Результаты поиска

Osteoporosis: Current Concepts.

Osteoporosis is a worldwide disease characterized by reduction of bone mass and alteration of bone architecture resulting in increased bone fragility and increased fracture risk. Causes of osteoporosis include increasing age, female sex, postmenopausal status, hypogonadism or premature ovarian failure, low body mass index, ethnic background, rheumatoid arthritis, low bone mineral density (BMD), vitamin D deficiency, low calcium intake, hyperkyphosis, current smoking, alcohol abuse, immobilization, and long-term use of certain medications. The diagnosis of osteoporosis is established by measure

Совпадение в полном тексте источника
… They are classified as markers of bone formation (total alkaline phosphatase [total ALP], bone-specific alkaline phosphatase [B-ALP], osteocalcin [OC], procollagen type 1 N-terminal propeptide [P1NP], and procollagen type 1 C-terminal propeptide [P1CP]) and markers of bone resorption (hydroxyproline …

Талидомид взаимодействует с воспалением в идиопатическом фиброзе легких.

" Трагедия Талидомида " является важной вехой в истории фармацевтической промышленности. Несмотря на ограниченные клинические испытания, прилагаются постоянные усилия по изучению Талидомида в качестве лекарства от рака и подстрекательских заболеваний, таких, как ревматуидный артрит, проказа, и COVID-19. В рамках этого обзора основное внимание уделяется возможностям борьбы с воспалением путем повторного использования талидомида для лечения идиопатического фиброза легких (ИПФ). Статьи были найдены в базе данных Scopus, сортированы и рассмотрены отдельные статьи. Содержание включает в с

Совпадение в полном тексте источника
… It showed reduction of IL-1β, IL-6, TGF)-β1, myeloperoxidase (MPO), NO, and hydroxyproline levels (Amirshahrokhi 2013 ) 11 Thalidomide suppressed the inflammatory pathway in the lungs and reduced the release of cytokines and interferons in H1N1-infected BALB/c mice (Zhu et al. 2014 ) 12 Thalidomide inhibited … It showed reduction of IL-1β, IL-6, TGF)-β1, myeloperoxidase (MPO), NO, and hydroxyproline levels | (Amirshahrokhi 2013 ) 11 | Thalidomide suppressed the inflammatory pathway in the lungs and reduced the release of cytokines and interferons in H1N1-infected BALB/c mice | (Zhu et al. 2014 ) 12 | Thalidomide …

A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis.

ObjectiveThis meta-analysis aimed to determine the efficacy of curcumin in preventing liver fibrosis in animal models.MethodsA systematic search was conducted on studies published from establishment to November 2023 in PubMed, Web of Science, Embase, Cochrane Library, and other databases. The methodological quality was assessed using Sycle's RoB tool. An analysis of sensitivity and subgroups were performed when high heterogeneity was observed. A funnel plot was used to assess publication bias.ResultsThis meta-analysis included 24 studies involving 440 animals with methodological quality scores

Совпадение в полном тексте источника
… levels, 3 studies that reported mRNA of TGF-β mRNA, 4 studies that reported mRNA of nuclear factor κB (NF-κb) levels, 3 studies that reported triglyceride (TG) levels, 3 studies that reported superoxide dismutase (SOD) levels, 8 studies that reported Glutathione (GSH) levels, 2 studies that reported Hydroxyproline … damage-associated molecular patterns ECM | extracellular matrix FFA | free fatty acids GSH | Glutathione HBV | hepatitis B virus HCV | hepatitis C virus HE | hematoxylin and eosin HIF-1α | hypoxia-inducible factor-1α HMGB1 | high-mobility group protein HO-1 | heme oxygenase 1 HSC | hepatic stellate cells HYP | Hydroxyproline …

Management of osteoporosis in the aging male: focus on zoledronic acid.

