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Нацеливание на природные полифенолы антиоксидантов в целях защиты от нейроинфламмации и нейродегенеративных заболеваний: всеобъемлющий обзор.

Полифенолы, природные фитонутриенты, встречающиеся в растительных продуктах питания, привлекли значительное внимание к их потенциальному терапевтическому воздействию в неврологических заболеваниях и нейроинфламмации. Эти соединения обладают различными возможностями нейрозащиты, включая антиоксидантные, антивоспалительные и антиамильоидные свойства, которые способствуют смягчению развития таких нейродегенеративных заболеваний, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), деменция, множественный склероз (MS), Строк и болезнь Хантингтона (HD). Полифенолы были тщательно изучены на предме

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… Polyphenols are inherent substances present in a variety of plant-derived foods, including fruits, vegetables, tea, coffee, and red wine ( Thakur and Kumar, 2024 ). … Resveratrol, an enormous polyphenol in the red wines and grapes, suppressed the expression of Aβ 42 fibril and regulated the Aβ neurotoxicity through suppressing the inhibition of the induceable nitric oxide synthase ( Shah et al., 2024 ). …

Lifestyle factors of smoking, BMI and alcohol on the risk of Non-Melanoma Skin Cancer in adults: a systematic review.

BACKGROUND: Non-melanoma skin cancer is the most common cancer in humans and the most important risk factors are thought to be age, skin typ … carcinoma (1 study). Similar results were found irrespective of the type of alcohol assessed (beer, wine, or spirits) for basal cell carcinoma and cutaneous squamous cell carcinoma. A pooled analysis of five studies found a non-significant decrease in the risk of basal cell carcinoma associated with a higher body mass index (Odds Ratio 0.94, 95% CI 0.8 …

Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

Ferroptosis is distinctive type programmed cell death. Tumor cells, with their higher iron levels, render them more susceptible to ferroptosis Inducing ferroptosis can activate immune cells, regulate immune evasion, and inhibit the biology activity of cancer cells. Therefore, ferroptosis-induced cancer cell death could become a promising approach for cancer treatment. Dietary compounds are an important source for drug discovery, and there has been an increasing amount of literature on food-derived ferroptosis inducers and their applications in cancer treatment. This review provides an overview

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… , tea, beans and tomatoes | liver cancer HepG2, Hep3B and MDA-MB-231; colorectal cancer HCT116 | 50µM for 24h | Induces EB-mediated lysosomal activation, increases ferritin degradation | Wang et al. ( 86 ) Quercetin | apples, asparagus, berries, onions, red wine, tea, beans and tomatoes | AGS, HGC-27 … Quercetin Quercetin (QUE) is found in vegetables and fruits, such as apples, asparagus, berries, onions, and tomatoes, beans, red wine, and tea ( 149 ). Wang et al. reported that QUE increased P53-independent cell death in liver and colorectal cancer cell lines. …

Role of Dietary Antioxidants in p53-Mediated Cancer Chemoprevention and Tumor Suppression.

Cancer arises through a complex interplay between genetic, behavioral, metabolic, and environmental factors that combined trigger cellular changes that over time promote malignancy. In terms of cancer prevention, behavioral interventions such as diet can promote genetic programs that may facilitate tumor suppression; and one of the key tumor suppressors responsible for initiating such programs is p53. The p53 protein is activated by various cellular events such as DNA damage, hypoxia, heat shock, and overexpression of oncogenes. Due to its role in cell fate decisions after DNA damage, regulato

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… Another study investigated the effect of red wine on anticancer and chemopreventive properties. Polyphenol-rich red wine extracted from grapes could increase the active phosphorylated p53 in human lung cancer cells [ 182 ]. 6.5. … Polyphenols found in fruits, vegetables, herbs, wine, and teas are safe for consumption. Thus, dietary polyphenols offer multitargeted therapeutic effects than a single drug. …

Final report of the safety assessment of Urea.

Although Urea is officially described as a buffering agent, humectant, and skin-conditioning agent-humectant for use in cosmetic products, t … free fats or oil, and dry solids with the surface of fat or oil; and to facilitate fermentation of wine. Urea is the end product of mammalian protein metabolism and the chief nitrogenous compound of urine. Urea concentrations in muscle, liver, and fetuses of rats increased after a subcutaneous injection of Urea. Urea diffused readily through the place …

Полифенолы и нейродегенеративные заболевания: понимание знаний, механистические свидетельства и новые виды применения в области питания.

