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[RECONSTRUCTING THE LIFE OF AN UNKNOWN MAN--INTERDISCIPLINARY APPROACH].

The remains of a tomb were discovered below the foundations of the Roman church of “Majka Bozja Gorska” in Lobor in 2002. It was a vaulted t … he person had access to water of a good quality, possibly from a well and did not eat fish or drink wine. We do not know whether the person from grave 107 was a member of the clergy or nobility, but was most likely a member of the social elite.

Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential.

Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and phys

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… It is also found in processed plant products; its presence in red wine (concentrations of 0.1–14.3 mg/L) has been proposed as a possible explanation for the “French paradox,” the observation of an unusually low rate of heart disease among Southern French people who drink a lot of red wine, despite a … Red wine is a rich source of RVT having approximately 1.98–7.13 mg/L of RVT. …

Alcohol Consumption and Autoimmune Diseases.

Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths and is associated with significant behavioral, social, and economic difficulties. As alcohol consumption may modulate the immune system's regulatory mechanisms to avoid attacking the body's tissues, it has been proven to play a dichotomic role in autoimmune diseases (ADs) based on the quantity of consumption. In this review, we report updated evidence on the role of alcohol in ADs, with a focus on alcohol addiction and the human biological immun

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… between red wine consumption and positive health outcomes [ 20 ]. … For instance, red wine is particularly noted for its high content of polyphenols like resveratrol, which have antioxidant and anti-inflammatory properties contributing to the protective effects seen with moderate wine consumption [ 111 , 112 , 113 , 114 ]. …

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets.

Resveratrol (3,4',5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tum

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… The results of this study demonstrates that resveratrol in wine was quickly absorbed, reaching its peak concentration approximately 60 min after wine ingestion and it was detectable in the liver and kidneys after 30 min [ 21 ]. The resveratrol is well absorbed in humans as well. … Trace amounts of trans-resveratrol were detected in blood samples after 30 min of red wine ingestion and resveratrol glucuronides were predominant after longer times [ 23 ]. It seems that health benefits of red wine consumption are due to the whole antioxidant active ingredients in red wine. …

Remote psychophysical evaluation of olfactory and gustatory functions in early-stage coronavirus disease 2019 patients: the Bologna experience of 300 cases.

BACKGROUND: An objective evaluation of coronavirus disease 2019 in the first days of infection is almost impossible, as affected individuals are generally in home quarantine, and there is limited accessibility for the operator who should perform the test. To overcome this limitation, a recently validated psychophysical self-administered test was used, which can be performed remotely in the assessment of early-stage coronavirus disease 2019 patients. METHODS: Olfactory and gustatory functions were objectively assessed in 300 patients in the first 7 days from coronavirus disease 2019 symptom on

A Narrative Review on the Antitumoral Effects of Selected Mediterranean Plant Products from Southern Italy.

Natural products are a valuable source of bioactive compounds with established roles in oncology. Their structural diversity and ability to target multiple cancer-related pathways make them promising candidates for anticancer drug development. Increasing preclinical and clinical data highlight their potential not only to exert direct antitumor effects but also to enhance patient tolerance to conventional therapies by reducing side effects and improving treatment adherence. The Mediterranean region, known for its biodiversity and traditional dietary habits, provides a rich array of natural comp

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… Several studies have highlighted how the moderate consumption of wine, particularly red wine during meals, can exert beneficial effects on human health, especially on the cardiovascular system. … Although resveratrol concentration in wine is relatively low, usually only a few milligrams per liter, the repeated intake through moderate, regular wine consumption could contribute to its observed biological effects. …

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer.

Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention str

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… Antiangiogenic Polyphenols from Fruits and Red Wine The MD is characterized by a high consumption of fruits and vegetables. It may also include having a glass of wine with lunch every day—mainly red wine, which has been shown to exert a positive influence upon health. … Several non-alcoholic components of wine, mainly polyphenols, which are also present in grapes and other fruits, may be responsible for a considerable part of the reported cardioprotective effects of a moderate wine intake [ 94 ]. …

Tumor angiogenesis as a target for dietary cancer prevention.

Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain,

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… Fresh grape skins contain 50–100 μ g resveratrol per g and yield a concentration in Italian red wine of 1.5–3 mg/L [ 188 ]. White wine contains minimal levels of resveratrol. … Notably, there was a 61% risk reduction for men drinking at least one glass of red wine per day [ 194 ]. …

MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations.

UNLABELLED: Capillary malformations (CM) are slow-flow vascular abnormalities present at birth and predominantly manifest as cutaneous lesio … pical blood vessel overgrowth in the skin, brain and eye. It is associated with facial CM (aka port wine birthmark), leptomeningeal CM in the brain visible with MRI, and glaucoma. Theneurological sequalae involve seizures, cerebral atrophies and calcification, and intellectual disorders. Currently there are no molecularly targeted therapies for non-syn …

Hemodynamic impairment, venous segmental disease, and clinical severity scoring in limbs with Klippel-Trenaunay syndrome.

BACKGROUND: Klippel-Trenaunay syndrome (KTS) is a complex congenital anomaly featuring two or more of the following: (1) capillary malformations (port-wine stains), (2) soft tissue or bony hypertrophy (or both), and (3) varicose veins or venous malformations. With the purpose of determining the actual significance of venous impairment in patients with KTS, we quantified the venous valvular competency and calf muscle pump function and examined their effect on clinical severity. METHODS: Included were patients with near-normal function of affected limb(s) and minimal/small foot hypertrophy. Exc…

[Simultaneous determination of three tryptamines in foods by ultra performance liquid chromatography-tandem mass spectrometry coupled with hydrophilic column separation].

The illegal addition of substances in ordinary food poses a serious threat to food safety. Therefore， the detection and identification of su … sive investigation was conducted on ten types of actual food samples， including candies， beverages， wines， succade， coffee， health care products， condiments， cooked meat products， spices and hot pot sauce. As a result， out of 100 samples， 14 samples were found to contain bufotenine. Additionally， one sample had a bufotenine concentration of 7.6 mg/kg. …

[After-effects in untreated progenies from chickens treated with the products from resistant interspecific grape-vine hybrids].

Feeding hens and cocks for 6-8 weeks with the products - wines and juices - from ± resistant interspecific grapevine varieties (F1, F2R), i.e. from crosses between sensitive types of Vitis vinifera and ± resistant American wild types, led to physiological changes of the treated animals. These changes became evident by more than 40% of malformations, especially of legs and plumage, among the individuals of their untreated F1 progeny. These effects proved to be reproducable.Among the F2-individuals from crosses between untreated F1 brothers and sisters 8-11 % of the chickens again carried anomal…

Influence of the Mediterranean Diet on Healthy Aging.

The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved in aging. Likewise, the gut microbiota, which is influenced by environmental factors such as diet, plays a crucial role in the modulation of these mechanisms. The Mediterranean diet, as well as the components present in it, offer some proof of this. Achieving healthy aging should be focused on the promotion of healthy lifestyle habits that reduce the development of pathologi

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… In fact, mitochondrial dysfunction is critical in the early stages of AD and PD, and the antioxidant power of wine polyphenols can protect organelles [ 200 , 223 , 224 ]. … Thus, light to moderate wine intake in humans can favor the expression of antioxidant enzymes in the blood [ 231 ]. …

A comprehensive review with future perspectives of Rhizoma Cibotii (Gou Ji): botany, ethnopharmacology, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Cibotii (Gou Ji) is derived from the dried rhizome of the plant Cibotium barometz (L.) J. Sm (In thi … ing, and thermal treatments such as steaming, stir-frying, or roasting with various adjuncts (e.g., wine, vinegar, salt, or ginger juice), which are employed to enhance therapeutic efficacy, reduce toxicity, or facilitate storage. These aim to enhance its efficacy in tonifying the liver and kidneys and strengthening tendons and bones. The processing pr …

Factors influencing COVID-19 Infection in older individuals: History of Alcohol Use Disorder, Major Depressive illness, genetic variation and current use of alcohol.