Osteoporosis in the aging male remains an important yet under-recognized and undertreated disease. Current US estimates indicate that over 14 million men have osteoporosis or low bone mass, and men suffer approximately 500,000 osteoporotic fractures each year. Men experience fewer osteoporotic fractures than women but have higher mortality after fracture. Bisphosphonates are potent antiresorptive agents that inhibit osteoclast activity, suppress in vivo markers of bone turnover, increase bone mineral density, decrease fractures, and improve survival in men with osteoporosis. Intravenous zoledr

Совпадение в полном тексте источника
… At three years, the investigators found significant reductions in urinary hydroxyproline and serum alkaline phosphatase and significant increases in BMD at the lumbar spine (See Table 2 ). Men and women had similar increase in BMD in response to pamidronate. … With pamidronate treatment, the differences in urinary hydroxyproline and serum alkaline phosphatase between the initial study groups disappeared. …

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

Kidney fibrosis is a common process that leads to the progression of various types of kidney disease. We used an integrated computational and experimental systems biology approach to identify protein kinases that regulate gene expression changes in the kidneys of human immunodeficiency virus (HIV) transgenic mice (Tg26 mice), which have both tubulointerstitial fibrosis and glomerulosclerosis. We identified homeo-domain interacting protein kinase 2 (HIPK2) as a key regulator of kidney fibrosis. HIPK2 was upregulated in the kidneys of Tg26 mice and in those of patients with various kidney diseas

Comparative efficacy and safety of bone-modifying agents for the treatment of bone metastases in patients with advanced renal cell carcinoma: a systematic review and meta-analysis.

ObjectiveTo determine the comparative efficacy and safety of all available bone-modifying agents (BMAs) for the treatment of bone metastases in patients with advanced renal cell carcinoma (RCC).ResultsThree studies (259 patients) were identified for the systematic review. Two studies that compared zoledronic acid with placebo or no zoledronic acid showed that zoledronic acid reduced the risk of skeletal-related events (SREs) by 68% (pooled hazard ratio [HR]: 0.32; 95% confidence interval [CI]: 0.19-0.55). The quality of evidence was moderate. The incidence of serious adverse events (AEs) was i

Совпадение в полном тексте источника
… | 55 | | | 19 | Skeletal-related events, adverse events, response rate, overall survival | Unclear | Patients in the 8/4 mg zoledronic acid arm were excluded from analyses ( n = 28) Vinholes et al. [ 19 ] | 1997 | - | Randomized, double-blind trial | Unicenter | 1 | | | 1 | | Urinary calcium, hydroxyproline …

Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis.

The antiresorptive drug elcatonin (ECT) is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. Two hundred and five postmenopausal osteoporotic women (mean age: 70 years) were recruited in our outpatient clinic. Forty-six women with back pain were treated with ALN and ECT (intramuscular, 20 units a week), and 159 women w

Совпадение в полном тексте источника
… intramuscular injections of ECT at a dose of 20 units reportedly increased lumbar BMD by 1.87% from baseline over six months in postmenopausal Japanese women with osteoporosis. 17 The mechanism for this positive effect of ECT on lumbar BMD remains unexplained, since bone turnover markers such as urinary hydroxyproline …

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications.

This review explores the application of molecularly imprinted polymers (MIPs) in detecting bone turnover biomarkers and advancing osteogenic treatment strategies. MIPs, designed to mimic biological recognition sites, offer innovative solutions for precise molecular recognition in bone health management. Chemical methodologies for MIPs synthesis and their integration into diagnostic systems for detecting bone resorption markers are highlighted. Furthermore, MIP-driven therapeutic advancements, including controlled drug release, cell imprinting for osteogenic differentiation, and functional scaf

Совпадение в полном тексте источника
… These markers are classified into bone formation markers [including alkaline phosphatase (ALP), procollagen type 1N‐terminal propeptide (P1NP), procollagen type 1C‐terminal propeptide (P1CP), and osteocalcin (OC)] and bone resorption markers [such as hydroxyproline (HOP), pyridinoline (Pyr), deoxypyridinoline … (DPD), L‐Hydroxyproline (L‐HYP), C‐terminal telopeptide of type 1 collagen (CTX‐1), N‐terminal telopeptide of type 1 collagen (NTX‐1), tartrate‐resistant acid phosphatase 5b (TRAP 5b), and interleukin‐6 (IL‐6)]. [ 94 ] These markers provide insights into bone metabolic activity and are valuable for …

Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal Traits translational Network") Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art

Совпадение в полном тексте источника
… spectroscopy, the sample is irradiated with a specific wavelength, which leads to changes in the vibrational modes of specific molecules, allowing to detect mineral-related components in a spectrum (peaks of phosphate, carbonate) and protein-related components (peaks of amide I and II, phenylalanine, hydroxyproline …

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside.