Полифенолы представляют собой разнообразную группу биоактивных веществ растительного происхождения, которые были исследованы в качестве многоцелевых возможностей для потенциальной профилактики и лечения нейродегенеративных заболеваний (НДИ). Мы провели комплексный библиометрический и механистический обзор, охватывающий 12 классов полифенола и семь основных НИЗ, с использованием записей из PubMed, Embase, Cochrane Bibrary и Web of Science (1940-2024). Для картирования исследовательских ландшафтов и новых тем использовались ключевые слова, анализы по группам и модели BERTopic. Механистические до

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… Found abundantly in fruits, vegetables, tea, and wine, polyphenols are recognized for their potent antioxidant, anti-inflammatory, and neuro-modulatory properties [ 4 , 5 , 6 ]. … ClinicalTrials.gov Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health. [(accessed on 14 February 2025)];2022 Available online: https://clinicaltrials.gov/ct2/show/NCT05541887 . 59. …

Физическая активность в период отдыха, воздействие солнца и риск множественных склерозов: тематическое исследование по вопросам контроля за населением.

Физическая активность способствует возникновению симптомов и функций у людей с множественным склерозом (MS), однако ее актуальность для MS-чувствительности остается неопределенной и может быть трудно отделить от корреляционного образа жизни и экологических факторов, включая воздействие на солнце. МЕТОДЫ: В рамках данного исследования по вопросам контроля за положением населения в Швеции было проведено, в частности, следующее: 3,008 случаи ДБ и 5773 Совпадающие с контрольными. Анализы проводились только для участников, у которых в рамках системы контроля был установлен соответствующий базисный

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… Alcohol use was reported as weekly intake of beer, wine, strong wine, and liquor, and converted to grams/week. Body mass index (BMI) at age 20 years. …

Вытяжка из листа EGb 761* в качестве образца продукта по концепции процесса.

Часто недооценивается тот факт, что экстракты, получаемые с одного и того же растения, могут существенно различаться по их фитохимическому составу, а также по их фармакокинетическим и фармакодинамическим свойствам, которые лежат в основе их клинической эффективности и безопасности. Специальная экстрактная EGb 761- Это... one из наиболее изученных выдержек растений в мире. В настоящем обзоре, используя этот экстракт в качестве парадигмы, мы рассказываем о том, как климат, район сбора урожая, обработка растительного материала, процесс сушки, экстракционные растворители и детали последующих этапо

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… This blending process for constant quality can be regarded analogous to wine blends referred as cuvée. The blend of G. biloba leaves is extracted by 60% (m/m) aqueous acetone. … What is commonplace to the vintner, applies even more to the science of phytopharmacology: All beverages sold under the label “wine” should fulfil a modicum of characteristics regarding its manufacturing–which is analogous to the European pharmacopoeia regulations for Ginkgo extract–but not all wines …

Recommendations for the management of the haematological and onco-haematological aspects of Gaucher disease.

Current knowledge of the haematological and onco-haematological complications of type 1 Gaucher disease has been reviewed with the aim of identifying best clinical practice for treatment and disease management. It was concluded that: (i) Awareness of typical patterns of cytopenia can help clinicians distinguish haematological co-morbidities. (ii) Red blood cell studies and complete iron metabolism evaluation at baseline are recommended. (iii) Haemoglobin levels defining anaemia should be raised and used in Gaucher disease treatment and monitoring. (iv) Surgeons should be aware of potential ble

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… In a retrospective study of paediatric type 1 Gaucher patients, 21 of 23 children (average age: 8·5 years) already had hypergammaglobulinaemia (single or predominantly, multiple immunoglobulin isotypes) ( Wine et al , 2007 ). … Again greater improvement was noted in IgA and IgM levels ( Wine et al , 2007 ). There are no consistent data on the effects of higher enzyme doses on MGUS and potential B-cell malignancies. …

Alcohol consumption, drinking patterns and cancer incidence in an Australian cohort of 226,162 participants aged 45 years and over.