INTRODUCTION: The Coronavirus Disease 2019 (COVID-19) pandemic continues to be a major public health problem. Vulnerable populations include … to drink more liquor than those who were positive, an average of about one drink per day. Beer and wine consumption were not statistically significant. A diagnosis of alcohol use disorder at baseline evaluation was not a significant predictor of being COVID positive or negative.Self-reported current depression or depression in the past only was not a …

Resveratrol and Its Role in the Management of B-Cell Malignancies-A Recent Update.

The growing incidence of B cell malignancies globally has prompted research on the pharmacological properties of phytoconstituents in cancer management. Resveratrol, a polyphenolic stilbenoid widely found in nature, has been explored for its anti-inflammatory and antioxidant properties, and promising results from different pre-clinical studies have indicated its potential for management of B cell malignancies. However, these claims must be substantiated by a greater number of clinical trials in diverse populations, in order to establish its safety and efficacy profile. In addition to this, the

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… Composition | Product | Dose | Indication and Key benefits Resveratrol red wine extract capsules | 21st century resveratrol red wine extract- Dietary supplement | 200 mg red wine complex+ Ascorbic acid (60 mg), Once a day | Reduction of oxidative stress, improvement of immune system functioning, reduction … Despite being prominent consumers of wine, these countries show a greater incidence of B cell malignancies, relative to the rest of the world. …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Weixiong Brand Horse Deer Antler and Western Ginseng Wine | Testudinis Carapax Et Plastrum, Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis, Lycii Frustus, Longan Arillus, Cervi Cornu Pantotrichum, Panacis Quinquefolii Radix | G20220341 Haizao | Foucauld’s Seaweed Oral Liquid | Sargassum, Honey … Radix, Ganoderma, Polygonati Rhizoma, Lycii Frustus, Hippophae Fructus, Fructus Mori | G20110717 Zhangzisong Brand Antler Maidenhair Wine | Cervi Cornu Pantotrichum, Angelicae Sinensis Radix, Lycii Frustus, Ligustri Lucidi Fructus, Crystal sugar, White spirits, Purified water | G20130403 Tongrentang …

(Поли) фенолы и множественный склероз: результаты межсекционного исследования наблюдений.

(Поли) фенолы представляют собой широкий и разнородный класс веществ с рядом потенциальных преимуществ для здоровья. Их роль в нейрозащите и когниции по-прежнему вызывает сомнения. Цель этого исследования заключается в изучении возможной взаимосвязи между общим и индивидуальным (поли)поглощением фенола, основными источниками питания и остротой множественного склероза (МС) в группе пациентов, страдающих НР. Были собраны демографические данные, данные о физической активности участников, данные о курении и рационе питания наряду с клиническими параметрами, включая Расширенный цикл оценки инвалидн

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… Being (poly)phenols contained in plant-derived foods and beverages [ 6 ], their major dietary sources are fruit and vegetables, coffee, tea, cocoa, and its derivatives (i.e., chocolate), red wine, and curcumin [ 7 , 8 ]. … HCAs are one of the most widely diffused (poly)phenols in nature and are present in great amounts in vegetables, fruits, cocoa, wine, tea, and coffee [ 56 ]. …

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have f

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… Resveratrol is present in common foods like red grapes and wine, peanuts, and berries [ 44 ]. … Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation. Nutrition, Metabolism and Cardiovascular Diseases. 2001;11(1):25–29. 95. Bertelli A. A. A., Das D. K. Grapes, wines, resveratrol, and heart health. …

Appraisal of joint tobacco and alcohol tax interventions for harm reduction in the UK: the SYNTAX integrated evidence synthesis project.

BACKGROUND: Alcohol and tobacco are risk factors for non-communicable disease and deaths in England. People using both substances have incre … estimate consumer responses (own-price and cross-price elasticities) for 12 products (beer, cider, wine, spirits and ready-to-drinks, split off-trade/on-trade; cigarettes, roll-your-own tobacco). Work package 4 developed tax modelling for the Sheffield Tobacco and Alcohol Policy Model (v2.1.0) to analyse work package 1 policy options. Later, version v …