This review covers the basic aspects of small interfering RNA delivery by lipid nano-particles (LNPs) and elaborates on the current status of clinical trials for these systems. We briefly describe the roles of all LNP components and possible strategies for their improvement. We also focus on the current clinical trials using LNP-formulated RNA and the possible outcomes for therapy in the near future. Also, we present a critical analysis of selected clinical trials that reveals the common logic behind target selection. We address this review to a wide audience, especially to medical doctors who

Совпадение в полном тексте источника
… of VLDL from VLDL1 to poor VLDL2 during insulin stimulation. 71 Primary hyperoxaluria type I (PH1) is a rare recessive disorder (5 per 1 million births) caused by a mutation in the alanine glyoxylate aminotransferase (AGT) protein, which is encoded by the AGXT gene and is involved in breakdown of hydroxyproline …

Ferroptosis: Frenemy of Radiotherapy.

Recently, it was established that ferroptosis, a type of iron-dependent regulated cell death, plays a prominent role in radiotherapy-triggered cell death. Accordingly, ferroptosis inducers attracted a lot of interest as potential radio-synergizing drugs, ultimately enhancing radioresponses and patient outcomes. Nevertheless, the tumor microenvironment seems to have a major impact on ferroptosis induction. The influence of hypoxic conditions is an area of interest, as it remains the principal hurdle in the field of radiotherapy. In this review, we focus on the implications of hypoxic conditions

Совпадение в полном тексте источника
… Additionally, the fibrotic severity was scored higher, and the expression levels of hydroxyproline, a major component of collagen, were increased in the lungs of irradiated mice. ROS levels and pro-inflammatory cytokines, especially TGF-β, were elevated after radiation of the lungs. … Tissue of Interest | Irradiation Source/Dose | Parameters Investigated Lung | TBI γ-Ray (17 Gy) | Collagen deposition Thorax irradiation X-ray (15 Gy) [ 164 ] | Szapiel score, Ashcroft score and hydroxyproline content Thorax irradiation X-ray (15 Gy) [ 165 ] | Lung injury score (Szapiel) Thorax irradiation …

Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling.

BACKGROUND: Medications, including chemotherapeutic drugs, contribute to male infertility as external factors by inducing oxidative stress in testicular cells. Shilajit is a naturally occurring bioactive antioxidant used in Ayurvedic medicine to treat a variety of ailments. OBJECTIVE: This study examines the potential of Shilajit to counteract the negative effects of the chemotherapeutic drug cyclophosphamide (CPA) on testicular germ cell dynamics. MATERIAL AND METHODS: Male Parkes mice received single intraperitoneal CPA injection (200 mg/kg BW) on day one, followed by daily supplementation

Совпадение в полном тексте источника
… The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels J Int Soc Sports Nutr 16 2019 10.1186/S12970-019-0270-2 PMC6364418 30728074 21 Wilson E. Rajamanickam GV Dubey GP Klose P Musial F Saha FJ. …

Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer.

There is a high risk for bone loss and skeletal-related events, including bone metastases, in postmenopausal women with hormone receptor-positive breast cancer. Both the disease itself and its therapeutic treatments can negatively impact bone, resulting in decreases in bone mineral density and increases in bone loss. These negative effects on the bone can significantly impact morbidity and mortality. Effective management and minimization of bone-related complications in postmenopausal women with hormone receptor-positive breast cancer remain essential. This review discusses the current underst

Совпадение в полном тексте источника
… complication versus placebo (13.9 vs 7.0 months; P >0.001). 74 The Phase II Protocol 18 trial from the same group demonstrated that pamidronate decreased skeletal morbidity rate and increased time to first SRE versus placebo, and a sustained reduction in bone turnover markers (ie, urinary calcium, hydroxyproline …

FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.

Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease with increasingly recognized autoimmune features. We found elevated expression of FK506-binding protein 11 (FKBP11) in IPF lungs where FKBP11 specifically localized to antibody-producing plasma cells. Suggesting a general role in plasma cells, plasma cell-specific FKBP11 expression was equally observed in lympha

Совпадение в полном тексте источника
… Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline. J. Biol. Chem. 2017;292:9273–9282. doi: 10.1074/jbc.M116.772657. 60. Krämer P.M., Weber C.M., Forster S., Rauch P., Kremmer E. …

Bone loss induced by cancer treatments in breast and prostate cancer patients.

