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[Etiopathogenetic significance of bone changes in spontaneous gonarthritis in the mouse].

In the C57 Black, STR/IN and MAGf strains of mice, which are prone to develop spontaneous osteo-arthritis of the knee, histomorphological ex … strain almost regularly shows genu varum; no distinct tendency is detectable in MAGf mice. Like the osteophytes, the enlarged menisci with obligatory ossification centres invariably seen in conjunction with osteoarthritis apparently help to compensate for the condylar incongruence caused by the degenerative process, prevent partial dislocations, and hence im …

Coracoacromial ligament division.

The object of this paper is to report on the findings of a retrospective study of 40 patients with 41 shoulders with persistent painful arc … or cuff problems, and lesions of the acromioclavicular joint. Any patients with significantly large osteophytes under the anterior acromion were excluded. Forty patients (41 shoulders) were questioned and examined in followup. There were 29 males and 11 females. The ages ranged from 21 to 72 years (average 43.5 years). In 21 shoulders (51%), there was a hist …

Basic calcium phosphate crystals aggravate senescence-related osteoarthritis through GPX4-NRF2-mediated ferroptosis.

Osteoarthritis (OA) is a degenerative joint disorder strongly associated with senescence, involving pathological processes such as reactive … trated that BCP crystals accelerated cartilage senescence, worsened cartilage degradation, promoted osteophyte formation, and induced ferroptosis in the joint synovium. In vitro, BCP crystals intensified ferroptosis and oxidative stress in rat chondrocytes, increased ROS production, and further promoted mitochondrial dysfunction and chondrocyte senescence. M …

Intra-articular metformin and chlorogenic acid synergistically protect against cartilage degeneration by suppressing NF-κB/NLRP3 inflammasome axis in osteoarthritis.

Osteoarthritis (OA) is a leading cause of disability, driven by cartilage degradation, subchondral bone remodeling, and synovial inflammatio … and hematological and synovial fluid analyses. MIA induced OA manifested by joint space narrowing, osteophyte formation, and cartilage erosion, accompanied by elevated serum CRP, increased synovial IL-1β, IL-6, and TNF-α, and upregulation of NF-κB, NLRP3, caspase-1, GSDMD, IRF-1, and cartilage-degrading enzymes. MET or CGA alone significantly attenuated the …

Biomechanical analysis of ACL, PCL, and/or meniscus transection in Turkey: A potential large OA animal model.

Osteoarthritis (OA) is a progressive disease characterized by cartilage degradation, subchondral bone remodeling, and osteophyte formation, leading to pain and functional decline. Animal models are crucial for studying injury mechanisms, biomechanical changes, and potential OA treatment. The bipedal turkey model shows promise as a valuable large-animal model due to its arthroscopic feasibility and relevance to traumatic knee injury research. However, the underlying kinematic mechanisms remain poorly understood. This study aimed to elucidate these mechanisms through biomechanical analysis of th…

Impact of Lumbar Degenerative Changes on Vertebral Bone Strength: A Finite Element Analysis.

Assessing the bone condition in patients with spinal disease is clinically valuable. However, evaluating bone strength in the presence of sp … e strength predicted by FEA were collected. The degree of degeneration was evaluated by classifying osteophyte formation, disc height narrowing, vertebral sclerosis, and spondylolisthesis into a grading scale ranging from 0 to 2. Multiple linear regression analysis was conducted to assess the effect of each factor on bone strength predicted by FEA. Of 127 pa …

Cadmium exposure and its role in joint disease: A brief review of experimental and population-based evidence.

Cadmium is a toxic metal released into the environment mainly by mining and industrial activities, posing health risks through inhalation an … bone tissue. Cadmium accumulation also disrupts joint homeostasis, promoting cartilage degradation, osteophyte formation, and synovitis. This may result from its interference with essential metals such as Zinc, Iron, Manganese, and Chromium, which are critical for the extracellular matrix. Cadmium has also been linked to rheumatoid arthritis by disrupting im …

Cross-regulation of inflammation and metabolic mechanisms in osteoarthritis: recent advances bridging the gap to novel treatments.

