in detecting and treating vision loss-related conditions in children. Despite this, … th those who did not; however, American Indian or Alaska Native children had a higher prevalence of amblyopia (5.2% [95% CI, 3.8%-6.5%] vs 3.7% [95% CI, 3.6%-3.8%]) and several refractive error conditions, including astigmatism (17.4% [95% CI, 15.3%-19.7%] vs 12.5% [95% CI, 12.3%-12.6%]), hyperopia (13.3% [95% CI, 11.2%-15.3%] vs 10.7% [95% CI, 10.6%-10.9%] …

Visual Outcomes of Children With Primary Congenital Glaucoma Receiving Different Refractive Corrections: The CLEVR-PCG Randomized Clinical Trial.

IMPORTANCE: Primary congenital glaucoma (PCG) surgery often leaves residual visual impairment in children. Evidence comparing rigid gas-perm … h 21, 2024. INTERVENTIONS: RGPCLs (n = 29) vs spectacles (n = 27) for 12 months, plus standardized amblyopia patching. MAIN OUTCOMES AND MEASURES: The primary outcome was change in worse-eye best-corrected visual acuity (BCVA) at 12 months measured by the Early Treatment Diabetic Retinopathy Study chart with tumbling-E optotypes with children wearing thei …

[Prognosis of corneal transplantation after penetrating eye injury].

BACKGROUND: The success of penetrating keratoplasty (PKP) after penetrating eye injuries is often worse than in keratoplasty with Fuchs' end … ions consisted of secondary glaucoma (S 27 %, K 4 %), immunological rejections (S 18 %, K 0 %), and amblyopia (S 14 %, K 0 %). CONCLUSION: Compared to patients with Fuchs' dystrophy the results of grafting after eye injuries are significantly worse. This relates to BCVA, astigmatism, frequency of secondary glaucoma and graft rejection.

Congenital cataract: a guide to genetic and clinical management.

UNLABELLED: Worldwide 20,000-40,000 children with congenital or childhood cataract are born every year with varying degrees and patterns of … surgery and close follow up in ophthalmology is important to optimise visual potential and prevent amblyopia. Routine genetic testing is essential for the complete clinical management of patients, with next-generation sequencing of 115 genes shown to expedite molecular diagnosis, streamline care pathways and inform genetic counselling and reproductive opti …

Digital technologies in enhancing hierarchical vision health management for the next 1000 days of children's life: multi-component economic evaluation.

BACKGROUND: Visual impairment in the next 1000 days of children's life presents heavy medical and economic burdens. It is urgent to bridge t … strategy reduced total myopia prevalence by 26.51%, high myopia by 15.35%, and combined strabismus, amblyopia and hyperopia by 12.6%. In urban areas, the corresponding reductions were 19.94%, 15.03%, and 5.97%. By further comparison, without LLM-based health promotion, costs were higher for achieving health benefits, which resulted in a cost increase of $14 …

[Monocanalicular silicone stent implantation in children with congenital nasolacrimal duct obstruction].

UNLABELLED: Összefoglaló. Bevezetés: Csecsemőkorban a könnyezés gyakori oka a könnycsatorna veleszületett elzáródása, mely az esetek nagy ré … 0) patients, while chronic blepharitis and conjunctivitis occurred in 10 (33.33%, n = 30) children. Amblyopia or significant astigmatism was not observed in any case. Stent was removed after 3.5 ± 1.0 (n = 30) months. At one week postoperatively 24 (80%, n = 30), at 3 months 28 (93.33%, n = 30) and at 6 months 24 (88.89%, n = 27) eyes were asymptomatic. CO …

Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics.

BACKGROUND: Drug metabolism va-specific dosing. Strychnine, the primary active compound in strychnine-based alkaloids, is used for treatment of hemiplegia or amblyopia. However, knowledge of sex-based difference in the pharmacokinetics of strychnine remains limited, increasing the risk of dosage error and potential toxicity in patient.ries between men and women derived from the difference in body fat distribution and hormone secretion, necessitating sex. METHOD: Rats were divided into intact (possessing reproductive organ) and gonadectomized (GDX) groups, including 6 males and 6 females in ea…

Kabuki Syndrome-Clinical Review with Molecular Aspects.

Kabuki syndrome (KS) is a rare developmental disorder principally comprised of developmental delay, hypotonia and a clearly defined dysmorphism: elongation of the structures surrounding the eyes, a shortened and depressed nose, thinning of the upper lip and thickening of the lower lip, large and prominent ears, hypertrichosis and scoliosis. Other characteristics include poor physical growth, cardiac, gastrointestinal and renal anomalies as well as variable behavioral issues, including autistic features. De novo or inherited pathogenic/likely pathogenic variants in the KMT2D gene are the most c

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… Ocular signs comprise amblyopia (“lazy eye”), refractive error, strabismus, nystagmus, microphthalmia, retinal or disc coloboma, and optic disc anomalies [ 123 , 125 , 126 ]. … The prevalence of amblyopia and impaired acuity may be underestimated because many patients with intellectual disability do not undergo visual acuity tests. …

Acquired mitochondrial impairment as a cause of optic nerve disease.

