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Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation.

Cyanobacteria-derived peptides represent a promising class of anticancer agents due to their structural diversity and potent bioactivity. They exert cytotoxic effects through mechanisms including microtubule disruption, histone deacetylase inhibition, and apoptosis induction. Several peptides-most notably the dolastatin-derived auristatins-have achieved clinical success as cytotoxic payloads in antibody-drug conjugates (ADCs). However, challenges such as limited tumor selectivity, systemic toxicity, and production scalability remain barriers to broader application. Recent advances in targeted

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… Monks N.R., Liu S., Xu Y., Yu H., Bendelow A.S., Moscow J.A. Potent Cytotoxicity of the Phosphatase Inhibitor Microcystin LR and Microcystin Analogues in OATP1B1- and OATP1B3-Expressing HeLa Cells. Mol. Cancer Ther. 2007;6:587–598. doi: 10.1158/1535-7163.MCT-06-0500. 15. …

Abstract

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Ход работы сессии 28th Европейский конгресс педиатрической ремуматологии (ПСР) 2022) Прага, Чешская Республика. 20-23 сентябрь 2022.

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Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers.

BackgroundAging in humans is a heterogeneous process influenced by both biological and chronological factors. Biological age reflects an individual's physiological reserve and functional status. Increasing evidence suggests that cancer and its therapies accelerate biological aging. Many biomarkers have been evaluated to assess the biological age of patients with cancer. These biomarkers are emerging as potential tools to predict cancer-related toxicity and an individual's functional capacity as well as to individualize treatment.MethodsThis review summarizes the current literature on aging bio

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… Introducing the Epigenetic Clock Hypothesis,” Biochemistry (Moscow) 78, no. 9 (2013): 1048–1053. 56. Xiao C., Beitler J. …

Автоматическое отслеживание активного движения в многоразовом склерозе с использованием неконтролируемого машинного обучения

Справочная информация: Выявление активных повреждений в магнитно-резонансной съемке (MRI) имеет решающее значение для диагностики и планирования лечения множественных склерозов (MS). Активные повреждения МРТ выявляются после применения противопоказательных агентов на основе гадолиния (ГБЦА). Однако недавние исследования показали, что неоднократное применение ГБЦН приводит к накоплению ГД в тканях. Кроме того, администрация ГБКА увеличивает расходы на медицинское обслуживание. Таким образом, для повышения безопасности пациентов и снижения расходов на медицинское обслуживание важное значение име

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… Boundary loss for remote sensing imagery semantic segmentation Proceedings of the International Symposium on Neural Networks Moscow, Russia 10–12 July 2019 Springer Berlin, Germany 2019 388 401 44. Falk Delgado A. Van Westen D. Nilsson M. Knutsson L. Sundgren P.C. Larsson E.M. Falk Delgado A. …

Abstracts from the 11th International Conference for Healthcare and Medical Students (ICHAMS) : Virtual. 10-12 February 2022.

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… Oral Session O1: Deprivation and mortality in 0 to 17 years old Russian youth Anastasia Zelenina 1 1 National Medical Research Center for Therapy and Preventive Medicine Russian Federation, Moscow, Russia Background According to numerous studies, the relationship has been established between children's … P32: Prevalence of myocarditis and cardiomyopathies in cardiology in-patient department Denis Ruchkin, Anna Nartova, Anna Zaitseva, Yulia Lutokhina, Olga Blagova First Moscow State Medical University, Russian Federation Correspondence: Denis Ruchkin Introduction The prevalence of myocarditis and …

Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence.

On 4 September 2024, the Reagan-Udall Foundation for the FDA (FDA Foundation) in collaboration with the Food and Drug Administration (FDA) and the Gates Foundation hosted a workshop titled "Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence". The event brought together a diverse group of experts, including international regulatory bodies, regulated industries, healthcare professionals, patients, academic researchers and global health advocates, to discuss the rapid advancements in gene therapy and the pressing need for equitable access in low-and middle-

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… Salgado R., Moore H., Martens J.W.M., Lively T., Malik S., McDermott U., Michiels S., Moscow J.A., Tejpar S., Mckee T., et al. Societal challenges of precision medicine: Bringing order to chaos. Eur. J. Cancer. 2017;84:325–334. doi: 10.1016/j.ejca.2017.07.028. 15. …

Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa.