Osteoarthritis (OA) is a debilitating degenerative disease of the joints and one of the most prevalent joint disorders affecting millions of … he endpoint of complex pathologic processes culminating with synovitis, subchondral bone sclerosis, osteophyte formation, aberrant remodeling, and ultimately articular cartilage degradation. There remains a great need for identifying early markers and a "window of opportunity" to enable timely interventions in OA. However, this effort is hampered by the comp …

Evaluation of the healing effect of kappa-carrageenan combined with dental pulp stem cell-derived exosomes on induced knee osteoarthritis in male rats.

BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease that causes pain and reduces quality of life. Exosomes, dental pulp stem cel … somes, Carrageenan, HDPSCs (ECD group) showed the most substantial reduction in Total Radiology and Osteophyte scores (p < 0.0001 and p = 0.0003, respectively). The exosome with HDPSCs group also showed significant improvements (p = 0.0002 and p = 0.0005). Histopathological analysis showed that the ECD group had significantly better cartilage integrity, matr …

Targeted S100A8 PP-Cas9@PLGA-apt microparticles reduced cartilage degradation and subchondral bone isomerism in osteoarthritis treatment through JAK/STAT3 pathway modulation.

Synovial inflammation caused by osteoarthritis (OA) results in the release of numerous pro-inflammatory factors that promote cartilage degra … ced mice, this inhibition reduced pro-inflammatory responses, cartilage degradation, and attenuated osteophyte volume. Our findings first established PP-Cas9-S100A8@PLGA-apt as an efficient and safe Cas9 delivery tool, advancing studies of JAK/STAT3 pathway inhibition and the clinical translation of gene therapy for OA.

Disability in medieval Poulton (Cheshire): A case of hand amputation.

OBJECTIVE: Amputations are rarely identified in the British archaeological record from the Middle Ages, with survival following hand removal … . RESULTS: The left hand was absent, with the distal radius and ulna showing remodelling, marginal osteophyte growth, and a healed amputation surface. No cut marks or skeletal atrophy were observed. Directional asymmetry and robust entheses suggest continued use of the limb post-amputation. Differential diagnoses were excluded on morphological and contextua …

A standardized, open-source, portable model for noninvasive joint injury in mice.

OBJECTIVE: Preclinical models of osteoarthritis (OA) are crucial for the study of disease mechanisms and development of disease-modifying th … cluding progressive hyperalgesia, histological and μCT evidence of cartilage damage, synovitis, and osteophyte formation, and increased expansion of fibroblasts, endothelial cells, and myeloid cells by flow cytometry. CONCLUSIONS: Increased standardization of joint injury is a critical aspect of the overall refinement of animal models of OA. The MoJO repres …

Quantitative meniscus imaging and analysis: A narrative review.

OBJECTIVE: In this review, we summarize the literature on the evolution of magnetic resonance imaging (MRI), segmentation, and quantitative … es of meniscal extrusion were found to be robust predictors of various imaging endpoints, including osteophyte formation, subchondral bone changes, cartilage loss, as well as significant clinical outcomes. CONCLUSIONS: The emergence of quantitative meniscus measurement technology has revamped the field of meniscal imaging research, providing accurate 3D ana …

Диметил Фумарат смягчает синовиальное воспаление, уменьшает нозицепцию и препятствует развитию посттравматического остеоартрита.

