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OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.

Stem-like T cells selectively contribute to autoimmunity, but the activities that promote their pathogenicity are incompletely understood. Here, we identify the transcription coregulator OCA-B as a driver of the pathogenic maturation of stem-like CD4+ T cells to promote autoimmune demyelination. Using 2 human multiple sclerosis (MS) datasets, we show that POU2AF1, the gene encoding OCA-B, is elevated in CD4+ T cells from patients with MS. We show that T cell-intrinsic OCA-B loss protects mice from experimental autoimmune encephalomyelitis (EAE) while preserving responses to viral CNS infection…

Резюме, представленные на 32nd Ежегодная конференция Международного общества по изучению качества жизни.

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Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

Mechanistic considerations for the use of monoclonal antibodies for cancer therapy.

Since the approval of rituximab in 1997, monoclonal antibodies (mAbs) have become an increasingly important component of therapeutic regimens in oncology. The success of mAbs as a therapeutic class is a result of great strides that have been made in molecular biology and in biotechnology over the past several decades. Currently, there are 14 approved mAb products for oncology indications, and there are ten additional mAbs in late stages of clinical trials. Compared to traditional chemotherapeutic agents, mAbs have several advantages, including a long circulating half-life and high target speci

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… Alemtuzumab was withdrawn from the market in 2012, but its sponsors are seeking to rebrand it as a treatment for multiple sclerosis. …

Повторное регулирование веса после трансплантации печени с использованием глюкагонового пептида one агонисты желудочно-кишечного ингибитора полипептида.

Ожирение является сложным осложнением, с которым сталкиваются многие реципиенты, реципиенты трансплантации печени. Пересадка печени является единственной жизненно важной процедурой во многих конечных болезнях печени, однако лежащая в ее основе патология, помимо некоторых иммунодепрессивных режимов, может ухудшить метаболическое состояние многих пациентов. Для получения благоприятного прогноза и улучшения качества жизни необходим комплексный план управления, направленный на предотвращение дальнейших осложнений, связанных с метаболической дисфункцией, ситуативной болезнью печени, хронической дис

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… Their use to mitigate the consequences associated with post-transplant multiple sclerosis (MS) such as PTDM, cardiovascular and renal complication in addition to recurrent liver pathologies and increased mortality is supported by growing clinical evidence though still the data about the use of GLP-1 …

Clinical Associations with Hospital Escalation Among COVID-19 Patients Receiving Remdesivir in a Hospital-at-Home Service: A Real-World Cohort Study.

Background/Objectives: Hospital-at-home (HaH) programs expanded hospital capacity during the COVID-19 pandemic, but data on which HaH patients receiving intravenous (IV) remdesivir may require hospital escalation is limited. We therefore aimed to explore clinical characteristics associated with escalation to inpatient care. Methods: Single-center, retrospective cohort of adults with confirmed COVID-19 who received IV remdesivir via a HaH service was employed (September 2020-September 2024). Primary outcome was hospital escalation. Associations between baseline variables and escalation were ass

Множественные склерозы и припадки: клинические, диагностические и терапевтические корреляции.

ВВЕДЕНИЕ: Изъятия происходят чаще среди лиц с множественным склерозом (ПМС), чем среди населения в целом. В настоящее время не проводится никаких исследований, в которых соотносятся клинические, диагностические и терапевтические результаты ПМС и изъятия. Определяем распространенность припадков (припадков) у людей с синдромом MS/Clinical Insidential (CIS) и характеризуем популяцию PCMS/CIS и припадки (припадки). Мы использовали регистр MS в Южном Уэльсе для идентификации всех людей, имеющих MS/CIS и всю историю припадков, проживающих в Кардиффе и Вале. Из электронных записей были получены ретро

Совпадение в аннотации оригинала
INTRODUCTION: Seizures occur more commonly in people with multiple sclerosis (pwMS) than in the general population. Existing studies correlating clinical, diagnostic and therapeutic outcomes for pwMS and seizures are lacking. We determine the prevalence of seizure(s) in people with MS/clinically isolated syndrome (CIS) and characterize a population-based coh…

Вирус Эпштейн-Барр и иммунная микроокружающая среда в множестве склерозов: Отличения от высокомерной съемки тканей мозга.