Cancer and cancer therapies are a major factor risk for osteoporosis due to bone loss and deterioration of bone microarchitecture. Both factors contribute to a decrease in bone strength and, consequently, increased bone fragility and risk of fracture. Cancer-associated bone loss is a multifactorial process, and optimal interdisciplinary management of skeletal health, accurate assessment of bone density, and early diagnosis are essential when making decisions aimed at reducing bone loss and fracture risk in patients who have received or are receiving treatment for cancer. In this document, a mu

Совпадение в полном тексте источника
… Bone resorption markers (BRMs), which derive from the resorption processes and reflect osteoclastic activity: cross-linked carboxy- and amino-terminal telopeptides of type I collagen (CTX and NTX), tartrate-resistant acid phosphatase (TRAP), pyridinolines and deoxypyridinolines, hydroxyproline and sialoprotein …

Translating IL-6 biology into effective treatments.

In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still's disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and

Совпадение в полном тексте источника
… In the bleomycin-induced mouse model of SSc, IL-6 blockade reduced skin fibrosis, α-smooth-muscle actin protein expression, hydroxyproline content and myofibroblast counts 116 . …

Current options for the treatment of Paget's disease of the bone.

Paget's disease of bone (PDB) is a chronic bone remodelling disorder characterized by increased osteoclast-mediated bone resorption, with subsequent compensatory increases in new bone formation, resulting in a disorganized mosaic of woven and lamellar bone at affected skeletal sites. This disease is most often asymptomatic but can be associated with bone pain or deformity, fractures, secondary arthritis, neurological complications, deafness, contributing to substantial morbidity and reduced quality of life. Neoplastic degeneration of pagetic bone is a relatively rare event, occurring with an i

Совпадение в полном тексте источника
… A significant reduction in bone-resorption markers (24-hour urinary hydroxyproline/creatinine excretion (OHP) and 24-hour urinary calcium/creatinine excretion) was observed with the 216 µg and 400 µg doses (20% to 50% in the urinary OHP and 40% to 70% for urinary calcium/creatinine). …

Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics.

Background and objectivesOsteoarthritis (OA) is a chronic degenerative joint disease. Approximately 300 million people worldwide suffer from OA, which shows a high incidence in middle-aged and elderly populations, with a prevalence of 50% among individuals aged over 60 years. Its core clinical symptoms consist of joint pain, swelling, and dysfunction. Studies have shown that arginine and proline metabolism play an important role in the pathogenesis and progression of OA, but the specific mechanism is still unclear. This study aimed to identify biomarkers and drug therapeutic targets for OA ass

Совпадение в полном тексте источника
… Concurrently, multi-omics analysis of paired OA synovial tissue and fluid has detected enrichment of proline-related metabolic pathways and elevated hydroxyproline levels, reflecting active collagen degradation ( Ge et al., 2025 ). …

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis.

Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells. EVs are recognized as powerful means of intercellular communication since they contain many signaling molecules (including lipids, proteins, and nucleic acids). In parallel, changes in epigenetic processes can lead to changes in gene function and finally lead to disease onset and progression. Recent breakthroughs have revealed the complex roles of non-coding RNAs (microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)) in epigenetic regulation. Moreover, a substantial body of evidence demonstrates tha

Совпадение в полном тексте источника
… The second class includes hydroxyproline (HYP), pyridinoline, tartrate-resistant acid phosphatase 5b (TRAP 5b), deoxypyridinoline (DPD), carboxy-terminal cross-linked telopeptide of type 1 collagen (CTX-1), and amino-terminal cross-linked telopeptide of type 1 collagen (NTX-1). 1.3. …

Bioabsorbable polymers in cancer therapy: latest developments.

Cancer is a devastating disease, being responsible for 13 % of all deaths worldwide. One of the main challenges in treating cancer concerns the fact that anti-cancer drugs are not highly specific for the cancer cells and the "death" of healthy cells in the course of chemotherapy treatment is inevitable. In this sense, the use of drug delivery systems (DDS) can be seen as a powerful tool to minimize or overcome this very important issue. DDS can be designed to target specific tissues in order to mitigate side effects. Bioabsorbable polymers, due to their inherent characteristics, and because th

Совпадение в полном тексте источника
… Glycine, proline, and hydroxyproline form the remaining part of the protein chain (Fig. 6 ) [ 30 ]. Fig. 6 Structure of gelatin Fig. 6 Structure of gelatin Gelatin undergoes a sol-gel transition in aqueous solution when the temperature is lowered below 35 °C. …