BACKGROUND: Blindness from an optic neuropathy recently occurred as an epidemic affecting 50,000 patients in Cuba (CEON) and had clinical features reminiscent of both tobacco-alcohol amblyopia (TAA) and Leber's hereditary optic neuropathy (Leber's; LHON). Selective damage to the papillomacular bundle was characteristic, and many patients also developed a peripheral neuropathy. Identified risk factors included vitamin deficiencies as well as exposure to methanol and cyanide. In all 3 syndromes, there is evidence that singular or combined insults to mitochondrial oxidative phosphorylation are as…

[Neuro-ophthalmological and ophthalmological findings in Joubert syndrome].

BACKGROUND: Joubert syndrome (JS) belongs to the ciliopathies and is a mostly autosomal recessively inherited disease (in the case of OFD1 mutations, JS is an X-linked trait). It is characterised by midbrain-hindbrain malformations with developmental delay, hypotonia and ataxia and a broad spectrum of other facultative findings. The aim of our study was to examine the ophthalmological and neuro-ophthalmological features of JS in our patients and to compare our findings to those of other studies. METHODS: In a retrospective study we evaluated the ophthalmological and neuro-ophthalmological fin

Погода за болью: роль температуры окружающей среды в хронических синдромах боли.

ЦЕЛЬ РАССМОТРЕНИЯ: Хроническая боль широко распространена и связана со сложным взаимодействием сенсорных, эмоциональных и когнитивных процессов, на которые в значительной степени влияет температура окружающей среды. Несмотря на успехи в борьбе с обезболиванием, многие пациенты по-прежнему испытывают недостаточное облегчение. Цель этого обзора заключается в обобщении и критической оценке текущих данных о воздействии температуры окружающей среды на такие хронические болевые условия, как фибромиалгиа (ФМ), множественный склероз (МС), сложный региональный синдром боли (КПИ) и остеоартрит (ОА).ПОСЛ

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… Multiple Sclerosis - Uhthoff Phenomenon The Uhthoff phenomenon was first described by Wilhelm Uhthoff, a German ophthalmologist, who noted exercise-induced amblyopia in patients with multiple sclerosis (MS) [ 20 ]. …

Extracting Quality of Life Information of Patients Diagnosed With Breast Cancer From Health Care Online Forum Posts: Data Feasibility Study.

BACKGROUND: Quality of life (QoL) questionnaires are used in many disease areas to measure the burden that a disease causes for patients, which help provide insights into disease impact, identify unmet medical needs, and inform patient-centered drug development and value assessment for treatments. The collection of data imposes both a significant burden on patients as well as effort on health care personnel, thus incurring high costs for the health care system. Given that patients share detailed information about their condition and treatment experiences on social media and patient forums, an

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… These diseases include Parkinson disease [ 9 , 10 ], amblyopia [ 41 ], presbyopia [ 42 , 49 ], cancer [ 16 , 30 , 48 , 51 ], dry eye disease [ 43 ], chronic ocular pain [ 44 ], Sjögren disease [ 11 ], chronic obstructive pulmonary disease [ 12 ], systemic lupus erythematosus [ 45 , 60 ], immunoglobulin … A social media listening study to understand the unmet needs and quality of life in adult and pediatric amblyopia patients. Ophthalmol Ther. 2022 Dec;11(6):2183–2196. doi: 10.1007/s40123-022-00571-2. doi. Medline. 42. Findley A, Sharma G, Bentley S, et al. …

Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD.

BACKGROUND: COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients. METHOD: Retrospective cohort study based on 2012-2013 electronic health records from 179 Dutch general practices. Comorbidities from patients with physician-diagnosed COPD were categorized according to International Classification of Primary Care (ICPC) codes. Chi-squared tests, uni- and multivariable logistic, and Cox regression analyses were used to study associations with exacerbations, de

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… ICPC code before 1-1-12 Other disease cardiovascular system K99, K99.01, K99.02, K 99.03, K99.04, K99.05, K99.06 ICPC code before 1-1-12 Blindness & low vision 13.8 (Diabetic/hypertensive) retinopathy F83, F83.01, F83.02 ICPC code before 1-1-12 Maculadegeneratie F84 ICPC code before 1-1-12 Blindness/amblyopia … 1-1-12 Other disease cardiovascular system | K99, K99.01, K99.02, K 99.03, K99.04, K99.05, K99.06 | ICPC code before 1-1-12 Blindness & low vision | 13.8 | (Diabetic/hypertensive) retinopathy | F83, F83.01, F83.02 | ICPC code before 1-1-12 Maculadegeneratie | F84 | ICPC code before 1-1-12 Blindness/amblyopia …

Deadbolt cataract due to misplanted minishunt.

A 62-year-old woman with stable unilateral glaucoma in the left eye presented for a cataract consultation. In 2010, laser peripheral iridoto … o notable for high refractive errors requiring continuous spectacles wear, possible mild refractive amblyopia of the left eye, history of submacular choroidal nevus with drusen in the right eye, and an epiretinal membrane (ERM) with macular pucker in the left eye. Her husband is an optician. Both inquire about refractive cataract surgery options to correct …

[Role of Ommaya reservoir in the management of neonates with post-hemorrhagic hydrocephalus].

OBJECTIVE: Intra-ventricular hemorrhage (IVH) is one of the most serious complications of preterm infants. Significant numbers of the surviv … eurodevelopmental outcome (both had spastic bilateral lower limbs paresis, and one of whom also had amblyopia) and the other had seizure disorder. CONCLUSION: The results from this series indicate that the placement of an Ommaya reservoir is relatively safe in newborn infants and is useful in the initial management of neonates with PHH and may be beneficia …