BackgroundAlthough overall alcohol consumption is known to increase the risk of a number of cancers internationally, evidence for Australia and evidence regarding the pattern of drinking and cancer risk is limited.MethodsAdjusted hazard ratios (HR) and 95% confidence intervals (CI) for cancer risk in relation to overall alcohol consumption (drinks/week) and pattern of drinking were calculated using Cox proportional hazard regressions for 226,162 participants aged ≥45 years (2006-2009) in the 45 and Up Study, an Australian prospective cohort study. Incident primary cancer cases were ascertained

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… One drink = a glass of wine, middy of beer or nip of spirits (put ‘0' if you do not drink, or have less than one drink each week)' and, ‘On how many days each week do you usually drink alcohol?'. Participants reported their response as an integer. … A comparison of gender-linked population cancer risks between alcohol and tobacco: how many cigarettes are there in a bottle of wine? BMC Public Health. 2019;19:316. doi: 10.1186/s12889-019-6576-9. 59. Millwood IY, Walters RG, Mei XW, Guo Y, Yang L, Bian Z, et al. …

Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis.

The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a

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… , corn, sorghum, oats, and buckwheat, among others., are rich sources of essential nutrients such as proteins, fats, minerals, vitamins, and fibers. [ 44 ] Figure 4 A diet rich in whole grains, fruits, vegetables, spices, and soy products can Reduce the risk of many types of cancer while red meat, wine … Anthocyanins, flavonoids, and resveratrol are abundant in grape skins, seeds, and red wine, which are considered to have strong antioxidant, anticancer, and anti‐inflammatory properties. [ 56 ] Several reviews and meta‐analyses of observational studies show that dietary flavonoids (total or individual …

Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis.

Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients' quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients' health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of

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… These recommendations constitute the basis of the Mediterranean diet (MD), which is characterized by plenty of cereals, fruits and vegetables, legumes, fish, nuts, and olive oil and a lower frequency of dairy food, red meat, and wine consumption. … Biomolecules | Foods | References resveratrol | grapes, red wine, peanuts, berries | [ 59 , 61 , 62 , 63 , 64 , 65 , 66 , 103 ] s-allylcysteine (SAC) s-allylmercaptocysteine (SAMC) | broccoli, Brussels sprouts, cauliflowers | [ 67 ] diallyl disulfide (DADS) | garlic | [ 68 , 69 ] (-)-oleocanthal | extra …

Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy.

Despite the advances in biomedical research and clinical applications, cancer remains a leading cause of death worldwide. Given the limitations of conventional chemotherapeutics, including serious toxicities and reduced quality of life for patients, the development of safe and efficacious alternatives with known mechanism of action is much needed. Prevention of cancer through dietary intervention may hold promise and has been investigated extensively in the recent years. AMP-activated protein kinase (AMPK) is an energy sensor that plays a key role in the regulation of protein and lipid metabol

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… Resveratrol Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a type of natural phenol that is present in grapes and a key antioxidant ingredient in red wine. The consumption of red wine has been correlated with the reduction of mortality rates from cardiovascular diseases and certain cancers. … Flavonoids and related compounds Flavonoids can be found in many different sources, including soy, berries, tea, wine, beer, chocolate, many vegetables, and most fruits. …

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach.

A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various physiological conditions are difficult to diagnose, the success rate of BT is not very high. This is the central issue faced during drug development and clinical trials with almost all types of neurodegenerative disorders. In the first part of this review, we focus on the concept of brain tumors, their barriers, and the types of delivery possible to target the b

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… The concentration of RES in various wines was examined the same year [ 5 ]. A 2001 study discovered a link between moderate-to-low wine consumption and a decreased risk of mortality from cardiovascular and cerebrovascular disorders. … RES—A General Concept and a Basic Outline RES is a plant-derived polyphenol found in berries, grapes, nuts, and red wine [ 1 ]. RES crosses the BBB, which may have an impact on the nervous system [ 41 ]. …

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects.

Resveratrol (RES), a naturally occurring polyphenolic compound, has garnered significant attention due to its diverse biological activities, which include anti-inflammatory, antioxidant, and antiaging properties. This review synthesizes current evidence concerning the molecular mechanisms, therapeutic efficacy, and safety profile of RES across a variety of pathologies, with an emphasis on the latest research conducted in recent years. Mechanistically, RES is known to modulate critical signaling pathways such as the activation of sirtuin 1. These actions collectively contribute to the attenuati

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… This paradox highlights the unusually low incidence of cardiovascular mortality in the French population, despite a diet rich in saturated fats, potentially attributed to their significant red wine consumption [ 6 ]. … Among these, grape‐derived products, particularly red wine, are the primary dietary contributors to RES intake [ 7 ]. …

Метод газовой хроматографии для количественного определения остаточных растворителей в наноформуляциях.