В настоящее время не существует лечения посттравматического остеоартрита (ПТОА) или лечения от болезней. Цель этого исследования заключается в оценке эффективности диметилфумарата (ДМФ), который является утвержденным в США лекарством против множественных склерозов в качестве средства лечения ПТОА. PTOA была вызвана крысами-мужчинами из Льюиса медиальной менезальной трансекции (MMT), а DMF был введён в действие один раз, через неделю после операции. Прогресс PTOA оценивался с помощью гистологического, молекулярного и радиографического анализа, в то время как вторичная аллодиния измерялась в про

Совпадение в аннотации оригинала
There is currently no cure or disease-modifying treatment for post-traumatic osteoarthritis (PTOA). This study aims to assess the efficacy o … treatment attenuated cartilage degradation by decreasing cartilage lesions, surface roughness, and osteophyte formation in the proximal tibiae. Histological analysis showed that DMF markedly inhibited cartilage erosion and cartilage surface fibrillation. Gene expression and Luminex analysis indicated that DMF suppressed joint inflammation by inhibiting infl …

Prevalence, Features, and Predictive Factors of Spontaneous Spinal Arthrodesis in Posttraumatic Thoracolumbar Kyphosis.

OBJECTIVE: Spontaneous spinal arthrodesis (SSA) is a phenomenon of spontaneous fusion, and SSA is not rare in posttraumatic thoracolumbar ky … A in PTK was 64%. Among 45 patients with PTK with SSA, SSA was present as a solid bridging anterior osteophyte along the vertebral bodies in 11 patients, posterior contiguous bony growth through the facet joints bilaterally in 13 patients, bony formation in both anterior and posterior elements in 18 patients, and direct contiguous bony formation from the inj …

Exploring Age-Related Variations in Carpal Bone Volume: Implications for Clinical Practice and Anatomical Understanding.

BACKGROUND: Clinically recognizing the changes in carpal bone volumes and understanding their implications in predicting osteoarthritis (OA) … NCLUSION: Trapezial volumes increase with age, potentially due to the presence of OA and consequent osteophyte formation. This pattern is more prevalent among older individuals and women. However, the positive correlation between carpal bone volume and age was consistent across all carpal bones and both genders, regardless of OA presence. These findings sugg …

Rehabilitative outcomes with preparatory suction prostheses following traumatic Gritti-Stokes amputation: A case series.

Gritti-Stokes amputation (GSA) is a knee disarticulation variant, where the femur is transected at the level of the epicondyle and the patel … th socket fit. Participant 1 required socket replacement because of residual limb pain secondary to osteophyte formation, and Participant 2 required component replacement because of weight gain. At definitive prosthesis evaluations, both participants were unlimited community ambulators; both successfully returned to work before provision of their definitive …

Arthroscopic Management of Posterior Ankle Impingement Syndrome - A Case Series.

INTRODUCTION: Posterior ankle impingement is a common cause of chronic ankle pain. Although nonoperative treatment is initially preferred, t … gy varied; one had os trigonum (OT), two had stieda processes (SP), and three had OT with posterior osteophyte complex as part of ankle arthritis. In this paper, we discuss the required clinical approach, preoperative investigations, surgical indications, functional outcomes, and complications of arthroscopic treatment. The patients were followed up for a mi …

Risk factors analysis and predictive model of degree I degenerative lumbar spondylolisthesis.

STUDY DESIGN: Retrospective Case-Control Study. BACKGROUND: There have been some previous studies on the risk factors associated with lumba … (FJA), Modic change (MC), Pfirrmann grade of intervertebral disc (PG), Facet joint effusion (FJE), osteophyte formation, and Percentage of the Fat Infiltration (FIA%) of multifidus muscle (MM). BMI, FJA, PG, and FI% of MM had a significant impact on disease progression in lumbar spondylolisthesis. CONCLUSION: BMI, FJA, PG, and FIA% of MM were independent r …

A case of glenohumeral joint impingement caused by a giant secondary synovial osteochondromatosis.

INTRODUCTION AND IMPORTANCE: Synovial osteochondromatosis of the shoulder joint is predominantly primary, characterized by multiple osteocho … ion. Radiographs and CT scans revealed an osteochondral loose body in the glenohumeral joint and an osteophyte on the anterior margin of the glenoid cavity. A lidocaine test in the glenohumeral joint was positive, suggesting impingement by the loose body, leading to its surgical removal. Arthroscopically, the loose body was grasped and removed from the anter …