Вирус Эпштейн-Барр (ЭБВ) во многом связан с патогенезом множественного склероза (МС), однако его точная роль в прогрессии заболеваний остается неясной. С использованием высокомерной системы обнаружения СО путем индексации, технологии пространственной съемки, в настоящем исследовании изучается клеточная микроокружающая среда поражения MS в вторичных прогрессивных MS и первичных прогрессивных MS. Мы проанализировали взаимодействие иммунной, глиальной, нейрональной и эндотелиальной клеток в MS-повреждениях и обычно встречающейся белой материи в двух независимых группах. Наши результаты свидетельс

Совпадение в аннотации оригинала
Epstein-Barr virus (EBV) is strongly implicated in the pathogenesis of multiple sclerosis (MS), yet its exact role in disease progression remains unclear. Using high-dimensional CO-detection by indexing, a technology for spatial imaging, this study examines the cellular microenvironment of MS lesions in secondary progressive MS and primary progressive MS. We…

Current status of immunisation for herpes zoster.

Herpes zoster (HZ) is increasingly common in the aging and is experienced by approximately one in three people in their lifetime. It is also relatively common in immune-compromised people. Acute HZ causes severe pain, reduced quality of life and severe complications, including prolonged pain, or postherpetic neuralgia (PHN), and ocular zoster, which may rarely progress to blindness. In severely immune-compromised people disseminated zoster may affect the brain and liver. A second-generation vaccine, the Recombinant Zoster Vaccine, consisting of recombinant viral glycoprotein E and the Adjuvant

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… HZ complications are increased threefold and include PHN. 12 Patients being treated for autoimmune diseases with immunosuppressive drugs and biologicals including disease modifying antirheumatic drugs (DMARDs, e.g., for rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis) are moderately …

Medication-related Osteonecrosis of the Jaw: A Review.

Medication-related osteonecrosis of the jaw (MRONJ) is a rare, severe debilitating condition from unknown causes. It is characterized by nonhealing exposed bone in a patient with a history of antiresorptive or antiangiogenic agents in the absence of radiation exposure to the head and neck region. The first case of MRONJ was reported in the early 2000s. Diagnostic criteria for MRONJ was developed by the American Association of Oral and Maxillofacial Surgeons (AAOMS) based on pharmacological history as well as clinical and radiographic features. Antiresorptive medications such as bisphosphonate

Association of Epistatic Effects of lncRNA GAS5, miR-146a, IRAK-1, and miR-155 Genetic Variants with Multiple Sclerosis Risk and Severity.

The complex genetic architecture of heritability in multiple sclerosis (MS) remains undisclosed mainly. Epistasis (gene-gene interaction) substantially impacts MS; however, it is largely unexplored, especially among the non-coding RNA genes and their targets. The long non-coding RNA GAS5 exacerbates demyelination and sponges miR-146a and miR-155, impeccable contributors to MS pathogenesis. miR-146a negatively regulates the immune responses by targeting IRAK-1. We investigated the association of epistatic effects and haplotypes of five single nucleotide polymorphisms (SNPs), GAS5 rs2067079, miR…

Burning Issues/Hot Topics: The Charcot Foot.

Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This art

The utility of stereotactic biopsy of intracranial lesions in the diagnosis of leukemia complicated by central nervous system lesions.

BACKGROUND: Leukemia complicated by central nervous system (CNS) lesions (LCNSL) includes leukemia involving the CNS (CNSL) and CNS secondary lesions related to leukemia treatment (e.g., CNS infections, leukoencephalopathy, inflammatory demyelination, and vascular diseases). The clinical manifestations and imaging characteristics of different types of LCL are similar, increasing the possibility of misdiagnosis. This study aimed to enhance our understanding and management of LCL. METHODS: We retrospectively collected clinical data from 22 patients with LCL and analyzed their magnetic resonance

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… Misdiagnosis rates of CNSL can be as high as 75%; CNSL is often misdiagnosed as intracranial hemorrhage, cerebral infarction, meningitis, infection, demyelination, multiple sclerosis, spinal cord compression, or Bálint syndrome [ 7 , 8 ]. …

Clinical Presentation, Renal Histopathological Findings, and Outcome in Patients with Monoclonal Gammopathy and Kidney Disease.

Monoclonal gammopathies are associated with acute and chronic kidney injury. Nephrotoxicity of the secreted monoclonal (M)-protein is related to its biological properties and blood concentration. Little is known about epidemiology, clinical manifestations, and outcome of monoclonal gammopathies in patients with kidney disease. We retrospectively collected data about demographics, clinical manifestations, and renal histological lesions of all patients (n = 1334) who underwent kidney biopsy between January 2000 and March 2017. Monoclonal gammopathy was detected in 174 (13%) patients with a mean

Травматический стресс затронул людей с множественным склерозом во время пандемии SARS-COV-2.