Cross-income-level collaboration (CILC) is crucial for developing global health approaches that benefit low- and middle-income countries (LMICs). Multiple myeloma (MM) is a representative example of a complex, understudied disease in sub-Saharan Africa (SSA). Based on publications, we developed a network analysis tool to assess scientific collaborations. Here, we present findings from a systematic analysis of publications retrieved from PubMed between January 2002 and June 2022. We evaluated individual institutional contributions and collaboration patterns using undirected weighted networks. O

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… (‘SBHI “CMPDHM”’ is short for ‘State Budgetary Healthcare Institution “Center of Medical Prevention of Department of Health of Moscow”’, ‘IBPTM NA MeSc’ is short for ‘Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences of Ukraine’). …

A rare presentation of langerhans cell histiocytosis tonsil infiltration: review of the literature: atypical presentation of langerhans cell histiocytosis.

MedImmune Vaccines (formerly Aviron) has developed a cold-adapted live influenza virus vaccine [FluMist] that can be administered by nasal s … the 2003-2004 season, FluMist will contain A/New Caledonia/20/99 (H1N1), A/Panama/2007/99 (H3N2) (A/Moscow/10/99-like) and B/Hong Kong/330/2001. Aviron was acquired by MedImmune on 15 January 2002. Aviron is now a wholly-owned subsidiary of MedImmune and is called MedImmune Vaccines. Aviron acquired FluMist in March 1995 through a Co-operative Research a …

Challenges Faced by Clinicians in the Personalized Treatment Planning: A Literature Review and the First Results of the Russian National Cancer Program.

Advances in cancer molecular profiling have enabled the development of more effective approaches to the diagnosis and personalized treatment of tumors. However, treatment planning has become more labor intensive, requiring hours or even days of clinician effort to optimize an individual patient case in a trial-and-error manner. Lessons learned from the world cancer programs provide insights into ways to develop approaches for the treatment strategy definition which can be introduced into clinical practice. This article highlights the variety of breakthroughs in patients' cancer treatment and s

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… Malignant Neoplasms in Russia in 2018 (Incidence and Mortality) Moscow, Russia: PubMed; 2019. 13. Siegel R. L., Miller K. D., Jemal A. Cancer statistics, 2020. CA: A Cancer Journal for Clinicians . 2020;70(1):7–30. doi: 10.3322/caac.21590. 14. Tsimberidou A.-M. Targeted therapy in cancer. …

Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

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The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session.

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… Ekaterina Pristanskova 1 , Elvira Volkova 1 , Oksana Blagonravova 1 , Nataliya Sidorova 1 , Veronika Konstantinova 1 , Elena Machneva 1 , Sergey Piliya 1 , Olga Filina 1 , Julia Nikolaeva 1 , Anastasiya Mezentseva 1 , Raisa Bembeeva 1 , Elena Skorobogatova 1 1 The Russian Children's Research Hospital, Moscow … , Russian Federation , 2 Dmitry Rogachev National Medical Research Center of Pediatric Hematology , Moscow, Russian Federation Background: HSCT for children with multiple sclerosis (MS) proved effectiveness and safety. …

Резюме ЭСП 2013.

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… Blokhin Russian Cancer Res., Dept. of Pathology of Human Tumors, Moscow, Russia Objective: The aim of the study was to investigate Cellular Retinoic Acid Binding protein type I (CRABP I) expression and its clinical significance in pancreatic neuroendocrine tumors (pNETs). …

Ход работы сессии 25th Европейский конгресс педиатрической ремуматологии (ПСР) 2018) Лиссабон, Португалия. 5-8 сентябрь 2018

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Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

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… Sechenov First Moscow State Medical University, Moscow, Russia; Institute for Medical Information Processing, Biometry, and Epidemiology (S Breitner DSc), Ludwig Maximilian University of Munich, Munich, Germany; Institute of Epidemiology (S Breitner DSc), German Research Center for Environmental Health …

37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3) : Brussels, Belgium. 21–24 March 2017

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