Описано разработку и проверку метода газовой хроматографии, который является чувствительным, быстрым и специфичным для оценки 19 распространенных растворителей класса 2 и класса 3, часто используемых в формулировке наномедицины. Проверка метода проводилась с использованием системы газовой хроматографии PerkinElmer с детектированием искровой ионизации и колонки Elite 624 Crossbond 6% цианопропилфенил-94% диметилполисилоксана или DB-Fatwax-Ultra Inert с гелием в качестве носителя. Оценены характеристики валидации, такие как линейность, восстановление при добавлении, точность метода, специфичност

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… Simultaneous analysis of organic acids, glycerol and phenolic acids in wines using gas chromatography-mass spectrometry. Foods. 2024;13:186. doi: 10.3390/foods13020186. 39. Zeppa G., Conterno L., Gerbi V. … Determination of free fatty acids and their ethyl esters in musts and wines. J. Chromatogr. A. 1997;776:283–291. doi: 10.1016/S0021-9673(97)00383-X. 41. Eberhart B.L., 2nd, Wilson A.S., O’Keefe S.J.D., Ramaboli M.C., Nesengani L.T. …

Питание пациентов с множественным склерозом, корреляция с качеством жизни и инвалидность - перспективное и квази-экспериментальное исследование.

Множественный склероз (MS) является многофакторным заболеванием, при этом питание и образ жизни играют важную роль в его развитии. Средиземноморское питание считается особенно полезным для пациентов с инфекциями. Цель настоящего исследования заключалась в изучении взаимосвязи между рационом питания и СУ, а также в оценке воздействия средиземноморского рациона питания на качество жизни и уровень инвалидности пациентов. Шестимесячное исследование охватывало 130 пациентов, которые были разделены на группу контроля и вмешательства. Инструменты сбора данных использовались для сбора данных о демогра

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… Its basic components include olive oil, olives, whole grains, wine, vegetables, fruits, fish, and seafood, which have contributed to the amalgamation of a rich and healthy cuisine. Hippocrates recognized the importance of the diet for physical and mental health. … Avoid excessive alcohol (a glass of wine is considered good) and soft drinks. Consume lots of fresh, seasonal fruits and vegetables. Consume fewer legumes and more oily fish. Consume unsalted nuts. Consume wholegrain cereals/pasta, potatoes, brown rice, multigrain bread. …

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy.

Background: Cancer has become a major disease endangering human health around the world. Conventional chemotherapy suffers from many side effects including pain, cardiotoxicity, hepatotoxicity, and renal toxicity. This review aims to describe a natural product of resveratrol as a chemoprotective and synergistic agent in the modulation of cancer chemotherapy. Methods: The publications were identified by comprehensive searching of SciFinder, PubMed, Web of Science, and our own reference library. Search terms included combinations of "resveratrol," "cancer," "natural products," "chemotherapy," an

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… Resveratrol (RES, 3,5,4′-trihydroxy- trans -stilbene) is a naturally occurring polyphenol presented in lots of dietary substances, such as grapes, wine, nuts, berries and many other human foods (Figure 1 ) ( Berman et al., 2017 ). … It is reported that the total content of RES is around 50–100 μg/g in fresh grape skin, 5.1 μg/g in boiled peanuts, 0.31 μg/g in peanut buffer and 0.98–1.80 mg/L in red wine ( Burns et al., 2002 ; Cal et al., 2003 ). …

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways.

Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or dietary supplements. A group of polyphenols that include apigenin, quercetin, curcumin, resveratrol, EGCG, and kaempferol have been shown to regulate signaling pathways that are central for cancer development, progression, and metastasis. Here, we describe novel mechanistic insights on the effect of this group of polyphenols on key elements of the signaling

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… More than 800 polyphenols have been identified in food sources, including cereals, cocoa, coffee, tea, wine, and berries ( Pérez-Jiménez et al., 2010 ). … Flavan-3-ols are found either in free form or as gallic acid esters in different food sources such as apples, black tea, green tea, dark chocolate, and red wine ( Rothwell et al., 2013 ). …

The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms.

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The in

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… The term polyphenol was first given to natural compounds bearing multiple (poly) phenol rings, which are widespread in various fruits, vegetables, wine, nuts, tea, coffee, and in many foods that are consumed daily by humans [ 7 ]. … Resveratrol Resveratrol (3,4′,5-trihydroxy-trans-stilbene), the main polyphenol in grapes and peanuts, exists in red wine at a concentration of about 0.1–1.8 g per 100 mL. …