Фон/цели: Травма представляет собой психологическое повреждение в результате тревожного или подавляющего события. Пандемия SARS-COV-2 была разрушительной и травмирующей для многих людей с множественным склерозом (pwMS). Взаимосвязь между характеристиками пациентов и травмами, полученными в ходе пандемии, еще не была тщательно изучена. Цель этого бицентрического перспективного когортного исследования состояла в том, чтобы проанализировать распространенность и развитие вероятного посттравматического стрессового расстройства (ПТСР) среди ПТСР во время пандемии SARS-COV-2 и определить параметры па

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Background/Objectives: Trauma is a psychological injury resulting from a distressing or overwhelming event. The SARS-CoV-2 pandemic has been disruptive and traumatic for many people with multiple sclerosis (pwMS). The relationship between patient characteristics and trauma in pwMS during the pandemic has not yet been thoroughly explored. The aim of this bice…

Autophagic mechanisms in longevity intervention: role of natural active compounds.

The term 'autophagy' literally translates to 'self-eating' and alterations to autophagy have been identified as one of the several molecular changes that occur with aging in a variety of species. Autophagy and aging, have a complicated and multifaceted relationship that has recently come to light thanks to breakthroughs in our understanding of the various substrates of autophagy on tissue homoeostasis. Several studies have been conducted to reveal the relationship between autophagy and age-related diseases. The present review looks at a few new aspects of autophagy and speculates on how they m

Гут микробиота и ее влияние на ось Гут-Брэйна в сравнении с пациентами, страдающими химиотерапией, и данными о безраковых методах контроля в вычислительной перспективе рака груди.

Рак груди (БК) по-прежнему является одной из основных причин связанных с раком заболеваний и смертности среди женщин во всем мире. Традиционное лечение включает хирургию, радиацию, гормональную терапию и химиотерапию, но эти методы часто сталкиваются с трудностями из - за изменчивости реакции пациента и неблагоприятных последствий. В рамках этого исследования изучалась взаимосвязь между разнообразием кишечного микробиома, составом общины и анализом путей развития у женщин, проходящих химиотерапию в Британской Колумбии (Время лечения - DT), по сравнению с мерами по борьбе с раком (КФК). Использ

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Breast cancer (BC) continues to be a major cause of cancer-related illness and death among women worldwide. Traditional treatments include s … ions such as autism spectrum disorder, Clostridium difficile infection, chronic kidney disease, and multiple sclerosis. Key KEGG pathways enriched in DT and CFC groups included the two-component system, tyrosine metabolism, and the pentose phosphate pathway. Conversely, dysbiosis or the presence of pathogenic bacteria (Ruminococcus) associated with the SOX8 gene cou …

Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients.

Patients with hematological malignancies undergo intensive treatment and prolonged hospitalization, thus having a variety of physical and psychosocial symptoms and worse quality of life (QOL). This study aimed to assess the QOL and investigate the symptoms of hospitalized hematological cancer patients. A cross-sectional study was conducted in the hematology clinics and day units of two general hospitals of Heraklion, Crete. Adult patients with hematological malignancy and an adequate understanding of the Greek language participated. A demographic questionnaire, the European Organization for Re

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… Altogether, the QOL of patients with hematological malignancy was significantly worse in comparison with the general population ( p < 0.001) but similar when compared with solid tumors and other chronic disabling diseases and lower than that due to multiple sclerosis ( p = 0.032) [ 20 ]. …

Antibodies to watch in 2021.

In this 12th annual installment of the Antibodies to Watch article series, we discuss key events in antibody therapeutics development that occurred in 2020 and forecast events that might occur in 2021. The coronavirus disease 2019 (COVID-19) pandemic posed an array of challenges and opportunities to the healthcare system in 2020, and it will continue to do so in 2021. Remarkably, by late November 2020, two anti-SARS-CoV antibody products, bamlanivimab and the casirivimab and imdevimab cocktail, were authorized for emergency use by the US Food and Drug Administration (FDA) and the repurposed an

Advances in Drug Delivery and Biomaterials: Facts and Vision.

Drug delivery and biomaterials are different fields of science but, at the same time, are tightly related and intertwined. The 2018 CRS Italy Chapter Annual Workshop aims to explore recent advances in design and development in these areas. Many colleagues from Europe participated to the Workshop, stimulating the discussion. To foster the discussion on recent research and networking opportunities, especially among younger attendees, all poster-presenting authors were asked to provide a short talk. The very friendly and stimulating atmosphere allowed the attendees to explore new frontiers and ta

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… In this regard, in the present investigation, solid lipid nanoparticles (SLN) have been considered as tools to treat neurological disorders, such as multiple sclerosis and post-traumatic stress. … Indeed, DMF is useful in relapsing remitting multiple sclerosis treatment, while CD can treat post-traumatic stress, anxiety, depression and neurodegenerative disorders such as multiple sclerosis. …